Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | 1,2-dimethylhydrazine | multiple interactions | EXP | | 6480464 | [1 and 2-Dimethylhydrazine co-treated with Folic Acid] results in decreased expression of PPFIA3 mRNA | CTD | PMID:22206623 | 1,2-dimethylhydrazine | decreases expression | EXP | | 6480464 | 1 and 2-Dimethylhydrazine results in decreased expression of PPFIA3 mRNA | CTD | PMID:22206623 | 17beta-estradiol | multiple interactions | ISO | PPFIA3 (Homo sapiens) | 6480464 | [Estradiol co-treated with TGFB1 protein] results in increased expression of PPFIA3 mRNA | CTD | PMID:30165855 | 17beta-hydroxy-5alpha-androstan-3-one | increases expression | ISO | PPFIA3 (Homo sapiens) | 6480464 | Dihydrotestosterone results in increased expression of PPFIA3 mRNA | CTD | PMID:29581250 | 2,2',4,4',5,5'-hexachlorobiphenyl | multiple interactions | EXP | | 6480464 | [2 more ... | CTD | PMID:25510870 | 2,2',4,4'-Tetrabromodiphenyl ether | decreases expression | ISO | Ppfia3 (Rattus norvegicus) | 6480464 | 2 more ... | CTD | PMID:21394737 | 2,2',5,5'-tetrachlorobiphenyl | multiple interactions | EXP | | 6480464 | [2 more ... | CTD | PMID:25510870 | 2,3',4,4',5-Pentachlorobiphenyl | decreases expression | EXP | | 6480464 | 2 more ... | CTD | PMID:31388691 | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in increased expression of PPFIA3 mRNA | CTD | PMID:15034205 | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | ISO | Ppfia3 (Rattus norvegicus) | 6480464 | Tetrachlorodibenzodioxin results in increased expression of PPFIA3 mRNA | CTD | PMID:32109520 and PMID:33387578 | 4,4'-sulfonyldiphenol | affects methylation | EXP | | 6480464 | bisphenol S affects the methylation of PPFIA3 exon and bisphenol S affects the methylation of PPFIA3 gene | CTD | PMID:31683443 and PMID:33297965 | 4,4'-sulfonyldiphenol | multiple interactions | ISO | Ppfia3 (Rattus norvegicus) | 6480464 | [bisphenol A co-treated with bisphenol F co-treated with bisphenol S] results in decreased expression of PPFIA3 mRNA | CTD | PMID:36041667 | Aflatoxin B2 alpha | increases methylation | ISO | PPFIA3 (Homo sapiens) | 6480464 | aflatoxin B2 results in increased methylation of PPFIA3 intron | CTD | PMID:30157460 | all-trans-retinoic acid | multiple interactions | EXP | | 6480464 | [mono-(2-ethylhexyl)phthalate co-treated with Tretinoin] results in decreased expression of PPFIA3 mRNA | CTD | PMID:36189433 | ammonium chloride | affects expression | ISO | Ppfia3 (Rattus norvegicus) | 6480464 | Ammonium Chloride affects the expression of PPFIA3 mRNA | CTD | PMID:16483693 | arsane | affects methylation | ISO | PPFIA3 (Homo sapiens) | 6480464 | Arsenic affects the methylation of PPFIA3 gene | CTD | PMID:25304211 | arsenic atom | affects methylation | ISO | PPFIA3 (Homo sapiens) | 6480464 | Arsenic affects the methylation of PPFIA3 gene | CTD | PMID:25304211 | atrazine | increases expression | ISO | PPFIA3 (Homo sapiens) | 6480464 | Atrazine results in increased expression of PPFIA3 mRNA | CTD | PMID:22378314 | atrazine | decreases expression | ISO | Ppfia3 (Rattus norvegicus) | 6480464 | Atrazine results in decreased expression of PPFIA3 mRNA | CTD | PMID:36841081 | benzo[a]pyrene | decreases expression | EXP | | 6480464 | Benzo(a)pyrene results in decreased expression of PPFIA3 mRNA | CTD | PMID:15034205 | benzo[a]pyrene | affects methylation | ISO | PPFIA3 (Homo sapiens) | 6480464 | Benzo(a)pyrene affects the methylation of PPFIA3 5' UTR and Benzo(a)pyrene affects the methylation of PPFIA3 intron | CTD | PMID:27901495 and PMID:30157460 | benzo[a]pyrene | increases methylation | ISO | PPFIA3 (Homo sapiens) | 6480464 | Benzo(a)pyrene results in increased methylation of PPFIA3 3' UTR and Benzo(a)pyrene results in increased methylation of PPFIA3 promoter | CTD | PMID:27901495 | bis(2-ethylhexyl) phthalate | multiple interactions | EXP | | 6480464 | Diethylhexyl Phthalate inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in increased expression of PPFIA3 mRNA] | CTD | PMID:33484791 | bisphenol A | multiple interactions | ISO | Ppfia3 (Rattus norvegicus) | 6480464 | [bisphenol A co-treated with bisphenol F co-treated with bisphenol S] results in decreased expression of PPFIA3 mRNA | CTD | PMID:36041667 | bisphenol F | multiple interactions | ISO | Ppfia3 (Rattus norvegicus) | 6480464 | [bisphenol A co-treated with bisphenol F co-treated with bisphenol S] results in decreased expression of PPFIA3 mRNA | CTD | PMID:36041667 | caffeine | affects phosphorylation | ISO | PPFIA3 (Homo sapiens) | 6480464 | Caffeine affects the phosphorylation of PPFIA3 protein | CTD | PMID:35688186 | carbon nanotube | decreases expression | EXP | | 6480464 | Nanotubes more ... | CTD | PMID:25554681 | CGP 52608 | multiple interactions | ISO | PPFIA3 (Homo sapiens) | 6480464 | CGP 52608 promotes the reaction [RORA protein binds to PPFIA3 gene] | CTD | PMID:28238834 | chrysene | increases expression | EXP | | 6480464 | chrysene results in increased expression of PPFIA3 mRNA | CTD | PMID:26377693 | cocaine | increases expression | ISO | PPFIA3 (Homo sapiens) | 6480464 | Cocaine results in increased expression of PPFIA3 protein | CTD | PMID:17075605 | crocidolite asbestos | increases expression | EXP | | 6480464 | Asbestos and Crocidolite results in increased expression of PPFIA3 mRNA | CTD | PMID:29279043 | diazinon | increases methylation | ISO | PPFIA3 (Homo sapiens) | 6480464 | Diazinon results in increased methylation of PPFIA3 gene | CTD | PMID:22964155 | dicrotophos | increases expression | ISO | PPFIA3 (Homo sapiens) | 6480464 | dicrotophos results in increased expression of PPFIA3 mRNA | CTD | PMID:28302478 | diquat | decreases expression | EXP | | 6480464 | Diquat results in decreased expression of PPFIA3 protein | CTD | PMID:36851058 | dorsomorphin | multiple interactions | ISO | PPFIA3 (Homo sapiens) | 6480464 | [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PPFIA3 mRNA | CTD | PMID:27188386 | ethanol | affects splicing | EXP | | 6480464 | Ethanol affects the splicing of PPFIA3 mRNA | CTD | PMID:30319688 | ethanol | increases expression | EXP | | 6480464 | Ethanol results in increased expression of PPFIA3 mRNA | CTD | PMID:30319688 | folic acid | multiple interactions | EXP | | 6480464 | [1 and 2-Dimethylhydrazine co-treated with Folic Acid] results in decreased expression of PPFIA3 mRNA | CTD | PMID:22206623 | FR900359 | affects phosphorylation | ISO | PPFIA3 (Homo sapiens) | 6480464 | FR900359 affects the phosphorylation of PPFIA3 protein | CTD | PMID:37730182 | gentamycin | increases expression | ISO | Ppfia3 (Rattus norvegicus) | 6480464 | Gentamicins results in increased expression of PPFIA3 mRNA | CTD | PMID:33387578 | maneb | multiple interactions | EXP | | 6480464 | [Maneb co-treated with Paraquat] results in decreased expression of PPFIA3 mRNA and [Maneb co-treated with Paraquat] results in increased expression of PPFIA3 mRNA | CTD | PMID:36117858 | mono(2-ethylhexyl) phthalate | multiple interactions | EXP | | 6480464 | [mono-(2-ethylhexyl)phthalate co-treated with Tretinoin] results in decreased expression of PPFIA3 mRNA | CTD | PMID:36189433 | N-ethyl-N-nitrosourea | increases mutagenesis | EXP | | 6480464 | Ethylnitrosourea results in increased mutagenesis of PPFIA3 gene | CTD | PMID:27776689 | niclosamide | increases expression | ISO | PPFIA3 (Homo sapiens) | 6480464 | Niclosamide results in increased expression of PPFIA3 mRNA | CTD | PMID:36318118 | paracetamol | affects expression | EXP | | 6480464 | Acetaminophen affects the expression of PPFIA3 mRNA | CTD | PMID:17562736 | paracetamol | increases expression | ISO | Ppfia3 (Rattus norvegicus) | 6480464 | Acetaminophen results in increased expression of PPFIA3 mRNA | CTD | PMID:33387578 | paraquat | multiple interactions | EXP | | 6480464 | [Maneb co-treated with Paraquat] results in decreased expression of PPFIA3 mRNA and [Maneb co-treated with Paraquat] results in increased expression of PPFIA3 mRNA | CTD | PMID:36117858 | PCB138 | multiple interactions | EXP | | 6480464 | [2 more ... | CTD | PMID:25510870 | phenylmercury acetate | decreases expression | ISO | PPFIA3 (Homo sapiens) | 6480464 | Phenylmercuric Acetate results in decreased expression of PPFIA3 mRNA | CTD | PMID:26272509 | phenylmercury acetate | multiple interactions | ISO | PPFIA3 (Homo sapiens) | 6480464 | [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PPFIA3 mRNA | CTD | PMID:27188386 | SB 431542 | multiple interactions | ISO | PPFIA3 (Homo sapiens) | 6480464 | [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PPFIA3 mRNA | CTD | PMID:27188386 | sodium arsenite | affects methylation | ISO | PPFIA3 (Homo sapiens) | 6480464 | sodium arsenite affects the methylation of PPFIA3 gene | CTD | PMID:28589171 | sotorasib | multiple interactions | ISO | PPFIA3 (Homo sapiens) | 6480464 | [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of PPFIA3 mRNA | CTD | PMID:36139627 | streptozocin | multiple interactions | EXP | | 6480464 | [Streptozocin co-treated with Dietary Fats] results in increased expression of PPFIA3 mRNA and Diethylhexyl Phthalate inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in increased expression of PPFIA3 mRNA] | CTD | PMID:33484791 | succimer | multiple interactions | EXP | | 6480464 | [Succimer binds to Magnetite Nanoparticles] which results in increased expression of PPFIA3 mRNA | CTD | PMID:21641980 | tamoxifen | increases expression | EXP | | 6480464 | Tamoxifen results in increased expression of PPFIA3 mRNA | CTD | PMID:25123088 | trametinib | multiple interactions | ISO | PPFIA3 (Homo sapiens) | 6480464 | [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of PPFIA3 mRNA | CTD | PMID:36139627 | triptonide | increases expression | EXP | | 6480464 | triptonide results in increased expression of PPFIA3 mRNA | CTD | PMID:33045310 | valproic acid | increases methylation | ISO | PPFIA3 (Homo sapiens) | 6480464 | Valproic Acid results in increased methylation of PPFIA3 gene | CTD | PMID:29154799 | valproic acid | affects expression | ISO | PPFIA3 (Homo sapiens) | 6480464 | Valproic Acid affects the expression of PPFIA3 mRNA | CTD | PMID:25979313 | | 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Gene Ontology Annotations Click to see Annotation Detail View
Biological Process
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Molecular Function
Phenotype Annotations Click to see Annotation Detail View
Mammalian Phenotype
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Gene-Chemical Interaction Annotations
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Gene Ontology Annotations
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Biological Process
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Phenotype Annotations
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Mammalian Phenotype
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References
References - curated
| # | Reference Title | Reference Citation |
| 1. | Data Import for Chemical-Gene Interactions | RGD automated import pipeline for gene-chemical interactions |
Additional References at PubMed
| PMID:8889548 | PMID:10349636 | PMID:11042159 | PMID:11076861 | PMID:11217851 | PMID:12466851 | PMID:12477932 | PMID:14610273 | PMID:15489334 | PMID:16141072 | PMID:16141073 | PMID:16186258 |
| PMID:16452087 | PMID:16512683 | PMID:16959763 | PMID:19013515 | PMID:19026994 | PMID:21267068 | PMID:21618221 | PMID:21873635 | PMID:22442722 | PMID:22794259 | PMID:23124857 | PMID:25911102 |
| PMID:27889896 | PMID:28671696 | PMID:29439199 | PMID:32005855 | PMID:32325033 | PMID:32581705 | PMID:33378226 | PMID:33601422 | PMID:34031393 | PMID:34321999 | PMID:34767769 | PMID:36417873 |
| PMID:38355793 |
Genomics
Comparative Map Data
| Ppfia3 (Mus musculus - house mouse) |
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| PPFIA3 (Homo sapiens - human) |
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| Ppfia3 (Rattus norvegicus - Norway rat) |
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| Ppfia3 (Chinchilla lanigera - long-tailed chinchilla) |
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| PPFIA3 (Pan paniscus - bonobo/pygmy chimpanzee) |
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| PPFIA3 (Canis lupus familiaris - dog) |
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| Ppfia3 (Ictidomys tridecemlineatus - thirteen-lined ground squirrel) |
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| PPFIA3 (Sus scrofa - pig) |
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| PPFIA3 (Chlorocebus sabaeus - green monkey) |
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| Ppfia3 (Heterocephalus glaber - naked mole-rat) |
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Variants
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Variants in Ppfia3
694 total Variants 
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