Fan1 (FANCD2/FANCI-associated nuclease 1) - Rat Genome Database

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Gene: Fan1 (FANCD2/FANCI-associated nuclease 1) Mus musculus
Analyze
Symbol: Fan1
Name: FANCD2/FANCI-associated nuclease 1
RGD ID: 1621218
MGI Page MGI
Description: Enables 5'-3' exonuclease activity. Predicted to be involved in double-strand break repair via homologous recombination; interstrand cross-link repair; and nucleotide-excision repair. Predicted to act upstream of or within DNA damage response. Predicted to be located in cytosol; intercellular bridge; and nucleoplasm. Predicted to be active in nucleus. Is expressed in ductus deferens; epididymis; and testis. Used to study karyomegalic interstitial nephritis. Human ortholog(s) of this gene implicated in karyomegalic interstitial nephritis. Orthologous to human FAN1 (FANCD2 and FANCI associated nuclease 1).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 6030441H18Rik; coiled-coil domain-containing protein MTMR15; fanconi-associated nuclease 1; mFAN1; Mtmr1; Mtmr15; myotubularin related protein 15; myotubularin-related protein 15
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39763,994,627 - 64,023,874 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl763,996,506 - 64,023,843 (-)EnsemblGRCm39 Ensembl
GRCm38764,345,385 - 64,374,128 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl764,346,758 - 64,374,095 (-)EnsemblGRCm38mm10GRCm38
MGSCv37771,491,644 - 71,518,981 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36764,225,708 - 64,253,042 (-)NCBIMGSCv36mm8
Celera761,791,712 - 61,822,604 (-)NCBICelera
Cytogenetic Map7CNCBI
cM Map734.64NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytosol  (ISO)
intercellular bridge  (ISO)
nucleoplasm  (ISO)
nucleus  (IBA,ISO)

Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
2. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:10349636   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12466851   PMID:12477932   PMID:14610273   PMID:15368895   PMID:16141072   PMID:16141073   PMID:18799693   PMID:21677750  
PMID:21873635   PMID:24194600   PMID:24569637   PMID:24981866   PMID:26658876   PMID:26797144   PMID:26980188   PMID:26980189   PMID:27026368   PMID:27568566   PMID:27626380   PMID:29990673  
PMID:31367016   PMID:32876667   PMID:34469738   PMID:34718701   PMID:38355793  


Genomics

Comparative Map Data
Fan1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39763,994,627 - 64,023,874 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl763,996,506 - 64,023,843 (-)EnsemblGRCm39 Ensembl
GRCm38764,345,385 - 64,374,128 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl764,346,758 - 64,374,095 (-)EnsemblGRCm38mm10GRCm38
MGSCv37771,491,644 - 71,518,981 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36764,225,708 - 64,253,042 (-)NCBIMGSCv36mm8
Celera761,791,712 - 61,822,604 (-)NCBICelera
Cytogenetic Map7CNCBI
cM Map734.64NCBI
FAN1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381530,903,852 - 30,943,108 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1530,890,559 - 30,943,108 (+)EnsemblGRCh38hg38GRCh38
GRCh371531,196,055 - 31,235,311 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361528,983,421 - 29,022,600 (+)NCBINCBI36Build 36hg18NCBI36
Celera158,921,590 - 8,960,771 (+)NCBICelera
Cytogenetic Map15q13.3NCBI
HuRef158,373,082 - 8,412,209 (+)NCBIHuRef
CHM1_11531,186,878 - 31,226,131 (+)NCBICHM1_1
T2T-CHM13v2.01528,697,834 - 28,737,186 (+)NCBIT2T-CHM13v2.0
Fan1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81127,327,098 - 127,356,807 (-)NCBIGRCr8
mRatBN7.21117,915,323 - 117,945,044 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1117,917,099 - 117,944,977 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1125,893,563 - 125,918,526 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01133,076,115 - 133,101,078 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01125,906,666 - 125,932,888 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01125,182,117 - 125,209,772 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1125,181,838 - 125,209,727 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01126,291,169 - 126,318,945 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41118,784,938 - 118,811,928 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1110,174,511 - 110,199,745 (-)NCBICelera
Cytogenetic Map1q22NCBI
Fan1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541629,722,280 - 29,757,742 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541629,722,280 - 29,757,960 (+)NCBIChiLan1.0ChiLan1.0
FAN1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21619,710,997 - 19,751,128 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11524,435,150 - 24,475,583 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0159,395,348 - 9,435,434 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11528,355,689 - 28,472,109 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1528,433,749 - 28,473,211 (+)Ensemblpanpan1.1panPan2
FAN1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1338,013,744 - 38,053,096 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl338,013,739 - 38,052,202 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha340,698,132 - 40,737,657 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0338,394,079 - 38,430,387 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl338,392,475 - 38,430,053 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1337,919,389 - 37,955,716 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0338,179,558 - 38,215,917 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0338,383,672 - 38,423,530 (-)NCBIUU_Cfam_GSD_1.0
Fan1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640145,384,633 - 145,418,106 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936483912,346 - 949,833 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936483916,377 - 949,833 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FAN1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1143,913,551 - 143,961,646 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11143,919,695 - 143,961,678 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21159,865,134 - 159,907,029 (-)NCBISscrofa10.2Sscrofa10.2susScr3
FAN1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12651,720,822 - 51,759,652 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2651,725,017 - 51,759,413 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604889,067,263 - 89,105,386 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Fan1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247681,923,777 - 1,955,255 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Fan1
1158 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:220
Count of miRNA genes:148
Interacting mature miRNAs:150
Transcripts:ENSMUST00000107514, ENSMUST00000123627, ENSMUST00000163289, ENSMUST00000177443
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300722Sle3_msystemic lupus erythmatosus susceptibility 3 (mouse)Not determined7351172887142720Mouse
38501068Tip1_mtuberculosis immunophenotype 1, spleen CFU (mouse)7360299972549748Mouse
25314307Mlh1fc2_mMLH1 foci count 2 (mouse)76502999133501729Mouse
12792978Fbmd3_mfemoral bone mineral density 3, females only (mouse)77050288142367832Mouse
10412199Sst2_msusceptibility to tuberculosis 2 (mouse)Not determined718728794119485380Mouse
1301158Eae4_msusceptibility to experimental allergic encephalomyelitis 4 (mouse)Not determined719147398141919804Mouse
4141805Sle19_msystematic lupus erythematosus susceptibility 19 (mouse)Not determined3003248581135653Mouse
26884404Huml1_mhumerus length 1, 5 week (mouse)730199425108999207Mouse
1301175Ap7q_malcohol preference 7 QTL (mouse)Not determined73171484565715077Mouse
1300996Aorls2_maortic lesion size 2 (mouse)Not determined73239453266394681Mouse
1559000Ossc1_mosteosarcoma susceptibility 1 (mouse)Not determined73405302568053223Mouse
10045622Heal20_mwound healing/regeneration 20 (mouse)Not determined73431688768317043Mouse
1357586Mdmsc3_mmodifier of muscularity 3 (mouse)Not determined73444786968448018Mouse
1301514Rigs1_mradiation induced gastroschisis 1 (mouse)Not determined73628001592394346Mouse
1301082Bbaa16_mB.burgdorferi-associated arthritis 16 (mouse)Not determined736280015116416877Mouse
25314301Vmm3_mvariable multisystem mineralization 3, lung (mouse)73729942572049748Mouse
25314303Vmm4_mvariable multisystem mineralization 4, kidney (mouse)73729942587049208Mouse
1300878Skts1_mskin tumor susceptibility 1 (mouse)Not determined73789138671891582Mouse
10402488Dipa2_mdrug induced psychomotor activation 2 (mouse)Not determined73842154872421684Mouse
1300791Abbp3_mA/J and C57BL/6 blood pressure 3 (mouse)Not determined739673887103510010Mouse
11252140Fdr1_mfat response to dietary restriction 1 (mouse)74114882075148965Mouse
4141929Chlq18_mcirculating hormone level QTL 18 (mouse)Not determined74114882075148965Mouse
10043926Bw1n_mbody weight 1 in NSY (mouse)Not determined745161966118693530Mouse
12880417V125Dq5_mvitamin D active form serum level QTL 5 (mouse)74524974879249748Mouse
25314302Vmm2_mvariable multisystem mineralization 2, heart (mouse)74714974874149748Mouse
12738423Lfibq6_mliver fibrosis QTL 6 (mouse)74769437866704862Mouse
1302141Fcsa6_mfemoral cross-sectional area 6 (mouse)Not determined74838446182384607Mouse
11532741Tbrs5_mtuberculosis resistance 5 (mouse)74915922783235415Mouse
1357752Tabw_mtally ho asscoiated body weight (mouse)Not determined74919327883193390Mouse
10053685Eae43_mexperimental allergic encephalomyelitis susceptibility 43 (mouse)Not determined75112495485125093Mouse
10054064Bwq11_mbody weight QTL 11 (mouse)Not determined75112495485125093Mouse
13208555Lgth10_mbody length 10 (mouse)751649748125599172Mouse
12880418V125Dq6_mvitamin D active form serum level QTL 6 (mouse)75214974886149748Mouse
27226751Femd5_mfemur midshaft diameter 5, 10 week (mouse)753249748143153737Mouse
25823170Hrsq7_mhost response to SARS QTL 7, log titer (mouse)754819589116822815Mouse
11565101Tsve1_mvariable short tail (Tsv) enhancer 1 (mouse)75588950887142720Mouse
27226778Femd11_mfemur midshaft diameter 11, 16 week (mouse)756949748134001729Mouse
1300952Hcs1_mhepatocarcinogenesis susceptibility 1 (mouse)Not determined75732612191326352Mouse
1301465Egrm3_mearly growth rate (mouse)Not determined75732612191326352Mouse
1301663Skull9_mskull morphology 9 (mouse)Not determined75732612191326352Mouse
13432171Rosd1_mrotarod saline difference 1 (mouse)75919437869004862Mouse
26884408Bzwq13_mbi-zygomatic width QTL 13, 16 week (mouse)761749748121399223Mouse
27095916Scvln15_msacral vertebrae length 2, 16 week (mouse)761749748123699223Mouse
25314305Vmm6_mvariable multisystem mineralization 6, eye (mouse)761849748102749207Mouse
13506761Tbthq1_mtrabecular bone thickness QTL 1 (mouse)76234974867749748Mouse


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000163289   ⟹   ENSMUSP00000130012
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl763,996,506 - 64,023,828 (-)Ensembl
GRCm38.p6 Ensembl764,346,758 - 64,374,080 (-)Ensembl
RefSeq Acc Id: ENSMUST00000206329
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl764,019,901 - 64,023,843 (-)Ensembl
GRCm38.p6 Ensembl764,370,153 - 64,374,095 (-)Ensembl
RefSeq Acc Id: ENSMUST00000206730
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl764,020,660 - 64,023,789 (-)Ensembl
GRCm38.p6 Ensembl764,370,912 - 64,374,041 (-)Ensembl
RefSeq Acc Id: ENSMUST00000206778
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl764,011,240 - 64,023,121 (-)Ensembl
GRCm38.p6 Ensembl764,361,492 - 64,373,373 (-)Ensembl
RefSeq Acc Id: NM_177893   ⟹   NP_808561
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39763,995,133 - 64,023,804 (-)NCBI
GRCm38764,345,385 - 64,374,056 (-)NCBI
MGSCv37771,491,644 - 71,518,981 (-)RGD
Celera761,791,712 - 61,822,604 (-)RGD
cM Map7 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006540958   ⟹   XP_006541021
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39763,994,627 - 64,023,872 (-)NCBI
GRCm38764,345,977 - 64,374,126 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006540959   ⟹   XP_006541022
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39764,011,816 - 64,023,874 (-)NCBI
GRCm38764,362,068 - 64,374,128 (-)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_808561   ⟸   NM_177893
- UniProtKB: Q14B88 (UniProtKB/Swiss-Prot),   Q8BVK2 (UniProtKB/Swiss-Prot),   Q69ZT1 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006541021   ⟸   XM_006540958
- Peptide Label: isoform X1
- UniProtKB: Q14B88 (UniProtKB/Swiss-Prot),   Q8BVK2 (UniProtKB/Swiss-Prot),   Q69ZT1 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006541022   ⟸   XM_006540959
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: ENSMUSP00000130012   ⟸   ENSMUST00000163289
Protein Domains
VRR-NUC

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q69ZT1-F1-model_v2 AlphaFold Q69ZT1 1-1020 view protein structure

Promoters
RGD ID:8664343
Promoter ID:EPDNEW_M10203
Type:single initiation site
Name:Fan1_2
Description:Mus musculus FANCD2/FANCI-associated nuclease 1 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M10204  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38764,373,597 - 64,373,657EPDNEW
RGD ID:8664347
Promoter ID:EPDNEW_M10204
Type:initiation region
Name:Fan1_1
Description:Mus musculus FANCD2/FANCI-associated nuclease 1 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M10203  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38764,374,056 - 64,374,116EPDNEW
RGD ID:6841656
Promoter ID:MM_KWN:50911
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   3T3L1_Day6,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:NM_177893,   OTTMUST00000064405,   UC009HGE.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36771,518,724 - 71,519,224 (-)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:3045266 AgrOrtholog
Ensembl Genes ENSMUSG00000033458 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000163289 ENTREZGENE
  ENSMUST00000163289.7 UniProtKB/Swiss-Prot
Gene3D-CATH 3.40.1350.10 UniProtKB/Swiss-Prot
InterPro Fan1-like UniProtKB/Swiss-Prot
  FAN1-like_euk UniProtKB/Swiss-Prot
  FAN1-like_TPR UniProtKB/Swiss-Prot
  FAN1-like_WH UniProtKB/Swiss-Prot
  Fan1_SAP_met UniProtKB/Swiss-Prot
  Rad18_UBZ4 UniProtKB/Swiss-Prot
  tRNA_endonuc-like_dom_sf UniProtKB/Swiss-Prot
  VRR_NUC UniProtKB/Swiss-Prot
KEGG Report mmu:330554 UniProtKB/Swiss-Prot
MGD MGI:3045266 ENTREZGENE
NCBI Gene 330554 ENTREZGENE
PANTHER FANCONI-ASSOCIATED NUCLEASE 1 UniProtKB/Swiss-Prot
  PTHR15749 UniProtKB/Swiss-Prot
Pfam FAN1_HTH UniProtKB/Swiss-Prot
  Fan1_SAP UniProtKB/Swiss-Prot
  FAN1_TPR UniProtKB/Swiss-Prot
  VRR_NUC UniProtKB/Swiss-Prot
PhenoGen Fan1 PhenoGen
PROSITE ZF_UBZ4 UniProtKB/Swiss-Prot
SMART VRR_NUC UniProtKB/Swiss-Prot
UniProt FAN1_MOUSE UniProtKB/Swiss-Prot
  Q14B88 ENTREZGENE
  Q69ZT1 ENTREZGENE
  Q8BVK2 ENTREZGENE
UniProt Secondary Q14B88 UniProtKB/Swiss-Prot
  Q8BVK2 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2011-07-27 Fan1  FANCD2/FANCI-associated nuclease 1  Mtmr15  myotubularin related protein 15  Symbol and/or name change 5135510 APPROVED