Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | 1,2-dichloroethane | decreases expression | EXP | | 6480464 | ethylene dichloride results in decreased expression of MBTD1 mRNA | CTD | PMID:28189721 and PMID:28960355 | 1,2-dimethylhydrazine | decreases expression | EXP | | 6480464 | 1 and 2-Dimethylhydrazine results in decreased expression of MBTD1 mRNA | CTD | PMID:22206623 | 17alpha-ethynylestradiol | multiple interactions | EXP | | 6480464 | [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of MBTD1 mRNA | CTD | PMID:17942748 | 17beta-estradiol | decreases expression | ISO | Mbtd1 (Rattus norvegicus) | 6480464 | Estradiol results in decreased expression of MBTD1 mRNA | CTD | PMID:32145629 | 2,2',4,4',5,5'-hexachlorobiphenyl | multiple interactions | EXP | | 6480464 | [2 more ... | CTD | PMID:25510870 | 2,2',5,5'-tetrachlorobiphenyl | multiple interactions | EXP | | 6480464 | [2 more ... | CTD | PMID:25510870 | 2,3,7,8-tetrachlorodibenzodioxine | multiple interactions | EXP | | 6480464 | [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of MBTD1 mRNA | CTD | PMID:17942748 | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | ISO | Mbtd1 (Rattus norvegicus) | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of MBTD1 mRNA | CTD | PMID:33387578 | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | ISO | Mbtd1 (Rattus norvegicus) | 6480464 | Tetrachlorodibenzodioxin results in increased expression of MBTD1 mRNA | CTD | PMID:32109520 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | EXP | | 6480464 | Tetrachlorodibenzodioxin affects the expression of MBTD1 mRNA | CTD | PMID:21570461 | 2-hydroxypropanoic acid | decreases expression | ISO | MBTD1 (Homo sapiens) | 6480464 | Lactic Acid results in decreased expression of MBTD1 mRNA | CTD | PMID:30851411 | 4,4'-diaminodiphenylmethane | affects expression | EXP | | 6480464 | 4 and 4'-diaminodiphenylmethane affects the expression of MBTD1 mRNA | CTD | PMID:18648102 | 4,4'-diaminodiphenylmethane | decreases expression | ISO | Mbtd1 (Rattus norvegicus) | 6480464 | 4 and 4'-diaminodiphenylmethane results in decreased expression of MBTD1 mRNA | CTD | PMID:30723492 | 6-propyl-2-thiouracil | decreases expression | ISO | Mbtd1 (Rattus norvegicus) | 6480464 | Propylthiouracil results in decreased expression of MBTD1 mRNA | CTD | PMID:30047161 | aflatoxin B1 | increases expression | EXP | | 6480464 | Aflatoxin B1 results in increased expression of MBTD1 mRNA | CTD | PMID:19770486 | aflatoxin B1 | decreases methylation | ISO | MBTD1 (Homo sapiens) | 6480464 | Aflatoxin B1 results in decreased methylation of MBTD1 gene | CTD | PMID:27153756 | all-trans-retinoic acid | decreases expression | ISO | MBTD1 (Homo sapiens) | 6480464 | Tretinoin results in decreased expression of MBTD1 mRNA | CTD | PMID:33167477 | amitrole | decreases expression | ISO | Mbtd1 (Rattus norvegicus) | 6480464 | Amitrole results in decreased expression of MBTD1 mRNA | CTD | PMID:30047161 | arsenous acid | decreases expression | EXP | | 6480464 | Arsenic Trioxide results in decreased expression of MBTD1 mRNA | CTD | PMID:35676786 | benzo[a]pyrene | increases methylation | ISO | MBTD1 (Homo sapiens) | 6480464 | Benzo(a)pyrene results in increased methylation of MBTD1 5' UTR | CTD | PMID:27901495 | bisphenol A | affects expression | ISO | Mbtd1 (Rattus norvegicus) | 6480464 | bisphenol A affects the expression of MBTD1 mRNA | CTD | PMID:30816183 | bisphenol A | increases expression | ISO | MBTD1 (Homo sapiens) | 6480464 | bisphenol A results in increased expression of MBTD1 mRNA | CTD | PMID:36232920 | bisphenol A | decreases expression | ISO | Mbtd1 (Rattus norvegicus) | 6480464 | bisphenol A results in decreased expression of MBTD1 mRNA | CTD | PMID:32145629 | butanal | decreases expression | ISO | MBTD1 (Homo sapiens) | 6480464 | butyraldehyde results in decreased expression of MBTD1 mRNA | CTD | PMID:26079696 | cadmium dichloride | increases expression | ISO | Mbtd1 (Rattus norvegicus) | 6480464 | Cadmium Chloride results in increased expression of MBTD1 mRNA | CTD | PMID:33453195 | calcitriol | increases expression | ISO | MBTD1 (Homo sapiens) | 6480464 | Calcitriol results in increased expression of MBTD1 mRNA | CTD | PMID:16002434 | carbon nanotube | decreases expression | EXP | | 6480464 | Nanotubes more ... | CTD | PMID:25554681 | chlordecone | decreases expression | EXP | | 6480464 | Chlordecone results in decreased expression of MBTD1 mRNA | CTD | PMID:33711761 | chlorpyrifos | decreases expression | EXP | | 6480464 | Chlorpyrifos results in decreased expression of MBTD1 mRNA | CTD | PMID:37019170 | cisplatin | decreases expression | ISO | MBTD1 (Homo sapiens) | 6480464 | Cisplatin results in decreased expression of MBTD1 mRNA | CTD | PMID:27594783 | cyclosporin A | decreases expression | ISO | MBTD1 (Homo sapiens) | 6480464 | Cyclosporine results in decreased expression of MBTD1 mRNA | CTD | PMID:25562108 | cytarabine | increases expression | ISO | MBTD1 (Homo sapiens) | 6480464 | Cytarabine results in increased expression of MBTD1 mRNA | CTD | PMID:21198554 | diarsenic trioxide | decreases expression | EXP | | 6480464 | Arsenic Trioxide results in decreased expression of MBTD1 mRNA | CTD | PMID:35676786 | dorsomorphin | multiple interactions | ISO | MBTD1 (Homo sapiens) | 6480464 | [NOG protein co-treated with trichostatin A co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... | CTD | PMID:27188386 | doxorubicin | decreases expression | ISO | MBTD1 (Homo sapiens) | 6480464 | Doxorubicin results in decreased expression of MBTD1 mRNA | CTD | PMID:29803840 | flutamide | decreases expression | ISO | Mbtd1 (Rattus norvegicus) | 6480464 | Flutamide results in decreased expression of MBTD1 mRNA | CTD | PMID:24136188 | formaldehyde | decreases expression | ISO | MBTD1 (Homo sapiens) | 6480464 | Formaldehyde results in decreased expression of MBTD1 mRNA | CTD | PMID:20655997 | FR900359 | increases phosphorylation | ISO | MBTD1 (Homo sapiens) | 6480464 | FR900359 results in increased phosphorylation of MBTD1 protein | CTD | PMID:37730182 | geldanamycin | increases expression | ISO | MBTD1 (Homo sapiens) | 6480464 | geldanamycin results in increased expression of MBTD1 mRNA | CTD | PMID:26705709 | lead diacetate | decreases expression | EXP | | 6480464 | lead acetate results in decreased expression of MBTD1 mRNA | CTD | PMID:21829687 | methimazole | decreases expression | ISO | Mbtd1 (Rattus norvegicus) | 6480464 | Methimazole results in decreased expression of MBTD1 mRNA | CTD | PMID:30047161 | nefazodone | decreases expression | ISO | Mbtd1 (Rattus norvegicus) | 6480464 | nefazodone results in decreased expression of MBTD1 mRNA | CTD | PMID:24136188 | nimesulide | decreases expression | ISO | Mbtd1 (Rattus norvegicus) | 6480464 | nimesulide results in decreased expression of MBTD1 mRNA | CTD | PMID:24136188 | paracetamol | affects expression | EXP | | 6480464 | Acetaminophen affects the expression of MBTD1 mRNA | CTD | PMID:17562736 | paracetamol | decreases expression | ISO | Mbtd1 (Rattus norvegicus) | 6480464 | Acetaminophen results in decreased expression of MBTD1 mRNA | CTD | PMID:33387578 | paracetamol | decreases expression | ISO | MBTD1 (Homo sapiens) | 6480464 | Acetaminophen results in decreased expression of MBTD1 mRNA | CTD | PMID:21420995 | PCB138 | multiple interactions | EXP | | 6480464 | [2 more ... | CTD | PMID:25510870 | phenobarbital | affects expression | EXP | | 6480464 | Phenobarbital affects the expression of MBTD1 mRNA | CTD | PMID:23091169 | rac-lactic acid | decreases expression | ISO | MBTD1 (Homo sapiens) | 6480464 | Lactic Acid results in decreased expression of MBTD1 mRNA | CTD | PMID:30851411 | rofecoxib | decreases expression | ISO | MBTD1 (Homo sapiens) | 6480464 | rofecoxib results in decreased expression of MBTD1 mRNA | CTD | PMID:17070997 | SB 431542 | multiple interactions | ISO | MBTD1 (Homo sapiens) | 6480464 | [NOG protein co-treated with trichostatin A co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... | CTD | PMID:27188386 | silicon dioxide | increases methylation | ISO | MBTD1 (Homo sapiens) | 6480464 | Silicon Dioxide results in increased methylation of MBTD1 gene | CTD | PMID:34973136 | sodium arsenate | increases expression | EXP | | 6480464 | sodium arsenate results in increased expression of MBTD1 mRNA | CTD | PMID:21795629 | sodium arsenite | decreases expression | ISO | MBTD1 (Homo sapiens) | 6480464 | sodium arsenite results in decreased expression of MBTD1 mRNA | CTD | PMID:28595984 and PMID:34032870 | succimer | multiple interactions | EXP | | 6480464 | [Succimer binds to Magnetite Nanoparticles] which results in decreased expression of MBTD1 mRNA and [Succimer co-treated with Magnetite Nanoparticles] affects the expression of MBTD1 mRNA | CTD | PMID:21641980 and PMID:26378955 | sulfadimethoxine | decreases expression | ISO | Mbtd1 (Rattus norvegicus) | 6480464 | Sulfadimethoxine results in decreased expression of MBTD1 mRNA | CTD | PMID:30047161 | sunitinib | increases expression | ISO | MBTD1 (Homo sapiens) | 6480464 | Sunitinib results in increased expression of MBTD1 mRNA | CTD | PMID:31533062 | thioacetamide | increases expression | ISO | Mbtd1 (Rattus norvegicus) | 6480464 | Thioacetamide results in increased expression of MBTD1 mRNA | CTD | PMID:34492290 | trichostatin A | decreases expression | ISO | MBTD1 (Homo sapiens) | 6480464 | trichostatin A results in decreased expression of MBTD1 mRNA | CTD | PMID:24935251 and PMID:26272509 | trichostatin A | multiple interactions | ISO | MBTD1 (Homo sapiens) | 6480464 | [NOG protein co-treated with trichostatin A co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of MBTD1 mRNA | CTD | PMID:27188386 | valproic acid | decreases methylation | ISO | MBTD1 (Homo sapiens) | 6480464 | Valproic Acid results in decreased methylation of MBTD1 gene | CTD | PMID:29154799 | valproic acid | decreases expression | ISO | MBTD1 (Homo sapiens) | 6480464 | Valproic Acid results in decreased expression of MBTD1 mRNA | CTD | PMID:23179753 more ... | valproic acid | multiple interactions | ISO | MBTD1 (Homo sapiens) | 6480464 | [NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of MBTD1 mRNA | CTD | PMID:27188386 | vincristine | increases expression | ISO | MBTD1 (Homo sapiens) | 6480464 | Vincristine results in increased expression of MBTD1 mRNA | CTD | PMID:23649840 | zinc atom | increases expression | ISO | MBTD1 (Homo sapiens) | 6480464 | Zinc deficiency results in increased expression of MBTD1 mRNA | CTD | PMID:18356318 | zinc(0) | increases expression | ISO | MBTD1 (Homo sapiens) | 6480464 | Zinc deficiency results in increased expression of MBTD1 mRNA | CTD | PMID:18356318 | | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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Gene Ontology Annotations Click to see Annotation Detail View
Biological Process
Cellular Component
Molecular Function
Phenotype Annotations Click to see Annotation Detail View
Mammalian Phenotype
Gene-Chemical Interaction Annotations
Click to see Annotation Detail View
Gene Ontology Annotations
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Biological Process
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Cellular Component
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Molecular Function
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Phenotype Annotations
Click to see Annotation Detail View
Mammalian Phenotype
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References
References - curated
| # | Reference Title | Reference Citation |
| 1. | Mouse MP Annotation Import Pipeline | RGD automated import pipeline |
| 2. | ClinVar Automated Import and Annotation Pipeline | RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations |
| 3. | Data Import for Chemical-Gene Interactions | RGD automated import pipeline for gene-chemical interactions |
Additional References at PubMed
| PMID:8889548 | PMID:10349636 | PMID:10834841 | PMID:10922068 | PMID:11042159 | PMID:11076861 | PMID:11217851 | PMID:11544199 | PMID:12466851 | PMID:12477932 | PMID:12520002 | PMID:14610273 |
| PMID:14966270 | PMID:15226823 | PMID:15237213 | PMID:15741177 | PMID:16107646 | PMID:16141072 | PMID:16141073 | PMID:16325481 | PMID:17967808 | PMID:18799693 | PMID:20059953 | PMID:21252303 |
| PMID:21677750 | PMID:21873635 | PMID:22496869 | PMID:23475131 | PMID:23892456 | PMID:24302573 | PMID:25256713 | PMID:25680957 | PMID:26206133 | PMID:27153538 | PMID:28185240 | PMID:30973865 |
| PMID:37523546 |
Genomics
Comparative Map Data
| Mbtd1 (Mus musculus - house mouse) |
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| MBTD1 (Homo sapiens - human) |
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| Mbtd1 (Rattus norvegicus - Norway rat) |
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| Mbtd1 (Chinchilla lanigera - long-tailed chinchilla) |
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| MBTD1 (Pan paniscus - bonobo/pygmy chimpanzee) |
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| MBTD1 (Canis lupus familiaris - dog) |
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| Mbtd1 (Ictidomys tridecemlineatus - thirteen-lined ground squirrel) |
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| MBTD1 (Sus scrofa - pig) |
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| MBTD1 (Chlorocebus sabaeus - green monkey) |
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| Mbtd1 (Heterocephalus glaber - naked mole-rat) |
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Variants
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Variants in Mbtd1
2028 total Variants 
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