Wee2 (WEE1 homolog 2 (S. pombe)) - Rat Genome Database

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Gene: Wee2 (WEE1 homolog 2 (S. pombe)) Mus musculus
Analyze
Symbol: Wee2
Name: WEE1 homolog 2 (S. pombe)
RGD ID: 1617198
MGI Page MGI
Description: Predicted to enable protein tyrosine kinase activity. Involved in several processes, including female meiotic nuclear division; female pronucleus assembly; and negative regulation of oocyte maturation. Located in cytoplasm and nucleus. Is expressed in early embryo; olfactory epithelium; and ovary. Orthologous to human WEE2 (WEE2 oocyte meiosis inhibiting kinase).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Gm1065; MGC60753; mWee1B; wee1-like protein kinase 1B; wee1-like protein kinase 2; Wee1B; wee1B kinase
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Related Pseudogenes: Gm11885   Gm18372  
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39640,412,180 - 40,443,749 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl640,416,022 - 40,443,747 (+)EnsemblGRCm39 Ensembl
GRCm38640,435,246 - 40,466,815 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl640,439,088 - 40,466,813 (+)EnsemblGRCm38mm10GRCm38
MGSCv37640,392,862 - 40,416,814 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36640,372,575 - 40,396,418 (+)NCBIMGSCv36mm8
Celera640,430,259 - 40,454,228 (+)NCBICelera
Cytogenetic Map6B1NCBI
cM Map618.82NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
2. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:10349636   PMID:10725249   PMID:10922068   PMID:11029659   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12466851   PMID:12477932   PMID:15489334   PMID:16141072   PMID:16141073  
PMID:16169490   PMID:17567914   PMID:20083600   PMID:21267068   PMID:21454751   PMID:21873635   PMID:22442484   PMID:23616086   PMID:24357321   PMID:29606300   PMID:31598710   PMID:37527245  


Genomics

Comparative Map Data
Wee2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39640,412,180 - 40,443,749 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl640,416,022 - 40,443,747 (+)EnsemblGRCm39 Ensembl
GRCm38640,435,246 - 40,466,815 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl640,439,088 - 40,466,813 (+)EnsemblGRCm38mm10GRCm38
MGSCv37640,392,862 - 40,416,814 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36640,372,575 - 40,396,418 (+)NCBIMGSCv36mm8
Celera640,430,259 - 40,454,228 (+)NCBICelera
Cytogenetic Map6B1NCBI
cM Map618.82NCBI
WEE2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh387141,708,353 - 141,731,271 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl7141,708,353 - 141,731,271 (+)EnsemblGRCh38hg38GRCh38
GRCh377141,408,153 - 141,431,071 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 367141,054,622 - 141,077,540 (+)NCBINCBI36Build 36hg18NCBI36
Build 347140,861,336 - 140,883,302NCBI
Celera7136,129,792 - 136,152,709 (+)NCBICelera
Cytogenetic Map7q34NCBI
HuRef7135,704,961 - 135,727,878 (+)NCBIHuRef
CHM1_17141,342,465 - 141,365,372 (+)NCBICHM1_1
T2T-CHM13v2.07143,024,205 - 143,047,114 (+)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v27140,745,872 - 140,768,791 (+)NCBI
Wee2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8470,204,459 - 70,228,813 (+)NCBIGRCr8
mRatBN7.2469,239,043 - 69,261,576 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl469,239,299 - 69,261,093 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.0468,604,770 - 68,631,341 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl468,608,137 - 68,629,925 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04133,391,852 - 133,417,020 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4467,997,589 - 68,021,263 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera464,238,994 - 64,263,937 (+)NCBICelera
Cytogenetic Map4q23NCBI
Wee2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554941,837,613 - 1,867,402 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554941,836,909 - 1,869,384 (-)NCBIChiLan1.0ChiLan1.0
WEE2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v26178,497,387 - 178,520,225 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1730,507,642 - 30,530,480 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v07133,635,359 - 133,663,153 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.17146,110,121 - 146,132,872 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl7146,110,121 - 146,132,872 (+)Ensemblpanpan1.1panPan2
WEE2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1167,466,651 - 7,485,150 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl167,467,266 - 7,499,130 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha168,311,310 - 8,343,770 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0167,388,266 - 7,420,732 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl167,388,878 - 7,420,732 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1167,341,543 - 7,374,003 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0167,183,901 - 7,216,532 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0167,251,671 - 7,284,345 (-)NCBIUU_Cfam_GSD_1.0
Wee2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440511813,610,770 - 13,635,773 (-)NCBIHiC_Itri_2
SpeTri2.0NW_0049365925,584,064 - 5,608,985 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
WEE2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl188,171,138 - 8,195,957 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1188,171,133 - 8,196,836 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2188,463,322 - 8,489,149 (-)NCBISscrofa10.2Sscrofa10.2susScr3
WEE2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.121110,450,650 - 110,485,249 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl21110,463,560 - 110,484,301 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660727,129,105 - 7,163,819 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Wee2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476521,719,053 - 21,742,458 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462476521,718,666 - 21,743,333 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Wee2
1069 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:405
Count of miRNA genes:325
Interacting mature miRNAs:372
Transcripts:ENSMUST00000038907, ENSMUST00000141490
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
25440480Moaq2_mmodifier of alien QTL 2 (mouse)63050001117476961Mouse
26884414Bzwq12_mbi-zygomatic width QTL 12, 16 week (mouse)63400000139076998Mouse
1300556Cia6_mcollagen induced arthritis QTL 6 (mouse)Not determined6446488487403016Mouse
11353840Bmiq2_mbody mass index QTL 2 (mouse)6450382345291115Mouse
1357520Axtq2_manxiety QTL 2 (mouse)Not determined6450382348703611Mouse
1357481Aaj2_manxiety in A/J 2 (mouse)Not determined6450382348703611Mouse
11353841Bmiq3_mbody mass index QTL 3 (mouse)6450382348703611Mouse
4142271Egq8_mearly growth QTL 8 (mouse)Not determined450382396633110Mouse
4142232W6q4_mweight 6 weeks QTL 4 (mouse)Not determined450382396633110Mouse
4142126W3q3_mweight 3 weeks QTL 3 (mouse)Not determined450382396633110Mouse
4142361W10q11_mweight 10 weeks QTL 11 (mouse)Not determined450382396633110Mouse
26884441Sklq3_mskull length QTL 3, 5 week (mouse)6760000080576983Mouse
1302051Sluc7_msusceptibility to lung cancer 7 (mouse)Not determined6929707443297168Mouse
10043869Cia6a_mcollagen induced arthritis QTL 6a (mouse)Not determined61211797146118069Mouse
4141749Obrq2_mobesity resistance QTL 2 (mouse)Not determined1275122146751333Mouse
1301998Bts2_mbladder tumor susceptibility 2 (mouse)Not determined61275122146751333Mouse
27226726Tibmd7_mtibia midshaft diameter 7, 16 week (mouse)61769999953476985Mouse
1301850Fglu_mfasting glucose (mouse)Not determined61771159851711719Mouse
1301724Pcd4ts1_mp-glycoprotein positive CD4 T cell subset 1 (mouse)Not determined61771159851711719Mouse
4140989Spqq2_msperm quality QTL 2 (mouse)Not determined1771159851711719Mouse
1357442Dbts1_mdiabetes 1 (mouse)Not determined61823414773364675Mouse
12904940Edlmmq5_mextensor digitorum longus muscle mass QTL 5 (mouse)61961634653616346Mouse
12904943Tammq4_mtibialis anterior muscle mass QTL 4 (mouse)61961634653616346Mouse
12904952Gmmq4_mgastrocnemius muscle mass QTL 4 (mouse)61961634653616346Mouse
10412213Sxbq2_mSGC/Knj cross B6 QTL 2 (mouse)Not determined61991268571299759Mouse
10412107Desp4_mdespair 4 (mouse)Not determined62004983054049830Mouse
14700690Ccs6_mcolon cancer susceptibility 6 (mouse)62377693457776934Mouse
13208564Bmiq7_mbody mass index QTL 7 (mouse)62499999979976983Mouse
4141988Obrq3_mobesity resistance QTL 3 (mouse)Not determined2829099362291115Mouse
4141454Obrq4_mobesity resistance QTL 4 (mouse)Not determined3170349965703611Mouse
12880425V25Dq5_mvitamin D inactive form serum level QTL 5 (mouse)63267698066676980Mouse
4141782Mrdq5_mmodifier of retinal degeneration QTL 5 (mouse)Not determined3282758578215957Mouse
1300959Lxw2_mlupus BXSB x NZW 2 (mouse)Not determined63387226167872400Mouse
11252142Mom12_mModifier of Min 12 (mouse)63387226167872400Mouse
1300767Aliq4_macute lung injury QTL 4 (mouse)Not determined63627333270273435Mouse
1357539Bsbob3_mBSB obesity 3 (mouse)Not determined63644845670448576Mouse
4141094Hrtr1_mheart rate 1 (mouse)Not determined3674146370741463Mouse
14746995Manh60_mmandible shape 60 (mouse)63720266271202662Mouse
1558984Cplaq9_mcircadian period of locomotor activity 9 (mouse)Not determined63864656092584431Mouse

Markers in Region
AU023319  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38640,466,574 - 40,466,664UniSTSGRCm38
MGSCv37640,416,573 - 40,416,663UniSTSGRCm37
Celera640,453,987 - 40,454,077UniSTS
Cytogenetic Map6B1UniSTS
Whitehead/MRC_RH6355.36UniSTS
UniSTS:235428  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38640,465,880 - 40,465,960UniSTSGRCm38
MGSCv37640,415,879 - 40,415,959UniSTSGRCm37
Celera640,453,293 - 40,453,373UniSTS
Cytogenetic Map6B1UniSTS
Wee2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38640,466,246 - 40,466,307UniSTSGRCm38
MGSCv37640,416,245 - 40,416,306UniSTSGRCm37
Celera640,453,659 - 40,453,720UniSTS
Cytogenetic Map6B1UniSTS
cM Map6 UniSTS


Expression


Sequence


RefSeq Acc Id: ENSMUST00000038907   ⟹   ENSMUSP00000038754
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl640,419,797 - 40,443,747 (+)Ensembl
GRCm38.p6 Ensembl640,442,863 - 40,466,813 (+)Ensembl
RefSeq Acc Id: ENSMUST00000141490   ⟹   ENSMUSP00000122678
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl640,419,871 - 40,421,088 (+)Ensembl
GRCm38.p6 Ensembl640,442,937 - 40,444,154 (+)Ensembl
RefSeq Acc Id: ENSMUST00000202464   ⟹   ENSMUSP00000144628
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl640,416,022 - 40,432,061 (+)Ensembl
GRCm38.p6 Ensembl640,439,088 - 40,455,127 (+)Ensembl
RefSeq Acc Id: NM_201370   ⟹   NP_958758
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39640,419,797 - 40,443,749 (+)NCBI
GRCm38640,442,863 - 40,466,815 (+)NCBI
MGSCv37640,392,862 - 40,416,814 (+)RGD
Celera640,430,259 - 40,454,228 (+)RGD
cM Map6 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006506326   ⟹   XP_006506389
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39640,412,180 - 40,443,454 (+)NCBI
GRCm38640,435,246 - 40,466,520 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006506327   ⟹   XP_006506390
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39640,412,180 - 40,443,454 (+)NCBI
GRCm38640,435,246 - 40,466,520 (+)NCBI
Sequence:
RefSeq Acc Id: NP_958758   ⟸   NM_201370
- UniProtKB: Q4U4S4 (UniProtKB/Swiss-Prot),   Q7TPV9 (UniProtKB/Swiss-Prot),   Q66JT0 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006506389   ⟸   XM_006506326
- Peptide Label: isoform X1
- UniProtKB: Q4U4S4 (UniProtKB/Swiss-Prot),   Q7TPV9 (UniProtKB/Swiss-Prot),   Q66JT0 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006506390   ⟸   XM_006506327
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: ENSMUSP00000144628   ⟸   ENSMUST00000202464
RefSeq Acc Id: ENSMUSP00000038754   ⟸   ENSMUST00000038907
RefSeq Acc Id: ENSMUSP00000122678   ⟸   ENSMUST00000141490
Protein Domains
Protein kinase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q66JT0-F1-model_v2 AlphaFold Q66JT0 1-555 view protein structure


Additional Information

Database Acc Id Source(s)
AGR Gene MGI:3027899 AgrOrtholog
Ensembl Genes ENSMUSG00000037159 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000038907 ENTREZGENE
  ENSMUST00000038907.9 UniProtKB/Swiss-Prot
  ENSMUST00000141490.2 UniProtKB/TrEMBL
  ENSMUST00000202464.4 UniProtKB/TrEMBL
Gene3D-CATH Transferase(Phosphotransferase) domain 1 UniProtKB/Swiss-Prot
InterPro Kinase-like_dom_sf UniProtKB/Swiss-Prot
  Prot_kinase_dom UniProtKB/Swiss-Prot
  Protein_kinase_ATP_BS UniProtKB/Swiss-Prot
  Ser/Thr_kinase_AS UniProtKB/Swiss-Prot
  Wee1-like_protein_kinase UniProtKB/Swiss-Prot
KEGG Report mmu:381759 UniProtKB/Swiss-Prot
MGD MGI:3027899 ENTREZGENE
NCBI Gene 381759 ENTREZGENE
PANTHER EUKARYOTIC TRANSLATION INITIATION FACTOR 2-ALPHA KINASE EIF2-ALPHA KINASE -RELATED UniProtKB/Swiss-Prot
  WEE1-LIKE PROTEIN KINASE 2 UniProtKB/Swiss-Prot
Pfam Pkinase UniProtKB/Swiss-Prot
PhenoGen Wee2 PhenoGen
PIRSF Wee1-like_protein_kinase UniProtKB/Swiss-Prot
PROSITE PROTEIN_KINASE_ATP UniProtKB/Swiss-Prot
  PROTEIN_KINASE_DOM UniProtKB/Swiss-Prot
  PROTEIN_KINASE_ST UniProtKB/Swiss-Prot
SMART S_TKc UniProtKB/Swiss-Prot
Superfamily-SCOP SSF56112 UniProtKB/Swiss-Prot
UniProt A0A0J9YVE7_MOUSE UniProtKB/TrEMBL
  D3Z4B4_MOUSE UniProtKB/TrEMBL
  Q4U4S4 ENTREZGENE
  Q66JT0 ENTREZGENE
  Q7TPV9 ENTREZGENE
  WEE2_MOUSE UniProtKB/Swiss-Prot
UniProt Secondary Q4U4S4 UniProtKB/Swiss-Prot
  Q7TPV9 UniProtKB/Swiss-Prot