Wee2 (WEE2 oocyte meiosis inhibiting kinase) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Gene: Wee2 (WEE2 oocyte meiosis inhibiting kinase) Heterocephalus glaber
Analyze
Symbol: Wee2
Name: WEE2 oocyte meiosis inhibiting kinase
RGD ID: 18900841
Description: ENCODES a protein that exhibits ATP binding (inferred); magnesium ion binding (inferred); metal ion binding (inferred); INVOLVED IN female meiotic nuclear division (ortholog); female pronucleus assembly (ortholog); negative regulation of meiotic cell cycle process involved in oocyte maturation (ortholog); ASSOCIATED WITH genetic disease (ortholog); Oocyte Maturation Defect 5 (ortholog); RASopathy (ortholog); FOUND IN cytosol (ortholog); nucleoplasm (ortholog); plasma membrane (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: WEE1 homolog 2; wee1-like protein kinase 2
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: HetGla 1.0 - Naked Mole-Rat female 1.0 Assembly
Position:
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476521,719,053 - 21,742,458 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462476521,718,666 - 21,743,333 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IEA)
cytosol  (ISO)
nucleoplasm  (ISO)
nucleus  (IEA)
plasma membrane  (ISO)

Molecular Function

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Wee2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476521,719,053 - 21,742,458 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462476521,718,666 - 21,743,333 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2
WEE2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh387141,708,353 - 141,731,271 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl7141,708,353 - 141,731,271 (+)EnsemblGRCh38hg38GRCh38
GRCh377141,408,153 - 141,431,071 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 367141,054,622 - 141,077,540 (+)NCBINCBI36Build 36hg18NCBI36
Build 347140,861,336 - 140,883,302NCBI
Celera7136,129,792 - 136,152,709 (+)NCBICelera
Cytogenetic Map7q34NCBI
HuRef7135,704,961 - 135,727,878 (+)NCBIHuRef
CHM1_17141,342,465 - 141,365,372 (+)NCBICHM1_1
T2T-CHM13v2.07143,024,205 - 143,047,114 (+)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v27140,745,872 - 140,768,791 (+)NCBI
Wee2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39640,412,180 - 40,443,749 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl640,416,022 - 40,443,747 (+)EnsemblGRCm39 Ensembl
GRCm38640,435,246 - 40,466,815 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl640,439,088 - 40,466,813 (+)EnsemblGRCm38mm10GRCm38
MGSCv37640,392,862 - 40,416,814 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36640,372,575 - 40,396,418 (+)NCBIMGSCv36mm8
Celera640,430,259 - 40,454,228 (+)NCBICelera
Cytogenetic Map6B1NCBI
cM Map618.82NCBI
Wee2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8470,204,459 - 70,228,813 (+)NCBIGRCr8
mRatBN7.2469,239,043 - 69,261,576 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl469,239,299 - 69,261,093 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.0468,604,770 - 68,631,341 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl468,608,137 - 68,629,925 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04133,391,852 - 133,417,020 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4467,997,589 - 68,021,263 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera464,238,994 - 64,263,937 (+)NCBICelera
Cytogenetic Map4q23NCBI
Wee2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554941,837,613 - 1,867,402 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554941,836,909 - 1,869,384 (-)NCBIChiLan1.0ChiLan1.0
WEE2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v26178,497,387 - 178,520,225 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1730,507,642 - 30,530,480 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v07133,635,359 - 133,663,153 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.17146,110,121 - 146,132,872 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl7146,110,121 - 146,132,872 (+)Ensemblpanpan1.1panPan2
WEE2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1167,466,651 - 7,485,150 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl167,467,266 - 7,499,130 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha168,311,310 - 8,343,770 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0167,388,266 - 7,420,732 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl167,388,878 - 7,420,732 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1167,341,543 - 7,374,003 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0167,183,901 - 7,216,532 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0167,251,671 - 7,284,345 (-)NCBIUU_Cfam_GSD_1.0
Wee2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440511813,610,770 - 13,635,773 (-)NCBIHiC_Itri_2
SpeTri2.0NW_0049365925,584,064 - 5,608,985 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
WEE2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl188,171,138 - 8,195,957 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1188,171,133 - 8,196,836 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2188,463,322 - 8,489,149 (-)NCBISscrofa10.2Sscrofa10.2susScr3
WEE2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.121110,450,650 - 110,485,249 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl21110,463,560 - 110,484,301 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660727,129,105 - 7,163,819 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSHGLT00000016495   ⟹   ENSHGLP00000016326
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_00462476521,719,053 - 21,742,458 (+)Ensembl
RefSeq Acc Id: XM_021263712   ⟹   XP_021119371
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462476521,718,666 - 21,743,333 (+)NCBI
RefSeq Acc Id: XM_021263713   ⟹   XP_021119372
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462476521,718,667 - 21,743,333 (+)NCBI
RefSeq Acc Id: XM_021263714   ⟹   XP_021119373
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462476521,718,671 - 21,743,333 (+)NCBI
RefSeq Acc Id: XM_021263715   ⟹   XP_021119374
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462476521,718,669 - 21,743,333 (+)NCBI
Protein Sequences
Protein RefSeqs XP_021119371 (Get FASTA)   NCBI Sequence Viewer  
  XP_021119372 (Get FASTA)   NCBI Sequence Viewer  
  XP_021119373 (Get FASTA)   NCBI Sequence Viewer  
  XP_021119374 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSHGLP00000016326
GenBank Protein JAO01916 (Get FASTA)   NCBI Sequence Viewer  
Reference Protein Sequences
RefSeq Acc Id: XP_021119371   ⟸   XM_021263712
- Peptide Label: isoform X1
- UniProtKB: A0A0P6JXI0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021119372   ⟸   XM_021263713
- Peptide Label: isoform X2
- UniProtKB: A0A0P6JXI0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021119374   ⟸   XM_021263715
- Peptide Label: isoform X4
- UniProtKB: G5B579 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021119373   ⟸   XM_021263714
- Peptide Label: isoform X3
- UniProtKB: A0A0P6JXI0 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSHGLP00000016326   ⟸   ENSHGLT00000016495


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSHGLG00000011701 Ensembl, ENTREZGENE
Ensembl Transcript ENSHGLT00000016495 ENTREZGENE
Gene3D-CATH Transferase(Phosphotransferase) domain 1 UniProtKB/TrEMBL
InterPro Kinase-like_dom_sf UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/TrEMBL
  Ser/Thr_kinase_AS UniProtKB/TrEMBL
  Wee1-like_protein_kinase UniProtKB/TrEMBL
NCBI Gene Wee2 ENTREZGENE
PANTHER EUKARYOTIC TRANSLATION INITIATION FACTOR 2-ALPHA KINASE EIF2-ALPHA KINASE -RELATED UniProtKB/TrEMBL
  WEE1-LIKE PROTEIN KINASE 2 UniProtKB/TrEMBL
Pfam Pkinase UniProtKB/TrEMBL
PIRSF Wee1-like_protein_kinase UniProtKB/TrEMBL
PROSITE PROTEIN_KINASE_ATP UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/TrEMBL
  PROTEIN_KINASE_ST UniProtKB/TrEMBL
SMART S_TKc UniProtKB/TrEMBL
Superfamily-SCOP SSF56112 UniProtKB/TrEMBL
UniProt A0A0P6JXI0 ENTREZGENE, UniProtKB/TrEMBL
  G5B579 ENTREZGENE, UniProtKB/TrEMBL