Rnf122 (ring finger protein 122) - Rat Genome Database

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Gene: Rnf122 (ring finger protein 122) Mus musculus
Analyze
Symbol: Rnf122
Name: ring finger protein 122
RGD ID: 1614340
MGI Page MGI
Description: Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in several processes, including negative regulation of mitochondrial membrane potential; proteasome-mediated ubiquitin-dependent protein catabolic process; and protein autoubiquitination. Predicted to be located in cytoplasm. Is expressed in cerebral cortex ventricular layer and cortical plate. Orthologous to human RNF122 (ring finger protein 122).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 1110063C11Rik; ring finger protein 122 homolog
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39831,601,855 - 31,623,346 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl831,601,848 - 31,621,510 (+)EnsemblGRCm39 Ensembl
GRCm38831,111,827 - 31,133,318 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl831,111,820 - 31,131,482 (+)EnsemblGRCm38mm10GRCm38
MGSCv37832,222,318 - 32,241,954 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36832,577,781 - 32,597,417 (+)NCBIMGSCv36mm8
Celera832,636,835 - 32,656,850 (+)NCBICelera
Cytogenetic Map8A3NCBI
cM Map817.97NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:8889548   PMID:10349636   PMID:10922068   PMID:11042159   PMID:11076861   PMID:11217851   PMID:11544199   PMID:12466851   PMID:12477932   PMID:15489334   PMID:16141072   PMID:16141073  
PMID:16602821   PMID:18799693   PMID:21267068   PMID:21677750   PMID:21873635   PMID:27506794   PMID:34321999  


Genomics

Comparative Map Data
Rnf122
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39831,601,855 - 31,623,346 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl831,601,848 - 31,621,510 (+)EnsemblGRCm39 Ensembl
GRCm38831,111,827 - 31,133,318 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl831,111,820 - 31,131,482 (+)EnsemblGRCm38mm10GRCm38
MGSCv37832,222,318 - 32,241,954 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36832,577,781 - 32,597,417 (+)NCBIMGSCv36mm8
Celera832,636,835 - 32,656,850 (+)NCBICelera
Cytogenetic Map8A3NCBI
cM Map817.97NCBI
RNF122
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38833,547,754 - 33,567,128 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl833,547,754 - 33,567,128 (-)EnsemblGRCh38hg38GRCh38
GRCh37833,405,272 - 33,424,646 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36833,524,815 - 33,544,185 (-)NCBINCBI36Build 36hg18NCBI36
Build 34833,524,814 - 33,544,185NCBI
Celera832,354,976 - 32,374,346 (-)NCBICelera
Cytogenetic Map8p12NCBI
HuRef831,937,179 - 31,956,552 (-)NCBIHuRef
CHM1_1833,606,757 - 33,626,126 (-)NCBICHM1_1
T2T-CHM13v2.0833,819,016 - 33,838,397 (-)NCBIT2T-CHM13v2.0
Rnf122
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81667,712,936 - 67,730,479 (-)NCBIGRCr8
mRatBN7.21661,009,879 - 61,027,429 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1661,009,879 - 61,027,448 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1666,325,271 - 66,342,813 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01669,739,776 - 69,757,318 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01664,966,230 - 64,983,651 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01664,766,878 - 64,787,308 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1664,766,903 - 64,784,433 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01664,424,229 - 64,429,199 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41664,918,701 - 64,926,204 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1659,014,621 - 59,019,591 (-)NCBICelera
Cytogenetic Map16q12.3NCBI
Rnf122
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554639,684,068 - 9,699,939 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554639,684,546 - 9,699,939 (-)NCBIChiLan1.0ChiLan1.0
RNF122
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2752,122,444 - 52,141,936 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1827,837,787 - 27,857,543 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0832,862,364 - 32,881,660 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1830,049,204 - 30,068,352 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl830,049,204 - 30,068,355 (-)Ensemblpanpan1.1panPan2
RNF122
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11631,132,478 - 31,145,642 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1631,135,971 - 31,144,909 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1631,656,051 - 31,670,766 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01633,158,385 - 33,173,092 (+)NCBIROS_Cfam_1.0
UMICH_Zoey_3.11631,254,566 - 31,269,247 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01631,833,629 - 31,848,331 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01631,872,341 - 31,887,067 (+)NCBIUU_Cfam_GSD_1.0
Rnf122
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494354,125,361 - 54,139,844 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936766386,176 - 399,234 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936766385,769 - 400,229 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
RNF122
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa10.21559,504,202 - 59,520,457 (+)NCBISscrofa10.2Sscrofa10.2susScr3
RNF122
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1831,630,559 - 31,650,321 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl831,630,244 - 31,650,398 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605210,400,752 - 10,421,285 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Rnf122
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462478010,391,180 - 10,408,755 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462478010,391,328 - 10,415,351 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Rnf122
753 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1174
Count of miRNA genes:625
Interacting mature miRNAs:761
Transcripts:ENSMUST00000046941, ENSMUST00000162640
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
27226756Femd2_mfemur midshaft diameter 2, 5 week (mouse)8495000035067154Mouse
1301128Sluc20_msusceptibility to lung cancer 20 (mouse)Not determined8810320142103372Mouse
1301160Eae14_msusceptibility to experimental allergic encephalomyelitis 14 (mouse)Not determined81945501853455150Mouse
13524525Bodwtq7_mbody wweight QTL 7 (mouse)82824955647027681Mouse
1300906Ap8q_malcohol preference 8 QTL (mouse)Not determined8798418941984342Mouse
1301088Alcw6_malcohol withdrawal 6 (mouse)Not determined81550657249506729Mouse
1301298Pgia4_mproteoglycan induced arthritis 4 (mouse)Not determined81656937350569697Mouse
1301550Fembrs2_mfemur breaking strength 2 (mouse)Not determined81832109752321225Mouse
1300603Cd8ts2_mCD8 T cell subset 2 (mouse)Not determined81945501853455150Mouse
10043974Obq30_mobesity QTL 30 (mouse)Not determined82658332260583322Mouse
11532713Sluc42_msusceptibility to lung cancer 42 (mouse)81344721035321225Mouse
4140978Nilac5_mnicotine induced locomotor activity 5 (mouse)Not determined8131773288Mouse
10412209Cypr7_mcytokine production 7 (mouse)Not determined8810320142103372Mouse
1301929Eae24_msusceptibility to experimental allergic encephalomyelitis 24 (mouse)Not determined8810320142103372Mouse
1300912Daq19_mdirectional asymmetry QTL 19 (mouse)Not determined81550657249506729Mouse
1558870Eae36_mexperimental allergic encephalomyelitis susceptibility 36 (mouse)Not determined81477316071498244Mouse
1301532Scc8_mcolon tumor susceptibility 8 (mouse)Not determined8721249935110107Mouse


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000046941   ⟹   ENSMUSP00000040478
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl831,601,848 - 31,621,510 (+)Ensembl
GRCm38.p6 Ensembl831,111,820 - 31,131,482 (+)Ensembl
RefSeq Acc Id: ENSMUST00000162640
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl831,601,858 - 31,612,113 (+)Ensembl
GRCm38.p6 Ensembl831,111,830 - 31,122,085 (+)Ensembl
RefSeq Acc Id: ENSMUST00000209547
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl831,601,892 - 31,604,005 (+)Ensembl
GRCm38.p6 Ensembl831,111,864 - 31,113,977 (+)Ensembl
RefSeq Acc Id: ENSMUST00000216520
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl831,601,859 - 31,608,559 (+)Ensembl
GRCm38.p6 Ensembl831,111,831 - 31,118,531 (+)Ensembl
RefSeq Acc Id: ENSMUST00000217278   ⟹   ENSMUSP00000150893
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl831,601,858 - 31,619,661 (+)Ensembl
GRCm38.p6 Ensembl831,111,830 - 31,129,633 (+)Ensembl
RefSeq Acc Id: NM_001368373   ⟹   NP_001355302
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39831,605,081 - 31,623,346 (+)NCBI
GRCm38831,115,053 - 31,133,318 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001368374   ⟹   NP_001355303
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39831,605,081 - 31,623,346 (+)NCBI
GRCm38831,115,053 - 31,133,318 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001368375   ⟹   NP_001355304
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39831,601,855 - 31,623,346 (+)NCBI
GRCm38831,111,827 - 31,133,318 (+)NCBI
Sequence:
RefSeq Acc Id: NM_175136   ⟹   NP_780345
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39831,601,855 - 31,623,346 (+)NCBI
GRCm38831,111,827 - 31,133,318 (+)NCBI
MGSCv37832,222,318 - 32,241,954 (+)RGD
Celera832,636,835 - 32,656,850 (+)RGD
cM Map8 ENTREZGENE
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_780345   ⟸   NM_175136
- Peptide Label: isoform 4
- UniProtKB: A0A0R4J0G8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001355304   ⟸   NM_001368375
- Peptide Label: isoform 3
- UniProtKB: Q8BP31 (UniProtKB/Swiss-Prot),   Q80VA7 (UniProtKB/Swiss-Prot),   Q8BGD3 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: NP_001355302   ⟸   NM_001368373
- Peptide Label: isoform 1
RefSeq Acc Id: NP_001355303   ⟸   NM_001368374
- Peptide Label: isoform 2
RefSeq Acc Id: ENSMUSP00000040478   ⟸   ENSMUST00000046941
RefSeq Acc Id: ENSMUSP00000150893   ⟸   ENSMUST00000217278
Protein Domains
RING-type

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q8BP31-F1-model_v2 AlphaFold Q8BP31 1-155 view protein structure

Promoters
RGD ID:8666833
Promoter ID:EPDNEW_M11447
Type:initiation region
Name:Rnf122_1
Description:Mus musculus ring finger protein 122 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38831,111,830 - 31,111,890EPDNEW
RGD ID:6843680
Promoter ID:MM_KWN:54087
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:OTTMUST00000067154,   OTTMUST00000067155,   UC009LJE.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36832,221,996 - 32,222,496 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1916117 AgrOrtholog
Ensembl Genes ENSMUSG00000039328 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000046941 ENTREZGENE
  ENSMUST00000046941.8 UniProtKB/TrEMBL
  ENSMUST00000217278 ENTREZGENE
  ENSMUST00000217278.2 UniProtKB/Swiss-Prot
Gene3D-CATH 3.30.40.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Znf_RING UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Znf_RING/FYVE/PHD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:68867 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:1916117 ENTREZGENE
NCBI Gene 68867 ENTREZGENE
PANTHER RING FINGER PROTEIN 122 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RING ZINC FINGER PROTEIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam zf-RING_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Rnf122 PhenoGen
PROSITE ZF_RING_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART RING UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP RING/U-box UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0R4J0G8 ENTREZGENE, UniProtKB/TrEMBL
  Q80VA7 ENTREZGENE
  Q8BGD3 ENTREZGENE
  Q8BP31 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary Q80VA7 UniProtKB/Swiss-Prot
  Q8BGD3 UniProtKB/Swiss-Prot