H2ac19 (H2A clustered histone 19) - Rat Genome Database

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Gene: H2ac19 (H2A clustered histone 19) Mus musculus
Analyze
No known orthologs.
Symbol: H2ac19
Name: H2A clustered histone 19
RGD ID: 1610492
MGI Page MGI
Description: Predicted to enable nucleosomal DNA binding activity. Predicted to be involved in heterochromatin formation. Predicted to be part of nucleosome. Predicted to be active in nucleus. Is expressed in several structures, including body cavity or lining; brain ventricular layer; integumental system; tail; and vertebral axis musculature. Orthologous to human H2AC18 (H2A clustered histone 18) and H2AC19 (H2A clustered histone 19).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: H2a-61; H2a-614; H2a-615; Hist2h; Hist2h2aa1; Hist2h2aa2; Hist2h3c2; Hist2h3ca2; histone 2, H2aa2; histone cluster 2, H2aa2; histone H2A type 2-A; histone H2A.2; MGC107211
RGD Orthologs
Alliance Orthologs
More Info homologs ...
Related Pseudogenes: H2af-ps1  
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39396,147,065 - 96,147,638 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl396,147,065 - 96,147,592 (-)EnsemblGRCm39 Ensembl
GRCm38396,239,779 - 96,240,374 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl396,239,749 - 96,240,276 (-)EnsemblGRCm38mm10GRCm38
MGSCv37396,049,504 - 96,049,896 (+)NCBIGRCm37MGSCv37mm9NCBIm37
Celera397,669,821 - 97,670,416 (-)NCBICelera
Cytogenetic Map3F2.1NCBI
cM Map341.69NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
nucleosome  (IBA)
nucleus  (IBA,ISO)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:8065931   PMID:10349636   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12408966   PMID:12466851   PMID:12477932   PMID:16141072   PMID:16141073   PMID:21267068   PMID:21873635  
PMID:29497044  


Genomics

Variants

.
Variants in H2ac19
12 total Variants

QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
26884436Zlq3_mzygomatic length QTL 3, 10 week (mouse)33265060142405761Mouse
4142399Aec1_mautoimmune exocrinopathy 1 (mouse)Not determined7586174102690034Mouse
26884427Cvht4_mcranial vault height 4, 10 week (mouse)316054164109707316Mouse
13207570Tcq12_mtotal cholesterol QTL 12 (mouse)316504164130163649Mouse
26884422Cvht7_mcranial vault height 7, 16 week (mouse)328954149118893649Mouse
1302056Orgwq4_morgan weight QTL 4 (mouse)Not determined330067588147304689Mouse
1301705Sles3_msystemic lupus erythmatosus suppressor 3 (mouse)Not determined337174862143353183Mouse
13208566Bmiq5_mbody mass index QTL 5 (mouse)340954435115793649Mouse
26884380Skwq1_mskull length QTL 1, 5 week (mouse)343954435101607316Mouse
26884378Skwq6_mskull length QTL 6, 10 week (mouse)351907421102307316Mouse
26884382Bzwq1_mbi-zygomatic width QTL 1, 5 week (mouse)352207421137205761Mouse
11039519Ltpr3_mLeishmania tropica response 3 (mouse)356704102100464137Mouse
1301971Cia5_mcollagen induced arthritis QTL 5 (mouse)Not determined366046658100046795Mouse
25314313Syncl1_msynaptonemal complex length 1 (mouse)367907333128393649Mouse
11251721Ewc3_methanol withdrawal and consumption 3 (mouse)369568554103568554Mouse
1301791Char4_mP. chabaudi malaria resistance QTL 4 (mouse)Not determined369625509100655290Mouse
1301422Sle11_msystematic lupus erythematosus susceptibility 11 (mouse)Not determined370208904104209042Mouse
11049572Lmr11c_mleishmaniasis resistance 11c (mouse)372139967106140094Mouse
1300982Lmr11_mleishmaniasis resistance 11 (mouse)Not determined372139967106140094Mouse
1300595Tmevd2_mTheiler's murine encephalomyelitis virus induced demyelinating disease susceptibility 2 (mouse)Not determined375463302109463549Mouse
1301392Eae3_msusceptibility to experimental allergic encephalomyelitis 3 (mouse)Not determined379548730113548837Mouse
1301947Pcfm3_mperiosteal circumference and femur length 3 (mouse)Not determined381084652115084797Mouse
1301904Iba2_minduction of brown adipocytes 2 (mouse)Not determined382147043116147184Mouse
11041900Lmr11a_mleishmaniasis resistance 11a (mouse)383463991117464137Mouse
11039510Ltpr3d_mLeishmania tropica response 3d (mouse)383463991117464137Mouse
11039511Ltpr3c_mLeishmania tropica response 3c (mouse)383463991117464137Mouse
11039507Ltpr3g_mLeishmania tropica response 3g (mouse)383463991117464137Mouse
11039508Ltpr3f_mLeishmania tropica response 3f (mouse)383463991117464137Mouse
11039509Ltpr3e_mLeishmania tropica response 3e (mouse)383463991117464137Mouse
11039512Ltpr3b_mLeishmania tropica response 3b (mouse)383463991117464137Mouse
1301272Cfsw1_mcystic fibrosis survival to weaning 1 (mouse)Not determined383882912117883044Mouse
4142099Cq3_mcholesterol QTL 3 (mouse)Not determined384888918118889067Mouse
14746984Manh54_mmandible shape 54 (mouse)385289152119289152Mouse
1357583Sle18_msystematic lupus erythematosus susceptibility 18 (mouse)Not determined387208904125316236Mouse
12738440Twq3_mtestis weight QTL 3 (mouse)387228015121228015Mouse
4142178Ctrq2_mC. trachomatis resistance QTL 2 (mouse)Not determined389139967137453008Mouse
10766455Sle22_msystematic lupus erythematosus susceptibility 22 (mouse)390376936124377072Mouse
14747001Mancz4_mmandible centroid size 4 (mouse)390378017124378017Mouse
1301398Rapop3_mradiation-induced apoptosis 3 (mouse)Not determined390511217100464137Mouse
1302052Etohcta4_methanol conditioned taste aversion 4 (mouse)Not determined391000105125008748Mouse
1301349Pgia26_mproteoglycan induced arthritis 26 (mouse)Not determined392251533126251650Mouse

Markers in Region
AI448581  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38396,245,999 - 96,246,080UniSTSGRCm38
GRCm38396,239,751 - 96,239,832UniSTSGRCm38
MGSCv37396,049,922 - 96,050,003UniSTSGRCm37
MGSCv37396,043,674 - 96,043,755UniSTSGRCm37
Celera397,669,793 - 97,669,874UniSTS
Cytogenetic Map3F2.1UniSTS
Cytogenetic Map3F1-F2UniSTS
Whitehead/MRC_RH31089.9UniSTS


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_178212 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC125099 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK002725 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK006728 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK016171 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK028129 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY158924 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY158953 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC010564 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC053966 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC062255 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC064002 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC089519 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC147778 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC147781 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U62674 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  Z30940 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSMUST00000074976   ⟹   ENSMUSP00000100581
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl396,147,065 - 96,147,592 (-)Ensembl
GRCm38.p6 Ensembl396,239,749 - 96,240,276 (-)Ensembl
RefSeq Acc Id: NM_178212   ⟹   NP_835584
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39396,147,065 - 96,147,638 (-)NCBI
GRCm38396,239,779 - 96,240,374 (-)NCBI
MGSCv37396,049,504 - 96,049,896 (+)RGD
Celera397,669,821 - 97,670,416 (-)NCBI
cM Map3 ENTREZGENE
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_835584   ⟸   NM_178212
- UniProtKB: Q811M3 (UniProtKB/Swiss-Prot),   Q6GSS7 (UniProtKB/Swiss-Prot),   B2RWH3 (UniProtKB/TrEMBL),   A0AUV1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000100581   ⟸   ENSMUST00000074976
Protein Domains
Histone H2A C-terminal   Histone H2A/H2B/H3

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q6GSS7-F1-model_v2 AlphaFold Q6GSS7 1-130 view protein structure

Promoters
RGD ID:6881656
Promoter ID:EPDNEW_M4279
Type:multiple initiation site
Name:Hist2h2aa2_1
Description:Mus musculus histone cluster 2, H2aa2 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38396,240,293 - 96,240,353EPDNEW
RGD ID:6881658
Promoter ID:EPDNEW_M4280
Type:multiple initiation site
Name:Hist2h3c1_1
Description:Mus musculus histone cluster 2, H3c1 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38396,245,538 - 96,245,598EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:2448283 AgrOrtholog
Ensembl Genes ENSMUSG00000063954 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSG00000064220 UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000074976 ENTREZGENE
  ENSMUST00000074976.8 UniProtKB/Swiss-Prot
  ENSMUST00000078756.7 UniProtKB/Swiss-Prot
Gene3D-CATH 1.10.20.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Histone-fold UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Histone_H2A UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Histone_H2A/H2B/H3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Histone_H2A_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Histone_H2A_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:15267 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  mmu:319192 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:2448283 ENTREZGENE
NCBI Gene 319192 ENTREZGENE
PANTHER HISTONE H2A TYPE 2-A UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR23430 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Histone UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Histone_H2A_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen H2ac19 PhenoGen
PRINTS HISTONEH2A UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE HISTONE_H2A UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART H2A UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF47113 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0AUV1 ENTREZGENE
  B2RWH3 ENTREZGENE, UniProtKB/TrEMBL
  H2A2A_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
  Q811M3 ENTREZGENE
UniProt Secondary P20670 UniProtKB/Swiss-Prot
  Q811M3 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-08-13 H2ac19  H2A clustered histone 19  Hist2h2aa2  histone cluster 2, H2aa2  Symbol and/or name change 5135510 APPROVED