MIR193B (microRNA 193b) - Rat Genome Database

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Gene: MIR193B (microRNA 193b) Homo sapiens
Analyze
Symbol: MIR193B
Name: microRNA 193b
RGD ID: 1603767
HGNC Page HGNC:32087
Description: Enables mRNA 3'-UTR binding activity and mRNA base-pairing translational repressor activity. Involved in miRNA-mediated post-transcriptional gene silencing. Located in extracellular exosome. Biomarker of colorectal adenoma; colorectal cancer; and stomach cancer.
Type: ncrna (Ensembl: miRNA)
RefSeq Status: PROVISIONAL
Previously known as: mir-193b; MIRN193B
RGD Orthologs
Mouse
Rat
Dog
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381614,303,967 - 14,304,049 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1614,303,967 - 14,304,049 (+)EnsemblGRCh38hg38GRCh38
GRCh371614,397,824 - 14,397,906 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361614,305,324 - 14,305,406 (+)NCBINCBI36Build 36hg18NCBI36
Celera1614,573,940 - 14,574,022 (+)NCBICelera
Cytogenetic Map16p13.12NCBI
HuRef1614,314,879 - 14,314,961 (+)NCBIHuRef
CHM1_11614,397,749 - 14,397,831 (+)NCBICHM1_1
T2T-CHM13v2.01614,341,202 - 14,341,284 (+)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. A Preliminary Study of the Value of Plasma microRNA-193b and Soluble Urokinase-Type Plasminogen Activator Receptor in Identifying Patients with Early-Stage Colorectal Cancer and. Liu KL, etal., Clin Lab. 2017 Nov 1;63(11):1949-1953. doi: 10.7754/Clin.Lab.2017.170726.
2. Association of miR-193b down-regulation and miR-196a up-regulation with clinicopathological features and prognosis in gastric cancer. Mu YP, etal., Asian Pac J Cancer Prev. 2014;15(20):8893-900. doi: 10.7314/apjcp.2014.15.20.8893.
3. LncRNA H19 regulates smooth muscle cell functions and participates in the development of aortic dissection through sponging miR-193b-3p. Ren M, etal., Biosci Rep. 2021 Jan 29;41(1):BSR20202298. doi: 10.1042/BSR20202298.
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
5. MicroRNA-193b inhibits the proliferation, migration and invasion of gastric cancer cells via targeting cyclin D1. Wang L, etal., Acta Histochem. 2016 May;118(4):323-30. doi: 10.1016/j.acthis.2016.02.001. Epub 2016 Apr 9.
Additional References at PubMed
PMID:15965474   PMID:16274478   PMID:16381832   PMID:17604727   PMID:17616659   PMID:19684618   PMID:19701247   PMID:19883314   PMID:20073067   PMID:20304954   PMID:20889907   PMID:21037258  
PMID:21512034   PMID:21724256   PMID:22491710   PMID:22674437   PMID:22752226   PMID:22797075   PMID:22986534   PMID:23335975   PMID:24374827   PMID:24496888   PMID:24778027   PMID:25034398  
PMID:25119742   PMID:25215905   PMID:25231743   PMID:25384965   PMID:25517434   PMID:25532038   PMID:25550792   PMID:25728278   PMID:25798837   PMID:25854561   PMID:25905463   PMID:25997995  
PMID:26020766   PMID:26526790   PMID:26549028   PMID:26822621   PMID:26878873   PMID:27176876   PMID:27380024   PMID:27802451   PMID:28093001   PMID:28542597   PMID:28708135   PMID:28795385  
PMID:28882999   PMID:29070803   PMID:29131440   PMID:29169729   PMID:29323744   PMID:29432078   PMID:29774080   PMID:29909906   PMID:30272274   PMID:30284194   PMID:30320920   PMID:30404587  
PMID:30451334   PMID:30650225   PMID:30824765   PMID:30854734   PMID:31126198   PMID:31225930   PMID:31262974   PMID:31705929   PMID:31721543   PMID:32377743   PMID:32580002   PMID:32596290  
PMID:32803505   PMID:33010605   PMID:33080315   PMID:33128433   PMID:33300066   PMID:33397284   PMID:33763470   PMID:34157861   PMID:34514705   PMID:34667159   PMID:34719090   PMID:34753401  
PMID:35240232   PMID:35712251   PMID:35718922   PMID:36700764   PMID:36799263   PMID:37166084   PMID:37231959   PMID:37340634   PMID:37686289  


Genomics

Comparative Map Data
MIR193B
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381614,303,967 - 14,304,049 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1614,303,967 - 14,304,049 (+)EnsemblGRCh38hg38GRCh38
GRCh371614,397,824 - 14,397,906 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361614,305,324 - 14,305,406 (+)NCBINCBI36Build 36hg18NCBI36
Celera1614,573,940 - 14,574,022 (+)NCBICelera
Cytogenetic Map16p13.12NCBI
HuRef1614,314,879 - 14,314,961 (+)NCBIHuRef
CHM1_11614,397,749 - 14,397,831 (+)NCBICHM1_1
T2T-CHM13v2.01614,341,202 - 14,341,284 (+)NCBIT2T-CHM13v2.0
Mir193b
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391613,267,387 - 13,267,465 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1613,267,387 - 13,267,465 (+)EnsemblGRCm39 Ensembl
GRCm381613,449,523 - 13,449,601 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1613,449,523 - 13,449,601 (+)EnsemblGRCm38mm10GRCm38
MGSCv371613,449,616 - 13,449,694 (+)NCBIGRCm37MGSCv37mm9NCBIm37
Celera1614,051,595 - 14,051,673 (+)NCBICelera
Cytogenetic Map16A1NCBI
cM Map169.29NCBI
Mir193b
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8101,824,944 - 1,825,026 (+)NCBIGRCr8
mRatBN7.2101,317,742 - 1,317,824 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl101,317,742 - 1,317,824 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx106,014,459 - 6,014,541 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01034,551,297 - 34,551,379 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0101,331,694 - 1,331,776 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01430,331,049 - 30,331,131 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1430,331,049 - 30,331,131 (-)EnsemblRnor6.0rn6Rnor6.0
Celera10380,964 - 381,046 (+)NCBICelera
Cytogenetic Map10q11NCBI
MIR193B
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1628,878,050 - 28,878,108 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl628,878,050 - 28,878,108 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha630,240,668 - 30,240,726 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0629,041,272 - 29,041,330 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl629,041,272 - 29,041,330 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1628,843,281 - 28,843,339 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0628,731,758 - 28,731,816 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0629,151,720 - 29,151,778 (-)NCBIUU_Cfam_GSD_1.0


Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 16p13.13-13.11(chr16:11967831-15162888)x1 copy number loss See cases [RCV000052484] Chr16:11967831..15162888 [GRCh38]
Chr16:12061688..15256745 [GRCh37]
Chr16:11969189..15164246 [NCBI36]
Chr16:16p13.13-13.11		 pathogenic
GRCh38/hg38 16p13.3-11.2(chr16:4644892-29170820)x3 copy number gain See cases [RCV000133809] Chr16:4644892..29170820 [GRCh38]
Chr16:4694893..29182141 [GRCh37]
Chr16:4634894..29089642 [NCBI36]
Chr16:16p13.3-11.2		 pathogenic
GRCh38/hg38 16p13.13-13.11(chr16:11952467-15186199)x1 copy number loss See cases [RCV000137596] Chr16:11952467..15186199 [GRCh38]
Chr16:12046324..15280056 [GRCh37]
Chr16:11953825..15187557 [NCBI36]
Chr16:16p13.13-13.11		 likely pathogenic
GRCh38/hg38 16p13.12(chr16:14140498-14686337)x3 copy number gain See cases [RCV000137490] Chr16:14140498..14686337 [GRCh38]
Chr16:14234355..14780194 [GRCh37]
Chr16:14141856..14687695 [NCBI36]
Chr16:16p13.12		 likely benign
GRCh38/hg38 16p13.3-13.11(chr16:666662-15743104)x3 copy number gain See cases [RCV000143710] Chr16:666662..15743104 [GRCh38]
Chr16:716662..15836961 [GRCh37]
Chr16:656663..15744462 [NCBI36]
Chr16:16p13.3-13.11		 pathogenic
GRCh37/hg19 16p13.3-11.2(chr16:102839-28327676)x3 copy number gain See cases [RCV000203445] Chr16:102839..28327676 [GRCh37]
Chr16:16p13.3-11.2		 pathogenic
GRCh37/hg19 16p13.3-11.2(chr16:1279324-31926800)x3 copy number gain Breast ductal adenocarcinoma [RCV000207053] Chr16:1279324..31926800 [GRCh37]
Chr16:16p13.3-11.2		 uncertain significance
GRCh37/hg19 16p13.3-12.3(chr16:1274615-19073133)x3 copy number gain Breast ductal adenocarcinoma [RCV000207326] Chr16:1274615..19073133 [GRCh37]
Chr16:16p13.3-12.3		 uncertain significance
GRCh37/hg19 16p13.3-q24.3(chr16:69193-90274381)x3 copy number gain See cases [RCV000446684] Chr16:69193..90274381 [GRCh37]
Chr16:16p13.3-q24.3		 pathogenic
GRCh37/hg19 16p13.2-q24.3(chr16:9273328-89548493)x3 copy number gain See cases [RCV000511622] Chr16:9273328..89548493 [GRCh37]
Chr16:16p13.2-q24.3		 uncertain significance
maternal UPD(16p) complex Hemimegalencephaly [RCV000494707] Chr16:1280042..33710558 [GRCh37]
Chr16:16p13.3-11.2		 pathogenic
GRCh37/hg19 16p13.3-q24.3(chr16:85881-90155062)x3 copy number gain See cases [RCV000512138] Chr16:85881..90155062 [GRCh37]
Chr16:16p13.3-q24.3		 pathogenic
GRCh37/hg19 16p13.3-12.3(chr16:85880-19806921)x3 copy number gain See cases [RCV000512194] Chr16:85880..19806921 [GRCh37]
Chr16:16p13.3-12.3		 pathogenic
GRCh37/hg19 16p13.3-q24.3(chr16:85881-90155062) copy number gain See cases [RCV000511296] Chr16:85881..90155062 [GRCh37]
Chr16:16p13.3-q24.3		 pathogenic
GRCh37/hg19 16p13.3-12.2(chr16:85880-22442007)x3 copy number gain See cases [RCV000511360] Chr16:85880..22442007 [GRCh37]
Chr16:16p13.3-12.2		 pathogenic
GRCh37/hg19 16p13.13-13.12(chr16:12007434-14781381)x1 copy number loss not provided [RCV000683763] Chr16:12007434..14781381 [GRCh37]
Chr16:16p13.13-13.12		 uncertain significance
GRCh37/hg19 16p13.3-q24.3(chr16:88165-90274695)x3 copy number gain not provided [RCV000738918] Chr16:88165..90274695 [GRCh37]
Chr16:16p13.3-q24.3		 pathogenic
GRCh37/hg19 16p13.3-q24.3(chr16:61451-90294632)x3 copy number gain not provided [RCV000738915] Chr16:61451..90294632 [GRCh37]
Chr16:16p13.3-q24.3		 pathogenic
GRCh37/hg19 16p13.3-q24.3(chr16:88165-90163275)x3 copy number gain not provided [RCV000738917] Chr16:88165..90163275 [GRCh37]
Chr16:16p13.3-q24.3		 pathogenic
GRCh37/hg19 16p13.3-11.2(chr16:4380767-30445350)x3 copy number gain not provided [RCV002472599] Chr16:4380767..30445350 [GRCh37]
Chr16:16p13.3-11.2		 pathogenic
GRCh37/hg19 16p13.3-11.2(chr16:5805001-34230001) copy number gain Microcephaly [RCV001252948] Chr16:5805001..34230001 [GRCh37]
Chr16:16p13.3-11.2		 pathogenic
GRCh37/hg19 16p13.3-11.2(chr16:2959279-30190593)x3 copy number gain See cases [RCV001263169] Chr16:2959279..30190593 [GRCh37]
Chr16:16p13.3-11.2		 pathogenic|likely pathogenic
NC_000016.9:g.(?_13915808)_(14724045_?)dup duplication Xeroderma pigmentosum, group F [RCV001997616] Chr16:13915808..14724045 [GRCh37]
Chr16:16p13.12		 uncertain significance
GRCh37/hg19 16p13.12-12.3(chr16:14365745-17052798)x3 copy number gain not provided [RCV002473916] Chr16:14365745..17052798 [GRCh37]
Chr16:16p13.12-12.3		 likely pathogenic
miRNA Target Status

Confirmed Targets
Gene TargetMature miRNAMethod NameResult TypeData TypeSupport TypePMID
CCND1hsa-miR-193b-3pMirtarbaseexternal_infoqRT-PCR//Luciferase reporter assay//Western blot//Functional MTI20304954
CCND1hsa-miR-193b-3pMirtarbaseexternal_infoLuciferase reporter assay//qRT-PCR//Western blotFunctional MTI20655737
CCND1hsa-miR-193b-3pMirtarbaseexternal_infoCLASHFunctional MTI (Weak)23622248
ESR1hsa-miR-193b-3pMirtarbaseexternal_infoLuciferase reporter assay//MicroarrayFunctional MTI19684618
PLAUhsa-miR-193b-3pMirtarbaseexternal_infoWestern blot//Luciferase reporter assayFunctional MTI19701247
PRAP1hsa-miR-193b-3pMirtarbaseexternal_infoLuciferase reporter assayFunctional MTI21779487
MCL1hsa-miR-193b-3pMirtarbaseexternal_infoLuciferase reporter assay//Western blotFunctional MTI20103677
MCL1hsa-miR-193b-3pMirtarbaseexternal_infoMicroarrayFunctional MTI (Weak)20304954
YWHAZhsa-miR-193b-3pMirtarbaseexternal_infoLuciferase reporter assay//Reporter assay;ProteomiFunctional MTI21512034
EPPK1hsa-miR-193b-3pMirtarbaseexternal_infoProteomicsFunctional MTI (Weak)21512034
SOAT1hsa-miR-193b-3pTarbaseexternal_infoMicroarrayPOSITIVE
YWHAZhsa-miR-193b-3pTarbaseexternal_infoReporter GenePOSITIVE
CCND1hsa-miR-193b-3pTarbaseexternal_infoqPCRPOSITIVE
CCND1hsa-miR-193b-3pTarbaseexternal_infoWesternblitPOSITIVE
CCND1hsa-miR-193b-3pTarbaseexternal_infoOtherPOSITIVE
NF1hsa-miR-193b-3pOncomiRDBexternal_infoNANA23335975
CCND1hsa-miR-193b-3pOncomiRDBexternal_infoNANA22188669
MCL1hsa-miR-193b-3pOncomiRDBexternal_infoNANA21893020
PLAUhsa-miR-193b-3pOncomiRDBexternal_infoNANA21670079
YWHAZhsa-miR-193b-3pOncomiRDBexternal_infoNANA21512034
VASPhsa-miR-193b-3pTarbaseexternal_infoProteomicsPOSITIVE
CCND1hsa-miR-193b-3pOncomiRDBexternal_infoNANA20655737
CCND1hsa-miR-193b-3pOncomiRDBexternal_infoNANA20304954
PLAUhsa-miR-193b-3pOncomiRDBexternal_infoNANA19701247
ESR1hsa-miR-193b-3pOncomiRDBexternal_infoNANA19684618
AENhsa-miR-193b-5pMirtarbaseexternal_infoCLASHFunctional MTI (Weak)23622248
ESR1hsa-miR-193b-5pMirecordsexternal_infoNANA19684618
PLAUhsa-miR-193b-5pMirecordsexternal_info{unchanged}NA19701247

Predicted Targets
Summary Value
Count of predictions:70881
Count of gene targets:20608
Count of transcripts:51022
Interacting mature miRNAs:hsa-miR-193b-3p, hsa-miR-193b-5p
Prediction methods:Microtar, Miranda, Pita, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system adipose tissue appendage entire extraembryonic component
High
Medium 5
Low 23 9 20 11 113 13 44 11 30 26 41 36 1 6 20 2
Below cutoff 18 14 10 2 20 1 33 22 34 9 14 8 1 14 15 1

Sequence


Reference Sequences
RefSeq Acc Id: ENST00000384907
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1614,303,967 - 14,304,049 (+)Ensembl
RefSeq Acc Id: NR_030177
RefSeq Status: PROVISIONAL
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381614,303,967 - 14,304,049 (+)NCBI
GRCh371614,397,824 - 14,397,906 (+)RGD
Celera1614,573,940 - 14,574,022 (+)RGD
HuRef1614,314,879 - 14,314,961 (+)RGD
CHM1_11614,397,749 - 14,397,831 (+)NCBI
T2T-CHM13v2.01614,341,202 - 14,341,284 (+)NCBI
Sequence:
Promoters
RGD ID:6814580
Promoter ID:HG_XEF:2953
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:HeLa_S3,   Lymphoblastoid
Transcripts:NR_030549,   NR_031097,   NR_031545,   NR_032437,   NR_032928
Position:
Human AssemblyChrPosition (strand)Source
Build 361614,304,346 - 14,305,497 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:32087 AgrOrtholog
COSMIC MIR193B COSMIC
Ensembl Genes ENSG00000207639 Ensembl, ENTREZGENE
Ensembl Transcript ENST00000384907 ENTREZGENE
GTEx ENSG00000207639 GTEx
HGNC ID HGNC:32087 ENTREZGENE
Human Proteome Map MIR193B Human Proteome Map
miRBase MI0003137 ENTREZGENE
NCBI Gene 574455 ENTREZGENE
OMIM 614734 OMIM
PharmGKB PA164722552 PharmGKB
RNAcentral URS00000AA464 RNACentral
  URS00000E1DC5 RNACentral
  URS000075BAEB RNACentral