Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | 1,2-dimethylhydrazine | multiple interactions | EXP | | 6480464 | [1 and 2-Dimethylhydrazine co-treated with Folic Acid] results in increased expression of MEPCE mRNA | CTD | PMID:22206623 | 1,2-dimethylhydrazine | increases expression | EXP | | 6480464 | 1 and 2-Dimethylhydrazine results in increased expression of MEPCE mRNA | CTD | PMID:22206623 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | EXP | | 6480464 | Tetrachlorodibenzodioxin affects the expression of MEPCE mRNA | CTD | PMID:21570461 | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | ISO | Mepce (Rattus norvegicus) | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of MEPCE mRNA | CTD | PMID:33387578 | 2-deoxy-D-glucose | increases expression | ISO | MEPCE (Homo sapiens) | 6480464 | Deoxyglucose results in increased expression of MEPCE mRNA | CTD | PMID:33770205 | 6-propyl-2-thiouracil | decreases expression | ISO | Mepce (Rattus norvegicus) | 6480464 | Propylthiouracil results in decreased expression of MEPCE mRNA | CTD | PMID:30047161 | amitrole | decreases expression | ISO | Mepce (Rattus norvegicus) | 6480464 | Amitrole results in decreased expression of MEPCE mRNA | CTD | PMID:30047161 | aristolochic acid A | increases expression | ISO | MEPCE (Homo sapiens) | 6480464 | aristolochic acid I results in increased expression of MEPCE mRNA | CTD | PMID:33212167 | atrazine | decreases expression | ISO | MEPCE (Homo sapiens) | 6480464 | Atrazine results in decreased expression of MEPCE mRNA | CTD | PMID:22378314 | benzo[a]pyrene | decreases methylation | ISO | MEPCE (Homo sapiens) | 6480464 | Benzo(a)pyrene results in decreased methylation of MEPCE exon | CTD | PMID:27901495 | benzo[a]pyrene diol epoxide I | increases expression | ISO | MEPCE (Homo sapiens) | 6480464 | 7 more ... | CTD | PMID:19150397 | bisphenol A | increases expression | ISO | Mepce (Rattus norvegicus) | 6480464 | bisphenol A results in increased expression of MEPCE mRNA | CTD | PMID:25181051 more ... | bisphenol A | affects expression | ISO | MEPCE (Homo sapiens) | 6480464 | bisphenol A affects the expression of MEPCE mRNA | CTD | PMID:30903817 | bisphenol A | decreases methylation | EXP | | 6480464 | bisphenol A results in decreased methylation of MEPCE promoter | CTD | PMID:27312807 | bleomycin A2 | increases expression | ISO | MEPCE (Homo sapiens) | 6480464 | Bleomycin results in increased expression of MEPCE mRNA | CTD | PMID:33770205 | butanal | decreases expression | ISO | MEPCE (Homo sapiens) | 6480464 | butyraldehyde results in decreased expression of MEPCE mRNA | CTD | PMID:26079696 | cadmium dichloride | decreases methylation | ISO | Mepce (Rattus norvegicus) | 6480464 | Cadmium Chloride results in decreased methylation of MEPCE promoter | CTD | PMID:22457795 | caffeine | increases phosphorylation | ISO | MEPCE (Homo sapiens) | 6480464 | Caffeine results in increased phosphorylation of MEPCE protein | CTD | PMID:35688186 | carbon nanotube | decreases expression | EXP | | 6480464 | Nanotubes more ... | CTD | PMID:25554681 | cocaine | increases expression | EXP | | 6480464 | Cocaine results in increased expression of MEPCE mRNA | CTD | PMID:18355967 | cocaine | multiple interactions | EXP | | 6480464 | FOS protein mutant form inhibits the reaction [Cocaine results in increased expression of MEPCE mRNA] | CTD | PMID:18355967 | copper(II) sulfate | decreases expression | ISO | MEPCE (Homo sapiens) | 6480464 | Copper Sulfate results in decreased expression of MEPCE mRNA | CTD | PMID:19549813 | coumarin | increases phosphorylation | ISO | MEPCE (Homo sapiens) | 6480464 | coumarin results in increased phosphorylation of MEPCE protein | CTD | PMID:35688186 | coumestrol | multiple interactions | ISO | MEPCE (Homo sapiens) | 6480464 | [Coumestrol co-treated with 2 and 3-bis(3'-hydroxybenzyl)butyrolactone] results in increased expression of MEPCE mRNA | CTD | PMID:19167446 | coumestrol | increases expression | ISO | MEPCE (Homo sapiens) | 6480464 | Coumestrol results in increased expression of MEPCE mRNA | CTD | PMID:19167446 | cyclosporin A | increases methylation | ISO | MEPCE (Homo sapiens) | 6480464 | Cyclosporine results in increased methylation of MEPCE promoter | CTD | PMID:27989131 | diazinon | increases methylation | ISO | MEPCE (Homo sapiens) | 6480464 | Diazinon results in increased methylation of MEPCE gene | CTD | PMID:22964155 | dorsomorphin | multiple interactions | ISO | MEPCE (Homo sapiens) | 6480464 | [NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of MEPCE mRNA | CTD | PMID:27188386 | doxorubicin | decreases expression | ISO | MEPCE (Homo sapiens) | 6480464 | Doxorubicin results in decreased expression of MEPCE mRNA | CTD | PMID:29803840 | endosulfan | increases expression | ISO | Mepce (Rattus norvegicus) | 6480464 | Endosulfan results in increased expression of MEPCE mRNA | CTD | PMID:29391264 | Enterolactone | multiple interactions | ISO | MEPCE (Homo sapiens) | 6480464 | [Coumestrol co-treated with 2 and 3-bis(3'-hydroxybenzyl)butyrolactone] results in increased expression of MEPCE mRNA | CTD | PMID:19167446 | enzyme inhibitor | multiple interactions | ISO | MEPCE (Homo sapiens) | 6480464 | [Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of MEPCE protein | CTD | PMID:23301498 | epoxiconazole | affects expression | EXP | | 6480464 | epoxiconazole affects the expression of MEPCE mRNA | CTD | PMID:35436446 | folic acid | multiple interactions | EXP | | 6480464 | [1 and 2-Dimethylhydrazine co-treated with Folic Acid] results in increased expression of MEPCE mRNA | CTD | PMID:22206623 | folic acid | increases expression | EXP | | 6480464 | Folic Acid results in increased expression of MEPCE mRNA | CTD | PMID:25629700 | FR900359 | affects phosphorylation | ISO | MEPCE (Homo sapiens) | 6480464 | FR900359 affects the phosphorylation of MEPCE protein | CTD | PMID:37730182 | gentamycin | increases expression | ISO | Mepce (Rattus norvegicus) | 6480464 | Gentamicins results in increased expression of MEPCE mRNA | CTD | PMID:33387578 | HC toxin | decreases expression | ISO | MEPCE (Homo sapiens) | 6480464 | HC toxin results in decreased expression of MEPCE mRNA | CTD | PMID:33770205 | iron dichloride | decreases expression | ISO | MEPCE (Homo sapiens) | 6480464 | ferrous chloride results in decreased expression of MEPCE mRNA | CTD | PMID:35984750 | leflunomide | decreases expression | ISO | MEPCE (Homo sapiens) | 6480464 | leflunomide results in decreased expression of MEPCE mRNA | CTD | PMID:28988120 | methimazole | decreases expression | ISO | Mepce (Rattus norvegicus) | 6480464 | Methimazole results in decreased expression of MEPCE mRNA | CTD | PMID:30047161 | ozone | multiple interactions | ISO | MEPCE (Homo sapiens) | 6480464 | [Air Pollutants results in increased abundance of Ozone] which affects the expression of MEPCE mRNA | CTD | PMID:35430440 | paracetamol | increases expression | ISO | Mepce (Rattus norvegicus) | 6480464 | Acetaminophen results in increased expression of MEPCE mRNA | CTD | PMID:33387578 | perfluorohexanesulfonic acid | decreases expression | EXP | | 6480464 | perfluorohexanesulfonic acid results in decreased expression of MEPCE mRNA | CTD | PMID:37995155 | pirinixic acid | increases expression | EXP | | 6480464 | pirinixic acid results in increased expression of MEPCE mRNA | CTD | PMID:17426115 | pregnenolone 16alpha-carbonitrile | decreases expression | ISO | Mepce (Rattus norvegicus) | 6480464 | Pregnenolone Carbonitrile results in decreased expression of MEPCE mRNA | CTD | PMID:30047161 | quercetin | decreases phosphorylation | ISO | MEPCE (Homo sapiens) | 6480464 | Quercetin results in decreased phosphorylation of MEPCE protein | CTD | PMID:35688186 | SB 431542 | multiple interactions | ISO | MEPCE (Homo sapiens) | 6480464 | [NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of MEPCE mRNA | CTD | PMID:27188386 | sulfadimethoxine | decreases expression | ISO | Mepce (Rattus norvegicus) | 6480464 | Sulfadimethoxine results in decreased expression of MEPCE mRNA | CTD | PMID:30047161 | trichloroethene | affects expression | EXP | | 6480464 | Trichloroethylene affects the expression of MEPCE mRNA | CTD | PMID:21135412 | trichloroethene | increases expression | ISO | Mepce (Rattus norvegicus) | 6480464 | Trichloroethylene results in increased expression of MEPCE mRNA | CTD | PMID:33387578 | trichostatin A | decreases expression | ISO | MEPCE (Homo sapiens) | 6480464 | trichostatin A results in decreased expression of MEPCE mRNA | CTD | PMID:24935251 and PMID:28542535 | urethane | increases expression | ISO | MEPCE (Homo sapiens) | 6480464 | Urethane results in increased expression of MEPCE mRNA | CTD | PMID:28818685 | valproic acid | decreases expression | EXP | | 6480464 | Valproic Acid results in decreased expression of MEPCE mRNA | CTD | PMID:19136453 | valproic acid | multiple interactions | ISO | MEPCE (Homo sapiens) | 6480464 | [NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of MEPCE mRNA | CTD | PMID:27188386 | valproic acid | decreases expression | ISO | MEPCE (Homo sapiens) | 6480464 | Valproic Acid results in decreased expression of MEPCE mRNA | CTD | PMID:19101580 more ... | valproic acid | decreases methylation | ISO | MEPCE (Homo sapiens) | 6480464 | Valproic Acid results in decreased methylation of MEPCE gene | CTD | PMID:29154799 | valproic acid | affects expression | ISO | MEPCE (Homo sapiens) | 6480464 | Valproic Acid affects the expression of MEPCE mRNA | CTD | PMID:25979313 | vinclozolin | increases expression | ISO | Mepce (Rattus norvegicus) | 6480464 | vinclozolin results in increased expression of MEPCE mRNA | CTD | PMID:23034163 | vorinostat | decreases expression | ISO | MEPCE (Homo sapiens) | 6480464 | vorinostat results in decreased expression of MEPCE mRNA | CTD | PMID:22083351 and PMID:27188386 | |