MEPCE (methylphosphate capping enzyme) - Rat Genome Database

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Gene: MEPCE (methylphosphate capping enzyme) Chlorocebus sabaeus
Analyze
Symbol: MEPCE
Name: methylphosphate capping enzyme
RGD ID: 18640179
Description: ENCODES a protein that exhibits 7SK snRNA binding (inferred); methyltransferase activity (inferred); O-methyltransferase activity (inferred); INVOLVED IN negative regulation of transcription by RNA polymerase II (ortholog); positive regulation of G1/S transition of mitotic cell cycle (ortholog); ASSOCIATED WITH pleomorphic xanthoastrocytoma (ortholog); FOUND IN 7SK snRNP (inferred); nucleus (inferred); ribonucleoprotein complex (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: 7SK snRNA methylphosphate capping enzyme
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: ChlSab1.1 - Green Monkey 1.1 Assembly
Position:
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12812,771,822 - 12,776,345 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2812,771,391 - 12,775,961 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660703,514,965 - 3,520,629 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References
Additional References at PubMed
PMID:30032202  


Genomics

Comparative Map Data
MEPCE
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12812,771,822 - 12,776,345 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2812,771,391 - 12,775,961 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660703,514,965 - 3,520,629 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
MEPCE
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh387100,428,790 - 100,434,118 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl7100,428,322 - 100,434,126 (+)EnsemblGRCh38hg38GRCh38
GRCh377100,026,413 - 100,031,741 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36799,865,465 - 99,869,677 (+)NCBINCBI36Build 36hg18NCBI36
Celera794,756,212 - 94,761,548 (+)NCBICelera
Cytogenetic Map7q22.1NCBI
HuRef794,659,849 - 94,665,185 (+)NCBIHuRef
CHM1_1799,957,026 - 99,962,362 (+)NCBICHM1_1
T2T-CHM13v2.07101,668,175 - 101,674,196 (+)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v2799,386,498 - 99,391,834 (+)NCBI
Mepce
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395137,780,168 - 137,785,915 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl5137,780,168 - 137,785,917 (-)EnsemblGRCm39 Ensembl
GRCm385137,781,906 - 137,786,701 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5137,781,906 - 137,787,655 (-)EnsemblGRCm38mm10GRCm38
MGSCv375138,223,134 - 138,227,929 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv365138,011,709 - 138,015,961 (-)NCBIMGSCv36mm8
Celera5134,768,335 - 134,773,130 (-)NCBICelera
Cytogenetic Map5G2NCBI
cM Map576.7NCBI
Mepce
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81224,548,596 - 24,553,315 (+)NCBIGRCr8
mRatBN7.21218,911,796 - 18,916,515 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1218,911,796 - 18,916,514 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1220,066,920 - 20,071,639 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01220,679,795 - 20,684,514 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01219,744,124 - 19,748,843 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01221,721,246 - 21,725,965 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1221,981,755 - 21,986,473 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0 Ensembl1221,721,837 - 21,725,435 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01223,742,114 - 23,746,833 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41219,848,913 - 19,853,632 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1220,717,705 - 20,722,424 (+)NCBICelera
Cytogenetic Map12q12NCBI
Mepce
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955573526,613 - 530,286 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955573526,083 - 531,222 (-)NCBIChiLan1.0ChiLan1.0
MEPCE
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v26118,342,164 - 118,347,440 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan17166,607,596 - 166,612,072 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0792,457,967 - 92,463,102 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.17105,859,584 - 105,865,312 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl7105,861,205 - 105,864,739 (+)Ensemblpanpan1.1panPan2
MEPCE
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.169,234,316 - 9,239,160 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl69,234,356 - 9,239,859 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha610,938,563 - 10,943,659 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.069,168,084 - 9,173,182 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl69,168,095 - 9,172,830 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.169,020,522 - 9,025,618 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.068,998,101 - 9,003,195 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.069,180,481 - 9,185,577 (-)NCBIUU_Cfam_GSD_1.0
Mepce
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024409344133,527,114 - 133,531,605 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936543504,671 - 509,497 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936543504,686 - 509,419 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MEPCE
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl38,357,289 - 8,364,661 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.138,356,602 - 8,361,798 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.237,700,143 - 7,704,903 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Mepce
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474016,641,484 - 16,644,989 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474016,640,777 - 16,645,788 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

endocrine system hemolymphoid system nervous system
High
Medium 36 13 35
Low 7 25
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts XM_008018552 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide JACDXN010000038 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSCSAT00000015990   ⟹   ENSCSAP00000013915
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1 Ensembl2812,771,391 - 12,775,961 (-)Ensembl
RefSeq Acc Id: XM_008018552   ⟹   XP_008016743
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.12812,771,822 - 12,776,345 (-)NCBI
Vero_WHO_p1.0NW_0236660703,514,965 - 3,520,629 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_008016743 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCSAP00000013915.1
Reference Protein Sequences
RefSeq Acc Id: XP_008016743   ⟸   XM_008018552
- UniProtKB: A0A0D9RZ76 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCSAP00000013915   ⟸   ENSCSAT00000015990


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCSAG00000017894 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCSAT00000015990.1 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.150 UniProtKB/TrEMBL
InterPro Bin3-like UniProtKB/TrEMBL
  Bin3_C UniProtKB/TrEMBL
  BIN3_SAM-bd_dom UniProtKB/TrEMBL
  SAM-dependent_MTases UniProtKB/TrEMBL
KEGG Report csab:103246740 UniProtKB/TrEMBL
NCBI Gene MEPCE ENTREZGENE
PANTHER 7SK SNRNA METHYLPHOSPHATE CAPPING ENZYME UniProtKB/TrEMBL
  PTHR12315 UniProtKB/TrEMBL
Pfam Bin3 UniProtKB/TrEMBL
PROSITE BIN3_SAM UniProtKB/TrEMBL
Superfamily-SCOP SSF53335 UniProtKB/TrEMBL
UniProt A0A0D9RZ76 ENTREZGENE, UniProtKB/TrEMBL