Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | (+)-schisandrin B | multiple interactions | ISO | Sccpdh (Rattus norvegicus) | 6480464 | schizandrin B inhibits the reaction [Carbon Tetrachloride results in decreased expression of SCCPDH mRNA] | CTD | PMID:31150632 | 1,2-dimethylhydrazine | multiple interactions | EXP | | 6480464 | [1 and 2-Dimethylhydrazine co-treated with Folic Acid] results in decreased expression of SCCPDH mRNA | CTD | PMID:22206623 | 2,3',4,4',5-Pentachlorobiphenyl | decreases expression | EXP | | 6480464 | 2 more ... | CTD | PMID:31388691 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | EXP | | 6480464 | Tetrachlorodibenzodioxin affects the expression of SCCPDH mRNA | CTD | PMID:21570461 | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | ISO | Sccpdh (Rattus norvegicus) | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of SCCPDH mRNA | CTD | PMID:32109520 | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in increased expression of SCCPDH mRNA | CTD | PMID:26290441 | 2,4,6-tribromophenol | decreases expression | ISO | SCCPDH (Homo sapiens) | 6480464 | 2 more ... | CTD | PMID:31675489 | 2,4-dinitrotoluene | affects expression | ISO | Sccpdh (Rattus norvegicus) | 6480464 | 2 and 4-dinitrotoluene affects the expression of SCCPDH mRNA | CTD | PMID:21346803 | 2-hydroxypropanoic acid | increases expression | ISO | SCCPDH (Homo sapiens) | 6480464 | Lactic Acid results in increased expression of SCCPDH mRNA | CTD | PMID:30851411 | 3,3',5,5'-tetrabromobisphenol A | decreases expression | ISO | SCCPDH (Homo sapiens) | 6480464 | tetrabromobisphenol A results in decreased expression of SCCPDH protein | CTD | PMID:31675489 | 5-fluorouracil | increases expression | ISO | SCCPDH (Homo sapiens) | 6480464 | Fluorouracil results in increased expression of SCCPDH mRNA | CTD | PMID:16101138 | aflatoxin B1 | affects expression | ISO | SCCPDH (Homo sapiens) | 6480464 | Aflatoxin B1 affects the expression of SCCPDH protein | CTD | PMID:20106945 | aflatoxin B1 | decreases expression | ISO | SCCPDH (Homo sapiens) | 6480464 | Aflatoxin B1 results in decreased expression of SCCPDH mRNA | CTD | PMID:27153756 | all-trans-retinoic acid | decreases expression | ISO | SCCPDH (Homo sapiens) | 6480464 | Tretinoin results in decreased expression of SCCPDH mRNA | CTD | PMID:15498508 and PMID:33167477 | amiodarone | decreases expression | ISO | Sccpdh (Rattus norvegicus) | 6480464 | Amiodarone results in decreased expression of SCCPDH mRNA | CTD | PMID:17991464 | benzatropine | decreases expression | ISO | SCCPDH (Homo sapiens) | 6480464 | Benztropine results in decreased expression of SCCPDH protein | CTD | PMID:34122009 | benzo[a]pyrene | decreases methylation | ISO | SCCPDH (Homo sapiens) | 6480464 | Benzo(a)pyrene results in decreased methylation of SCCPDH 3' UTR and Benzo(a)pyrene results in decreased methylation of SCCPDH promoter | CTD | PMID:27901495 | bisphenol A | increases expression | ISO | Sccpdh (Rattus norvegicus) | 6480464 | bisphenol A results in increased expression of SCCPDH mRNA | CTD | PMID:25181051 | bisphenol A | multiple interactions | ISO | SCCPDH (Homo sapiens) | 6480464 | [bisphenol A co-treated with Fulvestrant] results in increased methylation of SCCPDH gene | CTD | PMID:31601247 | bisphenol A | decreases expression | ISO | SCCPDH (Homo sapiens) | 6480464 | bisphenol A results in decreased expression of SCCPDH protein | CTD | PMID:31675489 | Bisphenol B | increases expression | ISO | SCCPDH (Homo sapiens) | 6480464 | bisphenol B results in increased expression of SCCPDH protein | CTD | PMID:34186270 | Brodifacoum | increases expression | ISO | Sccpdh (Rattus norvegicus) | 6480464 | bromfenacoum results in increased expression of SCCPDH protein | CTD | PMID:28903499 | cadmium atom | multiple interactions | ISO | SCCPDH (Homo sapiens) | 6480464 | [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of SCCPDH mRNA | CTD | PMID:35301059 | cadmium dichloride | multiple interactions | ISO | SCCPDH (Homo sapiens) | 6480464 | [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of SCCPDH mRNA | CTD | PMID:35301059 | caffeine | decreases phosphorylation | ISO | SCCPDH (Homo sapiens) | 6480464 | Caffeine results in decreased phosphorylation of SCCPDH protein | CTD | PMID:35688186 | chlordecone | decreases expression | EXP | | 6480464 | Chlordecone results in decreased expression of SCCPDH mRNA | CTD | PMID:29980752 | chloroquine | decreases expression | ISO | Sccpdh (Rattus norvegicus) | 6480464 | Chloroquine results in decreased expression of SCCPDH mRNA | CTD | PMID:19393257 | choline | multiple interactions | EXP | | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of SCCPDH mRNA | CTD | PMID:20938992 | cisplatin | increases expression | ISO | SCCPDH (Homo sapiens) | 6480464 | Cisplatin results in increased expression of SCCPDH mRNA | CTD | PMID:27594783 | cobalt dichloride | increases expression | ISO | Sccpdh (Rattus norvegicus) | 6480464 | cobaltous chloride results in increased expression of SCCPDH mRNA | CTD | PMID:24386269 | copper(II) sulfate | decreases expression | ISO | SCCPDH (Homo sapiens) | 6480464 | Copper Sulfate results in decreased expression of SCCPDH mRNA | CTD | PMID:19549813 | coumestrol | multiple interactions | ISO | SCCPDH (Homo sapiens) | 6480464 | [Coumestrol co-treated with 2 and 3-bis(3'-hydroxybenzyl)butyrolactone] results in decreased expression of SCCPDH mRNA | CTD | PMID:19167446 | cyclosporin A | decreases expression | ISO | SCCPDH (Homo sapiens) | 6480464 | Cyclosporine results in decreased expression of SCCPDH mRNA | CTD | PMID:20106945 | dicrotophos | decreases expression | ISO | SCCPDH (Homo sapiens) | 6480464 | dicrotophos results in decreased expression of SCCPDH mRNA | CTD | PMID:28302478 | diuron | decreases expression | ISO | Sccpdh (Rattus norvegicus) | 6480464 | Diuron results in decreased expression of SCCPDH mRNA | CTD | PMID:21551480 | dorsomorphin | multiple interactions | ISO | SCCPDH (Homo sapiens) | 6480464 | [NOG protein co-treated with Panobinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... | CTD | PMID:27188386 | doxorubicin | increases expression | ISO | SCCPDH (Homo sapiens) | 6480464 | Doxorubicin results in increased expression of SCCPDH mRNA | CTD | PMID:29803840 | Enterolactone | multiple interactions | ISO | SCCPDH (Homo sapiens) | 6480464 | [Coumestrol co-treated with 2 and 3-bis(3'-hydroxybenzyl)butyrolactone] results in decreased expression of SCCPDH mRNA | CTD | PMID:19167446 | ethanol | affects splicing | EXP | | 6480464 | Ethanol affects the splicing of SCCPDH mRNA | CTD | PMID:30319688 | fenthion | decreases expression | EXP | | 6480464 | Fenthion results in decreased expression of SCCPDH mRNA | CTD | PMID:34813904 | folic acid | multiple interactions | EXP | | 6480464 | [1 more ... | CTD | PMID:20938992 and PMID:22206623 | fulvestrant | multiple interactions | ISO | SCCPDH (Homo sapiens) | 6480464 | [bisphenol A co-treated with Fulvestrant] results in increased methylation of SCCPDH gene | CTD | PMID:31601247 | hydrogen sulfide | decreases expression | EXP | | 6480464 | Hydrogen Sulfide results in decreased expression of SCCPDH protein | CTD | PMID:29932956 | hydroquinone O-beta-D-glucopyranoside | increases expression | ISO | SCCPDH (Homo sapiens) | 6480464 | Arbutin results in increased expression of SCCPDH mRNA | CTD | PMID:17103032 | ivermectin | decreases expression | ISO | SCCPDH (Homo sapiens) | 6480464 | Ivermectin results in decreased expression of SCCPDH protein | CTD | PMID:32959892 | L-methionine | multiple interactions | EXP | | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of SCCPDH mRNA | CTD | PMID:20938992 | N-methyl-4-phenylpyridinium | decreases expression | ISO | SCCPDH (Homo sapiens) | 6480464 | 1-Methyl-4-phenylpyridinium results in decreased expression of SCCPDH protein | CTD | PMID:24806433 | N-nitrosodiethylamine | increases expression | EXP | | 6480464 | Diethylnitrosamine results in increased expression of SCCPDH mRNA | CTD | PMID:24535843 | nefazodone | increases expression | ISO | Sccpdh (Rattus norvegicus) | 6480464 | nefazodone results in increased expression of SCCPDH mRNA | CTD | PMID:24136188 | panobinostat | decreases expression | ISO | SCCPDH (Homo sapiens) | 6480464 | panobinostat results in decreased expression of SCCPDH mRNA | CTD | PMID:26272509 | panobinostat | multiple interactions | ISO | SCCPDH (Homo sapiens) | 6480464 | [NOG protein co-treated with Panobinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SCCPDH mRNA | CTD | PMID:27188386 | paracetamol | affects expression | EXP | | 6480464 | Acetaminophen affects the expression of SCCPDH mRNA | CTD | PMID:17562736 | paracetamol | decreases expression | ISO | Sccpdh (Rattus norvegicus) | 6480464 | Acetaminophen results in decreased expression of SCCPDH mRNA | CTD | PMID:33387578 | pirinixic acid | multiple interactions | EXP | | 6480464 | [pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of SCCPDH mRNA | CTD | PMID:19710929 | pirinixic acid | increases expression | EXP | | 6480464 | pirinixic acid results in increased expression of SCCPDH mRNA | CTD | PMID:23811191 | rac-lactic acid | increases expression | ISO | SCCPDH (Homo sapiens) | 6480464 | Lactic Acid results in increased expression of SCCPDH mRNA | CTD | PMID:30851411 | resveratrol | multiple interactions | ISO | SCCPDH (Homo sapiens) | 6480464 | [Plant Extracts co-treated with Resveratrol] results in increased expression of SCCPDH mRNA | CTD | PMID:23557933 | rotenone | increases expression | ISO | SCCPDH (Homo sapiens) | 6480464 | Rotenone results in increased expression of SCCPDH mRNA | CTD | PMID:33512557 | SB 431542 | multiple interactions | ISO | SCCPDH (Homo sapiens) | 6480464 | [LDN 193189 co-treated with 4-(5-benzo(1 more ... | CTD | PMID:27188386 and PMID:37664457 | sodium arsenite | decreases expression | ISO | SCCPDH (Homo sapiens) | 6480464 | sodium arsenite results in decreased expression of SCCPDH mRNA | CTD | PMID:34032870 | sodium fluoride | increases expression | EXP | | 6480464 | Sodium Fluoride results in increased expression of SCCPDH protein | CTD | PMID:28918527 | tamibarotene | decreases expression | ISO | SCCPDH (Homo sapiens) | 6480464 | tamibarotene results in decreased expression of SCCPDH mRNA | CTD | PMID:15498508 | tetrachloromethane | decreases expression | ISO | Sccpdh (Rattus norvegicus) | 6480464 | Carbon Tetrachloride results in decreased expression of SCCPDH mRNA | CTD | PMID:31150632 | tetrachloromethane | increases expression | EXP | | 6480464 | Carbon Tetrachloride results in increased expression of SCCPDH mRNA | CTD | PMID:31919559 | tetrachloromethane | multiple interactions | ISO | Sccpdh (Rattus norvegicus) | 6480464 | schizandrin B inhibits the reaction [Carbon Tetrachloride results in decreased expression of SCCPDH mRNA] | CTD | PMID:31150632 | thioacetamide | decreases expression | ISO | Sccpdh (Rattus norvegicus) | 6480464 | Thioacetamide results in decreased expression of SCCPDH mRNA | CTD | PMID:34492290 | trichloroethene | increases methylation | ISO | Sccpdh (Rattus norvegicus) | 6480464 | Trichloroethylene results in increased methylation of SCCPDH gene | CTD | PMID:27618143 | trichloroethene | increases expression | ISO | Sccpdh (Rattus norvegicus) | 6480464 | Trichloroethylene results in increased expression of SCCPDH mRNA | CTD | PMID:33387578 | trichostatin A | decreases expression | ISO | SCCPDH (Homo sapiens) | 6480464 | trichostatin A results in decreased expression of SCCPDH mRNA | CTD | PMID:24935251 and PMID:26272509 | trichostatin A | multiple interactions | ISO | SCCPDH (Homo sapiens) | 6480464 | [NOG protein co-treated with trichostatin A co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SCCPDH mRNA | CTD | PMID:27188386 | valproic acid | affects expression | ISO | SCCPDH (Homo sapiens) | 6480464 | Valproic Acid affects the expression of SCCPDH mRNA | CTD | PMID:25979313 | valproic acid | decreases expression | ISO | SCCPDH (Homo sapiens) | 6480464 | Valproic Acid results in decreased expression of SCCPDH mRNA | CTD | PMID:23179753 more ... | valproic acid | multiple interactions | ISO | SCCPDH (Homo sapiens) | 6480464 | [NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SCCPDH mRNA | CTD | PMID:27188386 | |