Pcsk5 (proprotein convertase subtilisin/kexin type 5) - Rat Genome Database

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Gene: Pcsk5 (proprotein convertase subtilisin/kexin type 5) Mus musculus
Analyze
Symbol: Pcsk5
Name: proprotein convertase subtilisin/kexin type 5
RGD ID: 1552230
MGI Page MGI
Description: Enables peptide binding activity and serine-type endopeptidase activity. Involved in several processes, including embryo implantation; embryonic digestive tract development; and signaling receptor ligand precursor processing. Acts upstream of or within cardiac septum development; coronary vasculature development; and determination of left/right symmetry. Located in extracellular space. Is expressed in several structures, including alimentary system; brain; embryo mesenchyme; genitourinary system; and sensory organ. Used to study VACTERL association; primary ciliary dyskinesia; and visceral heterotaxy. Orthologous to human PCSK5 (proprotein convertase subtilisin/kexin type 5).
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: b2b1549C; b2b1549Clo; b2b585C; b2b585Clo; PC; PC5; PC5/; PC5/6A; PC5A; PC6; proprotein convertase 5; proprotein convertase 6; proprotein convertase PC5; SP; SPC6; subtilisin-like proprotein convertase 6; subtilisin/kexin-like protease PC5
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391917,409,678 - 17,815,076 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1917,409,683 - 17,814,996 (-)EnsemblGRCm39 Ensembl
GRCm381917,432,314 - 17,837,712 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1917,432,319 - 17,837,632 (-)EnsemblGRCm38mm10GRCm38
MGSCv371917,507,322 - 17,912,122 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361917,499,851 - 17,993,244 (-)NCBIMGSCv36mm8
Celera1918,108,836 - 18,517,555 (-)NCBICelera
Cytogenetic Map19BNCBI
cM Map1912.86NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dichloroethane  (EXP)
1,2-dimethylhydrazine  (EXP)
17beta-estradiol  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (ISO)
2,4-dinitrotoluene  (ISO)
2-hydroxypropanoic acid  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
4,4'-sulfonyldiphenol  (EXP,ISO)
4-hydroxyphenyl retinamide  (EXP)
6-propyl-2-thiouracil  (ISO)
acrylamide  (ISO)
aflatoxin B1  (EXP,ISO)
Aflatoxin B2 alpha  (ISO)
all-trans-retinoic acid  (ISO)
arsenous acid  (ISO)
atrazine  (ISO)
benzene  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[e]pyrene  (ISO)
Benzo[k]fluoranthene  (EXP)
bisphenol A  (EXP,ISO)
butanal  (ISO)
cadmium dichloride  (ISO)
capsaicin  (ISO)
carbon nanotube  (EXP)
chloroprene  (EXP)
choline  (EXP)
clofibrate  (EXP)
copper(II) sulfate  (ISO)
cyclosporin A  (ISO)
cytarabine  (ISO)
decabromodiphenyl ether  (ISO)
diarsenic trioxide  (ISO)
diazinon  (ISO)
dibutyl phthalate  (EXP)
diuron  (ISO)
dorsomorphin  (ISO)
elemental selenium  (ISO)
endosulfan  (ISO)
entinostat  (ISO)
ethanol  (EXP)
fenvalerate  (ISO)
flavonoids  (ISO)
folic acid  (EXP)
genistein  (EXP)
gentamycin  (ISO)
indole-3-methanol  (ISO)
ketoconazole  (ISO)
L-methionine  (EXP)
methapyrilene  (ISO)
methylmercury chloride  (ISO)
N-ethyl-N-nitrosourea  (EXP)
ozone  (EXP,ISO)
paracetamol  (EXP,ISO)
perfluorononanoic acid  (ISO)
perfluorooctanoic acid  (ISO)
phenobarbital  (EXP)
pirinixic acid  (EXP,ISO)
progesterone  (ISO)
propiconazole  (EXP)
quercetin  (ISO)
rac-lactic acid  (ISO)
resveratrol  (ISO)
rotenone  (ISO)
SB 431542  (ISO)
selenium atom  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (EXP)
Soman  (ISO)
T-2 toxin  (ISO)
tetrachloromethane  (EXP)
theophylline  (ISO)
thioacetamide  (ISO)
titanium dioxide  (EXP)
trichloroethene  (ISO)
trichostatin A  (ISO)
triclosan  (ISO)
troglitazone  (EXP)
urethane  (ISO)
valproic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal autopod morphology  (IAGP)
abnormal body wall morphology  (IEA)
abnormal embryo size  (IEA)
abnormal facial morphology  (IEA)
abnormal femur morphology  (IAGP)
abnormal forelimb morphology  (IAGP)
abnormal heart morphology  (IAGP)
abnormal hindlimb morphology  (IAGP)
abnormal limb bud morphology  (IEA)
abnormal limb morphology  (IEA)
abnormal neural tube closure  (IEA)
abnormal palate morphology  (IAGP)
abnormal pelvic girdle bone morphology  (IAGP)
abnormal rectum morphology  (IAGP)
abnormal respiratory motile cilium physiology  (IEA)
abnormal skeleton morphology  (IAGP)
abnormal spinal cord morphology  (IAGP)
abnormal sternocostal joint morphology  (IAGP)
abnormal tail morphology  (IEA)
abnormal thymus lobule morphology  (IAGP)
abnormal tibia morphology  (IAGP)
abnormal urinary bladder morphology  (IAGP)
abnormal vertebral column morphology  (IAGP)
absent anus  (IAGP)
absent caudal vertebrae  (IAGP)
absent fibula  (IAGP)
absent kidney  (IAGP)
absent patella  (IAGP)
absent sacral vertebrae  (IAGP)
absent tail  (IAGP)
absent xiphoid process  (IAGP)
anal atresia  (IEA)
asymmetric sternocostal joints  (IAGP)
atelectasis  (IAGP)
atrial septal defect  (IAGP)
cleft palate  (IEA)
complete atrioventricular septal defect  (IEA)
d-loop transposition of the great arteries  (IEA)
decreased body size  (IAGP)
decreased circulating calcium level  (IEA)
decreased circulating cholesterol level  (IEA)
decreased circulating HDL cholesterol level  (IEA)
delayed bone ossification  (IAGP)
dextrocardia  (IAGP)
double aortic arch  (IEA)
double outlet right ventricle  (IAGP)
double outlet right ventricle with atrioventricular septal defect  (IEA)
embryonic growth retardation  (IEA)
embryonic lethality between implantation and somite formation, complete penetrance  (IAGP)
embryonic lethality, complete penetrance  (IAGP)
hemorrhage  (IAGP)
herniated intestine  (IAGP)
heterotaxia  (IEA)
hyperactivity  (IEA)
immotile respiratory cilia  (IEA)
increased bone mineral content  (IEA)
increased fasting circulating glucose level  (IEA)
increased heart weight  (IEA)
increased lean body mass  (IEA)
increased rib number  (IAGP)
increased thoracic vertebrae number  (IAGP)
mesocardia  (IEA)
neonatal lethality, complete penetrance  (IAGP)
omphalocele  (IAGP)
patent ductus arteriosus  (IAGP)
persistent truncus arteriosus  (IAGP)
polydactyly  (IEA)
preweaning lethality, complete penetrance  (IEA)
pulmonary hypoplasia  (IAGP)
respiratory failure  (IAGP)
right aortic arch  (IAGP)
short hindlimb  (IAGP)
short tail  (IAGP)
small lung  (IAGP)
small thymus  (IAGP)
syndactyly  (IEA)
tracheoesophageal fistula  (IAGP)
transposition of great arteries  (IAGP)
vascular ring  (IAGP)
ventricular septal defect  (IAGP)
vertebral transformation  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. cDNA structure of the mouse and rat subtilisin/kexin-like PC5: a candidate proprotein convertase expressed in endocrine and nonendocrine cells. Lusson J, etal., Proc Natl Acad Sci U S A 1993 Jul 15;90(14):6691-5.
2. The pro-protein convertase PC1 is induced in the transected sciatic nerve and is present in cultured Schwann cells: comparison with PC5, furin and PC7, implication in pro-BDNF processing. Marcinkiewicz M, etal., Brain Res Mol Brain Res. 1998 Aug 31;59(2):229-46.
3. MGDs mouse GO annotations MGD data from the GO Consortium
4. MGD IEA MGD IEA
5. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
6. Mouse MP Annotation Import Pipeline RGD automated import pipeline
7. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
8. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
9. Endoproteolytic activation of alpha(v) integrin by proprotein convertase PC5 is required for vascular smooth muscle cell adhesion to vitronectin and integrin-dependent signaling. Stawowy P, etal., Circulation. 2004 Feb 17;109(6):770-6.
10. Coordinated regulation and colocalization of alphav integrin and its activating enzyme proprotein convertase PC5 in vivo. Stawowy P, etal., Histochem Cell Biol. 2003 Mar;119(3):239-45. Epub 2003 Feb 20.
11. The proprotein convertase PC5/6 is protective against intestinal tumorigenesis: in vivo mouse model. Sun X, etal., Mol Cancer. 2009 Sep 8;8:73. doi: 10.1186/1476-4598-8-73.
12. VACTERL/caudal regression/Currarino syndrome-like malformations in mice with mutation in the proprotein convertase Pcsk5. Szumska D, etal., Genes Dev. 2008 Jun 1;22(11):1465-77. doi: 10.1101/gad.479408.
13. PCSK5 and GDF11 expression in the hindgut region of mouse embryos with anorectal malformations. Tsuda T, etal., Eur J Pediatr Surg. 2011 Aug;21(4):238-41. doi: 10.1055/s-0031-1273691. Epub 2011 Apr 8.
Additional References at PubMed
PMID:7782070   PMID:7819324   PMID:8335106   PMID:8468318   PMID:8698813   PMID:8940009   PMID:8947550   PMID:9067430   PMID:9107690   PMID:9242664   PMID:9291583   PMID:9826670  
PMID:9885250   PMID:10349636   PMID:10922068   PMID:11042159   PMID:11076861   PMID:11217851   PMID:11891916   PMID:12477932   PMID:12529374   PMID:15122044   PMID:15601911   PMID:15606899  
PMID:16135528   PMID:16141072   PMID:16141073   PMID:16141390   PMID:16163737   PMID:16266771   PMID:16354705   PMID:16829522   PMID:17050541   PMID:17242158   PMID:17645548   PMID:18039650  
PMID:18096669   PMID:18378898   PMID:18554181   PMID:18664504   PMID:18706457   PMID:18973680   PMID:20453200   PMID:20876279   PMID:20882679   PMID:21147780   PMID:21408162   PMID:21518694  
PMID:21681612   PMID:21700711   PMID:21873635   PMID:23686857   PMID:23918928   PMID:24006456   PMID:24194600   PMID:25807483   PMID:26552429   PMID:27626380   PMID:28446132   PMID:28468828  
PMID:28700664   PMID:28972540   PMID:29126984   PMID:32942293   PMID:34149625  


Genomics

Comparative Map Data
Pcsk5
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391917,409,678 - 17,815,076 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1917,409,683 - 17,814,996 (-)EnsemblGRCm39 Ensembl
GRCm381917,432,314 - 17,837,712 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1917,432,319 - 17,837,632 (-)EnsemblGRCm38mm10GRCm38
MGSCv371917,507,322 - 17,912,122 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361917,499,851 - 17,993,244 (-)NCBIMGSCv36mm8
Celera1918,108,836 - 18,517,555 (-)NCBICelera
Cytogenetic Map19BNCBI
cM Map1912.86NCBI
PCSK5
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38975,889,809 - 76,362,975 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl975,890,644 - 76,362,975 (+)EnsemblGRCh38hg38GRCh38
GRCh37978,505,589 - 78,977,891 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36977,695,441 - 77,998,164 (+)NCBINCBI36Build 36hg18NCBI36
Build 34975,735,174 - 76,037,889NCBI
Celera949,083,010 - 49,551,972 (+)NCBICelera
Cytogenetic Map9q21.13NCBI
HuRef948,336,126 - 48,806,234 (+)NCBIHuRef
CHM1_1978,651,993 - 79,121,401 (+)NCBICHM1_1
T2T-CHM13v2.0988,048,502 - 88,519,580 (+)NCBIT2T-CHM13v2.0
Pcsk5
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81224,263,823 - 224,694,350 (-)NCBIGRCr8
mRatBN7.21214,837,847 - 215,267,626 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1214,837,927 - 215,267,600 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1223,320,598 - 223,601,308 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01230,257,142 - 230,537,850 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01223,075,150 - 223,355,852 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01236,031,988 - 236,313,858 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1236,031,988 - 236,313,858 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01243,339,259 - 243,768,026 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41220,961,912 - 221,405,907 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11221,283,956 - 221,569,937 (-)NCBI
Celera1212,298,555 - 212,578,355 (-)NCBICelera
Cytogenetic Map1q43NCBI
Pcsk5
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555122,917,243 - 3,333,688 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555122,914,834 - 3,333,440 (-)NCBIChiLan1.0ChiLan1.0
PCSK5
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21175,063,314 - 75,524,928 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1975,069,756 - 75,532,735 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0948,480,607 - 48,943,331 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1974,745,187 - 75,224,347 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl974,745,761 - 75,220,502 (+)Ensemblpanpan1.1panPan2
PCSK5
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1182,088,090 - 82,506,131 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl182,090,664 - 82,555,145 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha182,554,152 - 83,012,101 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0182,504,812 - 82,963,105 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl182,506,866 - 82,963,633 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1182,293,218 - 82,750,127 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0182,009,456 - 82,467,391 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0182,737,312 - 83,195,037 (-)NCBIUU_Cfam_GSD_1.0
Pcsk5
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947129,415,166 - 129,706,026 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493650311,466,950 - 11,896,887 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493650311,466,955 - 11,896,887 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PCSK5
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1228,854,595 - 229,308,906 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11228,854,587 - 229,308,054 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21255,618,184 - 255,748,891 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PCSK5
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11286,907,173 - 87,367,935 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1287,042,557 - 87,367,033 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603875,357,152 - 75,822,509 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Pcsk5
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248113,453,218 - 3,862,970 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Pcsk5
16397 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1147
Count of miRNA genes:563
Interacting mature miRNAs:709
Transcripts:ENSMUST00000025618, ENSMUST00000050715
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300776Lfp3_mlong free running period 3 (mouse)Not determined19120328703Mouse
4142161Drinksac2_mdrink saccharin 2 (mouse)Not determined120695286Mouse
4142302Nstr1_mnerve sheath tumor resistance QTL 1 (mouse)Not determined19122371338Mouse
1301271Datd_mdopamine transporter density (mouse)Not determined19132340234Mouse
4142406Pbctlp1_mperipheral blood cytotoxic T lymphocyte percentage 1 (mouse)Not determined132875174Mouse
1300904Chab5_mcholesterol absorption 5 (mouse)Not determined19165376435653927Mouse
26884385Skwq14_mskull length QTL 14, 16 week (mouse)19325000035877400Mouse
1301800Faq10_mfluctuating asymmetry QTL 10 (mouse)Not determined19332321637323348Mouse
1300923Bits4_mbitterness sensitivity 4 (mouse)Not determined19332321637323348Mouse
1302126Skull26_mskull morphology 26 (mouse)Not determined19332321637323348Mouse
1300591Pas3_mpulmonary adenoma susceptibility 3 (mouse)Not determined19332321637323348Mouse
1357819Tgct2_mtesticular germ cell tumor 2 (mouse)Not determined19332855120539663Mouse
11039522Tbbr4_mTrypanosoma brucei brucei response 4 (mouse)19531332639313470Mouse
1301228Iba4_minduction of brown adipocytes 4 (mouse)Not determined19930571543305821Mouse
1302019Pgia23_mproteoglycan induced arthritis 23 (mouse)Not determined19978745343787602Mouse
38455997Cdtm2_mCD62L+ CD8 TM cells 2 (mouse)19997736419977364Mouse
14928311Manh85_mmandible shape 85 (mouse)191191478945914789Mouse
12801464Rta2_mretinal aging 2 (mouse)141230287425302874Mouse
10413881Moe2_mmodifier of epilepsy 2 (mouse)191492301648923138Mouse
1301336Alcp23_malcohol preference locus 23 (mouse)Not determined191591260749912719Mouse
1301633Alcp24_malcohol preference locus 24 (mouse)Not determined191591260749912719Mouse

Markers in Region
D17583  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381917,433,157 - 17,433,246UniSTSGRCm38
MGSCv371917,507,647 - 17,507,736UniSTSGRCm37
Celera1918,109,085 - 18,109,174UniSTS
Cytogenetic Map19BUniSTS
cM Map1918.0UniSTS
Whitehead/MRC_RH19186.96UniSTS
Pcsk5  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map19BUniSTS
cM Map1918.0UniSTS
cM Map1918.0UniSTS
D19Dcr4  
Mouse AssemblyChrPosition (strand)SourceJBrowse
MGSCv371154,942,092 - 154,942,187UniSTSGRCm37
MGSCv371917,573,052 - 17,573,152UniSTSGRCm37
Celera1918,175,631 - 18,175,689UniSTS
Celera1155,516,720 - 155,516,815UniSTS
Cytogenetic Map19BUniSTS
cM Map1918.0UniSTS
cM Map19 UniSTS
D19Dcr5  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381917,533,129 - 17,533,224UniSTSGRCm38
MGSCv371917,607,619 - 17,607,714UniSTSGRCm37
Celera1918,210,180 - 18,210,285UniSTS
Cytogenetic Map19BUniSTS
cM Map19 UniSTS
WI-15571  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381917,558,206 - 17,558,328UniSTSGRCm38
MGSCv371917,632,696 - 17,632,818UniSTSGRCm37
Celera1918,235,547 - 18,235,669UniSTS
Cytogenetic Map19BUniSTS
cM Map1918.0UniSTS
RH126545  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381917,693,264 - 17,693,509UniSTSGRCm38
GRCm381169,916,745 - 69,916,994UniSTSGRCm38
MGSCv371917,767,754 - 17,767,999UniSTSGRCm37
MGSCv371169,730,247 - 69,730,496UniSTSGRCm37
Celera1177,464,633 - 77,464,882UniSTS
Celera1918,373,033 - 18,373,278UniSTS
Cytogenetic Map11B4UniSTS
Cytogenetic Map19BUniSTS
Cytogenetic Map11B3UniSTS
cM Map1915.0UniSTS
cM Map11 UniSTS
Pcsk5  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map19BUniSTS
Pcsk5  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map19BUniSTS
cM Map1918.0UniSTS
D19Dcr4  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381917,498,562 - 17,498,662UniSTSGRCm38
MGSCv371917,573,052 - 17,573,152UniSTSGRCm37
Celera1918,175,631 - 18,175,689UniSTS
Cytogenetic Map19BUniSTS


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001163144 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001190483 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006526759 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006526760 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006526761 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011247162 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036161458 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_386446 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC125203 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC126940 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC133509 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC147369 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK032736 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK086210 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK087337 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK143998 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC013068 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  D12619 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  D17583 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  L14932 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSMUST00000025618   ⟹   ENSMUSP00000025618
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1917,409,683 - 17,814,996 (-)Ensembl
GRCm38.p6 Ensembl1917,432,319 - 17,837,632 (-)Ensembl
RefSeq Acc Id: ENSMUST00000050715   ⟹   ENSMUSP00000050272
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1917,535,538 - 17,814,996 (-)Ensembl
GRCm38.p6 Ensembl1917,558,174 - 17,837,632 (-)Ensembl
RefSeq Acc Id: ENSMUST00000235505
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1917,650,816 - 17,814,981 (-)Ensembl
GRCm38.p6 Ensembl1917,673,452 - 17,837,617 (-)Ensembl
RefSeq Acc Id: ENSMUST00000235828
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1917,540,092 - 17,814,996 (-)Ensembl
GRCm38.p6 Ensembl1917,562,728 - 17,837,632 (-)Ensembl
RefSeq Acc Id: ENSMUST00000237115
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1917,647,784 - 17,814,996 (-)Ensembl
GRCm38.p6 Ensembl1917,670,420 - 17,837,632 (-)Ensembl
RefSeq Acc Id: NM_001163144   ⟹   NP_001156616
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391917,535,523 - 17,814,996 (-)NCBI
GRCm381917,558,159 - 17,837,632 (-)NCBI
MGSCv371917,507,322 - 17,912,122 (-)RGD
Celera1918,108,843 - 18,517,555 (-)NCBI
cM Map19 ENTREZGENE
Sequence:
RefSeq Acc Id: NM_001190483   ⟹   NP_001177412
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391917,409,678 - 17,814,996 (-)NCBI
GRCm381917,432,314 - 17,837,632 (-)NCBI
MGSCv371917,507,322 - 17,912,122 (-)RGD
Celera1918,108,843 - 18,517,555 (-)NCBI
cM Map19 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006526759   ⟹   XP_006526822
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391917,410,217 - 17,815,076 (-)NCBI
GRCm381917,432,853 - 17,837,712 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006526760   ⟹   XP_006526823
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391917,449,137 - 17,815,076 (-)NCBI
GRCm381917,471,773 - 17,837,712 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006526761   ⟹   XP_006526824
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391917,483,649 - 17,815,076 (-)NCBI
GRCm381917,506,285 - 17,837,712 (-)NCBI
Sequence:
RefSeq Acc Id: XM_011247162   ⟹   XP_011245464
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391917,410,217 - 17,815,076 (-)NCBI
GRCm381917,432,853 - 17,837,712 (-)NCBI
Sequence:
RefSeq Acc Id: XM_036161458   ⟹   XP_036017351
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391917,410,217 - 17,689,295 (-)NCBI
Sequence:
RefSeq Acc Id: XR_386446
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391917,573,057 - 17,815,076 (-)NCBI
GRCm381917,595,693 - 17,837,712 (-)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_001177412   ⟸   NM_001190483
- Peptide Label: isoform 1 preproprotein
- UniProtKB: E9QPB7 (UniProtKB/Swiss-Prot),   Q62040 (UniProtKB/Swiss-Prot),   Q04592 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001156616   ⟸   NM_001163144
- Peptide Label: isoform 2 precursor
- UniProtKB: Q91VK0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006526822   ⟸   XM_006526759
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_006526823   ⟸   XM_006526760
- Peptide Label: isoform X4
- Sequence:
RefSeq Acc Id: XP_006526824   ⟸   XM_006526761
- Peptide Label: isoform X5
- Sequence:
RefSeq Acc Id: XP_011245464   ⟸   XM_011247162
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSMUSP00000025618   ⟸   ENSMUST00000025618
RefSeq Acc Id: ENSMUSP00000050272   ⟸   ENSMUST00000050715
RefSeq Acc Id: XP_036017351   ⟸   XM_036161458
- Peptide Label: isoform X3
Protein Domains
P/Homo B   Peptidase S8   PLAC

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q04592-F1-model_v2 AlphaFold Q04592 1-1877 view protein structure

Promoters
RGD ID:13679064
Promoter ID:EPDNEW_M23681
Type:multiple initiation site
Name:Pcsk5_1
Description:Mus musculus proprotein convertase subtilisin/kexin type 5 ,transcript variant 2, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381917,837,632 - 17,837,692EPDNEW
RGD ID:6830286
Promoter ID:MM_KWN:26603
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:ES_Cell,   Kidney,   Liver,   Lung
Transcripts:ENSMUST00000025618,   NM_001163144,   UC008GXR.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361917,911,466 - 17,912,077 (-)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:97515 AgrOrtholog
Ensembl Genes ENSMUSG00000024713 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000025618 ENTREZGENE
  ENSMUST00000025618.16 UniProtKB/Swiss-Prot
  ENSMUST00000050715 ENTREZGENE
  ENSMUST00000050715.10 UniProtKB/Swiss-Prot
Gene3D-CATH 3.30.70.850 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.40.50.200 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Galactose-binding domain-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro EGF-like_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Furin_repeat UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Galactose-bd-like_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GF_recep_IV UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Growth_fac_rcpt_cys_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Kexin/furin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  P_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_S8/S53_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_S8/S53_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_S8_Asp-AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_S8_His-AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_S8_Ser-AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_S8_subtilisin-rel UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PLAC UniProtKB/TrEMBL
  S8_pro-domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  S8_pro-domain_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:18552 UniProtKB/Swiss-Prot
MGD MGI:97515 ENTREZGENE
NCBI Gene 18552 ENTREZGENE
PANTHER NEUROENDOCRINE CONVERTASE 2 UniProtKB/Swiss-Prot
  PROPROTEIN CONVERTASE SUBTILISIN/KEXIN TYPE 5 UniProtKB/TrEMBL
  PROPROTEIN CONVERTASE SUBTILISIN/KEXIN-RELATED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam GF_recep_IV UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  P_proprotein UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_S8 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PLAC UniProtKB/TrEMBL
  S8_pro-domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Pcsk5 PhenoGen
PRINTS SUBTILISIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE P_HOMO_B UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PLAC UniProtKB/TrEMBL
  SUBTILASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SUBTILASE_ASP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SUBTILASE_HIS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SUBTILASE_SER UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART EGF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SM00261 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP Protease propeptides/inhibitors UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF49785 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF52743 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF57184 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt E9QPB7 ENTREZGENE
  PCSK5_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
  Q62040 ENTREZGENE
  Q91VK0 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary E9QPB7 UniProtKB/Swiss-Prot
  Q62040 UniProtKB/Swiss-Prot