Cbx7 (chromobox 7) - Rat Genome Database

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Gene: Cbx7 (chromobox 7) Mus musculus
Analyze
Symbol: Cbx7
Name: chromobox 7
RGD ID: 1550491
MGI Page MGI
Description: Enables chromatin binding activity; methylated histone binding activity; and single-stranded RNA binding activity. Acts upstream of or within sebaceous gland development. Located in nucleus. Part of PRC1 complex and heterochromatin. Is expressed in brain. Human ortholog(s) of this gene implicated in breast cancer; multiple myeloma; and myeloid leukemia. Orthologous to human CBX7 (chromobox 7).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 1600014J01Rik; AI851678; chromobox homolog 7; chromobox protein homolog 7; D15Ertd417; D15Ertd417e
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391579,800,005 - 79,855,344 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1579,800,008 - 79,855,320 (-)EnsemblGRCm39 Ensembl
GRCm381579,915,804 - 79,971,143 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1579,915,807 - 79,971,119 (-)EnsemblGRCm38mm10GRCm38
MGSCv371579,746,237 - 79,763,076 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361579,740,244 - 79,759,866 (-)NCBIMGSCv36mm8
Celera1582,033,986 - 82,050,640 (-)NCBICelera
Cytogenetic Map15E1NCBI
cM Map1537.85NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dichloroethane  (EXP)
1,2-dimethylhydrazine  (EXP)
1-naphthyl isothiocyanate  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (EXP)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,3,7,8-Tetrachlorodibenzofuran  (ISO)
2,4-dinitrotoluene  (ISO)
2,6-dinitrotoluene  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
6-propyl-2-thiouracil  (ISO)
acrylamide  (ISO)
all-trans-retinoic acid  (ISO)
amitrole  (ISO)
amphetamine  (ISO)
aripiprazole  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
benzo[a]pyrene  (EXP,ISO)
bisphenol A  (ISO)
bisphenol F  (ISO)
cadmium atom  (EXP)
cadmium dichloride  (EXP)
CGP 52608  (ISO)
cisplatin  (ISO)
copper(II) sulfate  (ISO)
crocidolite asbestos  (EXP)
cyclosporin A  (ISO)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
diethylstilbestrol  (ISO)
dopamine  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
elemental selenium  (ISO)
ethyl methanesulfonate  (ISO)
fenoldopam  (ISO)
folic acid  (EXP)
furan  (ISO)
genistein  (ISO)
gentamycin  (ISO)
hydralazine  (ISO)
hydrogen peroxide  (ISO)
indometacin  (ISO)
iron dichloride  (ISO)
ketamine  (ISO)
ketoconazole  (ISO)
lead diacetate  (EXP)
mercury atom  (EXP)
mercury(0)  (EXP)
methimazole  (ISO)
methylseleninic acid  (ISO)
N(4)-hydroxycytidine  (EXP)
nickel atom  (ISO)
ozone  (EXP,ISO)
paracetamol  (ISO)
PCB138  (EXP)
perfluorohexanesulfonic acid  (EXP)
perfluorooctane-1-sulfonic acid  (EXP)
phenobarbital  (ISO)
phenylmercury acetate  (ISO)
resveratrol  (ISO)
SB 431542  (ISO)
selenium atom  (ISO)
sulfadimethoxine  (ISO)
temozolomide  (ISO)
testosterone  (EXP)
tetrachloroethene  (EXP)
thimerosal  (ISO)
trichloroethene  (ISO)
trichostatin A  (ISO)
triptonide  (EXP)
urethane  (ISO)
valproic acid  (ISO)
vitamin E  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Common variation at 3q26.2, 6p21.33, 17p11.2 and 22q13.1 influences multiple myeloma risk. Chubb D, etal., Nat Genet. 2013 Oct;45(10):1221-5. doi: 10.1038/ng.2733. Epub 2013 Aug 18.
2. Polycomb genes are associated with response to imatinib in chronic myeloid leukemia. Crea F, etal., Epigenomics. 2015 Aug;7(5):757-65. doi: 10.2217/epi.15.35. Epub 2015 Sep 7.
3. Chromobox protein homologue 7 protein, with decreased expression in human carcinomas, positively regulates E-cadherin expression by interacting with the histone deacetylase 2 protein. Federico A, etal., Cancer Res. 2009 Sep 1;69(17):7079-87. doi: 10.1158/0008-5472.CAN-09-1542. Epub 2009 Aug 25.
4. CBX7 is a tumor suppressor in mice and humans. Forzati F, etal., J Clin Invest. 2012 Feb 1;122(2):612-23. doi: 10.1172/JCI58620. Epub 2012 Jan 3.
5. PRC1 complex diversity: where is it taking us? Gil J and O'Loghlen A, Trends Cell Biol. 2014 Jul 22. pii: S0962-8924(14)00102-0. doi: 10.1016/j.tcb.2014.06.005.
6. Polycomb CBX7 has a unifying role in cellular lifespan. Gil J, etal., Nat Cell Biol 2004 Jan;6(1):67-72. Epub 2003 Nov 30.
7. [Downregulation of chromobox protein homolog 7 expression in multiple human cancer tissues] Guan ZP, etal., Zhonghua Yu Fang Yi Xue Za Zhi. 2011 Jul;45(7):597-600.
8. Expression parameters of the polycomb group proteins BMI1, SUZ12, RING1 and CBX7 in urothelial carcinoma of the bladder and their prognostic relevance. Hinz S, etal., Tumour Biol. 2008;29(5):323-9. doi: 10.1159/000170879. Epub 2008 Nov 5.
9. Loss of the CBX7 protein expression correlates with a more aggressive phenotype in pancreatic cancer. Karamitopoulou E, etal., Eur J Cancer. 2010 May;46(8):1438-44. doi: 10.1016/j.ejca.2010.01.033. Epub 2010 Feb 23.
10. Functional annotation of a full-length mouse cDNA collection. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
11. CBX7 inhibits breast tumorigenicity through DKK-1-mediated suppression of the Wnt/beta-catenin pathway. Kim HY, etal., FASEB J. 2015 Jan;29(1):300-13. doi: 10.1096/fj.14-253997. Epub 2014 Oct 28.
12. Tracing dynamics and clonal heterogeneity of Cbx7-induced leukemic stem cells by cellular barcoding. Klauke K, etal., Stem Cell Reports. 2015 Jan 13;4(1):74-89. doi: 10.1016/j.stemcr.2014.10.012. Epub 2014 Nov 26.
13. Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Ko MS, etal., Development 2000 Apr;127(8):1737-49.
14. Altered expression of polycomb group genes in glioblastoma multiforme. Li G, etal., PLoS One. 2013 Nov 15;8(11):e80970. doi: 10.1371/journal.pone.0080970. eCollection 2013.
15. Identification of a New Pathway for Tumor Progression: MicroRNA-181b Up-Regulation and CBX7 Down-Regulation by HMGA1 Protein. Mansueto G, etal., Genes Cancer. 2010 Mar;1(3):210-24. doi: 10.1177/1947601910366860.
16. MGDs mouse GO annotations MGD data from the GO Consortium
17. CBX7 Expression in Oncocytic Thyroid Neoplastic Lesions (Hurthle Cell Adenomas and Carcinomas). Monaco M, etal., Eur Thyroid J. 2014 Dec;3(4):211-6. doi: 10.1159/000367989. Epub 2014 Oct 15.
18. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
19. Loss of the CBX7 gene expression correlates with a highly malignant phenotype in thyroid cancer. Pallante P, etal., Cancer Res. 2008 Aug 15;68(16):6770-8. doi: 10.1158/0008-5472.CAN-08-0695.
20. Mouse MP Annotation Import Pipeline RGD automated import pipeline
21. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
22. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
23. Role of the chromobox protein CBX7 in lymphomagenesis. Scott CL, etal., Proc Natl Acad Sci U S A. 2007 Mar 27;104(13):5389-94. Epub 2007 Mar 20.
24. Expression of chromobox homolog 7 (CBX7) is associated with poor prognosis in ovarian clear cell adenocarcinoma via TRAIL-induced apoptotic pathway regulation. Shinjo K, etal., Int J Cancer. 2014 Jul 15;135(2):308-18. doi: 10.1002/ijc.28692. Epub 2014 Jan 10.
25. Occupying chromatin: Polycomb mechanisms for getting to genomic targets, stopping transcriptional traffic, and staying put. Simon JA and Kingston RE, Mol Cell. 2013 Mar 7;49(5):808-24. doi: 10.1016/j.molcel.2013.02.013.
26. Oncogenic role of the chromobox protein CBX7 in gastric cancer. Zhang XW, etal., J Exp Clin Cancer Res. 2010 Aug 19;29:114. doi: 10.1186/1756-9966-29-114.
Additional References at PubMed
PMID:8889548   PMID:10349636   PMID:10512203   PMID:10922068   PMID:11042159   PMID:11076861   PMID:12477932   PMID:12520002   PMID:12904583   PMID:14610273   PMID:15489334   PMID:15782199  
PMID:15840001   PMID:16141072   PMID:16141073   PMID:16537902   PMID:16786585   PMID:17296600   PMID:17967808   PMID:18311137   PMID:18799693   PMID:19636380   PMID:20059953   PMID:20543829  
PMID:21267068   PMID:21677750   PMID:21873635   PMID:22056776   PMID:22226354   PMID:22325148   PMID:23273917   PMID:23395003   PMID:23502315   PMID:23870131   PMID:24034696   PMID:24194518  
PMID:24687849   PMID:24721909   PMID:25190058   PMID:25449062   PMID:26496610   PMID:27271093   PMID:27723458   PMID:28111200   PMID:28839133   PMID:29459770   PMID:30238429   PMID:30759399  
PMID:30973865   PMID:32415167   PMID:34637753   PMID:35435747   PMID:36920677   PMID:37158107  


Genomics

Comparative Map Data
Cbx7
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391579,800,005 - 79,855,344 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1579,800,008 - 79,855,320 (-)EnsemblGRCm39 Ensembl
GRCm381579,915,804 - 79,971,143 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1579,915,807 - 79,971,119 (-)EnsemblGRCm38mm10GRCm38
MGSCv371579,746,237 - 79,763,076 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361579,740,244 - 79,759,866 (-)NCBIMGSCv36mm8
Celera1582,033,986 - 82,050,640 (-)NCBICelera
Cytogenetic Map15E1NCBI
cM Map1537.85NCBI
CBX7
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382239,130,772 - 39,152,680 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2239,120,167 - 39,152,680 (-)EnsemblGRCh38hg38GRCh38
GRCh372239,526,777 - 39,548,685 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362237,856,723 - 37,878,484 (-)NCBINCBI36Build 36hg18NCBI36
Build 342237,851,280 - 37,873,038NCBI
Celera2223,328,820 - 23,350,581 (-)NCBICelera
Cytogenetic Map22q13.1NCBI
HuRef2222,493,890 - 22,515,575 (-)NCBIHuRef
CHM1_12239,485,611 - 39,507,403 (-)NCBICHM1_1
T2T-CHM13v2.02239,601,155 - 39,623,071 (-)NCBIT2T-CHM13v2.0
Cbx7
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr87113,341,030 - 113,358,716 (-)NCBIGRCr8
mRatBN7.27111,460,656 - 111,479,231 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7111,460,656 - 111,477,973 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx7113,208,676 - 113,225,978 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.07115,432,223 - 115,449,524 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.07115,401,568 - 115,418,871 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.07121,136,067 - 121,153,503 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7121,136,058 - 121,153,383 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.07121,126,405 - 121,144,401 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47118,148,413 - 118,165,701 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.17118,182,643 - 118,199,931 (-)NCBI
Celera7107,790,484 - 107,807,779 (-)NCBICelera
Cytogenetic Map7q34NCBI
Cbx7
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541325,086,186 - 25,100,039 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495541325,079,627 - 25,100,039 (-)NCBIChiLan1.0ChiLan1.0
CBX7
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22348,978,435 - 49,000,373 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12251,669,911 - 51,691,852 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02220,037,529 - 20,059,459 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12237,854,049 - 37,876,861 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2237,854,056 - 37,876,084 (-)Ensemblpanpan1.1panPan2
CBX7
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11025,876,022 - 25,896,284 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1025,876,016 - 25,893,501 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1025,810,682 - 25,832,138 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01026,627,291 - 26,648,764 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1026,627,343 - 26,648,764 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11026,340,710 - 26,362,175 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01026,661,555 - 26,681,886 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01026,836,680 - 26,858,133 (+)NCBIUU_Cfam_GSD_1.0
Cbx7
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244049459,400,883 - 9,418,070 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364922,410,308 - 2,428,682 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364922,411,171 - 2,428,484 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CBX7
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl59,070,353 - 9,087,634 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.159,070,312 - 9,090,467 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.256,355,114 - 6,372,426 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CBX7
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11921,776,618 - 21,798,525 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1921,775,931 - 21,798,309 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666045103,958,387 - 103,980,295 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Cbx7
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247529,133,569 - 9,151,934 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247529,133,587 - 9,151,216 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Cbx7
1770 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:2916
Count of miRNA genes:720
Interacting mature miRNAs:894
Transcripts:ENSMUST00000089293, ENSMUST00000109615, ENSMUST00000109616, ENSMUST00000128931, ENSMUST00000132821, ENSMUST00000146719, ENSMUST00000176639, ENSMUST00000177044, ENSMUST00000177061
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
27226734Tibmd5_mtibia midshaft diameter 5, 10 week (mouse)15612948186684201Mouse
26884442Sklq6_mskull length QTL 6, 5 week (mouse)156129481100797881Mouse
27226777Tibl8_mtibia length 8, 5 week (mouse)15692948184584201Mouse
1357526Hyplip2_mhyperlipidemia 2 (mouse)Not determined1512402203102896555Mouse
26884425Cvht2_mcranial vault height 2, 5 week (mouse)1528800146102008435Mouse
1558985Eae32_mexperimental allergic encephalomyelitis susceptibility 32 (mouse)Not determined1532578416103425899Mouse
27226729Tibmd2_mtibia midshaft diameter 2, 5 week (mouse)153800024486684201Mouse
26884402Cvht9_mcranial vault height 9, 16 week (mouse)154216339695497881Mouse
1357756Alaa4_malopecia areata 4 (mouse)Not determined154638964680389845Mouse
10755515Amzn3_manatomical modifier of Zfp423 3 (mouse)154638964680389845Mouse
1301006Hfib1_mhepatic fibrogenesis 1 (mouse)Not determined154730633481306479Mouse
1301860Gct3_mgranulosa cell tumorigenesis 3 (mouse)Not determined154740959681409691Mouse
26884397Humsd5_mhumerus midshaft diameter 5, 10 week (mouse)154836339698397881Mouse
26884399Humsd1_mhumerus midshaft diameter 1, 5 week (mouse)1548363396101708435Mouse
1301429Pcir3_mperiosteal circumference 3 (mouse)Not determined154846536282465496Mouse
4142198Hbtq_mhabituation QTL (mouse)Not determined155116070885160833Mouse
10045637Heal27_mwound healing/regeneration 29 (mouse)Not determined155141836185418511Mouse
10412067Pain2_mpain 2 (mouse)Not determined155164533985645626Mouse
1302080Szs13_mseizure susceptibility 13 (mouse)Not determined155168583285694449Mouse
1301708Cocrb14_mcocaine related behavior 14 (mouse)Not determined155180651585806651Mouse
38501067Tip3_mtuberculosis immunophenotype 3, IFN-g level (mouse)155356339689584203Mouse
13504731Cath5_mcarotid atherosclerosis 5 (mouse)155478912988789129Mouse
1302074Bmd4_mbone mineral density 4 (mouse)Not determined1556186708103425899Mouse
27095936Ulnl4_mulna length 4, 5 week (mouse)155676339687684201Mouse
1300800Ses3_msalmonella enteritidis susceptibility 3 (mouse)Not determined155711700591117153Mouse
1357407Pfat4_mpredicted fat percentage 4 (mouse)8.6Body fat amountpredicted fat percentage155711700591117153Mouse
12880420V25Dq8_mvitamin D inactive form serum level QTL 8 (mouse)156158420095584200Mouse
1301601Faq9_mfluctuating asymmetry QTL 9 (mouse)Not determined156316390397163995Mouse
1558786Msq1_mMAV-1 susceptibility QTL 1 (mouse)Not determined156338964681086436Mouse
1302197Bhr2_mbronchial hyperresponsiveness 2 (mouse)Not determined1564306334103425899Mouse
4141135Cia35_mcollagen induced arthritis 35 (mouse)Not determined156481182698811946Mouse
1301119Drb7_mdopamine receptor binding 7 (mouse)Not determined156533657899341028Mouse
1301171Brm2_mbrachyury modifier 2 (mouse)Not determined156552537699525499Mouse
4141921Pstc3_mperiosteal circumference 3 (mouse)Not determined1567270698101270847Mouse
1300627Sluc26_msusceptibility to lung cancer 26 (mouse)Not determined1570345653104073951Mouse
1300648Dbsty4_mdiabesity 4 (mouse)Not determined1570349271104073951Mouse
1300726Pitm4_mprion incubation time 4 (mouse)Not determined1570349271104073951Mouse
1302002Cocia2_mcocaine induced activation 2 (mouse)Not determined157237245979899178Mouse
14747011Mancz13_mmandible centroid size 13 (mouse)1572382669104073951Mouse
12791003Aath8_maortic arch atherosclerosis 8 (mouse)1573430144104073951Mouse
15092079Igly6_mIgG glycosylation 6, GP6 (mouse)157410054082674156Mouse
1301472Pain1_mpain 1 (mouse)Not determined157532084690813185Mouse
1300851Heal4_mwound healing/regeneration 4 (mouse)Not determined1577527592104073951Mouse
15092080Igly7_mIgG glycosylation 7, GP10 (mouse)157779491982674156Mouse
4142060W3q6_mweight 3 weeks QTL 6 (mouse)Not determined78601103102901704Mouse
1357894Epfpq3_mepididymal fat percentage QTL 3 (mouse)Not determined1578601103102901704Mouse
14928306Manh79_mmandible shape 79 (mouse)1578847557104073951Mouse
12880411V125Dq11_mvitamin D active form serum level QTL 11 (mouse)1578897881104073951Mouse
10402490Dipa5_mdrug induced psychomotor activation 5 (mouse)Not determined1579163411104073951Mouse

Markers in Region
AI851678  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381579,915,996 - 79,916,143UniSTSGRCm38
MGSCv371579,746,426 - 79,746,573UniSTSGRCm37
Celera1582,034,175 - 82,034,322UniSTS
Cytogenetic Map15E1UniSTS
cM Map1546.0UniSTS
Whitehead/MRC_RH15681.56UniSTS
RH127217  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381579,917,522 - 79,917,744UniSTSGRCm38
MGSCv371579,747,952 - 79,748,174UniSTSGRCm37
Celera1582,035,708 - 82,035,930UniSTS
Cytogenetic Map15E1UniSTS
cM Map1546.0UniSTS
Whitehead/MRC_RH15678.47UniSTS


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_144811 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006521144 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006521147 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006521148 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011245690 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011245691 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011245692 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_003951404 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_384025 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB221539 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC113595 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK005457 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK045714 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK192508 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY453793 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC030919 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC042657 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BQ571764 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466550 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CU019616 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MN581682 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSMUST00000089293   ⟹   ENSMUSP00000086708
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1579,800,011 - 79,816,840 (-)Ensembl
GRCm38.p6 Ensembl1579,915,810 - 79,932,639 (-)Ensembl
RefSeq Acc Id: ENSMUST00000109615   ⟹   ENSMUSP00000105244
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1579,802,311 - 79,816,741 (-)Ensembl
GRCm38.p6 Ensembl1579,918,110 - 79,932,540 (-)Ensembl
RefSeq Acc Id: ENSMUST00000109616   ⟹   ENSMUSP00000105245
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1579,800,008 - 79,816,853 (-)Ensembl
GRCm38.p6 Ensembl1579,915,807 - 79,932,652 (-)Ensembl
RefSeq Acc Id: ENSMUST00000128931   ⟹   ENSMUSP00000118813
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1579,802,618 - 79,855,320 (-)Ensembl
GRCm38.p6 Ensembl1579,918,417 - 79,971,119 (-)Ensembl
RefSeq Acc Id: ENSMUST00000132821   ⟹   ENSMUSP00000118871
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1579,802,650 - 79,855,319 (-)Ensembl
GRCm38.p6 Ensembl1579,918,449 - 79,971,118 (-)Ensembl
RefSeq Acc Id: ENSMUST00000146719   ⟹   ENSMUSP00000120748
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1579,802,349 - 79,818,100 (-)Ensembl
GRCm38.p6 Ensembl1579,918,148 - 79,933,899 (-)Ensembl
RefSeq Acc Id: ENSMUST00000176639
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1579,800,014 - 79,816,969 (-)Ensembl
GRCm38.p6 Ensembl1579,915,813 - 79,932,768 (-)Ensembl
RefSeq Acc Id: ENSMUST00000177044   ⟹   ENSMUSP00000135246
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1579,803,122 - 79,816,717 (-)Ensembl
GRCm38.p6 Ensembl1579,918,921 - 79,932,516 (-)Ensembl
RefSeq Acc Id: ENSMUST00000177061
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1579,814,749 - 79,818,031 (-)Ensembl
GRCm38.p6 Ensembl1579,930,548 - 79,933,830 (-)Ensembl
RefSeq Acc Id: NM_144811   ⟹   NP_659060
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391579,800,008 - 79,816,847 (-)NCBI
GRCm381579,915,807 - 79,932,646 (-)NCBI
MGSCv371579,746,237 - 79,763,076 (-)RGD
Celera1582,033,986 - 82,050,640 (-)RGD
cM Map15 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006521144   ⟹   XP_006521207
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391579,800,005 - 79,818,381 (-)NCBI
GRCm381579,915,804 - 79,932,798 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006521147   ⟹   XP_006521210
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391579,800,005 - 79,818,381 (-)NCBI
GRCm381579,915,804 - 79,932,795 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006521148   ⟹   XP_006521211
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391579,800,005 - 79,855,343 (-)NCBI
GRCm381579,915,804 - 79,971,142 (-)NCBI
Sequence:
RefSeq Acc Id: XM_011245690   ⟹   XP_011243992
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391579,800,005 - 79,855,344 (-)NCBI
GRCm381579,915,804 - 79,971,143 (-)NCBI
Sequence:
RefSeq Acc Id: XM_011245691   ⟹   XP_011243993
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391579,800,005 - 79,855,344 (-)NCBI
GRCm381579,915,804 - 79,971,143 (-)NCBI
Sequence:
RefSeq Acc Id: XM_011245692   ⟹   XP_011243994
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391579,800,005 - 79,810,834 (-)NCBI
GRCm381579,915,804 - 79,925,453 (-)NCBI
Sequence:
RefSeq Acc Id: XR_003951404
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391579,800,005 - 79,818,381 (-)NCBI
GRCm381579,915,804 - 79,932,792 (-)NCBI
Sequence:
RefSeq Acc Id: XR_384025
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391579,800,005 - 79,818,381 (-)NCBI
GRCm381579,915,804 - 79,932,798 (-)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_659060   ⟸   NM_144811
- UniProtKB: Q8VDS3 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006521211   ⟸   XM_006521148
- Peptide Label: isoform X5
- Sequence:
RefSeq Acc Id: XP_006521207   ⟸   XM_006521144
- Peptide Label: isoform X1
- UniProtKB: F8WHN2 (UniProtKB/TrEMBL),   A0A6M8AZW7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006521210   ⟸   XM_006521147
- Peptide Label: isoform X4
- Sequence:
RefSeq Acc Id: XP_011243992   ⟸   XM_011245690
- Peptide Label: isoform X2
- UniProtKB: A0A6M8AZW7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_011243993   ⟸   XM_011245691
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_011243994   ⟸   XM_011245692
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: ENSMUSP00000135246   ⟸   ENSMUST00000177044
RefSeq Acc Id: ENSMUSP00000118871   ⟸   ENSMUST00000132821
RefSeq Acc Id: ENSMUSP00000120748   ⟸   ENSMUST00000146719
RefSeq Acc Id: ENSMUSP00000086708   ⟸   ENSMUST00000089293
RefSeq Acc Id: ENSMUSP00000105245   ⟸   ENSMUST00000109616
RefSeq Acc Id: ENSMUSP00000105244   ⟸   ENSMUST00000109615
RefSeq Acc Id: ENSMUSP00000118813   ⟸   ENSMUST00000128931
Protein Domains
Chromo

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q8VDS3-F1-model_v2 AlphaFold Q8VDS3 1-158 view protein structure

Promoters
RGD ID:6825843
Promoter ID:MM_KWN:19094
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   Spleen
Transcripts:ENSMUST00000109615,   ENSMUST00000109616,   UC007WUW.1,   UC007WUX.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361579,762,904 - 79,763,404 (-)MPROMDB
RGD ID:6825844
Promoter ID:MM_KWN:19095
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:ES_Cell
Transcripts:OTTMUST00000041849
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361579,763,841 - 79,764,341 (-)MPROMDB
RGD ID:8684384
Promoter ID:EPDNEW_M20222
Type:initiation region
Name:Cbx7_1
Description:Mus musculus chromobox 7 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381579,932,729 - 79,932,789EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1196439 AgrOrtholog
Ensembl Genes ENSMUSG00000053411 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000089293 ENTREZGENE
  ENSMUST00000089293.11 UniProtKB/TrEMBL
  ENSMUST00000109615.8 UniProtKB/Swiss-Prot
  ENSMUST00000109616 ENTREZGENE
  ENSMUST00000109616.9 UniProtKB/Swiss-Prot
  ENSMUST00000128931.8 UniProtKB/TrEMBL
  ENSMUST00000132821.8 UniProtKB/TrEMBL
  ENSMUST00000146719.9 UniProtKB/TrEMBL
  ENSMUST00000177044.2 UniProtKB/TrEMBL
Gene3D-CATH 2.40.50.40 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro CBX7 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CBX7_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Chromo-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Chromo/chromo_shadow_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Chromo_dom_subgr UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Chromo_domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Chromodomain_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:52609 UniProtKB/Swiss-Prot
MGD MGI:1196439 ENTREZGENE
NCBI Gene 52609 ENTREZGENE
PANTHER CHROMOBOX PROTEIN HOMOLOG 7 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR47277 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam CBX7_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Chromo UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Cbx7 PhenoGen
PRINTS CHROMODOMAIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE CHROMO_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CHROMO_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART CHROMO UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF54160 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A6M8AZW7 ENTREZGENE, UniProtKB/TrEMBL
  CBX7_MOUSE UniProtKB/Swiss-Prot
  D3YY71_MOUSE UniProtKB/TrEMBL
  D3YYK4_MOUSE UniProtKB/TrEMBL
  F6WJA6_MOUSE UniProtKB/TrEMBL
  F8WHN2 ENTREZGENE, UniProtKB/TrEMBL
  H3BK45_MOUSE UniProtKB/TrEMBL
  Q8VDS3 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2012-07-10 Cbx7  chromobox 7  Cbx7  chromobox homolog 7  Symbol and/or name change 5135510 APPROVED