RGD Reference Report - PRC1 complex diversity: where is it taking us? - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

PRC1 complex diversity: where is it taking us?

Authors: Gil, J  O'Loghlen, A 
Citation: Gil J and O'Loghlen A, Trends Cell Biol. 2014 Jul 22. pii: S0962-8924(14)00102-0. doi: 10.1016/j.tcb.2014.06.005.
RGD ID: 9479060
Pubmed: PMID:25065329   (View Abstract at PubMed)
DOI: DOI:10.1016/j.tcb.2014.06.005   (Journal Full-text)

Polycomb group proteins (PcGs) are essential epigenetic regulators that play key roles in development, pluripotency, senescence, and cancer. Recent reports have found that the composition of mammalian Polycomb repressive complex 1 (PRC1) is far more varied than previously thought. PRC1 diversity largely depends on the presence of CBX proteins, dividing them into canonical and non-canonical, the existence of redundant subunits, and different binding affinities and/or regulation. However, there is no clear insight into how many functional PRC1 complexes exist and what the biological relevance is for such diversification. In this review we focus on mammalian PRC1 and discuss the mechanisms by which canonical and non-canonical PRC1 are recruited to chromatin, their role in normal development and disease, and emerging evidence for PRC1 as a transcriptional activator.

Molecular Pathway Annotations    Click to see Annotation Detail View

RGD Manual Annotations

Objects Annotated

Genes (Rattus norvegicus)
Bmi1  (BMI1 proto-oncogene, polycomb ring finger)
Cbx2  (chromobox 2)
Cbx4  (chromobox 4)
Cbx6  (chromobox 6)
Cbx7  (chromobox 7)
Cbx8  (chromobox 8)
Pcgf1  (polycomb group ring finger 1)
Pcgf3  (polycomb group ring finger 3)
Pcgf5  (polycomb group ring finger 5)
Pcgf6  (polycomb group ring finger 6)
Phc1  (polyhomeotic homolog 1)
Phc2  (polyhomeotic homolog 2)
Phc3  (polyhomeotic homolog 3)
Ring1  (ring finger protein 1)
Rnf2  (ring finger protein 2)

Genes (Mus musculus)
Bmi1  (Bmi1 polycomb ring finger oncogene)
Cbx2  (chromobox 2)
Cbx4  (chromobox 4)
Cbx6  (chromobox 6)
Cbx7  (chromobox 7)
Cbx8  (chromobox 8)
Pcgf1  (polycomb group ring finger 1)
Pcgf2  (polycomb group ring finger 2)
Pcgf3  (polycomb group ring finger 3)
Pcgf5  (polycomb group ring finger 5)
Pcgf6  (polycomb group ring finger 6)
Phc1  (polyhomeotic 1)
Phc2  (polyhomeotic 2)
Phc3  (polyhomeotic 3)
Ring1  (ring finger protein 1)
Rnf2  (ring finger protein 2)

Genes (Homo sapiens)
BMI1  (BMI1 proto-oncogene, polycomb ring finger)
CBX2  (chromobox 2)
CBX4  (chromobox 4)
CBX6  (chromobox 6)
CBX7  (chromobox 7)
CBX8  (chromobox 8)
PCGF1  (polycomb group ring finger 1)
PCGF2  (polycomb group ring finger 2)
PCGF3  (polycomb group ring finger 3)
PCGF5  (polycomb group ring finger 5)
PCGF6  (polycomb group ring finger 6)
PHC1  (polyhomeotic homolog 1)
PHC2  (polyhomeotic homolog 2)
PHC3  (polyhomeotic homolog 3)
RING1  (ring finger protein 1)
RNF2  (ring finger protein 2)


Additional Information