Akr1b8 (aldo-keto reductase family 1, member B8) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Gene: Akr1b8 (aldo-keto reductase family 1, member B8) Mus musculus
Analyze
No known orthologs.
Symbol: Akr1b8
Name: aldo-keto reductase family 1, member B8
RGD ID: 1550101
MGI Page MGI
Description: Predicted to enable several functions, including NADP binding activity; geranylgeranyl reductase activity; and oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor. Predicted to be located in extracellular region and lysosome. Predicted to be active in cytosol and mitochondrion. Is expressed in several structures, including alimentary system; central nervous system; ear; genitourinary system; and respiratory system. Orthologous to several human genes including AKR1B10 (aldo-keto reductase family 1 member B10).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: aldehyde reductase; aldose reductase-related protein 2; AR; Fg; Fgf; Fgfrp; Fgrp; fibroblast growth factor regulated protein; fibroblast growth factor-regulated protein; FR-1
RGD Orthologs
Alliance Orthologs
More Info homologs ...
Related Pseudogenes: Gm18799   Gm18832   Gm18835   Gm5649  
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39634,331,081 - 34,345,396 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl634,331,054 - 34,345,398 (+)EnsemblGRCm39 Ensembl
GRCm38634,354,146 - 34,368,461 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl634,354,119 - 34,368,463 (+)EnsemblGRCm38mm10GRCm38
MGSCv37634,304,164 - 34,318,454 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36634,284,322 - 34,298,612 (+)NCBIMGSCv36mm8
Celera634,351,110 - 34,365,396 (+)NCBICelera
Cytogenetic Map6B1NCBI
cM Map614.91NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IEA)
cytosol  (IBA,ISO)
extracellular region  (ISO)
lysosome  (ISO)
mitochondrion  (IBA,ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. MGDs mouse GO annotations MGD data from the GO Consortium
2. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
3. Mouse MP Annotation Import Pipeline RGD automated import pipeline
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:7510692   PMID:7578036   PMID:8526877   PMID:8541228   PMID:10092857   PMID:10725249   PMID:12477932   PMID:14681479   PMID:15489334   PMID:15782199   PMID:16602821   PMID:17381426  
PMID:21087085   PMID:21179467   PMID:21267068   PMID:21873635   PMID:24194600   PMID:25120755   PMID:25538260   PMID:26291391   PMID:27626380   PMID:28245920   PMID:28700664   PMID:30146317  
PMID:31911858   PMID:33593819   PMID:33644071   PMID:34954342   PMID:36518763   PMID:38355793  


Genomics

Variants

.
Variants in Akr1b8
563 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:192
Count of miRNA genes:178
Interacting mature miRNAs:182
Transcripts:ENSMUST00000038406, ENSMUST00000133370
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4142126W3q3_mweight 3 weeks QTL 3 (mouse)Not determined450382396633110Mouse
10043869Cia6a_mcollagen induced arthritis QTL 6a (mouse)Not determined61211797146118069Mouse
12904943Tammq4_mtibialis anterior muscle mass QTL 4 (mouse)61961634653616346Mouse
1302051Sluc7_msusceptibility to lung cancer 7 (mouse)Not determined6929707443297168Mouse
4142361W10q11_mweight 10 weeks QTL 11 (mouse)Not determined450382396633110Mouse
26884441Sklq3_mskull length QTL 3, 5 week (mouse)6760000080576983Mouse
15039372Nmrs22_mNAFLD-associated magnetic resonance shift 22 (mouse)6147633435476334Mouse
4141749Obrq2_mobesity resistance QTL 2 (mouse)Not determined1275122146751333Mouse
4141454Obrq4_mobesity resistance QTL 4 (mouse)Not determined3170349965703611Mouse
12880425V25Dq5_mvitamin D inactive form serum level QTL 5 (mouse)63267698066676980Mouse
4140989Spqq2_msperm quality QTL 2 (mouse)Not determined1771159851711719Mouse
12904940Edlmmq5_mextensor digitorum longus muscle mass QTL 5 (mouse)61961634653616346Mouse
10412213Sxbq2_mSGC/Knj cross B6 QTL 2 (mouse)Not determined61991268571299759Mouse
11353841Bmiq3_mbody mass index QTL 3 (mouse)6450382348703611Mouse
13208564Bmiq7_mbody mass index QTL 7 (mouse)62499999979976983Mouse
11353840Bmiq2_mbody mass index QTL 2 (mouse)6450382345291115Mouse
1301724Pcd4ts1_mp-glycoprotein positive CD4 T cell subset 1 (mouse)Not determined61771159851711719Mouse
10412107Desp4_mdespair 4 (mouse)Not determined62004983054049830Mouse
26884414Bzwq12_mbi-zygomatic width QTL 12, 16 week (mouse)63400000139076998Mouse
27226726Tibmd7_mtibia midshaft diameter 7, 16 week (mouse)61769999953476985Mouse
1301998Bts2_mbladder tumor susceptibility 2 (mouse)Not determined61275122146751333Mouse
12904952Gmmq4_mgastrocnemius muscle mass QTL 4 (mouse)61961634653616346Mouse
1357520Axtq2_manxiety QTL 2 (mouse)Not determined6450382348703611Mouse
1300959Lxw2_mlupus BXSB x NZW 2 (mouse)Not determined63387226167872400Mouse
11252142Mom12_mModifier of Min 12 (mouse)63387226167872400Mouse
1300731Smdq3_msegregation of mitochondrial DNA QTL 3 (mouse)Not determined6424920638249325Mouse
1301850Fglu_mfasting glucose (mouse)Not determined61771159851711719Mouse
1357442Dbts1_mdiabetes 1 (mouse)Not determined61823414773364675Mouse
11352717Obrq2a_mobesity resistance QTL 2a (mouse)63169434134847895Mouse
1357481Aaj2_manxiety in A/J 2 (mouse)Not determined6450382348703611Mouse
4142271Egq8_mearly growth QTL 8 (mouse)Not determined450382396633110Mouse
14700690Ccs6_mcolon cancer susceptibility 6 (mouse)62377693457776934Mouse
4141988Obrq3_mobesity resistance QTL 3 (mouse)Not determined2829099362291115Mouse
4141782Mrdq5_mmodifier of retinal degeneration QTL 5 (mouse)Not determined3282758578215957Mouse
25440480Moaq2_mmodifier of alien QTL 2 (mouse)63050001117476961Mouse
1300556Cia6_mcollagen induced arthritis QTL 6 (mouse)Not determined6446488487403016Mouse
4142232W6q4_mweight 6 weeks QTL 4 (mouse)Not determined450382396633110Mouse

Markers in Region
U04204  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38634,368,244 - 34,368,419UniSTSGRCm38
MGSCv37634,318,244 - 34,318,419UniSTSGRCm37
Celera634,365,186 - 34,365,361UniSTS
Cytogenetic Map6B1UniSTS
cM Map613.0UniSTS
Whitehead_YAC6 UniSTS
D6Mit269  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38634,359,005 - 34,359,111UniSTSGRCm38
MGSCv37634,309,005 - 34,309,111UniSTSGRCm37
Celera634,355,951 - 34,356,053UniSTS
Cytogenetic Map6B1UniSTS
cM Map615.7UniSTS
Whitehead Genetic67.7UniSTS
Whitehead/MRC_RH6270.2UniSTS
Whitehead_YAC6 UniSTS
UniSTS:235404  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38634,368,210 - 34,368,417UniSTSGRCm38
MGSCv37634,318,210 - 34,318,417UniSTSGRCm37
Celera634,365,152 - 34,365,359UniSTS
Cytogenetic Map6B1UniSTS
cM Map613.0UniSTS


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000038406   ⟹   ENSMUSP00000040244
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl634,331,054 - 34,345,398 (+)Ensembl
GRCm38.p6 Ensembl634,354,119 - 34,368,463 (+)Ensembl
RefSeq Acc Id: ENSMUST00000133370
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl634,333,050 - 34,342,174 (+)Ensembl
GRCm38.p6 Ensembl634,356,115 - 34,365,239 (+)Ensembl
RefSeq Acc Id: NM_008012   ⟹   NP_032038
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39634,331,081 - 34,345,396 (+)NCBI
GRCm38634,354,146 - 34,368,461 (+)NCBI
MGSCv37634,304,164 - 34,318,454 (+)RGD
Celera634,351,110 - 34,365,396 (+)RGD
cM Map6 ENTREZGENE
Sequence:
Protein Sequences
Protein RefSeqs NP_032038 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA16953 (Get FASTA)   NCBI Sequence Viewer  
  AAH05789 (Get FASTA)   NCBI Sequence Viewer  
  EDL13693 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSMUSP00000040244
  ENSMUSP00000040244.6
GenBank Protein P45377 (Get FASTA)   NCBI Sequence Viewer  
Reference Protein Sequences
RefSeq Acc Id: NP_032038   ⟸   NM_008012
- UniProtKB: Q99JN4 (UniProtKB/Swiss-Prot),   P45377 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSMUSP00000040244   ⟸   ENSMUST00000038406

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P45377-F1-model_v2 AlphaFold P45377 1-316 view protein structure

Promoters
RGD ID:6838920
Promoter ID:MM_KWN:45524
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day4,   3T3L1_Day6,   MEF_B6
Transcripts:OTTMUST00000035091
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36634,303,864 - 34,304,364 (+)MPROMDB
RGD ID:6889284
Promoter ID:EPDNEW_M8093
Type:initiation region
Name:Akr1b8_1
Description:Mus musculus aldo-keto reductase family 1, member B8 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38634,354,164 - 34,354,224EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:107673 AgrOrtholog
Ensembl Genes ENSMUSG00000029762 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000038406 ENTREZGENE
  ENSMUST00000038406.7 UniProtKB/Swiss-Prot
Gene3D-CATH 3.20.20.100 UniProtKB/Swiss-Prot
InterPro Aldo/ket_reductase_CS UniProtKB/Swiss-Prot
  Aldo/keto_reductase UniProtKB/Swiss-Prot
  NADP_OxRdtase_dom UniProtKB/Swiss-Prot
  NADP_OxRdtase_dom_sf UniProtKB/Swiss-Prot
KEGG Report mmu:14187 UniProtKB/Swiss-Prot
MGD MGI:107673 ENTREZGENE
NCBI Gene 14187 ENTREZGENE
PANTHER ALDO-KETO REDUCTASE FAMILY 1 MEMBER B10 UniProtKB/Swiss-Prot
  ALDO/KETO REDUCTASE UniProtKB/Swiss-Prot
Pfam Aldo_ket_red UniProtKB/Swiss-Prot
PhenoGen Akr1b8 PhenoGen
PIRSF AKR UniProtKB/Swiss-Prot
PRINTS ALDKETRDTASE UniProtKB/Swiss-Prot
PROSITE ALDOKETO_REDUCTASE_1 UniProtKB/Swiss-Prot
  ALDOKETO_REDUCTASE_2 UniProtKB/Swiss-Prot
  ALDOKETO_REDUCTASE_3 UniProtKB/Swiss-Prot
Superfamily-SCOP SSF51430 UniProtKB/Swiss-Prot
UniProt ALD2_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
  Q99JN4 ENTREZGENE
UniProt Secondary Q99JN4 UniProtKB/Swiss-Prot