GFRA4 (GDNF family receptor alpha 4)

Gene: GFRA4 (GDNF family receptor alpha 4) Sus scrofa

Analyze

Symbol:

GFRA4

Name:

GDNF family receptor alpha 4

RGD ID:

14002985

Description:

ENCODES a protein that exhibits glial cell-derived neurotrophic factor receptor activity (ortholog); INVOLVED IN negative regulation of ossification (ortholog); ossification (ortholog); ASSOCIATED WITH fetal akinesia deformation sequence syndrome 1 (ortholog); Huntington's disease-like 1 (ortholog); Inosine Triphosphatase Deficiency (ortholog); FOUND IN extracellular space (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

GDNF family receptor alpha-4

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

Sscrofa11.1 - Pig Sscrofa11.1 Assembly

Position:

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	17	32,040,235 - 32,046,105 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	17	32,040,183 - 32,044,396 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	17	36,367,615 - 36,372,394 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

fetal akinesia deformation sequence syndrome 1 (ISO)

Huntington's disease-like 1 (ISO)

Inosine Triphosphatase Deficiency (ISO)

pantothenate kinase-associated neurodegeneration (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

glial cell-derived neurotrophic factor receptor signaling pathway (IEA)

negative regulation of ossification (IEA,ISO)

nervous system development (IBA,IEA)

ossification (IEA,ISO)

Cellular Component

external side of plasma membrane (IBA,IEA)

extracellular space (ISO)

plasma membrane (IEA)

receptor complex (IBA,IEA)

Molecular Function

glial cell-derived neurotrophic factor receptor activity (IBA,IEA,ISO)

signaling receptor activity (IEA)

References

Additional References at PubMed

PMID:30032202

Genomics

Comparative Map Data

GFRA4
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	17	32,040,235 - 32,046,105 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	17	32,040,183 - 32,044,396 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	17	36,367,615 - 36,372,394 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

GFRA4
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	20	3,659,248 - 3,663,399 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	20	3,659,248 - 3,663,399 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	20	3,639,895 - 3,644,046 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	20	3,587,939 - 3,592,046 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	20	3,587,938 - 3,592,046	NCBI
Celera	20	3,701,823 - 3,705,927 (-)	NCBI		Celera
Cytogenetic Map	20	p13	NCBI
HuRef	20	3,588,274 - 3,592,378 (-)	NCBI		HuRef
CHM1_1	20	3,640,254 - 3,644,358 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	20	3,690,188 - 3,694,336 (-)	NCBI		T2T-CHM13v2.0

Gfra4
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	2	130,881,552 - 130,885,008 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	2	130,881,552 - 130,885,008 (-)	Ensembl		GRCm39 Ensembl
GRCm38	2	131,039,632 - 131,043,088 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	2	131,039,632 - 131,043,088 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	2	130,865,912 - 130,868,824 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	2	130,731,617 - 130,734,123 (-)	NCBI		MGSCv36	mm8
Celera	2	132,264,900 - 132,267,812 (-)	NCBI		Celera
Cytogenetic Map	2	F1	NCBI
cM Map	2	63.26	NCBI

Gfra4
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	3	138,707,970 - 138,715,279 (-)	NCBI		GRCr8
mRatBN7.2	3	118,254,937 - 118,262,252 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	3	118,255,402 - 118,258,329 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	3	122,149,255 - 122,152,241 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	3	130,747,254 - 130,750,240 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	3	128,405,366 - 128,408,352 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	3	123,573,394 - 123,582,431 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	3	123,578,997 - 123,581,518 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	3	130,077,877 - 130,081,784 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	3	118,712,252 - 118,714,773 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	3	118,617,824 - 118,620,346 (-)	NCBI
Celera	3	117,065,274 - 117,067,795 (-)	NCBI		Celera
Cytogenetic Map	3	q36	NCBI

Gfra4
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0	NW_004955415	14,513,183 - 14,514,140 (-)	NCBI	ChiLan1.0	ChiLan1.0

GFRA4
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	21	4,621,663 - 4,626,719 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	20	4,618,488 - 4,623,544 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	20	3,740,538 - 3,745,601 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	20	3,499,690 - 3,503,081 (-)	NCBI	panpan1.1	PanPan1.1	panPan2

GFRA4
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	24	17,685,888 - 17,690,747 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	24	17,686,817 - 17,690,056 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	24	17,515,732 - 17,520,613 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	24	18,104,690 - 18,109,573 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	24	18,105,641 - 18,109,587 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	24	17,699,436 - 17,704,303 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	24	17,811,187 - 17,816,066 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	24	18,138,277 - 18,143,160 (+)	NCBI		UU_Cfam_GSD_1.0

Gfra4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024408640	166,703,881 - 166,708,001 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936485	15,135,245 - 15,139,000 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936485	15,135,245 - 15,139,639 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

GFRA4
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Vero_WHO_p1.0	NW_023666071	10,096,841 - 10,106,162 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Gfra4
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624741	4,753,792 - 4,757,642 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624741	4,752,376 - 4,757,642 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in GFRA4
136 total Variants

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	hemolymphoid system	musculoskeletal system	nervous system	respiratory system
High
Medium
Low	2			9
Below cutoff		1	1	6	1

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_021077388	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AEMK02000106	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CU467609	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CU468397	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	GFLN01130092	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSSSCT00000052547 ⟹ ENSSSCP00000031769

Type:

CODING

Position:

Pig Assembly	Chr	Position (strand)	Source
Sscrofa11.1 Ensembl	17	32,041,828 - 32,046,105 (+)	Ensembl

RefSeq Acc Id:

ENSSSCT00000071032 ⟹ ENSSSCP00000069811

Type:

CODING

Position:

Pig Assembly	Chr	Position (strand)	Source
Sscrofa11.1 Ensembl	17	32,040,235 - 32,044,950 (+)	Ensembl

RefSeq Acc Id:

ENSSSCT00000073334 ⟹ ENSSSCP00000059894

Type:

CODING

Position:

Pig Assembly	Chr	Position (strand)	Source
Sscrofa11.1 Ensembl	17	32,040,863 - 32,052,741 (+)	Ensembl

RefSeq Acc Id:

XM_021077388 ⟹ XP_020933047

Type:

CODING

Position:

Pig Assembly	Chr	Position (strand)	Source
Sscrofa11.1	17	32,040,183 - 32,044,396 (+)	NCBI

Sequence:

show sequence

GTGGGGGGGTGGGGTCCATCTAGGTACATTCAGGCCCCAGACTCAGTGGGGGCGGGGAGTCATT
CCTAATGCAAGAGCTCCTCCCACAGAAGAGCACATTAGTGCAGACACCTGGGTTTCCACCTCAC
TGTGGCTCAGGGGAGCTGGGAAGGAGGCACCTTTTGACCGGGGCTCTGCCTCCGGTCAGCCTCT
CCTCTGCTGCCCAGCATGGCTAGCTGCTTGGCACCTGCGCTGCTGCTGCTGCTGCTTCTGGGCT
CGCCGAGCTCTGCTGCACGGAACCGATGCGTGGACGCGGCTGAGGCGTGCACTGCGGACACGCG
GTGCCGTCGGCTGCGCACCGCCTATGTGGCGCAGTGCCTGGGTCCCGCCTCGCCGGGGAGCTGC
CCACGCGCCCGCTGCCGCCGTGCCCTGCGCCGCTTCTTCGCCCGCGGGCCACCTCCGCTCACTC
ACGCGCTGCTCTTCTGCCCGTGCGGTGGCCCCGCGTGCGCTGAGCGCCGGCGCCAGACCTTCGT
GCCTTCCTGCGCCTTCTCGGGGCCTGGCGCGGCACCGCCCTCCTGCCTCGCGTCCCTAGAAGCC
TGCGAGCGAAGCCGGGTCTGCAGGCCCCGCCTCTTGGCCTTCCAGGCCTCCTGTGGGCCCGCCC
CCAGCGCCTCGGACCTCTGCCAGGGGCACCAGGCCCCCAGCTGCCTGAGCGCCTATGCCGGCCT
CGTGGGCACCGCCGTCACCCCCAACTACGTGGACAATGCGAGCGCGCGTGTGGCACCTTGGTGC
GACTGCGGAGCCAGTGGAAACCGGCGTGAGGAGTGCGAAGCCTTCCGGGGGCTTTTTACTAGGA
ACCGCTGCCTGGATGGCGCCATTCAGGCCTTTGATGGTTGGCCCCCAATCCTACATGACNACCT
GGACCCTCACCAGGACTCTGAGCACAGCCTCCTGCAGGCGTCCTCTGCAGACCGGCTCCTGGAG
GGGAGCTCCCTGCTCTCCATGCTCCCTGTCCTGGCTCTTCAGCCCCTGCTCTAACTGGGACGGC
AGACCTTGGATGACAGCCAACTGTCCCACCCTGCCTGGGATACTGGGCCTCATCGGTGCCCCAC
TGGAAGGGACCAGCTTACCTCCCAAGCTGGCCCCAGTGCTCTTGCGCCA

hide sequence

Protein Sequences


Protein RefSeqs	XP_020933047	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSSSCP00000031769.2
	ENSSSCP00000069811
	ENSSSCP00000069811.2
	ENSSSCP00050036799.1
	ENSSSCP00065035290.1
	ENSSSCP00070037894.1

RefSeq Acc Id:

XP_020933047 ⟸ XM_021077388

- UniProtKB:

A0A4X1V8C5 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MASCLAPALLLLLLLGSPSSAARNRCVDAAEACTADTRCRRLRTAYVAQCLGPASPGSCPRARC
RRALRRFFARGPPPLTHALLFCPCGGPACAERRRQTFVPSCAFSGPGAAPPSCLASLEACERSR
VCRPRLLAFQASCGPAPSASDLCQGHQAPSCLSAYAGLVGTAVTPNYVDNASARVAPWCDCGAS
GNRREECEAFRGLFTRNRCLDGAIQAFDGWPPILHDXLDPHQDSEHSLLQASSADRLLEGSSLL
SMLPVLALQPLL

hide sequence

RefSeq Acc Id:

ENSSSCP00000031769 ⟸ ENSSSCT00000052547

RefSeq Acc Id:

ENSSSCP00000059894 ⟸ ENSSSCT00000073334

RefSeq Acc Id:

ENSSSCP00000069811 ⟸ ENSSSCT00000071032

Protein Domains

GDNF/GAS1

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSSSCG00000021401	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
	ENSSSCG00050062930	UniProtKB/TrEMBL
	ENSSSCG00065059220	UniProtKB/TrEMBL
	ENSSSCG00070022644	UniProtKB/TrEMBL
Ensembl Transcript	ENSSSCT00000052547.2	UniProtKB/TrEMBL
	ENSSSCT00000071032	ENTREZGENE
	ENSSSCT00000071032.2	UniProtKB/TrEMBL
	ENSSSCT00050085707.1	UniProtKB/TrEMBL
	ENSSSCT00065081053.1	UniProtKB/TrEMBL
	ENSSSCT00070044989.1	UniProtKB/TrEMBL
Gene3D-CATH	GDNF binding domain	UniProtKB/TrEMBL
InterPro	GDNF/GAS1	UniProtKB/TrEMBL
	GDNF_alpha	UniProtKB/TrEMBL
	GDNF_rcpt	UniProtKB/TrEMBL
NCBI Gene	GFRA4	ENTREZGENE
PANTHER	GDNF FAMILY RECEPTOR ALPHA-4	UniProtKB/TrEMBL
	PTHR10269	UniProtKB/TrEMBL
Pfam	GDNF	UniProtKB/TrEMBL
PRINTS	GDNFRECEPTOR	UniProtKB/TrEMBL
SMART	GDNF	UniProtKB/TrEMBL
Superfamily-SCOP	SSF110035	UniProtKB/TrEMBL
UniProt	A0A286ZJN2_PIG	UniProtKB/TrEMBL
	A0A4X1V8C5	ENTREZGENE, UniProtKB/TrEMBL
	A0A5G2QY14_PIG	UniProtKB/TrEMBL
VGNC ID	VGNC:95595	ENTREZGENE

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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