MIR125A (microRNA 125a) - Rat Genome Database

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Pathways
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Gene: MIR125A (microRNA 125a) Homo sapiens
Analyze
Symbol: MIR125A
Name: microRNA 125a
RGD ID: 1353053
HGNC Page HGNC:31505
Description: Enables mRNA 3'-UTR binding activity and mRNA base-pairing translational repressor activity. Involved in several processes, including positive regulation of endothelial cell apoptotic process; regulation of angiogenesis; and regulation of gene expression. Acts upstream of or within negative regulation of interleukin-6-mediated signaling pathway and negative regulation of leukocyte adhesion to vascular endothelial cell. Located in extracellular exosome. Biomarker of hepatocellular carcinoma and stomach cancer.
Type: ncrna (Ensembl: miRNA)
RefSeq Status: PROVISIONAL
Previously known as: mir-125a; MIRN125A; miRNA125A
RGD Orthologs
Mouse
Rat
Dog
Pig
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381951,693,254 - 51,693,339 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1951,693,254 - 51,693,339 (+)EnsemblGRCh38hg38GRCh38
GRCh371952,196,507 - 52,196,592 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361956,888,318 - 56,888,403 (+)NCBINCBI36Build 36hg18NCBI36
Celera1949,246,042 - 49,246,127 (+)NCBICelera
Cytogenetic Map19q13.41NCBI
HuRef1948,527,448 - 48,527,533 (+)NCBIHuRef
CHM1_11952,198,304 - 52,198,389 (+)NCBICHM1_1
T2T-CHM13v2.01954,780,417 - 54,780,502 (+)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
BMP signaling pathway  (ISO)
cellular response to cortisone stimulus  (ISO)
cellular response to estrogen stimulus  (ISO)
cellular response to glucose stimulus  (ISO)
cellular response to interleukin-6  (ISO)
cellular response to leukemia inhibitory factor  (ISO)
cellular response to lipopolysaccharide  (ISO)
cellular response to platelet-derived growth factor stimulus  (ISO)
cellular response to transforming growth factor beta stimulus  (ISO)
L-ascorbic acid metabolic process  (ISO)
long-term synaptic potentiation  (ISO)
miRNA-mediated gene silencing by inhibition of translation  (IDA,ISO)
miRNA-mediated gene silencing by mRNA destabilization  (IDA)
miRNA-mediated post-transcriptional gene silencing  (HDA,IDA,IEA,ISO)
negative regulation of angiogenesis  (IMP)
negative regulation of cytokine production involved in inflammatory response  (ISS)
negative regulation of cytokine-mediated signaling pathway  (ISS)
negative regulation of gene expression  (IDA)
negative regulation of glomerular mesangial cell proliferation  (IDA)
negative regulation of interleukin-16 production  (IDA)
negative regulation of interleukin-17 production  (ISO)
negative regulation of interleukin-6 production  (ISO)
negative regulation of interleukin-6-mediated signaling pathway  (IGI)
negative regulation of leukocyte adhesion to vascular endothelial cell  (IGI)
negative regulation of neutrophil activation  (ISS)
negative regulation of osteoblast differentiation  (ISO)
negative regulation of receptor signaling pathway via STAT  (IGI)
negative regulation of stem cell differentiation  (ISO)
negative regulation of transforming growth factor beta production  (ISO)
negative regulation of vascular associated smooth muscle cell migration  (ISO)
negative regulation of vascular associated smooth muscle cell proliferation  (ISO)
negative regulation of vascular endothelial growth factor production  (HMP)
neuron fate specification  (IMP)
ossification  (ISO)
positive regulation of cellular process  (ISO)
positive regulation of endothelial cell apoptotic process  (IDA)
positive regulation of fat cell differentiation  (ISO)
positive regulation of gene expression  (IDA)
positive regulation of sprouting angiogenesis  (IDA)
positive regulation of vascular associated smooth muscle cell apoptotic process  (ISO)
positive regulation of vascular associated smooth muscle cell migration  (ISO)
positive regulation of vascular associated smooth muscle cell proliferation  (ISO)
regulation of cytokine production involved in inflammatory response  (ISO)
regulation of erythrocyte differentiation  (ISO)
regulation of progesterone biosynthetic process  (ISO)
stem cell differentiation  (ISO)

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Epigenetic silenced miR-125a-5p could be self-activated through targeting Suv39H1 in gastric cancer. Cai M, etal., J Cell Mol Med. 2018 Oct;22(10):4721-4731. doi: 10.1111/jcmm.13716. Epub 2018 Aug 17.
2. MiR-125a-5p ameliorates monocrotaline-induced pulmonary arterial hypertension by targeting the TGF-β1 and IL-6/STAT3 signaling pathways. Cai Z, etal., Exp Mol Med. 2018 Apr 27;50(4):45. doi: 10.1038/s12276-018-0068-3.
3. Correlation Between the Hepatic Expression of Human MicroRNA hsa-miR-125a-5p and the Progression of Fibrosis in Patients With Overt and Occult HBV Infection. Coppola N, etal., Front Immunol. 2018 Jun 13;9:1334. doi: 10.3389/fimmu.2018.01334. eCollection 2018.
4. Decreased microRNA-125a-3p contributes to upregulation of p38 MAPK in rat trigeminal ganglions with orofacial inflammatory pain. Dong Y, etal., PLoS One. 2014 Nov 7;9(11):e111594. doi: 10.1371/journal.pone.0111594. eCollection 2014.
5. Down-regulation of miR-125a-3p in human gastric cancer and its clinicopathological significance. Hashiguchi Y, etal., Int J Oncol. 2012 May;40(5):1477-82. doi: 10.3892/ijo.2012.1363. Epub 2012 Feb 9.
6. MiR-125a-5p Alleviates Dysfunction and Inflammation of Pentylenetetrazol- induced Epilepsy Through Targeting Calmodulin-dependent Protein Kinase IV (CAMK4). Liu Q, etal., Curr Neurovasc Res. 2019;16(4):365-372. doi: 10.2174/1567202616666190906125444.
7. Dysregulation of microRNA-125a contributes to obesity-associated insulin resistance and dysregulates lipid metabolism in mice. Liu R, etal., Biochim Biophys Acta Mol Cell Biol Lipids. 2020 May;1865(5):158640. doi: 10.1016/j.bbalip.2020.158640. Epub 2020 Jan 25.
8. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
9. SVCT2, a potential therapeutic target, protects against oxidative stress during ethanol-induced neurotoxicity via JNK/p38 MAPKs, NF-κB and miRNA125a-5p. Tian H, etal., Free Radic Biol Med. 2016 Jul;96:362-73. doi: 10.1016/j.freeradbiomed.2016.03.039. Epub 2016 Apr 13.
10. Astemizole promotes the anti-tumor effect of vitamin D through inhibiting miR-125a-5p-meidated regulation of VDR in HCC. Xu J, etal., Biomed Pharmacother. 2018 Nov;107:1682-1691. doi: 10.1016/j.biopha.2018.08.153. Epub 2018 Sep 8.
11. miR-125a-3p decreases levels of interlukin-17 and suppresses renal fibrosis via down-regulating TGF-β1 in systemic lupus erythematosus mediated Lupus nephritic mice. Zhang Y, etal., Am J Transl Res. 2019 Mar 15;11(3):1843-1853. eCollection 2019.
12. Interfering histone deacetylase 4 inhibits the proliferation of vascular smooth muscle cells via regulating MEG3/miR-125a-5p/IRF1. Zheng X, etal., Cell Adh Migr. 2019 Dec;13(1):41-49. doi: 10.1080/19336918.2018.1506653. Epub 2018 Aug 29.
Additional References at PubMed
PMID:12007417   PMID:16381832   PMID:17400653   PMID:17604727   PMID:17616659   PMID:18320040   PMID:19048628   PMID:19411564   PMID:19702827   PMID:19818772   PMID:19875930   PMID:19881956  
PMID:19950226   PMID:20190813   PMID:20569443   PMID:20665731   PMID:21037258   PMID:21220473   PMID:21317190   PMID:21777146   PMID:21788734   PMID:21931172   PMID:22357933   PMID:22550173  
PMID:22644326   PMID:22690848   PMID:22747700   PMID:22768249   PMID:23079745   PMID:23327190   PMID:23525486   PMID:23583196   PMID:23595744   PMID:23606749   PMID:23618359   PMID:23783428  
PMID:23843939   PMID:24044511   PMID:24139697   PMID:24334759   PMID:24360988   PMID:24402874   PMID:24484870   PMID:24675842   PMID:24690917   PMID:24737570   PMID:24759737   PMID:24819167  
PMID:24824183   PMID:24877885   PMID:24896104   PMID:24901105   PMID:24913817   PMID:24945821   PMID:24990808   PMID:25109760   PMID:25116893   PMID:25231560   PMID:25256711   PMID:25336585  
PMID:25370896   PMID:25406362   PMID:25479352   PMID:25504437   PMID:25542152   PMID:25560389   PMID:25598421   PMID:25673044   PMID:25755772   PMID:25772251   PMID:25800681   PMID:25815788  
PMID:25833836   PMID:25863684   PMID:25962054   PMID:25963922   PMID:25998575   PMID:26011312   PMID:26017674   PMID:26071398   PMID:26151241   PMID:26227218   PMID:26270249   PMID:26297542  
PMID:26389681   PMID:26398444   PMID:26424054   PMID:26531722   PMID:26563755   PMID:26646586   PMID:26646931   PMID:26693202   PMID:26713860   PMID:26731991   PMID:26758190   PMID:26766902  
PMID:26782438   PMID:26800505   PMID:26875774   PMID:26962687   PMID:27000524   PMID:27014994   PMID:27074047   PMID:27094723   PMID:27133073   PMID:27133078   PMID:27220320   PMID:27231954  
PMID:27252357   PMID:27424784   PMID:27522004   PMID:27693788   PMID:27698367   PMID:27814341   PMID:27836539   PMID:27888002   PMID:27903586   PMID:27982429   PMID:28140520   PMID:28402230  
PMID:28405612   PMID:28408353   PMID:28445974   PMID:28467514   PMID:28596599   PMID:28631574   PMID:28646161   PMID:28695772   PMID:28724745   PMID:28732738   PMID:28761107   PMID:28771224  
PMID:28798470   PMID:28800792   PMID:28859241   PMID:28939591   PMID:28950256   PMID:28982331   PMID:29076440   PMID:29106389   PMID:29121972   PMID:29133857   PMID:29179212   PMID:29209130  
PMID:29344850   PMID:29345059   PMID:29505034   PMID:29634399   PMID:29635126   PMID:29663500   PMID:29689270   PMID:29693153   PMID:29749475   PMID:29750426   PMID:29767234   PMID:30076753  
PMID:30089723   PMID:30132551   PMID:30149002   PMID:30153074   PMID:30187954   PMID:30203815   PMID:30225271   PMID:30226579   PMID:30237316   PMID:30242085   PMID:30245693   PMID:30302847  
PMID:30370524   PMID:30372804   PMID:30387833   PMID:30394225   PMID:30412716   PMID:30536969   PMID:30670152   PMID:30782086   PMID:30785086   PMID:30843663   PMID:30868841   PMID:31014918  
PMID:31042422   PMID:31112584   PMID:31114983   PMID:31115097   PMID:31141316   PMID:31254127   PMID:31301414   PMID:31325708   PMID:31349052   PMID:31452281   PMID:31489990   PMID:31499051  
PMID:31527306   PMID:31558421   PMID:31575334   PMID:31595566   PMID:31646555   PMID:31683458   PMID:31696556   PMID:31698596   PMID:31702027   PMID:31764100   PMID:31820498   PMID:31821602  
PMID:31894257   PMID:31930562   PMID:31967348   PMID:31991700   PMID:31992303   PMID:32077163   PMID:32122654   PMID:32185824   PMID:32232900   PMID:32266868   PMID:32281166   PMID:32309886  
PMID:32321346   PMID:32410140   PMID:32468257   PMID:32473637   PMID:32484698   PMID:32504357   PMID:32595646   PMID:32614237   PMID:32638950   PMID:32697386   PMID:32709089   PMID:32785981  
PMID:32802182   PMID:33000203   PMID:33038923   PMID:33040804   PMID:33077307   PMID:33130085   PMID:33283704   PMID:33284463   PMID:33370717   PMID:33426087   PMID:33524878   PMID:33528317  
PMID:33554442   PMID:33577860   PMID:33735868   PMID:33760137   PMID:33760213   PMID:33866896   PMID:33866949   PMID:33948855   PMID:34134454   PMID:34195280   PMID:34195933   PMID:34229060  
PMID:34243103   PMID:34396443   PMID:34421353   PMID:34549308   PMID:34575957   PMID:34581942   PMID:34708891   PMID:34708894   PMID:34714963   PMID:34747340   PMID:34854396   PMID:34922539  
PMID:35064698   PMID:35081873   PMID:35136075   PMID:35178127   PMID:35332852   PMID:35394705   PMID:35401562   PMID:35475469   PMID:35486286   PMID:35588895   PMID:35993694   PMID:36082867  
PMID:36142632   PMID:36164970   PMID:36469904   PMID:36497052   PMID:36516216   PMID:37099789   PMID:37803894   PMID:37917636   PMID:38505605  


Genomics

Comparative Map Data
MIR125A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381951,693,254 - 51,693,339 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1951,693,254 - 51,693,339 (+)EnsemblGRCh38hg38GRCh38
GRCh371952,196,507 - 52,196,592 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361956,888,318 - 56,888,403 (+)NCBINCBI36Build 36hg18NCBI36
Celera1949,246,042 - 49,246,127 (+)NCBICelera
Cytogenetic Map19q13.41NCBI
HuRef1948,527,448 - 48,527,533 (+)NCBIHuRef
CHM1_11952,198,304 - 52,198,389 (+)NCBICHM1_1
T2T-CHM13v2.01954,780,417 - 54,780,502 (+)NCBIT2T-CHM13v2.0
Mir125a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391718,051,074 - 18,051,141 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1718,051,074 - 18,051,141 (+)EnsemblGRCm39 Ensembl
GRCm381717,830,812 - 17,830,879 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1717,830,812 - 17,830,879 (+)EnsemblGRCm38mm10GRCm38
MGSCv371717,967,776 - 17,967,843 (+)NCBIGRCm37MGSCv37mm9NCBIm37
Celera1718,771,463 - 18,771,530 (+)NCBICelera
Cytogenetic Map17A3.2NCBI
cM Map1710.5NCBI
Mir125a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8167,350,675 - 67,350,759 (+)NCBIGRCr8
mRatBN7.2158,677,626 - 58,677,710 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl158,677,626 - 58,677,710 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx163,502,214 - 63,502,298 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0172,194,878 - 72,194,962 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0165,412,260 - 65,412,344 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0159,704,827 - 59,704,911 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl159,704,827 - 59,704,911 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0160,624,485 - 60,624,569 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera154,858,584 - 54,858,668 (+)NCBICelera
Cytogenetic Map1q12NCBI
MIR125A
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11105,400,273 - 105,400,332 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1105,400,270 - 105,400,337 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1104,973,786 - 104,973,845 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01105,910,190 - 105,910,249 (-)NCBIROS_Cfam_1.0
UMICH_Zoey_3.11105,582,422 - 105,582,481 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01105,223,538 - 105,223,597 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01106,018,313 - 106,018,372 (-)NCBIUU_Cfam_GSD_1.0
MIR125A
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl658,331,566 - 58,331,645 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1658,331,566 - 58,331,645 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2651,858,852 - 51,858,931 (+)NCBISscrofa10.2Sscrofa10.2susScr3


Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 19q13.33-13.43(chr19:50191219-58535818)x3 copy number gain See cases [RCV000050883] Chr19:50191219..58535818 [GRCh38]
Chr19:50694476..59047185 [GRCh37]
Chr19:55386288..63738997 [NCBI36]
Chr19:19q13.33-13.43		 pathogenic
GRCh38/hg38 19q13.33-13.43(chr19:47929575-58572206)x3 copy number gain See cases [RCV000052915] Chr19:47929575..58572206 [GRCh38]
Chr19:48432832..59083573 [GRCh37]
Chr19:53124644..63775385 [NCBI36]
Chr19:19q13.33-13.43		 pathogenic
GRCh38/hg38 19q13.33-13.43(chr19:49907832-58557889)x3 copy number gain See cases [RCV000052925] Chr19:49907832..58557889 [GRCh38]
Chr19:50411089..59069256 [GRCh37]
Chr19:55102901..63761068 [NCBI36]
Chr19:19q13.33-13.43		 pathogenic
GRCh38/hg38 19q13.41-13.43(chr19:51141518-58539965)x3 copy number gain See cases [RCV000052926] Chr19:51141518..58539965 [GRCh38]
Chr19:51644775..59051332 [GRCh37]
Chr19:56336587..63743144 [NCBI36]
Chr19:19q13.41-13.43		 pathogenic
GRCh38/hg38 19q13.33-13.43(chr19:47908540-58539965)x3 copy number gain See cases [RCV000052914] Chr19:47908540..58539965 [GRCh38]
Chr19:48411797..59051332 [GRCh37]
Chr19:53103609..63743144 [NCBI36]
Chr19:19q13.33-13.43		 pathogenic
GRCh38/hg38 19q13.33-13.43(chr19:50152520-58581203)x3 copy number gain See cases [RCV000135843] Chr19:50152520..58581203 [GRCh38]
Chr19:50655777..59092570 [GRCh37]
Chr19:55347589..63784382 [NCBI36]
Chr19:19q13.33-13.43		 pathogenic
GRCh38/hg38 19q13.41(chr19:51681235-51936423)x3 copy number gain See cases [RCV000138486] Chr19:51681235..51936423 [GRCh38]
Chr19:52184488..52439676 [GRCh37]
Chr19:56876300..57131488 [NCBI36]
Chr19:19q13.41		 likely benign
GRCh38/hg38 19q13.41(chr19:51202361-51993020)x3 copy number gain See cases [RCV000143450] Chr19:51202361..51993020 [GRCh38]
Chr19:51705617..52496273 [GRCh37]
Chr19:56397429..57188085 [NCBI36]
Chr19:19q13.41		 uncertain significance
GRCh37/hg19 19q13.33-13.43(chr19:50489390-59095359)x3 copy number gain See cases [RCV000445925] Chr19:50489390..59095359 [GRCh37]
Chr19:19q13.33-13.43		 pathogenic
GRCh37/hg19 19p13.3-q13.43(chr19:260912-58956888) copy number gain See cases [RCV000512296] Chr19:260912..58956888 [GRCh37]
Chr19:19p13.3-q13.43		 pathogenic
GRCh37/hg19 19p13.3-q13.43(chr19:260912-58956888)x3 copy number gain See cases [RCV000511289] Chr19:260912..58956888 [GRCh37]
Chr19:19p13.3-q13.43		 pathogenic|uncertain significance
GRCh37/hg19 19q13.41(chr19:52152017-52299885)x3 copy number gain not provided [RCV000752746] Chr19:52152017..52299885 [GRCh37]
Chr19:19q13.41		 benign
GRCh37/hg19 19p13.3-q13.43(chr19:68029-59110290)x3 copy number gain not provided [RCV000752439] Chr19:68029..59110290 [GRCh37]
Chr19:19p13.3-q13.43		 pathogenic
GRCh37/hg19 19p13.3-q13.43(chr19:260912-59097160)x3 copy number gain not provided [RCV000752444] Chr19:260912..59097160 [GRCh37]
Chr19:19p13.3-q13.43		 pathogenic
GRCh37/hg19 19q13.33-13.43(chr19:50740074-59097160)x3 copy number gain not provided [RCV000740208] Chr19:50740074..59097160 [GRCh37]
Chr19:19q13.33-13.43		 pathogenic
GRCh37/hg19 19q13.31-13.42(chr19:44738088-53621561)x3 copy number gain not provided [RCV001007050] Chr19:44738088..53621561 [GRCh37]
Chr19:19q13.31-13.42		 pathogenic
GRCh37/hg19 19q13.32-13.42(chr19:47939842-54626871) copy number gain not provided [RCV001249294] Chr19:47939842..54626871 [GRCh37]
Chr19:19q13.32-13.42		 not provided
GRCh37/hg19 19q13.33-13.43(chr19:48463931-57095254)x3 copy number gain not provided [RCV001259944] Chr19:48463931..57095254 [GRCh37]
Chr19:19q13.33-13.43		 pathogenic
GRCh37/hg19 19q13.33-13.41(chr19:49911081-53127438) copy number gain not specified [RCV002052689] Chr19:49911081..53127438 [GRCh37]
Chr19:19q13.33-13.41		 likely pathogenic
GRCh37/hg19 19q13.41(chr19:51769834-52415762)x3 copy number gain not provided [RCV001827892] Chr19:51769834..52415762 [GRCh37]
Chr19:19q13.41		 uncertain significance
GRCh37/hg19 19q13.33-13.43(chr19:49625130-57647352)x3 copy number gain not provided [RCV003485200] Chr19:49625130..57647352 [GRCh37]
Chr19:19q13.33-13.43		 likely pathogenic
miRNA Target Status

Confirmed Targets
Gene TargetMature miRNAMethod NameResult TypeData TypeSupport TypePMID
IP6K2hsa-miR-125a-3pMirtarbaseexternal_infoCLASHFunctional MTI (Weak)23622248
TNFAIP3hsa-miR-125a-5pMirtarbaseexternal_infoqRT-PCR//Western blotFunctional MTI22550173
CDKN1Ahsa-miR-125a-5pMirtarbaseexternal_infoqRT-PCR//Luciferase reporter assay//Western blotFunctional MTI20190813
LIN28Ahsa-miR-125a-5pMirtarbaseexternal_infoLuciferase reporter assayFunctional MTI16227573
NTRK3hsa-miR-125a-5pMirtarbaseexternal_infoLuciferase reporter assay//Western blotFunctional MTI17483472
NTRK3hsa-miR-125a-5pMirtarbaseexternal_infoLuciferase reporter assayFunctional MTI19179615
NTRK3hsa-miR-125a-5pMirtarbaseexternal_infoLuciferase reporter assayFunctional MTI18973228
CD34hsa-miR-125a-5pMirtarbaseexternal_infoLuciferase reporter assay//Microarray//Western bloFunctional MTI18308931
TP53hsa-miR-125a-5pMirtarbaseexternal_infoLuciferase reporter assay//Northern blot//qRT-PCR/Functional MTI19818772
LIFhsa-miR-125a-5pMirtarbaseexternal_infoELISANon-Functional MTI (Weak)19011087
MTUS1hsa-miR-125a-5pMirtarbaseexternal_infoMicroarray//Northern blotFunctional MTI (Weak)16331254
VEGFAhsa-miR-125a-5pMirtarbaseexternal_infoELISA//Luciferase reporter assayNon-Functional MTI18320040
ERBB3hsa-miR-125a-5pMirtarbaseexternal_infoLuciferase reporter assay//Northern blot//qRT-PCR/Functional MTI17110380
ERBB3hsa-miR-125a-5pMirtarbaseexternal_infoLuciferase reporter assay//Microarray//Western bloFunctional MTI20864407
ERBB2hsa-miR-125a-5pMirtarbaseexternal_infoLuciferase reporter assayFunctional MTI21220473
KLF13hsa-miR-125a-5pMirtarbaseexternal_infoELISA//Luciferase reporter assay//qRT-PCR//WesternFunctional MTI20589685
ARID3Bhsa-miR-125a-5pMirtarbaseexternal_infoImmunofluorescence//qRT-PCR//Western blotFunctional MTI19881956
BAK1hsa-miR-125a-5pMirtarbaseexternal_infoFlow//Luciferase reporter assay//qRT-PCR//Western Functional MTI20616003
ELAVL1hsa-miR-125a-5pMirtarbaseexternal_infoLuciferase reporter assay//Western blotFunctional MTI19875930
CCL5hsa-miR-125a-5pMirtarbaseexternal_infoELISAFunctional MTI (Weak)20589685
MMP11hsa-miR-125a-5pMirtarbaseexternal_infoImmunohistochemistry//Luciferase reporter assay//qFunctional MTI22768249
HK2hsa-miR-125a-5pMirtarbaseexternal_infoLuciferase reporter assayFunctional MTI22593586
ARPC5hsa-miR-125a-5pMirtarbaseexternal_infoSequencingFunctional MTI (Weak)20371350
YES1hsa-miR-125a-5pMirtarbaseexternal_infoCLASHFunctional MTI (Weak)23622248
ERBB3hsa-miR-125a-5pTarbaseexternal_infoNothernblot POSITIVE
CD34hsa-miR-125a-5pTarbaseexternal_infoReporter GenePOSITIVE
CD34hsa-miR-125a-5pTarbaseexternal_infoWesternblitPOSITIVE
ZFAND1hsa-miR-125a-5pTarbaseexternal_infoSequencingPOSITIVE
ERBB2hsa-miR-125a-5pMirecordsexternal_info{changed}NA17110380
LIN28Ahsa-miR-125a-5pMirecordsexternal_infoNANA16227573
ARID3Bhsa-miR-125a-5pMirecordsexternal_infoNANA19881956
ELAVL1hsa-miR-125a-5pMirecordsexternal_info{unchanged}NA19875930
SIRT7hsa-miR-125a-5pOncomiRDBexternal_infoNANA23079745
MMP11hsa-miR-125a-5pOncomiRDBexternal_infoNANA22768249
TNFAIP3hsa-miR-125a-5pOncomiRDBexternal_infoNANA22550173
ERBB2hsa-miR-125a-5pOncomiRDBexternal_infoNANA21220473
PDPNhsa-miR-125a-5pOncomiRDBexternal_infoNANA20665731
NTRK3hsa-miR-125a-5pOncomiRDBexternal_infoNANA18973228
NTRK3hsa-miR-125a-5pOncomiRDBexternal_infoNANA17483472
ERBB2hsa-miR-125a-5pOncomiRDBexternal_infoNANA17110380
LIN28AP1hsa-miR-125a-5pTarbaseexternal_infoOtherPOSITIVE

Predicted Targets
Summary Value
Count of predictions:43169
Count of gene targets:14215
Count of transcripts:30662
Interacting mature miRNAs:hsa-miR-125a-3p, hsa-miR-125a-5p
Prediction methods:Microtar, Miranda, Pita, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system entire extraembryonic component
High
Medium 1
Low 4 1 6 1 9 3 8 14 16 11 12 18 1
Below cutoff 4 1 4 2 9 3 12 18 15 6 9 13

Sequence


Reference Sequences
RefSeq Acc Id: ENST00000385273
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1951,693,254 - 51,693,339 (+)Ensembl
RefSeq Acc Id: NR_029693
RefSeq Status: PROVISIONAL
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381951,693,254 - 51,693,339 (+)NCBI
GRCh371952,196,507 - 52,196,592 (+)RGD
Celera1949,246,042 - 49,246,127 (+)RGD
HuRef1948,527,448 - 48,527,533 (+)ENTREZGENE
CHM1_11952,198,304 - 52,198,389 (+)NCBI
T2T-CHM13v2.01954,780,417 - 54,780,502 (+)NCBI
Sequence:

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:31505 AgrOrtholog
COSMIC MIR125A COSMIC
Ensembl Genes ENSG00000208008 Ensembl, ENTREZGENE
Ensembl Transcript ENST00000385273 ENTREZGENE
GTEx ENSG00000208008 GTEx
HGNC ID HGNC:31505 ENTREZGENE
Human Proteome Map MIR125A Human Proteome Map
miRBase MI0000469 ENTREZGENE
NCBI Gene 406910 ENTREZGENE
OMIM 611191 OMIM
PharmGKB PA164722401 PharmGKB
RNAcentral URS00001F0C23 RNACentral
  URS00005A4DCF RNACentral
  URS000075D168 RNACentral