MIR326 (microRNA 326) - Rat Genome Database

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Gene: MIR326 (microRNA 326) Homo sapiens
Analyze
Symbol: MIR326
Name: microRNA 326
RGD ID: 1348728
HGNC Page HGNC:31769
Description: Enables mRNA 3'-UTR binding activity and mRNA base-pairing translational repressor activity. Involved in epithelial to mesenchymal transition and miRNA-mediated gene silencing by mRNA destabilization. Predicted to be part of RISC complex.
Type: ncrna (Ensembl: miRNA)
RefSeq Status: PROVISIONAL
Previously known as: hsa-mir-326; mir-326; MIRN326
RGD Orthologs
Mouse
Rat
Dog
Pig
Alliance Orthologs
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381175,335,092 - 75,335,186 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1175,335,092 - 75,335,186 (-)EnsemblGRCh38hg38GRCh38
GRCh371175,046,136 - 75,046,230 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361174,723,783 - 74,723,877 (-)NCBINCBI36Build 36hg18NCBI36
Celera1172,352,689 - 72,352,783 (-)NCBICelera
Cytogenetic Map11q13.4NCBI
HuRef1171,343,379 - 71,343,473 (-)NCBIHuRef
CHM1_11174,929,706 - 74,929,800 (-)NCBICHM1_1
T2T-CHM13v2.01175,264,687 - 75,264,781 (-)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
RISC complex  (IEA)

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Human Phenotype
References

References - curated
# Reference Title Reference Citation
1. MicroRNA-9 regulates fetal alcohol-induced changes in D2 receptor to promote prolactin production. Gangisetty O, etal., J Endocrinol. 2017 Oct;235(1):1-14. doi: 10.1530/JOE-17-0135. Epub 2017 Jul 14.
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:14691248   PMID:15634332   PMID:16381832   PMID:17604727   PMID:19838199   PMID:19883630   PMID:19955368   PMID:20667897   PMID:20889907   PMID:21037258   PMID:22069274   PMID:23142363  
PMID:23292865   PMID:23302469   PMID:23341351   PMID:23869222   PMID:24279830   PMID:24675081   PMID:24792898   PMID:24960647   PMID:25138213   PMID:25173582   PMID:25205106   PMID:25630670  
PMID:25714665   PMID:25742499   PMID:25760058   PMID:25875481   PMID:26111641   PMID:26239225   PMID:26359764   PMID:26548724   PMID:26840018   PMID:27045550   PMID:27460077   PMID:27723574  
PMID:27733214   PMID:27819521   PMID:28050891   PMID:28716052   PMID:28975990   PMID:29115574   PMID:29466672   PMID:29601850   PMID:29630744   PMID:29658350   PMID:29658868   PMID:29899085  
PMID:29956752   PMID:30078204   PMID:30096248   PMID:30243091   PMID:30362512   PMID:30456527   PMID:30485570   PMID:30742932   PMID:30848579   PMID:31069801   PMID:31136754   PMID:31273188  
PMID:31304776   PMID:31311830   PMID:31352762   PMID:31548493   PMID:31595632   PMID:31599663   PMID:31626960   PMID:31838741   PMID:31957831   PMID:32090087   PMID:32118359   PMID:32129446  
PMID:32204685   PMID:32228617   PMID:32266816   PMID:32271422   PMID:32495883   PMID:32506729   PMID:32513696   PMID:32567935   PMID:32743904   PMID:32820513   PMID:32920979   PMID:33044324  
PMID:33210403   PMID:33507382   PMID:33580459   PMID:33649821   PMID:33760216   PMID:33783904   PMID:33789359   PMID:33813342   PMID:33895481   PMID:33913391   PMID:33928608   PMID:34077002  
PMID:34077004   PMID:34152928   PMID:34169652   PMID:34370713   PMID:34619576   PMID:34696659   PMID:34742151   PMID:34808619   PMID:35012553   PMID:35081534   PMID:35081872   PMID:35154515  
PMID:35209928   PMID:35220907   PMID:35338412   PMID:35345980   PMID:35352610   PMID:35715760   PMID:35796297   PMID:35975539   PMID:36001185   PMID:36030691   PMID:36374774   PMID:36394255  
PMID:36694453   PMID:37004604   PMID:37303938   PMID:37429610   PMID:37511365   PMID:37565582   PMID:37647209   PMID:38184700  


Genomics

Comparative Map Data
MIR326
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381175,335,092 - 75,335,186 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1175,335,092 - 75,335,186 (-)EnsemblGRCh38hg38GRCh38
GRCh371175,046,136 - 75,046,230 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361174,723,783 - 74,723,877 (-)NCBINCBI36Build 36hg18NCBI36
Celera1172,352,689 - 72,352,783 (-)NCBICelera
Cytogenetic Map11q13.4NCBI
HuRef1171,343,379 - 71,343,473 (-)NCBIHuRef
CHM1_11174,929,706 - 74,929,800 (-)NCBICHM1_1
T2T-CHM13v2.01175,264,687 - 75,264,781 (-)NCBIT2T-CHM13v2.0
Mir326
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39799,201,476 - 99,201,570 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl799,201,476 - 99,201,570 (+)EnsemblGRCm39 Ensembl
GRCm38799,552,269 - 99,552,363 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl799,552,269 - 99,552,363 (+)EnsemblGRCm38mm10GRCm38
MGSCv377106,700,779 - 106,700,873 (+)NCBIGRCm37MGSCv37mm9NCBIm37
Celera799,877,151 - 99,877,245 (+)NCBICelera
Cytogenetic Map7E1NCBI
cM Map754.1NCBI
Mir326
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81163,266,165 - 163,266,259 (+)NCBIGRCr8
mRatBN7.21153,854,029 - 153,854,123 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1153,854,029 - 153,854,123 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1161,849,938 - 161,850,032 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01169,030,085 - 169,030,179 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01161,903,617 - 161,903,711 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01164,518,401 - 164,518,495 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1164,518,401 - 164,518,495 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01170,722,071 - 170,722,165 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera1151,940,711 - 151,940,805 (+)NCBICelera
Cytogenetic Map1q32NCBI
MIR326
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12123,240,463 - 23,240,553 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2123,240,463 - 23,240,553 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2123,006,165 - 23,006,255 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02123,443,489 - 23,443,579 (+)NCBIROS_Cfam_1.0
UMICH_Zoey_3.12123,241,804 - 23,241,894 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02123,438,052 - 23,438,142 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02123,356,030 - 23,356,120 (+)NCBIUU_Cfam_GSD_1.0
MIR326
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl99,581,944 - 9,582,034 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.199,581,944 - 9,582,034 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2910,800,191 - 10,800,281 (-)NCBISscrofa10.2Sscrofa10.2susScr3


Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 11q13.4-14.1(chr11:71923251-79662025)x1 copy number loss Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052684]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052684]|See cases [RCV000052684] Chr11:71923251..79662025 [GRCh38]
Chr11:71634297..79373069 [GRCh37]
Chr11:71311945..79050717 [NCBI36]
Chr11:11q13.4-14.1		 pathogenic
GRCh38/hg38 11q13.4-13.5(chr11:71928796-77064521)x1 copy number loss See cases [RCV000052708] Chr11:71928796..77064521 [GRCh38]
Chr11:71639842..76751808 [GRCh37]
Chr11:71317490..76453216 [NCBI36]
Chr11:11q13.4-13.5		 pathogenic
GRCh38/hg38 11q13.4-14.1(chr11:71969881-78232895)x1 copy number loss See cases [RCV000052709] Chr11:71969881..78232895 [GRCh38]
Chr11:71680927..77943941 [GRCh37]
Chr11:71358575..77621589 [NCBI36]
Chr11:11q13.4-14.1		 pathogenic
GRCh37/hg19 11q13.4(chr11:74580424-75099464)x3 copy number gain See cases [RCV000448058] Chr11:74580424..75099464 [GRCh37]
Chr11:11q13.4		 uncertain significance
GRCh37/hg19 11p15.5-q25(chr11:230616-134938470) copy number gain See cases [RCV000511729] Chr11:230616..134938470 [GRCh37]
Chr11:11p15.5-q25		 pathogenic
GRCh37/hg19 11p15.5-q25(chr11:230616-134938470)x3 copy number gain See cases [RCV000510881] Chr11:230616..134938470 [GRCh37]
Chr11:11p15.5-q25		 pathogenic
GRCh37/hg19 11q13.4-23.3(chr11:71588805-116680918)x3 copy number gain not provided [RCV000683374] Chr11:71588805..116680918 [GRCh37]
Chr11:11q13.4-23.3		 pathogenic
GRCh37/hg19 11p15.5-q25(chr11:198510-134934063)x3 copy number gain not provided [RCV000737348] Chr11:198510..134934063 [GRCh37]
Chr11:11p15.5-q25		 pathogenic
GRCh37/hg19 11p15.5-q25(chr11:70864-134938470)x3 copy number gain not provided [RCV000749874] Chr11:70864..134938470 [GRCh37]
Chr11:11p15.5-q25		 pathogenic
Single allele deletion Intellectual disability [RCV001293382] Chr11:118359328..118372573 [GRCh37]
Chr11:11p15.3-q23.3		 pathogenic
GRCh37/hg19 11q13.4-13.5(chr11:74839014-75366449) copy number gain not specified [RCV002052937] Chr11:74839014..75366449 [GRCh37]
Chr11:11q13.4-13.5		 uncertain significance
NC_000011.9:g.(?_71146421)_(75283128_?)dup duplication 3-methylglutaconic aciduria, type VIIB [RCV003122786] Chr11:71146421..75283128 [GRCh37]
Chr11:11q13.4-13.5		 uncertain significance
GRCh37/hg19 11p13-q25(chr11:32799481-134938470)x3 copy number gain MISSED ABORTION [RCV002282973] Chr11:32799481..134938470 [GRCh37]
Chr11:11p13-q25		 pathogenic
GRCh37/hg19 11q12.2-13.5(chr11:59923608-76272324)x3 copy number gain not provided [RCV003484842] Chr11:59923608..76272324 [GRCh37]
Chr11:11q12.2-13.5		 pathogenic
miRNA Target Status

Confirmed Targets
Gene TargetMature miRNAMethod NameResult TypeData TypeSupport TypePMID
GLI1hsa-miR-326Mirtarbaseexternal_infoLuciferase reporter assayFunctional MTI18756266
SMOhsa-miR-326Mirtarbaseexternal_infoWestern blotFunctional MTI23341351
NOTCH1hsa-miR-326Mirtarbaseexternal_infoWestern blot//Luciferase reporter assayFunctional MTI19955368
MSH3hsa-miR-326Mirtarbaseexternal_infoLuciferase reporter assay//Microarray//qRT-PCR//WeFunctional MTI19883630
PKMhsa-miR-326Mirtarbaseexternal_infoLuciferase reporter assay//qRT-PCR//Western blotFunctional MTI20667897
SMOhsa-miR-326Mirtarbaseexternal_infoLuciferase reporter assay//Western blotFunctional MTI20216554
PKMhsa-miR-326Mirtarbaseexternal_infoCLASHFunctional MTI (Weak)23622248
CD9hsa-miR-326Mirtarbaseexternal_infoWestern blot;qRT-PCRFunctional MTI19883630
SMOhsa-miR-326Mirtarbaseexternal_infoLuciferase reporter assay//Western blotFunctional MTI18756266
CD9hsa-miR-326Tarbaseexternal_infoqPCRPOSITIVE
CD9hsa-miR-326Tarbaseexternal_infoWesternblitPOSITIVE
SMOhsa-miR-326Mirecordsexternal_info{changed}NA18756266
PKMhsa-miR-326OncomiRDBexternal_infoNANA20667897
NOTCH1hsa-miR-326OncomiRDBexternal_infoNANA19955368
ABCC1hsa-miR-326OncomiRDBexternal_infoNANA19883630

Predicted Targets
Summary Value
Count of predictions:38451
Count of gene targets:14180
Count of transcripts:31106
Interacting mature miRNAs:hsa-miR-326
Prediction methods:Microtar, Miranda, Pita, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system adipose tissue appendage entire extraembryonic component
High
Medium 1 5 1 1
Low 66 23 25 10 68 13 60 26 55 19 63 70 6 14 3
Below cutoff 73 36 15 6 40 6 50 44 67 15 19 41 1 19 21

Sequence


Reference Sequences
RefSeq Acc Id: ENST00000362220
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1175,335,092 - 75,335,186 (-)Ensembl
RefSeq Acc Id: NR_029891
RefSeq Status: PROVISIONAL
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381175,335,092 - 75,335,186 (-)NCBI
GRCh371175,046,136 - 75,046,230 (-)RGD
Celera1172,352,689 - 72,352,783 (-)RGD
HuRef1171,343,379 - 71,343,473 (-)ENTREZGENE
CHM1_11174,929,706 - 74,929,800 (-)NCBI
T2T-CHM13v2.01175,264,687 - 75,264,781 (-)NCBI
Sequence:

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:31769 AgrOrtholog
COSMIC MIR326 COSMIC
Ensembl Genes ENSG00000199090 Ensembl, ENTREZGENE
Ensembl Transcript ENST00000362220 ENTREZGENE
GTEx ENSG00000199090 GTEx
HGNC ID HGNC:31769 ENTREZGENE
Human Proteome Map MIR326 Human Proteome Map
miRBase MI0000808 ENTREZGENE
NCBI Gene 442900 ENTREZGENE
OMIM 613755 OMIM
PharmGKB PA164722659 PharmGKB
RNAcentral URS00000A939F RNACentral
  URS00006A8564 RNACentral