U2AF1L4 (U2 small nuclear RNA auxiliary factor 1 like 4) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Gene: U2AF1L4 (U2 small nuclear RNA auxiliary factor 1 like 4) Homo sapiens
Analyze
Symbol: U2AF1L4
Name: U2 small nuclear RNA auxiliary factor 1 like 4
RGD ID: 1343980
HGNC Page HGNC:23020
Description: Predicted to enable pre-mRNA 3'-splice site binding activity. Predicted to be involved in mRNA splicing, via spliceosome. Predicted to be located in nucleoplasm. Predicted to be part of U2AF complex and spliceosomal complex.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: FLJ35525; MGC33901; splicing factor U2AF 26 kDa subunit; U2 auxiliary factor 26; U2 small nuclear RNA auxiliary factor 1-like 3; U2 small nuclear RNA auxiliary factor 1-like 4; U2 small nuclear RNA auxiliary factor 1-like protein 3; U2 small nuclear RNA auxiliary factor 1-like protein 4; U2(RNU2) small nuclear RNA auxiliary factor 1-like 3; U2(RNU2) small nuclear RNA auxiliary factor 1-like protein 3; U2AF1-like 4; U2AF1-like protein 3; U2AF1-RS3; U2AF1L3; U2AF1L3V1; U2AF1RS3; U2af26
RGD Orthologs
Mouse
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Genes
More Info more info ...
Related Pseudogenes: AP000593.1  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381935,742,464 - 35,745,418 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1935,742,464 - 35,745,445 (-)EnsemblGRCh38hg38GRCh38
GRCh371936,233,365 - 36,236,319 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361940,925,268 - 40,928,176 (-)NCBINCBI36Build 36hg18NCBI36
Build 341940,925,272 - 40,928,146NCBI
Celera1932,946,905 - 32,949,813 (-)NCBICelera
Cytogenetic Map19q13.12NCBI
HuRef1932,738,416 - 32,741,324 (-)NCBIHuRef
CHM1_11936,234,748 - 36,237,646 (-)NCBICHM1_1
T2T-CHM13v2.01938,287,776 - 38,290,728 (-)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (IEA)
nuclear speck  (IEA)
nucleoplasm  (TAS)
nucleus  (IEA)
spliceosomal complex  (IBA,IEA)
U2AF complex  (IBA,IEA)

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Human Phenotype
Dystonia  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. GOAs Human GO annotations GOA_HUMAN data from the GO Consortium
2. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:8586425   PMID:8630064   PMID:8889548   PMID:11739736   PMID:12477932   PMID:14702039   PMID:16147880   PMID:18460468   PMID:19322201   PMID:20696395   PMID:21873635   PMID:22022969  
PMID:23246698   PMID:24457600   PMID:27143377   PMID:27684187   PMID:28514442   PMID:28515276   PMID:29845934   PMID:30979931   PMID:32116123   PMID:33596420   PMID:33961781   PMID:35264565  
PMID:36373674  


Genomics

Comparative Map Data
U2AF1L4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381935,742,464 - 35,745,418 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1935,742,464 - 35,745,445 (-)EnsemblGRCh38hg38GRCh38
GRCh371936,233,365 - 36,236,319 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361940,925,268 - 40,928,176 (-)NCBINCBI36Build 36hg18NCBI36
Build 341940,925,272 - 40,928,146NCBI
Celera1932,946,905 - 32,949,813 (-)NCBICelera
Cytogenetic Map19q13.12NCBI
HuRef1932,738,416 - 32,741,324 (-)NCBIHuRef
CHM1_11936,234,748 - 36,237,646 (-)NCBICHM1_1
T2T-CHM13v2.01938,287,776 - 38,290,728 (-)NCBIT2T-CHM13v2.0
U2af1l4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39730,262,765 - 30,264,789 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl730,262,769 - 30,267,385 (+)EnsemblGRCm39 Ensembl
GRCm39 Ensembl730,262,726 - 30,264,790 (+)EnsemblGRCm39 Ensembl
GRCm38730,563,340 - 30,565,364 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl730,563,344 - 30,567,960 (+)EnsemblGRCm38mm10GRCm38
GRCm38.p6 Ensembl730,563,301 - 30,565,365 (+)EnsemblGRCm38mm10GRCm38
MGSCv37731,348,359 - 31,350,383 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36730,272,100 - 30,274,124 (+)NCBIMGSCv36mm8
Celera725,155,101 - 25,157,125 (+)NCBICelera
Cytogenetic Map7B1NCBI
cM Map718.61NCBI
U2af1l4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8194,943,684 - 94,945,906 (+)NCBIGRCr8
mRatBN7.2185,816,268 - 85,818,462 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl185,815,101 - 85,818,462 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx191,233,050 - 91,235,194 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0199,699,215 - 99,701,359 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0192,991,331 - 92,993,475 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0189,017,414 - 89,019,651 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl189,017,479 - 89,019,937 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0190,172,229 - 90,174,953 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4185,608,372 - 85,610,419 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1185,686,482 - 85,688,530 (+)NCBI
Celera180,187,746 - 80,189,793 (+)NCBICelera
Cytogenetic Map1q21NCBI
U2AF1L4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22041,736,801 - 41,739,749 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11943,722,105 - 43,725,074 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01932,672,304 - 32,675,256 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11941,406,661 - 41,409,548 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1941,406,661 - 41,409,548 (-)Ensemblpanpan1.1panPan2
U2AF1L4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11116,888,680 - 116,890,911 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1116,888,720 - 116,890,923 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1116,293,931 - 116,296,172 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01117,491,646 - 117,493,887 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1117,491,675 - 117,497,074 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11117,055,022 - 117,057,262 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01116,678,643 - 116,680,884 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01117,734,028 - 117,736,264 (+)NCBIUU_Cfam_GSD_1.0
U2af1l4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934911,065,553 - 11,067,704 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936570578,178 - 580,133 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936570578,088 - 580,321 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
U2AF1L4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl645,168,927 - 45,172,305 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1645,167,556 - 45,172,382 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2640,625,562 - 40,627,833 (-)NCBISscrofa10.2Sscrofa10.2susScr3
U2AF1L4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1630,652,352 - 30,655,077 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_0236660738,443,549 - 8,446,421 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Variants

.
Variants in U2AF1L4
16 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
NM_144987.3(U2AF1L4):c.501C>T (p.Pro167=) single nucleotide variant Malignant melanoma [RCV000072095] Chr19:35742706 [GRCh38]
Chr19:36233607 [GRCh37]
Chr19:40925447 [NCBI36]
Chr19:19q13.12		 not provided
GRCh38/hg38 19p13.2-q13.31(chr19:11227942-44626354)x3 copy number gain See cases [RCV000133888] Chr19:11227942..44626354 [GRCh38]
Chr19:11338618..45129651 [GRCh37]
Chr19:11199618..49821491 [NCBI36]
Chr19:19p13.2-q13.31		 pathogenic
GRCh38/hg38 19q12-13.13(chr19:29661858-38114723)x1 copy number loss See cases [RCV000135879] Chr19:29661858..38114723 [GRCh38]
Chr19:30152765..38605363 [GRCh37]
Chr19:34844605..43297203 [NCBI36]
Chr19:19q12-13.13		 pathogenic
GRCh38/hg38 19q12-13.13(chr19:29671324-37902990)x1 copy number loss See cases [RCV000136794] Chr19:29671324..37902990 [GRCh38]
Chr19:30162231..38393630 [GRCh37]
Chr19:34854071..43085470 [NCBI36]
Chr19:19q12-13.13		 pathogenic
GRCh37/hg19 19q13.12(chr19:36227660-36250792)x3 copy number gain Breast ductal adenocarcinoma [RCV000207170] Chr19:36227660..36250792 [GRCh37]
Chr19:19q13.12		 likely pathogenic|uncertain significance
GRCh37/hg19 19q13.12(chr19:36227660-36268769)x3 copy number gain Breast ductal adenocarcinoma [RCV000207261] Chr19:36227660..36268769 [GRCh37]
Chr19:19q13.12		 uncertain significance
GRCh37/hg19 19q13.12(chr19:36147111-37249653)x1 copy number loss See cases [RCV000511504] Chr19:36147111..37249653 [GRCh37]
Chr19:19q13.12		 uncertain significance
NM_001040425.3(U2AF1L4):c.8A>G (p.Glu3Gly) single nucleotide variant Inborn genetic diseases [RCV003282315] Chr19:35745384 [GRCh38]
Chr19:36236285 [GRCh37]
Chr19:19q13.12		 uncertain significance
GRCh37/hg19 19p13.3-q13.43(chr19:260912-58956888)x3 copy number gain See cases [RCV000511289] Chr19:260912..58956888 [GRCh37]
Chr19:19p13.3-q13.43		 pathogenic|uncertain significance
GRCh37/hg19 19p13.3-q13.43(chr19:260912-58956888) copy number gain See cases [RCV000512296] Chr19:260912..58956888 [GRCh37]
Chr19:19p13.3-q13.43		 pathogenic
GRCh37/hg19 19p13.3-q13.43(chr19:68029-59110290)x3 copy number gain not provided [RCV000752439] Chr19:68029..59110290 [GRCh37]
Chr19:19p13.3-q13.43		 pathogenic
GRCh37/hg19 19p13.3-q13.43(chr19:260912-59097160)x3 copy number gain not provided [RCV000752444] Chr19:260912..59097160 [GRCh37]
Chr19:19p13.3-q13.43		 pathogenic
GRCh37/hg19 19q13.11-13.12(chr19:35111811-37744992) copy number loss Generalized epilepsy with febrile seizures plus, type 1 [RCV000767768] Chr19:35111811..37744992 [GRCh37]
Chr19:19q13.11-13.12		 pathogenic
GRCh37/hg19 19q13.11-13.12(chr19:35043556-36316644) copy number loss not provided [RCV000767769] Chr19:35043556..36316644 [GRCh37]
Chr19:19q13.11-13.12		 pathogenic
GRCh37/hg19 19q11-13.33(chr19:28271106-49213832)x3 copy number gain not provided [RCV000845733] Chr19:28271106..49213832 [GRCh37]
Chr19:19q11-13.33		 pathogenic
NC_000019.9:g.(?_33167170)_(36643309_?)dup duplication Hereditary spastic paraplegia 75 [RCV003107659] Chr19:33167170..36643309 [GRCh37]
Chr19:19q13.11-13.12		 uncertain significance
Single allele deletion Dystonic disorder [RCV001003865] Chr19:35553425..36264299 [GRCh37]
Chr19:19q13.12		 pathogenic
GRCh37/hg19 19p13.11-q13.2(chr19:19546923-41313229)x3 copy number gain Specific learning disability [RCV001801194] Chr19:19546923..41313229 [GRCh37]
Chr19:19p13.11-q13.2		 pathogenic
NC_000019.9:g.(?_35521725)_(36643309_?)del deletion Brugada syndrome 5 [RCV001910265] Chr19:35521725..36643309 [GRCh37]
Chr19:19q13.12		 uncertain significance
GRCh37/hg19 19q13.12(chr19:36019064-36516110)x3 copy number gain not provided [RCV001833065] Chr19:36019064..36516110 [GRCh37]
Chr19:19q13.12		 uncertain significance
NM_001040425.3(U2AF1L4):c.458G>T (p.Arg153Leu) single nucleotide variant Inborn genetic diseases [RCV002945670] Chr19:35743812 [GRCh38]
Chr19:36234713 [GRCh37]
Chr19:19q13.12		 uncertain significance
NM_001040425.3(U2AF1L4):c.235C>T (p.Arg79Trp) single nucleotide variant Inborn genetic diseases [RCV002773226] Chr19:35744142 [GRCh38]
Chr19:36235043 [GRCh37]
Chr19:19q13.12		 uncertain significance
NM_001040425.3(U2AF1L4):c.*30A>G single nucleotide variant Inborn genetic diseases [RCV002782267] Chr19:35742689 [GRCh38]
Chr19:36233590 [GRCh37]
Chr19:19q13.12		 uncertain significance
NM_001040425.3(U2AF1L4):c.76G>T (p.Val26Phe) single nucleotide variant Inborn genetic diseases [RCV002664529] Chr19:35745181 [GRCh38]
Chr19:36236082 [GRCh37]
Chr19:19q13.12		 uncertain significance
NM_001040425.3(U2AF1L4):c.467C>T (p.Pro156Leu) single nucleotide variant Inborn genetic diseases [RCV003003664] Chr19:35742798 [GRCh38]
Chr19:36233699 [GRCh37]
Chr19:19q13.12		 uncertain significance
NM_001040425.3(U2AF1L4):c.176A>G (p.Glu59Gly) single nucleotide variant Inborn genetic diseases [RCV002673955] Chr19:35744378 [GRCh38]
Chr19:36235279 [GRCh37]
Chr19:19q13.12		 uncertain significance
NM_001040425.3(U2AF1L4):c.371G>C (p.Cys124Ser) single nucleotide variant Inborn genetic diseases [RCV002919810] Chr19:35743899 [GRCh38]
Chr19:36234800 [GRCh37]
Chr19:19q13.12		 uncertain significance
NM_001040425.3(U2AF1L4):c.229A>G (p.Lys77Glu) single nucleotide variant Inborn genetic diseases [RCV002963965] Chr19:35744325 [GRCh38]
Chr19:36235226 [GRCh37]
Chr19:19q13.12		 uncertain significance
NM_001040425.3(U2AF1L4):c.*74T>C single nucleotide variant Inborn genetic diseases [RCV002919860] Chr19:35742645 [GRCh38]
Chr19:36233546 [GRCh37]
Chr19:19q13.12		 uncertain significance
NM_001040425.3(U2AF1L4):c.440A>G (p.Tyr147Cys) single nucleotide variant Inborn genetic diseases [RCV002677895] Chr19:35743830 [GRCh38]
Chr19:36234731 [GRCh37]
Chr19:19q13.12		 uncertain significance
NM_001040425.3(U2AF1L4):c.257G>C (p.Arg86Pro) single nucleotide variant Inborn genetic diseases [RCV003284490] Chr19:35744120 [GRCh38]
Chr19:36235021 [GRCh37]
Chr19:19q13.12		 uncertain significance
NM_001040425.3(U2AF1L4):c.99C>G (p.Cys33Trp) single nucleotide variant Inborn genetic diseases [RCV003338321] Chr19:35745158 [GRCh38]
Chr19:36236059 [GRCh37]
Chr19:19q13.12		 uncertain significance
NM_001040425.3(U2AF1L4):c.*45C>T single nucleotide variant Inborn genetic diseases [RCV003349945] Chr19:35742674 [GRCh38]
Chr19:36233575 [GRCh37]
Chr19:19q13.12		 likely benign
NM_001040425.3(U2AF1L4):c.399G>T (p.Met133Ile) single nucleotide variant Inborn genetic diseases [RCV003347790] Chr19:35743871 [GRCh38]
Chr19:36234772 [GRCh37]
Chr19:19q13.12		 uncertain significance
Single allele deletion not provided [RCV003448708] Chr19:35225414..37357598 [GRCh37]
Chr19:19q13.11-13.12		 pathogenic
GRCh37/hg19 19q11-13.2(chr19:28271146-41508851)x3 copy number gain not specified [RCV003986115] Chr19:28271146..41508851 [GRCh37]
Chr19:19q11-13.2		 pathogenic
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:5226
Count of miRNA genes:903
Interacting mature miRNAs:1076
Transcripts:ENST00000292879, ENST00000378975, ENST00000412391, ENST00000585554, ENST00000585771, ENST00000586476, ENST00000587886, ENST00000587987, ENST00000588100, ENST00000588892, ENST00000588980, ENST00000589429, ENST00000590135, ENST00000590650, ENST00000591084, ENST00000591855, ENST00000592913, ENST00000594792, ENST00000600296, ENST00000601236
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Markers in Region
RH99245  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371936,234,775 - 36,235,278UniSTSGRCh37
Build 361940,926,615 - 40,927,118RGDNCBI36
Celera1932,948,252 - 32,948,755RGD
Cytogenetic Map19q13.12UniSTS
HuRef1932,739,763 - 32,740,266UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system visual system adipose tissue appendage entire extraembryonic component pharyngeal arch
High
Medium 2225 2429 1489 411 1363 255 3886 1699 3141 156 1264 1365 162 1 1195 2616 3
Low 214 562 237 213 588 210 471 498 593 263 196 248 12 9 172 3 2
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts NG_027934 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001040425 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001369824 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_144987 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NR_110173 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NR_163169 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NR_163170 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NR_163171 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NR_163172 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NR_163173 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AD000671 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AI767079 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK092844 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK094213 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK303983 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY461582 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY569437 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC010865 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC021186 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC049208 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC062474 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BM696851 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CD175846 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CP068259 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DC415103 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000292879   ⟹   ENSP00000292879
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1935,742,532 - 35,745,445 (-)Ensembl
RefSeq Acc Id: ENST00000378975   ⟹   ENSP00000368258
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1935,742,527 - 35,745,418 (-)Ensembl
RefSeq Acc Id: ENST00000412391   ⟹   ENSP00000397645
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1935,742,529 - 35,745,442 (-)Ensembl
RefSeq Acc Id: ENST00000585554
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1935,742,529 - 35,745,397 (-)Ensembl
RefSeq Acc Id: ENST00000585771
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1935,744,104 - 35,745,398 (-)Ensembl
RefSeq Acc Id: ENST00000586476
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1935,743,011 - 35,745,442 (-)Ensembl
RefSeq Acc Id: ENST00000587886   ⟹   ENSP00000467441
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1935,744,347 - 35,745,422 (-)Ensembl
RefSeq Acc Id: ENST00000587987   ⟹   ENSP00000465170
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1935,742,531 - 35,745,414 (-)Ensembl
RefSeq Acc Id: ENST00000588100
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1935,744,663 - 35,745,441 (-)Ensembl
RefSeq Acc Id: ENST00000588892
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1935,742,533 - 35,745,414 (-)Ensembl
RefSeq Acc Id: ENST00000588980
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1935,742,532 - 35,745,402 (-)Ensembl
RefSeq Acc Id: ENST00000589429   ⟹   ENSP00000473940
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1935,742,532 - 35,744,687 (-)Ensembl
RefSeq Acc Id: ENST00000590135
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1935,742,529 - 35,744,660 (-)Ensembl
RefSeq Acc Id: ENST00000590650
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1935,744,795 - 35,745,353 (-)Ensembl
RefSeq Acc Id: ENST00000591057   ⟹   ENSP00000465242
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1935,742,464 - 35,745,418 (-)Ensembl
RefSeq Acc Id: ENST00000591084   ⟹   ENSP00000475046
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1935,742,527 - 35,744,699 (-)Ensembl
RefSeq Acc Id: ENST00000591855
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1935,742,531 - 35,744,563 (-)Ensembl
RefSeq Acc Id: ENST00000592913
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1935,742,532 - 35,745,426 (-)Ensembl
RefSeq Acc Id: ENST00000594792   ⟹   ENSP00000471804
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1935,742,531 - 35,745,157 (-)Ensembl
RefSeq Acc Id: ENST00000600296   ⟹   ENSP00000474493
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1935,742,531 - 35,745,176 (-)Ensembl
RefSeq Acc Id: ENST00000601236   ⟹   ENSP00000469891
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1935,743,849 - 35,745,416 (-)Ensembl
RefSeq Acc Id: NM_001040425   ⟹   NP_001035515
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381935,742,527 - 35,745,418 (-)NCBI
GRCh371936,233,428 - 36,236,409 (-)NCBI
Build 361940,925,268 - 40,928,176 (-)NCBI Archive
Celera1932,946,905 - 32,949,813 (-)RGD
HuRef1932,738,416 - 32,741,331 (-)NCBI
CHM1_11936,234,748 - 36,237,653 (-)NCBI
T2T-CHM13v2.01938,287,839 - 38,290,728 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001369824   ⟹   NP_001356753
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381935,742,464 - 35,745,418 (-)NCBI
T2T-CHM13v2.01938,287,776 - 38,290,728 (-)NCBI
Sequence:
RefSeq Acc Id: NM_144987   ⟹   NP_659424
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381935,742,527 - 35,745,418 (-)NCBI
GRCh371936,233,428 - 36,236,409 (-)NCBI
Build 361940,925,268 - 40,928,176 (-)NCBI Archive
Celera1932,946,905 - 32,949,813 (-)RGD
HuRef1932,738,416 - 32,741,331 (-)NCBI
CHM1_11936,234,748 - 36,237,653 (-)NCBI
T2T-CHM13v2.01938,287,839 - 38,290,728 (-)NCBI
Sequence:
RefSeq Acc Id: NR_110173
RefSeq Status: VALIDATED
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381935,742,527 - 35,745,418 (-)NCBI
HuRef1932,738,416 - 32,741,331 (-)NCBI
CHM1_11936,234,748 - 36,237,653 (-)NCBI
T2T-CHM13v2.01938,287,839 - 38,290,728 (-)NCBI
Sequence:
RefSeq Acc Id: NR_163169
RefSeq Status: VALIDATED
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381935,742,527 - 35,745,418 (-)NCBI
T2T-CHM13v2.01938,287,839 - 38,290,728 (-)NCBI
Sequence:
RefSeq Acc Id: NR_163170
RefSeq Status: VALIDATED
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381935,742,527 - 35,745,418 (-)NCBI
T2T-CHM13v2.01938,287,839 - 38,290,728 (-)NCBI
Sequence:
RefSeq Acc Id: NR_163171
RefSeq Status: VALIDATED
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381935,742,527 - 35,745,418 (-)NCBI
T2T-CHM13v2.01938,287,839 - 38,290,728 (-)NCBI
Sequence:
RefSeq Acc Id: NR_163172
RefSeq Status: VALIDATED
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381935,742,464 - 35,745,418 (-)NCBI
T2T-CHM13v2.01938,287,776 - 38,290,728 (-)NCBI
Sequence:
RefSeq Acc Id: NR_163173
RefSeq Status: VALIDATED
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381935,742,527 - 35,745,418 (-)NCBI
T2T-CHM13v2.01938,287,839 - 38,290,728 (-)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_659424   ⟸   NM_144987
- Peptide Label: isoform 2
- UniProtKB: Q8WU68 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001035515   ⟸   NM_001040425
- Peptide Label: isoform 1
- UniProtKB: Q56UU3 (UniProtKB/Swiss-Prot),   A6NKI8 (UniProtKB/Swiss-Prot),   Q8WU68 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001356753   ⟸   NM_001369824
- Peptide Label: isoform 3
RefSeq Acc Id: ENSP00000471804   ⟸   ENST00000594792
RefSeq Acc Id: ENSP00000292879   ⟸   ENST00000292879
RefSeq Acc Id: ENSP00000397645   ⟸   ENST00000412391
RefSeq Acc Id: ENSP00000465170   ⟸   ENST00000587987
RefSeq Acc Id: ENSP00000467441   ⟸   ENST00000587886
RefSeq Acc Id: ENSP00000474493   ⟸   ENST00000600296
RefSeq Acc Id: ENSP00000473940   ⟸   ENST00000589429
RefSeq Acc Id: ENSP00000368258   ⟸   ENST00000378975
RefSeq Acc Id: ENSP00000469891   ⟸   ENST00000601236
RefSeq Acc Id: ENSP00000475046   ⟸   ENST00000591084
RefSeq Acc Id: ENSP00000465242   ⟸   ENST00000591057
Protein Domains
C3H1-type   RRM

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q8WU68-F1-model_v2 AlphaFold Q8WU68 1-220 view protein structure

Promoters
RGD ID:7239571
Promoter ID:EPDNEW_H25532
Type:initiation region
Name:U2AF1L4_2
Description:U2 small nuclear RNA auxiliary factor 1 like 4
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H25533  EPDNEW_H25535  
Experiment Methods:Single-end sequencing.; Paired-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381935,744,660 - 35,744,720EPDNEW
RGD ID:7239575
Promoter ID:EPDNEW_H25533
Type:initiation region
Name:U2AF1L4_3
Description:U2 small nuclear RNA auxiliary factor 1 like 4
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H25532  EPDNEW_H25535  
Experiment Methods:Single-end sequencing.; Paired-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381935,744,929 - 35,744,989EPDNEW
RGD ID:7239577
Promoter ID:EPDNEW_H25535
Type:initiation region
Name:U2AF1L4_1
Description:U2 small nuclear RNA auxiliary factor 1 like 4
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H25532  EPDNEW_H25533  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381935,745,418 - 35,745,478EPDNEW
RGD ID:6796153
Promoter ID:HG_KWN:29679
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell_2Hour
Transcripts:UC002OBH.1
Position:
Human AssemblyChrPosition (strand)Source
Build 361940,927,196 - 40,927,696 (-)MPROMDB
RGD ID:6795966
Promoter ID:HG_KWN:29680
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   CD4+TCell_12Hour,   HeLa_S3,   Jurkat,   K562,   Lymphoblastoid,   NB4
Transcripts:ENST00000392196,   NM_001040425,   NM_144987,   NM_172341,   UC002OBG.1,   UC002OBJ.1,   UC002OBK.1,   UC010EEJ.1
Position:
Human AssemblyChrPosition (strand)Source
Build 361940,927,331 - 40,928,362 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:23020 AgrOrtholog
COSMIC U2AF1L4 COSMIC
Ensembl Genes ENSG00000161265 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENST00000292879 ENTREZGENE
  ENST00000292879.9 UniProtKB/Swiss-Prot
  ENST00000378975 ENTREZGENE
  ENST00000378975.8 UniProtKB/Swiss-Prot
  ENST00000412391.6 UniProtKB/Swiss-Prot
  ENST00000587886.2 UniProtKB/TrEMBL
  ENST00000587987 ENTREZGENE
  ENST00000587987.5 UniProtKB/TrEMBL
  ENST00000589429.5 UniProtKB/TrEMBL
  ENST00000591057.5 UniProtKB/TrEMBL
  ENST00000591084.5 UniProtKB/TrEMBL
  ENST00000592913 ENTREZGENE
  ENST00000594792.5 UniProtKB/TrEMBL
  ENST00000600296.5 UniProtKB/TrEMBL
  ENST00000601236.1 UniProtKB/TrEMBL
Gene3D-CATH 3.30.70.330 UniProtKB/Swiss-Prot
GTEx ENSG00000161265 GTEx
HGNC ID HGNC:23020 ENTREZGENE
Human Proteome Map U2AF1L4 Human Proteome Map
InterPro Nucleotide-bd_a/b_plait_sf UniProtKB/Swiss-Prot
  RBD_domain_sf UniProtKB/Swiss-Prot
  RRM_dom UniProtKB/Swiss-Prot
  RRM_dom_euk UniProtKB/Swiss-Prot
  U2AF_small UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Znf_CCCH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Znf_CCCH_sf UniProtKB/TrEMBL
KEGG Report hsa:199746 UniProtKB/Swiss-Prot
NCBI Gene 199746 ENTREZGENE
OMIM 601080 OMIM
PANTHER PTHR12620 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SPLICING FACTOR U2AF 26 KDA SUBUNIT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam RRM_1 UniProtKB/Swiss-Prot
  zf-CCCH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA164742763 PharmGKB
PRINTS U2AUXFACTOR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE RRM UniProtKB/Swiss-Prot
  ZF_C3H1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART RRM_1 UniProtKB/Swiss-Prot
  ZnF_C3H1 UniProtKB/Swiss-Prot
Superfamily-SCOP SSF54928 UniProtKB/Swiss-Prot
  SSF90229 UniProtKB/TrEMBL
UniProt A0A1D5RMU4_HUMAN UniProtKB/TrEMBL
  A6NKI8 ENTREZGENE
  K7EJH3_HUMAN UniProtKB/TrEMBL
  K7EJM7_HUMAN UniProtKB/TrEMBL
  M0QYK5_HUMAN UniProtKB/TrEMBL
  M0R1E1_HUMAN UniProtKB/TrEMBL
  Q56UU3 ENTREZGENE
  Q8WU68 ENTREZGENE
  S4R353_HUMAN UniProtKB/TrEMBL
  S4R3L8_HUMAN UniProtKB/TrEMBL
  S4R443_HUMAN UniProtKB/TrEMBL
  U2AF4_HUMAN UniProtKB/Swiss-Prot
UniProt Secondary A6NKI8 UniProtKB/Swiss-Prot
  Q56UU3 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-07-19 U2AF1L4  U2 small nuclear RNA auxiliary factor 1 like 4    U2 small nuclear RNA auxiliary factor 1-like 4  Symbol and/or name change 5135510 APPROVED