PTGDR2 (prostaglandin D2 receptor 2) - Rat Genome Database

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Gene: PTGDR2 (prostaglandin D2 receptor 2) Homo sapiens
Analyze
Symbol: PTGDR2
Name: prostaglandin D2 receptor 2
RGD ID: 1323730
HGNC Page HGNC:4502
Description: Enables prostaglandin D receptor activity. Involved in G protein-coupled receptor signaling pathway; calcium-mediated signaling; and chemotaxis. Predicted to be located in plasma membrane. Predicted to be active in neuron projection. Implicated in asthma. Biomarker of cystic fibrosis and rhinitis.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: CD294; chemoattractant receptor homologous molecule expressed on T helper type 2 cells; chemoattractant receptor-homologous molecule expressed on TH2 cells; CRTH2; DL1R; DP2; G protein-coupled receptor 44; G-protein coupled receptor 44; GPR44; putative G-protein coupled receptor 44
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381160,850,933 - 60,855,950 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1160,850,933 - 60,855,950 (-)EnsemblGRCh38hg38GRCh38
GRCh371160,618,406 - 60,623,423 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361160,374,974 - 60,380,020 (-)NCBINCBI36Build 36hg18NCBI36
Build 341160,374,982 - 60,380,020NCBI
Celera1157,979,245 - 57,984,291 (-)NCBICelera
Cytogenetic Map11q12.2NCBI
HuRef1156,964,519 - 56,969,565 (-)NCBIHuRef
CHM1_11160,484,721 - 60,489,767 (-)NCBICHM1_1
T2T-CHM13v2.01160,802,052 - 60,807,069 (-)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
membrane  (IEA)
neuron projection  (IBA)
plasma membrane  (IBA,IEA,TAS)

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Human Phenotype
References

References - curated
# Reference Title Reference Citation
1. Genetic variation in CRTh2 influences development of allergic phenotypes. Cameron L, etal., Allergy. 2009 Oct;64(10):1478-85. Epub 2009 Apr 14.
2. GOAs Human GO annotations GOA_HUMAN data from the GO Consortium
3. Role of prostaglandin D2 receptor CRTH2 in sustained eosinophil accumulation in the airways of mice with chronic asthma. Kagawa S, etal., Int Arch Allergy Immunol. 2011;155 Suppl 1:6-11. Epub 2011 Jun 1.
4. CRTH2 antagonism significantly ameliorates airway hyperreactivity and downregulates inflammation-induced genes in a mouse model of airway inflammation. Lukacs NW, etal., Am J Physiol Lung Cell Mol Physiol. 2008 Nov;295(5):L767-79. Epub 2008 Aug 29.
5. Genetic variability in CRTH2 polymorphism increases eotaxin-2 levels in patients with aspirin exacerbated respiratory disease. Palikhe NS, etal., Allergy. 2010 Mar;65(3):338-46. Epub 2009 Oct 1.
6. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
7. Accumulation of CRTH2-positive leukocytes in human allergic nasal mucosa. Shirasaki H, etal., Ann Allergy Asthma Immunol. 2009 Feb;102(2):110-5.
8. Novel tricyclic antagonists of the prostaglandin D2 receptor DP2 with efficacy in a murine model of allergic rhinitis. Stearns BA, etal., Bioorg Med Chem Lett. 2009 Aug 15;19(16):4647-51. Epub 2009 Jun 25.
9. Profound functional and signaling changes in viable inflammatory neutrophils homing to cystic fibrosis airways. Tirouvanziam R, etal., Proc Natl Acad Sci U S A. 2008 Mar 18;105(11):4335-9. Epub 2008 Mar 11.
10. Transcriptomic characteristics of bronchoalveolar lavage fluid and peripheral blood mononuclear cells in COVID-19 patients. Xiong Y, etal., Emerg Microbes Infect. 2020 Dec;9(1):761-770. doi: 10.1080/22221751.2020.1747363.
Additional References at PubMed
PMID:2834384   PMID:9973380   PMID:10036181   PMID:11208866   PMID:11801628   PMID:12230502   PMID:12477932   PMID:14668348   PMID:15065763   PMID:15345705   PMID:15489334   PMID:15507393  
PMID:15789622   PMID:16030019   PMID:16378605   PMID:17016057   PMID:17541272   PMID:17714552   PMID:17878378   PMID:17910949   PMID:18577758   PMID:18777142   PMID:18802357   PMID:18835884  
PMID:19010788   PMID:19247692   PMID:19290788   PMID:19423540   PMID:19494281   PMID:19839971   PMID:19913121   PMID:20035740   PMID:20107720   PMID:20406964   PMID:20438785   PMID:20491797  
PMID:20628086   PMID:20858065   PMID:20959461   PMID:21624751   PMID:21762224   PMID:21873635   PMID:21909091   PMID:21930295   PMID:22101342   PMID:22442685   PMID:22465717   PMID:22627365  
PMID:22705147   PMID:22947041   PMID:23128233   PMID:23168411   PMID:23226366   PMID:23798571   PMID:24922638   PMID:24929001   PMID:25850654   PMID:26194547   PMID:26482433   PMID:26928963  
PMID:27103662   PMID:27317944   PMID:27872865   PMID:28222358   PMID:29268008   PMID:29743346   PMID:29848886   PMID:29969451   PMID:29970474   PMID:30220562   PMID:30268119   PMID:30730082  
PMID:30825455   PMID:32694731   PMID:32851567   PMID:32941618   PMID:34341104   PMID:34750492  


Genomics

Comparative Map Data
PTGDR2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381160,850,933 - 60,855,950 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1160,850,933 - 60,855,950 (-)EnsemblGRCh38hg38GRCh38
GRCh371160,618,406 - 60,623,423 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361160,374,974 - 60,380,020 (-)NCBINCBI36Build 36hg18NCBI36
Build 341160,374,982 - 60,380,020NCBI
Celera1157,979,245 - 57,984,291 (-)NCBICelera
Cytogenetic Map11q12.2NCBI
HuRef1156,964,519 - 56,969,565 (-)NCBIHuRef
CHM1_11160,484,721 - 60,489,767 (-)NCBICHM1_1
T2T-CHM13v2.01160,802,052 - 60,807,069 (-)NCBIT2T-CHM13v2.0
Ptgdr2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391910,901,883 - 10,919,875 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1910,914,524 - 10,919,875 (+)EnsemblGRCm39 Ensembl
GRCm381910,924,519 - 10,942,511 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1910,937,160 - 10,942,511 (+)EnsemblGRCm38mm10GRCm38
MGSCv371911,011,650 - 11,017,001 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361911,004,205 - 11,009,556 (+)NCBIMGSCv36mm8
Celera1911,630,059 - 11,635,420 (+)NCBICelera
Cytogenetic Map19ANCBI
cM Map197.4NCBI
Ptgdr2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81217,010,183 - 217,015,044 (+)NCBIGRCr8
mRatBN7.21207,585,088 - 207,590,275 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1207,587,917 - 207,589,213 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1215,962,754 - 215,964,050 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01223,023,462 - 223,024,758 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01215,717,153 - 215,718,449 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01226,976,455 - 226,995,641 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1226,993,250 - 226,994,849 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01234,055,957 - 234,061,329 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41213,437,202 - 213,438,498 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11213,595,631 - 213,596,928 (+)NCBI
Celera1205,079,903 - 205,081,199 (+)NCBICelera
Cytogenetic Map1q43NCBI
Ptgdr2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555115,536,642 - 5,537,926 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555115,536,602 - 5,539,944 (-)NCBIChiLan1.0ChiLan1.0
PTGDR2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2962,020,551 - 62,059,863 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11163,064,279 - 63,103,748 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01156,114,166 - 56,153,820 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11159,554,874 - 59,557,653 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1159,556,460 - 59,557,647 (-)Ensemblpanpan1.1panPan2
PTGDR2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11855,426,632 - 55,431,916 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1855,429,308 - 55,430,510 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1854,002,288 - 54,003,490 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01856,474,768 - 56,479,958 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1856,477,498 - 56,478,700 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11855,534,988 - 55,536,190 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01855,156,526 - 55,157,727 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01856,037,704 - 56,038,906 (+)NCBIUU_Cfam_GSD_1.0
Ptgdr2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494711,955,087 - 11,958,521 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365812,067,546 - 2,070,893 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365812,069,355 - 2,072,535 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PTGDR2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl210,892,011 - 10,903,017 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1210,891,280 - 10,897,194 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2210,489,025 - 10,494,383 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PTGDR2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1112,989,750 - 12,994,979 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl112,992,188 - 12,993,378 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666038110,356,771 - 110,361,853 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ptgdr2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_004624926263,942 - 268,875 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in PTGDR2
22 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh37/hg19 11p15.5-q25(chr11:230616-134938470) copy number gain See cases [RCV000511729] Chr11:230616..134938470 [GRCh37]
Chr11:11p15.5-q25		 pathogenic
GRCh37/hg19 11p15.5-q25(chr11:230616-134938470)x3 copy number gain See cases [RCV000510881] Chr11:230616..134938470 [GRCh37]
Chr11:11p15.5-q25		 pathogenic
NM_004778.3(PTGDR2):c.824A>G (p.Asn275Ser) single nucleotide variant Inborn genetic diseases [RCV003282339] Chr11:60852899 [GRCh38]
Chr11:60620372 [GRCh37]
Chr11:11q12.2		 uncertain significance
GRCh37/hg19 11q12.1-12.3(chr11:58935215-62177656)x3 copy number gain not provided [RCV000683362] Chr11:58935215..62177656 [GRCh37]
Chr11:11q12.1-12.3		 likely pathogenic
GRCh37/hg19 11p15.5-q25(chr11:198510-134934063)x3 copy number gain not provided [RCV000737348] Chr11:198510..134934063 [GRCh37]
Chr11:11p15.5-q25		 pathogenic
GRCh37/hg19 11q12.2(chr11:60526573-60628691)x1 copy number loss not provided [RCV000737539] Chr11:60526573..60628691 [GRCh37]
Chr11:11q12.2		 benign
GRCh37/hg19 11p15.5-q25(chr11:70864-134938470)x3 copy number gain not provided [RCV000749874] Chr11:70864..134938470 [GRCh37]
Chr11:11p15.5-q25		 pathogenic
NM_004778.3(PTGDR2):c.841C>T (p.Leu281Phe) single nucleotide variant not provided [RCV000923710] Chr11:60852882 [GRCh38]
Chr11:60620355 [GRCh37]
Chr11:11q12.2		 likely benign
NM_004778.3(PTGDR2):c.449_450del (p.Lys150fs) deletion not provided [RCV000971057] Chr11:60853273..60853274 [GRCh38]
Chr11:60620746..60620747 [GRCh37]
Chr11:11q12.2		 benign
GRCh37/hg19 11q12.2-12.3(chr11:60385382-62456278)x3 copy number gain not provided [RCV001006412] Chr11:60385382..62456278 [GRCh37]
Chr11:11q12.2-12.3		 uncertain significance
GRCh37/hg19 11q12.2(chr11:60499486-61529578)x3 copy number gain not provided [RCV000848682] Chr11:60499486..61529578 [GRCh37]
Chr11:11q12.2		 uncertain significance
NM_004778.3(PTGDR2):c.541A>G (p.Met181Val) single nucleotide variant Inborn genetic diseases [RCV003239345] Chr11:60853182 [GRCh38]
Chr11:60620655 [GRCh37]
Chr11:11q12.2		 uncertain significance
NM_004778.3(PTGDR2):c.922T>C (p.Cys308Arg) single nucleotide variant Inborn genetic diseases [RCV003276716] Chr11:60852801 [GRCh38]
Chr11:60620274 [GRCh37]
Chr11:11q12.2		 uncertain significance
Single allele deletion Intellectual disability [RCV001293382] Chr11:118359328..118372573 [GRCh37]
Chr11:11p15.3-q23.3		 pathogenic
NC_000011.9:g.(?_59596957)_(68707199_?)dup duplication Familial temporal lobe epilepsy 8 [RCV001372442] Chr11:59596957..68707199 [GRCh37]
Chr11:11q12.1-13.3		 uncertain significance
NC_000011.9:g.(?_58916346)_(64972349_?)dup duplication Leukocyte adhesion deficiency 3 [RCV003113394]|not provided [RCV003113393] Chr11:58916346..64972349 [GRCh37]
Chr11:11q12.1-13.1		 uncertain significance|no classifications from unflagged records
NM_004778.3(PTGDR2):c.154G>C (p.Val52Leu) single nucleotide variant Inborn genetic diseases [RCV003255776] Chr11:60853569 [GRCh38]
Chr11:60621042 [GRCh37]
Chr11:11q12.2		 likely benign
NM_004778.3(PTGDR2):c.241T>A (p.Ser81Thr) single nucleotide variant Inborn genetic diseases [RCV003255777] Chr11:60853482 [GRCh38]
Chr11:60620955 [GRCh37]
Chr11:11q12.2		 likely benign
GRCh37/hg19 11p11.2-q12.2(chr11:51581311-54891247)x3 copy number gain See cases [RCV002286338] Chr11:51581311..54891247 [GRCh37]
Chr11:11p11.2-q12.2		 pathogenic
GRCh37/hg19 11p13-q25(chr11:32799481-134938470)x3 copy number gain MISSED ABORTION [RCV002282973] Chr11:32799481..134938470 [GRCh37]
Chr11:11p13-q25		 pathogenic
NM_004778.3(PTGDR2):c.434T>G (p.Val145Gly) single nucleotide variant Inborn genetic diseases [RCV003276886] Chr11:60853289 [GRCh38]
Chr11:60620762 [GRCh37]
Chr11:11q12.2		 uncertain significance
NM_004778.3(PTGDR2):c.404G>C (p.Arg135Pro) single nucleotide variant Inborn genetic diseases [RCV002991926] Chr11:60853319 [GRCh38]
Chr11:60620792 [GRCh37]
Chr11:11q12.2		 uncertain significance
NM_004778.3(PTGDR2):c.965T>C (p.Val322Ala) single nucleotide variant Inborn genetic diseases [RCV002794534] Chr11:60852758 [GRCh38]
Chr11:60620231 [GRCh37]
Chr11:11q12.2		 uncertain significance
NM_004778.3(PTGDR2):c.922T>G (p.Cys308Gly) single nucleotide variant Inborn genetic diseases [RCV002821403] Chr11:60852801 [GRCh38]
Chr11:60620274 [GRCh37]
Chr11:11q12.2		 uncertain significance
NM_004778.3(PTGDR2):c.1001G>A (p.Gly334Asp) single nucleotide variant Inborn genetic diseases [RCV002925514] Chr11:60852722 [GRCh38]
Chr11:60620195 [GRCh37]
Chr11:11q12.2		 uncertain significance
NM_004778.3(PTGDR2):c.1036T>A (p.Ser346Thr) single nucleotide variant Inborn genetic diseases [RCV002957095] Chr11:60852687 [GRCh38]
Chr11:60620160 [GRCh37]
Chr11:11q12.2		 uncertain significance
NM_004778.3(PTGDR2):c.454T>G (p.Cys152Gly) single nucleotide variant Inborn genetic diseases [RCV002954524] Chr11:60853269 [GRCh38]
Chr11:60620742 [GRCh37]
Chr11:11q12.2		 uncertain significance
NM_004778.3(PTGDR2):c.949C>T (p.Arg317Cys) single nucleotide variant Inborn genetic diseases [RCV002719739] Chr11:60852774 [GRCh38]
Chr11:60620247 [GRCh37]
Chr11:11q12.2		 uncertain significance
NM_004778.3(PTGDR2):c.812G>A (p.Arg271Gln) single nucleotide variant Inborn genetic diseases [RCV002936925] Chr11:60852911 [GRCh38]
Chr11:60620384 [GRCh37]
Chr11:11q12.2		 uncertain significance
NM_004778.3(PTGDR2):c.851G>A (p.Arg284His) single nucleotide variant Inborn genetic diseases [RCV002648496] Chr11:60852872 [GRCh38]
Chr11:60620345 [GRCh37]
Chr11:11q12.2		 uncertain significance
NM_004778.3(PTGDR2):c.41T>C (p.Leu14Pro) single nucleotide variant Inborn genetic diseases [RCV002678707] Chr11:60853682 [GRCh38]
Chr11:60621155 [GRCh37]
Chr11:11q12.2		 uncertain significance
NM_004778.3(PTGDR2):c.1086A>C (p.Glu362Asp) single nucleotide variant Inborn genetic diseases [RCV002652918] Chr11:60852637 [GRCh38]
Chr11:60620110 [GRCh37]
Chr11:11q12.2		 uncertain significance
NM_004778.3(PTGDR2):c.1111G>C (p.Gly371Arg) single nucleotide variant Inborn genetic diseases [RCV003302257] Chr11:60852612 [GRCh38]
Chr11:60620085 [GRCh37]
Chr11:11q12.2		 uncertain significance
NM_004778.3(PTGDR2):c.765C>A (p.Phe255Leu) single nucleotide variant Inborn genetic diseases [RCV003183906] Chr11:60852958 [GRCh38]
Chr11:60620431 [GRCh37]
Chr11:11q12.2		 uncertain significance
NM_004778.3(PTGDR2):c.695G>T (p.Arg232Leu) single nucleotide variant Inborn genetic diseases [RCV003339382] Chr11:60853028 [GRCh38]
Chr11:60620501 [GRCh37]
Chr11:11q12.2		 uncertain significance
NM_004778.3(PTGDR2):c.740T>C (p.Leu247Pro) single nucleotide variant Inborn genetic diseases [RCV003371052] Chr11:60852983 [GRCh38]
Chr11:60620456 [GRCh37]
Chr11:11q12.2		 uncertain significance
GRCh37/hg19 11q12.2-13.5(chr11:59923608-76272324)x3 copy number gain not provided [RCV003484842] Chr11:59923608..76272324 [GRCh37]
Chr11:11q12.2-13.5		 pathogenic
GRCh37/hg19 11q12.1-13.3(chr11:56895955-69295402)x3 copy number gain not specified [RCV003986944] Chr11:56895955..69295402 [GRCh37]
Chr11:11q12.1-13.3		 likely pathogenic
GRCh37/hg19 11p11.12-q13.1(chr11:50398499-63924462)x3 copy number gain not specified [RCV003986918] Chr11:50398499..63924462 [GRCh37]
Chr11:11p11.12-q13.1		 likely pathogenic
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:777
Count of miRNA genes:567
Interacting mature miRNAs:632
Transcripts:ENST00000332539
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Markers in Region
RH67900  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371160,618,181 - 60,618,273UniSTSGRCh37
GRCh37727,530,831 - 27,530,923UniSTSGRCh37
Build 36727,497,356 - 27,497,448RGDNCBI36
Celera727,519,449 - 27,519,541RGD
Celera1157,979,028 - 57,979,120UniSTS
Cytogenetic Map7p15.2UniSTS
Cytogenetic Map11q12.2UniSTS
Cytogenetic Map11q12-q13.3UniSTS
HuRef1156,964,302 - 56,964,394UniSTS
HuRef727,411,397 - 27,411,489UniSTS
CRA_TCAGchr7v2727,582,014 - 27,582,106UniSTS
RH11821  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371160,618,478 - 60,618,599UniSTSGRCh37
Build 361160,375,054 - 60,375,175RGDNCBI36
Celera1157,979,325 - 57,979,446RGD
Cytogenetic Map11q12-q13.3UniSTS
Cytogenetic Map11q12.2UniSTS
HuRef1156,964,599 - 56,964,720UniSTS
GeneMap99-GB4 RH Map11227.62UniSTS
NCBI RH Map11499.1UniSTS
IB1021  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371160,618,443 - 60,618,593UniSTSGRCh37
Build 361160,375,019 - 60,375,169RGDNCBI36
Celera1157,979,290 - 57,979,440RGD
Cytogenetic Map11q12-q13.3UniSTS
Cytogenetic Map11q12.2UniSTS
HuRef1156,964,564 - 56,964,714UniSTS
TNG Radiation Hybrid Map1126665.0UniSTS
Stanford-G3 RH Map112646.0UniSTS
NCBI RH Map11546.1UniSTS
GeneMap99-G3 RH Map112646.0UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system visual system adipose tissue appendage entire extraembryonic component
High
Medium 449 13 16 15 95 15 2 20 1 1 2
Low 1598 906 411 177 688 170 2118 1937 3386 98 819 423 11 1 460 1554 1
Below cutoff 381 1993 1229 419 981 270 2192 249 312 271 614 1119 160 742 1206 4

Sequence


Reference Sequences
RefSeq Acc Id: ENST00000332539   ⟹   ENSP00000332812
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1160,850,933 - 60,855,950 (-)Ensembl
RefSeq Acc Id: NM_004778   ⟹   NP_004769
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381160,850,933 - 60,855,950 (-)NCBI
GRCh371160,618,398 - 60,623,444 (-)ENTREZGENE
Build 361160,374,974 - 60,380,020 (-)NCBI Archive
HuRef1156,964,519 - 56,969,565 (-)ENTREZGENE
CHM1_11160,484,721 - 60,489,767 (-)NCBI
T2T-CHM13v2.01160,802,052 - 60,807,069 (-)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_004769   ⟸   NM_004778
- UniProtKB: O94765 (UniProtKB/Swiss-Prot),   Q4QRI6 (UniProtKB/Swiss-Prot),   Q9Y5Y4 (UniProtKB/Swiss-Prot),   A8K5Q6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSP00000332812   ⟸   ENST00000332539
Protein Domains
G-protein coupled receptors family 1 profile

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9Y5Y4-F1-model_v2 AlphaFold Q9Y5Y4 1-395 view protein structure

Promoters
RGD ID:6788974
Promoter ID:HG_KWN:13026
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   HeLa_S3,   K562
Transcripts:UC009YNH.1
Position:
Human AssemblyChrPosition (strand)Source
Build 361160,376,701 - 60,378,447 (-)MPROMDB
RGD ID:7220491
Promoter ID:EPDNEW_H15992
Type:multiple initiation site
Name:PTGDR2_2
Description:prostaglandin D2 receptor 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H15993  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381160,855,519 - 60,855,579EPDNEW
RGD ID:7220493
Promoter ID:EPDNEW_H15993
Type:initiation region
Name:PTGDR2_1
Description:prostaglandin D2 receptor 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H15992  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381160,855,950 - 60,856,010EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:4502 AgrOrtholog
COSMIC PTGDR2 COSMIC
Ensembl Genes ENSG00000183134 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENST00000332539 ENTREZGENE
  ENST00000332539.5 UniProtKB/Swiss-Prot
Gene3D-CATH Rhodopsin 7-helix transmembrane proteins UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx ENSG00000183134 GTEx
HGNC ID HGNC:4502 ENTREZGENE
Human Proteome Map PTGDR2 Human Proteome Map
InterPro Formyl_rcpt-rel UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_Rhodpsn UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_Rhodpsn_7TM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:11251 UniProtKB/Swiss-Prot
NCBI Gene 11251 ENTREZGENE
OMIM 604837 OMIM
PANTHER CHEMOTACTIC RECEPTOR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  G_PROTEIN_RECEP_F1_2 DOMAIN-CONTAINING PROTEIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam 7tm_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA28891 PharmGKB
PRINTS FMETLEUPHER UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCRRHODOPSN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE G_PROTEIN_RECEP_F1_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  G_PROTEIN_RECEP_F1_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP Family A G protein-coupled receptor-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A8K5Q6 ENTREZGENE, UniProtKB/TrEMBL
  O94765 ENTREZGENE
  PD2R2_HUMAN UniProtKB/Swiss-Prot
  Q4QRI6 ENTREZGENE
  Q9Y5Y4 ENTREZGENE
UniProt Secondary O94765 UniProtKB/Swiss-Prot
  Q4QRI6 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2011-11-22 PTGDR2  prostaglandin D2 receptor 2  GPR44  G protein-coupled receptor 44  Symbol and/or name change 5135510 APPROVED