Ptgdr2 (prostaglandin D2 receptor 2) - Rat Genome Database

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Gene: Ptgdr2 (prostaglandin D2 receptor 2) Mus musculus
Analyze
Symbol: Ptgdr2
Name: prostaglandin D2 receptor 2
RGD ID: 1323731
MGI Page MGI
Description: Enables prostaglandin D receptor activity; prostaglandin F receptor activity; and prostaglandin J receptor activity. Acts upstream of or within several processes, including adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway; negative regulation of male germ cell proliferation; and positive regulation of G protein-coupled receptor signaling pathway. Predicted to be located in plasma membrane. Predicted to be active in neuron projection. Human ortholog(s) of this gene implicated in asthma. Orthologous to human PTGDR2 (prostaglandin D2 receptor 2).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: chemoattractant receptor-homologous molecule expressed on TH2 cells; Crth; Crth2; G protein-coupled receptor 44; G-protein coupled receptor 44; Gpr; Gpr44; Grp45; MGC130436; PGD2 receptor; prostaglandin D2 receptor CRTH2; putative G-protein coupled receptor 44
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391910,901,883 - 10,919,875 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1910,914,524 - 10,919,875 (+)EnsemblGRCm39 Ensembl
GRCm381910,924,519 - 10,942,511 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1910,937,160 - 10,942,511 (+)EnsemblGRCm38mm10GRCm38
MGSCv371911,011,650 - 11,017,001 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361911,004,205 - 11,009,556 (+)NCBIMGSCv36mm8
Celera1911,630,059 - 11,635,420 (+)NCBICelera
Cytogenetic Map19ANCBI
cM Map197.4NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Genetic variation in CRTh2 influences development of allergic phenotypes. Cameron L, etal., Allergy. 2009 Oct;64(10):1478-85. Epub 2009 Apr 14.
2. Role of prostaglandin D2 receptor CRTH2 in sustained eosinophil accumulation in the airways of mice with chronic asthma. Kagawa S, etal., Int Arch Allergy Immunol. 2011;155 Suppl 1:6-11. Epub 2011 Jun 1.
3. CRTH2 antagonism significantly ameliorates airway hyperreactivity and downregulates inflammation-induced genes in a mouse model of airway inflammation. Lukacs NW, etal., Am J Physiol Lung Cell Mol Physiol. 2008 Nov;295(5):L767-79. Epub 2008 Aug 29.
4. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
5. MGDs mouse GO annotations MGD data from the GO Consortium
6. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
7. Genetic variability in CRTH2 polymorphism increases eotaxin-2 levels in patients with aspirin exacerbated respiratory disease. Palikhe NS, etal., Allergy. 2010 Mar;65(3):338-46. Epub 2009 Oct 1.
8. Mouse MP Annotation Import Pipeline RGD automated import pipeline
9. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
10. Accumulation of CRTH2-positive leukocytes in human allergic nasal mucosa. Shirasaki H, etal., Ann Allergy Asthma Immunol. 2009 Feb;102(2):110-5.
11. Novel tricyclic antagonists of the prostaglandin D2 receptor DP2 with efficacy in a murine model of allergic rhinitis. Stearns BA, etal., Bioorg Med Chem Lett. 2009 Aug 15;19(16):4647-51. Epub 2009 Jun 25.
12. Profound functional and signaling changes in viable inflammatory neutrophils homing to cystic fibrosis airways. Tirouvanziam R, etal., Proc Natl Acad Sci U S A. 2008 Mar 18;105(11):4335-9. Epub 2008 Mar 11.
Additional References at PubMed
PMID:9931443   PMID:10349636   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12477932   PMID:12878180   PMID:14610273   PMID:15065763   PMID:15563582   PMID:16030019   PMID:16081770  
PMID:16141072   PMID:16141073   PMID:16602821   PMID:16617107   PMID:16888024   PMID:17910949   PMID:18097056   PMID:18390753   PMID:18477017   PMID:19060214   PMID:19066314   PMID:19066315  
PMID:19346259   PMID:20713302   PMID:21166666   PMID:21267068   PMID:21703412   PMID:21873635   PMID:21943706   PMID:22440736   PMID:22544936   PMID:22997255   PMID:23190891   PMID:23374103  
PMID:23624557   PMID:24298012   PMID:24333565   PMID:24523542   PMID:25142465   PMID:25362177   PMID:25362470   PMID:25698598   PMID:25850654   PMID:26792210   PMID:26928963   PMID:27317944  
PMID:28341703   PMID:28623133   PMID:29335338   PMID:29743346   PMID:29970474   PMID:30326727   PMID:30825455   PMID:31151773   PMID:31518163   PMID:31900341   PMID:33978990   PMID:34223653  
PMID:34283207   PMID:34389796   PMID:35132998   PMID:35354317   PMID:37459233   PMID:37666361  


Genomics

Comparative Map Data
Ptgdr2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391910,901,883 - 10,919,875 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1910,914,524 - 10,919,875 (+)EnsemblGRCm39 Ensembl
GRCm381910,924,519 - 10,942,511 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1910,937,160 - 10,942,511 (+)EnsemblGRCm38mm10GRCm38
MGSCv371911,011,650 - 11,017,001 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361911,004,205 - 11,009,556 (+)NCBIMGSCv36mm8
Celera1911,630,059 - 11,635,420 (+)NCBICelera
Cytogenetic Map19ANCBI
cM Map197.4NCBI
PTGDR2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381160,850,933 - 60,855,950 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1160,850,933 - 60,855,950 (-)EnsemblGRCh38hg38GRCh38
GRCh371160,618,406 - 60,623,423 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361160,374,974 - 60,380,020 (-)NCBINCBI36Build 36hg18NCBI36
Build 341160,374,982 - 60,380,020NCBI
Celera1157,979,245 - 57,984,291 (-)NCBICelera
Cytogenetic Map11q12.2NCBI
HuRef1156,964,519 - 56,969,565 (-)NCBIHuRef
CHM1_11160,484,721 - 60,489,767 (-)NCBICHM1_1
T2T-CHM13v2.01160,802,052 - 60,807,069 (-)NCBIT2T-CHM13v2.0
Ptgdr2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81217,010,183 - 217,015,044 (+)NCBIGRCr8
mRatBN7.21207,585,088 - 207,590,275 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1207,587,917 - 207,589,213 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1215,962,754 - 215,964,050 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01223,023,462 - 223,024,758 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01215,717,153 - 215,718,449 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01226,976,455 - 226,995,641 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1226,993,250 - 226,994,849 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01234,055,957 - 234,061,329 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41213,437,202 - 213,438,498 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11213,595,631 - 213,596,928 (+)NCBI
Celera1205,079,903 - 205,081,199 (+)NCBICelera
Cytogenetic Map1q43NCBI
Ptgdr2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555115,536,642 - 5,537,926 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555115,536,602 - 5,539,944 (-)NCBIChiLan1.0ChiLan1.0
PTGDR2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2962,020,551 - 62,059,863 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11163,064,279 - 63,103,748 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01156,114,166 - 56,153,820 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11159,554,874 - 59,557,653 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1159,556,460 - 59,557,647 (-)Ensemblpanpan1.1panPan2
PTGDR2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11855,426,632 - 55,431,916 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1855,429,308 - 55,430,510 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1854,002,288 - 54,003,490 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01856,474,768 - 56,479,958 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1856,477,498 - 56,478,700 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11855,534,988 - 55,536,190 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01855,156,526 - 55,157,727 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01856,037,704 - 56,038,906 (+)NCBIUU_Cfam_GSD_1.0
Ptgdr2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494711,955,087 - 11,958,521 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365812,067,546 - 2,070,893 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365812,069,355 - 2,072,535 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PTGDR2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl210,892,011 - 10,903,017 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1210,891,280 - 10,897,194 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2210,489,025 - 10,494,383 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PTGDR2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1112,989,750 - 12,994,979 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl112,992,188 - 12,993,378 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666038110,356,771 - 110,361,853 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ptgdr2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_004624926263,942 - 268,875 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Ptgdr2
637 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:398
Count of miRNA genes:303
Interacting mature miRNAs:347
Transcripts:ENSMUST00000037261
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300776Lfp3_mlong free running period 3 (mouse)Not determined19120328703Mouse
4142161Drinksac2_mdrink saccharin 2 (mouse)Not determined120695286Mouse
4142302Nstr1_mnerve sheath tumor resistance QTL 1 (mouse)Not determined19122371338Mouse
1301271Datd_mdopamine transporter density (mouse)Not determined19132340234Mouse
4142406Pbctlp1_mperipheral blood cytotoxic T lymphocyte percentage 1 (mouse)Not determined132875174Mouse
1300904Chab5_mcholesterol absorption 5 (mouse)Not determined19165376435653927Mouse
26884385Skwq14_mskull length QTL 14, 16 week (mouse)19325000035877400Mouse
1301800Faq10_mfluctuating asymmetry QTL 10 (mouse)Not determined19332321637323348Mouse
1300923Bits4_mbitterness sensitivity 4 (mouse)Not determined19332321637323348Mouse
1302126Skull26_mskull morphology 26 (mouse)Not determined19332321637323348Mouse
1300591Pas3_mpulmonary adenoma susceptibility 3 (mouse)Not determined19332321637323348Mouse
1357819Tgct2_mtesticular germ cell tumor 2 (mouse)Not determined19332855120539663Mouse
11039522Tbbr4_mTrypanosoma brucei brucei response 4 (mouse)19531332639313470Mouse
1301228Iba4_minduction of brown adipocytes 4 (mouse)Not determined19930571543305821Mouse
1302019Pgia23_mproteoglycan induced arthritis 23 (mouse)Not determined19978745343787602Mouse
38455997Cdtm2_mCD62L+ CD8 TM cells 2 (mouse)19997736419977364Mouse


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000037261   ⟹   ENSMUSP00000036159
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1910,914,524 - 10,919,875 (+)Ensembl
GRCm38.p6 Ensembl1910,937,160 - 10,942,511 (+)Ensembl
RefSeq Acc Id: NM_009962   ⟹   NP_034092
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391910,914,524 - 10,919,875 (+)NCBI
GRCm381910,937,160 - 10,942,511 (+)NCBI
MGSCv371911,011,650 - 11,017,001 (+)RGD
Celera1911,630,059 - 11,635,420 (+)RGD
cM Map19 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006526695   ⟹   XP_006526758
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391910,914,658 - 10,919,816 (+)NCBI
GRCm381910,937,722 - 10,941,496 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006526696   ⟹   XP_006526759
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391910,915,774 - 10,919,816 (+)NCBI
GRCm381910,938,410 - 10,941,496 (+)NCBI
Sequence:
RefSeq Acc Id: XM_011247148   ⟹   XP_011245450
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391910,901,883 - 10,919,816 (+)NCBI
GRCm381910,924,519 - 10,941,496 (+)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_034092   ⟸   NM_009962
- UniProtKB: Q54A00 (UniProtKB/Swiss-Prot),   Q9Z2J6 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006526758   ⟸   XM_006526695
- Peptide Label: isoform X1
- UniProtKB: Q54A00 (UniProtKB/Swiss-Prot),   Q9Z2J6 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006526759   ⟸   XM_006526696
- Peptide Label: isoform X1
- UniProtKB: Q54A00 (UniProtKB/Swiss-Prot),   Q9Z2J6 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_011245450   ⟸   XM_011247148
- Peptide Label: isoform X1
- UniProtKB: Q54A00 (UniProtKB/Swiss-Prot),   Q9Z2J6 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSMUSP00000036159   ⟸   ENSMUST00000037261

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9Z2J6-F1-model_v2 AlphaFold Q9Z2J6 1-382 view protein structure

Promoters
RGD ID:13678944
Promoter ID:EPDNEW_M23621
Type:initiation region
Name:Ptgdr2_1
Description:Mus musculus prostaglandin D2 receptor 2 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381910,937,160 - 10,937,220EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1330275 AgrOrtholog
Ensembl Genes ENSMUSG00000034117 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000037261 ENTREZGENE
  ENSMUST00000037261.4 UniProtKB/Swiss-Prot
Gene3D-CATH Rhodopsin 7-helix transmembrane proteins UniProtKB/Swiss-Prot
InterPro Formyl_rcpt-rel UniProtKB/Swiss-Prot
  GPCR_Rhodpsn UniProtKB/Swiss-Prot
  GPCR_Rhodpsn_7TM UniProtKB/Swiss-Prot
KEGG Report mmu:14764 UniProtKB/Swiss-Prot
MGD MGI:1330275 ENTREZGENE
NCBI Gene 14764 ENTREZGENE
PANTHER CHEMOTACTIC RECEPTOR UniProtKB/Swiss-Prot
  G_PROTEIN_RECEP_F1_2 DOMAIN-CONTAINING PROTEIN UniProtKB/Swiss-Prot
Pfam 7tm_1 UniProtKB/Swiss-Prot
PhenoGen Ptgdr2 PhenoGen
PRINTS FMETLEUPHER UniProtKB/Swiss-Prot
  GPCRRHODOPSN UniProtKB/Swiss-Prot
PROSITE G_PROTEIN_RECEP_F1_1 UniProtKB/Swiss-Prot
  G_PROTEIN_RECEP_F1_2 UniProtKB/Swiss-Prot
Superfamily-SCOP Family A G protein-coupled receptor-like UniProtKB/Swiss-Prot
UniProt PD2R2_MOUSE UniProtKB/Swiss-Prot
  Q54A00 ENTREZGENE
  Q9Z2J6 ENTREZGENE
UniProt Secondary Q54A00 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2014-05-07 Ptgdr2  prostaglandin D2 receptor 2  Gpr44  G protein-coupled receptor 44  Symbol and/or name change 5135510 APPROVED