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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1323730
Species: Homo sapiens
RGD Object: Gene
Symbol: PTGDR2
Name: prostaglandin D2 receptor 2
Acc ID: CHEBI:49662
Term: indometacin
Definition: A member of the class of indole-3-acetic acids that is indole-3-acetic acid in which the indole ring is substituted at positions 1, 2 and 5 by p-chlorobenzoyl, methyl, and methoxy groups, respectively. A non-steroidal anti-inflammatory drug, it is used in the treatment of musculoskeletal and joint disorders including osteoarthritis, rheumatoid arthritis, gout, bursitis and tendinitis.
Chemical ID: MESH:D007213
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
PTGDR2increases activityEXP 6480464CTDIndomethacin results in increased activity of PTGDR2 proteinPMID:11801628
PTGDR2multiple interactionsEXP 6480464CTDIndomethacin binds to and results in increased activity of PTGDR2 protein; ramatroban inhibits the reaction [Indomethacin binds to and results in increased activity of PTGDR2 protein]PMID:16256979
PTGDR2affects bindingISOPtgdr2 (Mus musculus)6480464CTDIndomethacin binds to PTGDR2 proteinPMID:15563582
PTGDR2multiple interactionsISOPtgdr2 (Rattus norvegicus)6480464CTDIndomethacin binds to and results in increased activity of PTGDR2 proteinPMID:15528449
PTGDR2multiple interactionsISOPtgdr2 (Mus musculus)6480464CTD[Indomethacin binds to PTGDR2 protein] which results in decreased abundance of Cyclic AMP; Indomethacin inhibits the reaction [Prostaglandin D2 binds to PTGDR2 protein]PMID:12721327 PMID:15563582
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