Lrrc18 (leucine rich repeat containing 18) - Rat Genome Database

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Gene: Lrrc18 (leucine rich repeat containing 18) Mus musculus
Analyze
Symbol: Lrrc18
Name: leucine rich repeat containing 18
RGD ID: 1323351
MGI Page MGI
Description: Predicted to be located in cytoplasm. Orthologous to human LRRC18 (leucine rich repeat containing 18).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 4930442L21Rik; leucine-rich repeat-containing protein 18; mtL; MTLR1; testis-specific LRR protein
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391432,713,339 - 32,737,257 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1432,713,339 - 32,737,248 (+)EnsemblGRCm39 Ensembl
GRCm381432,991,382 - 33,015,300 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1432,991,382 - 33,015,291 (+)EnsemblGRCm38mm10GRCm38
MGSCv371433,804,568 - 33,828,478 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361431,820,492 - 31,844,384 (+)NCBIMGSCv36mm8
Celera1429,251,093 - 29,275,024 (+)NCBICelera
Cytogenetic Map14BNCBI
cM Map1419.61NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Functional annotation of a full-length mouse cDNA collection. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
2. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
3. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:10349636   PMID:11042159   PMID:11076861   PMID:11544199   PMID:12477932   PMID:15489334   PMID:15707978   PMID:16141072   PMID:16141073   PMID:21267068   PMID:21677750   PMID:21873635  


Genomics

Comparative Map Data
Lrrc18
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391432,713,339 - 32,737,257 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1432,713,339 - 32,737,248 (+)EnsemblGRCm39 Ensembl
GRCm381432,991,382 - 33,015,300 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1432,991,382 - 33,015,291 (+)EnsemblGRCm38mm10GRCm38
MGSCv371433,804,568 - 33,828,478 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361431,820,492 - 31,844,384 (+)NCBIMGSCv36mm8
Celera1429,251,093 - 29,275,024 (+)NCBICelera
Cytogenetic Map14BNCBI
cM Map1419.61NCBI
LRRC18
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381048,909,480 - 48,939,840 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1048,909,480 - 48,939,840 (-)EnsemblGRCh38hg38GRCh38
GRCh371050,117,525 - 50,147,885 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361049,787,534 - 49,792,286 (-)NCBINCBI36Build 36hg18NCBI36
Build 341049,787,536 - 49,792,288NCBI
Celera1043,703,127 - 43,707,879 (-)NCBICelera
Cytogenetic Map10q11.23NCBI
HuRef1044,382,681 - 44,387,433 (-)NCBIHuRef
CHM1_11050,399,155 - 50,403,907 (-)NCBICHM1_1
T2T-CHM13v2.01049,758,686 - 49,789,019 (-)NCBIT2T-CHM13v2.0
Lrrc18
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8168,259,083 - 8,283,722 (+)NCBIGRCr8
mRatBN7.2168,253,524 - 8,277,141 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl168,254,352 - 8,277,437 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx168,273,142 - 8,291,825 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0169,418,043 - 9,436,726 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0168,266,491 - 8,284,806 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0169,234,341 - 9,258,849 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl169,235,888 - 9,258,538 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01611,196,474 - 11,218,933 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4168,529,683 - 8,554,281 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1168,529,680 - 8,554,277 (+)NCBI
Celera166,928,507 - 6,951,792 (-)NCBICelera
Cytogenetic Map16p16NCBI
Lrrc18
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555561,213,517 - 1,237,275 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555561,213,871 - 1,237,281 (+)NCBIChiLan1.0ChiLan1.0
LRRC18
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2861,174,202 - 61,205,658 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11061,179,521 - 61,210,977 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01045,309,911 - 45,331,912 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
LRRC18
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.128822,579 - 856,329 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl28830,105 - 834,201 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha281,051,350 - 1,084,412 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.028998,365 - 1,031,443 (-)NCBIROS_Cfam_1.0
UMICH_Zoey_3.128808,202 - 830,558 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.028840,839 - 873,922 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.028963,920 - 996,994 (-)NCBIUU_Cfam_GSD_1.0
Lrrc18
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440721380,100,224 - 80,128,753 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049367281,326,723 - 1,327,490 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049367281,306,756 - 1,327,490 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LRRC18
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1489,571,919 - 89,577,303 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11489,571,911 - 89,589,479 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21497,366,156 - 97,387,555 (-)NCBISscrofa10.2Sscrofa10.2susScr3
LRRC18
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1942,861,868 - 42,887,733 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl942,861,657 - 42,889,270 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660482,629,901 - 2,649,307 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Lrrc18
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624928980,389 - 1,004,137 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624928980,324 - 1,004,150 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Lrrc18
882 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1089
Count of miRNA genes:590
Interacting mature miRNAs:726
Transcripts:ENSMUST00000038956, ENSMUST00000120588, ENSMUST00000120866, ENSMUST00000120951, ENSMUST00000123822, ENSMUST00000123910
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
27226748Femd8_mfemur midshaft diameter 8, 10 week (mouse)141376927346737457Mouse
10043886Cia49_mcollagen induced arthritis QTL 49 (mouse)Not determined142999699463997133Mouse
1357527Epfpq1_mepididymal fat percentage QTL 1 (mouse)Not determined142106245071885801Mouse
14746973Manh76_mmandible shape 76 (mouse)142228721756287217Mouse
4142485Modor2_mmodifier of ocular retardation 2 (mouse)Not determined142492624858179769Mouse
1301372Sluc13_msusceptibility to lung cancer 13 (mouse)Not determined141882760452827726Mouse
13506929Recrq10_mrecombination rate in male meiosis QTL 10 (mouse)142792195761137449Mouse
1300909Ath13_matherosclerosis 13 (mouse)Not determined143033525064335381Mouse
1300998Cia17_mcollagen induced arthritis 17 (mouse)Not determined143033525064335381Mouse
1301991Wta3_mweight adult 3 (mouse)Not determined14388747337887650Mouse
4141864Mrdq4_mmodifier of retinal degeneration QTL 4 (mouse)Not determined992324548765082Mouse
1357589Kdnw2_mkidney weight 2 (mouse)Not determined1420887473121269804Mouse
27226752Femd4_mfemur midshaft diameter 4, 5 week (mouse)141376927347237457Mouse
27226774Tibl15_mtibia length 15, 10 week (mouse)143032195787937436Mouse
1300544Hypn_mhyperinsulinemia (mouse)Not determined141516061649160765Mouse
27226744Metcl6_mmetatarsal-calcaneal length 6, 5 week (mouse)143032195752937457Mouse
4141550Dbm3_mdiabetes modifier 3 (mouse)Not determined514347339143596Mouse
27226775Tibl7_mtibia length 7, 5 week (mouse)143032195748837457Mouse
1300779Dyscalc4_mdystrophic cardiac calcinosis 4 (mouse)Not determined141221287146213007Mouse

Markers in Region
D14Mit100  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381433,008,036 - 33,008,231UniSTSGRCm38
MGSCv371433,821,222 - 33,821,417UniSTSGRCm37
Celera1429,267,768 - 29,267,963UniSTS
Cytogenetic Map14BUniSTS
cM Map1411.5UniSTS
Whitehead Genetic1418.6UniSTS


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000038956   ⟹   ENSMUSP00000041199
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1432,713,339 - 32,737,248 (+)Ensembl
GRCm38.p6 Ensembl1432,991,382 - 33,015,291 (+)Ensembl
RefSeq Acc Id: ENSMUST00000120588   ⟹   ENSMUSP00000113825
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1432,713,360 - 32,730,635 (+)Ensembl
GRCm38.p6 Ensembl1432,991,403 - 33,008,678 (+)Ensembl
RefSeq Acc Id: ENSMUST00000120866   ⟹   ENSMUSP00000113608
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1432,713,355 - 32,731,353 (+)Ensembl
GRCm38.p6 Ensembl1432,991,398 - 33,009,396 (+)Ensembl
RefSeq Acc Id: ENSMUST00000120951   ⟹   ENSMUSP00000113965
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1432,713,415 - 32,736,112 (+)Ensembl
GRCm38.p6 Ensembl1432,991,458 - 33,014,155 (+)Ensembl
RefSeq Acc Id: ENSMUST00000123822   ⟹   ENSMUSP00000123178
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1432,713,403 - 32,730,796 (+)Ensembl
GRCm38.p6 Ensembl1432,991,446 - 33,008,839 (+)Ensembl
RefSeq Acc Id: ENSMUST00000123910
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1432,717,222 - 32,730,416 (+)Ensembl
GRCm38.p6 Ensembl1432,995,265 - 33,008,459 (+)Ensembl
RefSeq Acc Id: NM_001146021   ⟹   NP_001139493
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391432,713,339 - 32,731,355 (+)NCBI
GRCm381432,991,382 - 33,009,398 (+)NCBI
MGSCv371433,804,568 - 33,828,478 (+)RGD
Celera1429,251,093 - 29,275,024 (+)RGD
cM Map14 ENTREZGENE
Sequence:
RefSeq Acc Id: NM_026253   ⟹   NP_080529
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391432,713,339 - 32,737,249 (+)NCBI
GRCm381432,991,382 - 33,015,292 (+)NCBI
MGSCv371433,804,568 - 33,828,478 (+)RGD
Celera1429,251,093 - 29,275,024 (+)RGD
cM Map14 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006519457   ⟹   XP_006519520
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391432,714,139 - 32,737,257 (+)NCBI
GRCm381432,992,182 - 33,015,300 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006519458   ⟹   XP_006519521
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391432,714,139 - 32,737,257 (+)NCBI
GRCm381432,992,182 - 33,015,300 (+)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_080529   ⟸   NM_026253
- Peptide Label: isoform 1
- UniProtKB: Q9CW01 (UniProtKB/Swiss-Prot),   Q80ZT3 (UniProtKB/Swiss-Prot),   Q6P8T8 (UniProtKB/Swiss-Prot),   Q9DA89 (UniProtKB/Swiss-Prot),   Q9CQ07 (UniProtKB/Swiss-Prot),   D3Z3F9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001139493   ⟸   NM_001146021
- Peptide Label: isoform 2
- UniProtKB: D3Z3F9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006519521   ⟸   XM_006519458
- Peptide Label: isoform X1
- UniProtKB: Q9CW01 (UniProtKB/Swiss-Prot),   Q80ZT3 (UniProtKB/Swiss-Prot),   Q6P8T8 (UniProtKB/Swiss-Prot),   Q9DA89 (UniProtKB/Swiss-Prot),   Q9CQ07 (UniProtKB/Swiss-Prot),   D3Z3F9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006519520   ⟸   XM_006519457
- Peptide Label: isoform X1
- UniProtKB: Q9CW01 (UniProtKB/Swiss-Prot),   Q80ZT3 (UniProtKB/Swiss-Prot),   Q6P8T8 (UniProtKB/Swiss-Prot),   Q9DA89 (UniProtKB/Swiss-Prot),   Q9CQ07 (UniProtKB/Swiss-Prot),   D3Z3F9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000113608   ⟸   ENSMUST00000120866
RefSeq Acc Id: ENSMUSP00000113965   ⟸   ENSMUST00000120951
RefSeq Acc Id: ENSMUSP00000113825   ⟸   ENSMUST00000120588
RefSeq Acc Id: ENSMUSP00000123178   ⟸   ENSMUST00000123822
RefSeq Acc Id: ENSMUSP00000041199   ⟸   ENSMUST00000038956

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9CQ07-F1-model_v2 AlphaFold Q9CQ07 1-262 view protein structure

Promoters
RGD ID:8681888
Promoter ID:EPDNEW_M18975
Type:initiation region
Name:Lrrc18_1
Description:Mus musculus leucine rich repeat containing 18 , transcript variant1, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381432,991,446 - 32,991,506EPDNEW
RGD ID:6825144
Promoter ID:MM_KWN:16156
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Lung
Transcripts:OTTMUST00000069136
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361433,808,601 - 33,809,101 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1914830 AgrOrtholog
Ensembl Genes ENSMUSG00000041673 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000038956 ENTREZGENE
  ENSMUST00000038956.12 UniProtKB/Swiss-Prot
  ENSMUST00000120588.8 UniProtKB/TrEMBL
  ENSMUST00000120866 ENTREZGENE
  ENSMUST00000120866.8 UniProtKB/Swiss-Prot
  ENSMUST00000120951.2 UniProtKB/TrEMBL
  ENSMUST00000123822.8 UniProtKB/TrEMBL
Gene3D-CATH 3.80.10.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Leu-rich_rpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Leu-rich_rpt_typical-subtyp UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LRR_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:67580 UniProtKB/Swiss-Prot
MGD MGI:1914830 ENTREZGENE
NCBI Gene 67580 ENTREZGENE
PANTHER NON-SPECIFIC SERINE/THREONINE PROTEIN KINASE-RELATED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR48051 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam LRR_8 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Lrrc18 PhenoGen
PROSITE LRR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART LRR_TYP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP L domain-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt D3Z0P1_MOUSE UniProtKB/TrEMBL
  D3Z3F9 ENTREZGENE, UniProtKB/TrEMBL
  D3Z3X8_MOUSE UniProtKB/TrEMBL
  LRC18_MOUSE UniProtKB/Swiss-Prot
  Q6P8T8 ENTREZGENE
  Q80ZT3 ENTREZGENE
  Q9CQ07 ENTREZGENE
  Q9CW01 ENTREZGENE
  Q9DA89 ENTREZGENE
UniProt Secondary Q6P8T8 UniProtKB/Swiss-Prot
  Q80ZT3 UniProtKB/Swiss-Prot
  Q9CW01 UniProtKB/Swiss-Prot
  Q9DA89 UniProtKB/Swiss-Prot