LRRC18 (leucine rich repeat containing 18) - Rat Genome Database

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Gene: LRRC18 (leucine rich repeat containing 18) Chlorocebus sabaeus
Analyze
Symbol: LRRC18
Name: leucine rich repeat containing 18
RGD ID: 18763089
Description: ASSOCIATED WITH Cockayne syndrome B (ortholog); megacolon (ortholog); schizophrenia (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: leucine-rich repeat-containing protein 18
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: ChlSab1.1 - Green Monkey 1.1 Assembly
Position:
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1942,861,868 - 42,887,733 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl942,861,657 - 42,889,270 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660482,629,901 - 2,649,307 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Molecular Function

References
Additional References at PubMed
PMID:22301074  


Genomics

Comparative Map Data
LRRC18
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1942,861,868 - 42,887,733 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl942,861,657 - 42,889,270 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660482,629,901 - 2,649,307 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
LRRC18
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381048,909,480 - 48,939,840 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1048,909,480 - 48,939,840 (-)EnsemblGRCh38hg38GRCh38
GRCh371050,117,525 - 50,147,885 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361049,787,534 - 49,792,286 (-)NCBINCBI36Build 36hg18NCBI36
Build 341049,787,536 - 49,792,288NCBI
Celera1043,703,127 - 43,707,879 (-)NCBICelera
Cytogenetic Map10q11.23NCBI
HuRef1044,382,681 - 44,387,433 (-)NCBIHuRef
CHM1_11050,399,155 - 50,403,907 (-)NCBICHM1_1
T2T-CHM13v2.01049,758,686 - 49,789,019 (-)NCBIT2T-CHM13v2.0
Lrrc18
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391432,713,339 - 32,737,257 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1432,713,339 - 32,737,248 (+)EnsemblGRCm39 Ensembl
GRCm381432,991,382 - 33,015,300 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1432,991,382 - 33,015,291 (+)EnsemblGRCm38mm10GRCm38
MGSCv371433,804,568 - 33,828,478 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361431,820,492 - 31,844,384 (+)NCBIMGSCv36mm8
Celera1429,251,093 - 29,275,024 (+)NCBICelera
Cytogenetic Map14BNCBI
cM Map1419.61NCBI
Lrrc18
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8168,259,083 - 8,283,722 (+)NCBIGRCr8
mRatBN7.2168,253,524 - 8,277,141 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl168,254,352 - 8,277,437 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx168,273,142 - 8,291,825 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0169,418,043 - 9,436,726 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0168,266,491 - 8,284,806 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0169,234,341 - 9,258,849 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl169,235,888 - 9,258,538 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01611,196,474 - 11,218,933 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4168,529,683 - 8,554,281 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1168,529,680 - 8,554,277 (+)NCBI
Celera166,928,507 - 6,951,792 (-)NCBICelera
Cytogenetic Map16p16NCBI
Lrrc18
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555561,213,517 - 1,237,275 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555561,213,871 - 1,237,281 (+)NCBIChiLan1.0ChiLan1.0
LRRC18
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2861,174,202 - 61,205,658 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11061,179,521 - 61,210,977 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01045,309,911 - 45,331,912 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
LRRC18
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.128822,579 - 856,329 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl28830,105 - 834,201 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha281,051,350 - 1,084,412 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.028998,365 - 1,031,443 (-)NCBIROS_Cfam_1.0
UMICH_Zoey_3.128808,202 - 830,558 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.028840,839 - 873,922 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.028963,920 - 996,994 (-)NCBIUU_Cfam_GSD_1.0
Lrrc18
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440721380,100,224 - 80,128,753 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049367281,326,723 - 1,327,490 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049367281,306,756 - 1,327,490 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LRRC18
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1489,571,919 - 89,577,303 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11489,571,911 - 89,589,479 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21497,366,156 - 97,387,555 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Lrrc18
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624928980,389 - 1,004,137 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624928980,324 - 1,004,150 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

endocrine system hemolymphoid system nervous system
High
Medium
Low 17 20 37
Below cutoff 19 23

Sequence


Reference Sequences
RefSeq Acc Id: ENSCSAT00000008465   ⟹   ENSCSAP00000006611
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1 Ensembl942,861,657 - 42,889,270 (+)Ensembl
RefSeq Acc Id: XM_038008913   ⟹   XP_037864841
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_0236660482,629,901 - 2,649,307 (+)NCBI
Protein Sequences
Protein RefSeqs XP_037864841 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCSAP00000006611.1
Reference Protein Sequences
RefSeq Acc Id: ENSCSAP00000006611   ⟸   ENSCSAT00000008465
RefSeq Acc Id: XP_037864841   ⟸   XM_038008913
- UniProtKB: A0A0D9RDC2 (UniProtKB/TrEMBL)


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCSAG00000010377 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCSAT00000008465.1 UniProtKB/TrEMBL
Gene3D-CATH 3.80.10.10 UniProtKB/TrEMBL
InterPro Leu-rich_rpt UniProtKB/TrEMBL
  Leu-rich_rpt_typical-subtyp UniProtKB/TrEMBL
  LRR_dom_sf UniProtKB/TrEMBL
KEGG Report csab:103215838 UniProtKB/TrEMBL
NCBI Gene LRRC18 ENTREZGENE
PANTHER NON-SPECIFIC SERINE/THREONINE PROTEIN KINASE-RELATED UniProtKB/TrEMBL
  PTHR48051 UniProtKB/TrEMBL
Pfam LRR_8 UniProtKB/TrEMBL
PROSITE LRR UniProtKB/TrEMBL
SMART LRR_TYP UniProtKB/TrEMBL
Superfamily-SCOP L domain-like UniProtKB/TrEMBL
UniProt A0A0D9RDC2 ENTREZGENE, UniProtKB/TrEMBL