Efnb2 (ephrin B2) - Rat Genome Database

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Gene: Efnb2 (ephrin B2) Mus musculus
Analyze
Symbol: Efnb2
Name: ephrin B2
RGD ID: 1319868
MGI Page MGI
Description: Enables signaling receptor binding activity. Involved in several processes, including adherens junction organization; positive regulation of cardiac muscle cell differentiation; and regulation of postsynaptic neurotransmitter receptor internalization. Acts upstream of or within several processes, including negative regulation of keratinocyte proliferation; positive regulation of aorta morphogenesis; and vasculature development. Located in plasma membrane. Is active in Schaffer collateral - CA1 synapse; glutamatergic synapse; and postsynaptic density membrane. Is expressed in several structures, including alimentary system; brain; cardiovascular system; sensory organ; and urinary system. Human ortholog(s) of this gene implicated in colon carcinoma; colorectal carcinoma; and esophagus squamous cell carcinoma. Orthologous to human EFNB2 (ephrin B2).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: ELF-; ELF-2; Ep; EPH-related receptor tyrosine kinase ligand 5; ephrin-B2; Epl; Epl5; Eplg5; HTK ligand; Htk-; Htk-L; Ler; LERK; LERK-5; Lerk5; NLER; NLERK-1
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3988,667,235 - 8,711,242 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl88,667,434 - 8,711,242 (-)EnsemblGRCm39 Ensembl
GRCm3888,617,235 - 8,661,242 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl88,617,434 - 8,661,242 (-)EnsemblGRCm38mm10GRCm38
MGSCv3788,617,439 - 8,660,773 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3688,617,406 - 8,660,745 (-)NCBIMGSCv36mm8
Celera88,790,063 - 8,833,410 (-)NCBICelera
Cytogenetic Map8A1.1NCBI
cM Map83.42NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
1,2-dimethylhydrazine  (EXP)
17beta-estradiol  (ISO)
17beta-estradiol 3-benzoate  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-methylcholine  (ISO)
4,4'-diaminodiphenylmethane  (EXP)
4,4'-sulfonyldiphenol  (EXP)
4-hydroxyphenyl retinamide  (EXP)
5-aza-2'-deoxycytidine  (EXP)
5-fluorouracil  (ISO)
7,12-dimethyltetraphene  (EXP)
acrylamide  (ISO)
actinomycin D  (ISO)
afimoxifene  (ISO)
all-trans-retinoic acid  (ISO)
amphetamine  (ISO)
aristolochic acid A  (ISO)
Aroclor 1254  (ISO)
arsane  (EXP)
arsenic atom  (EXP)
arsenite(3-)  (EXP)
atrazine  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (ISO)
Benzo[k]fluoranthene  (EXP)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP)
butanal  (ISO)
cadmium atom  (EXP)
cadmium dichloride  (EXP,ISO)
calcitriol  (ISO)
carbon nanotube  (EXP)
celastrol  (ISO)
chlordecone  (EXP)
chloropicrin  (ISO)
chlorpyrifos  (ISO)
choline  (EXP)
chromium(6+)  (EXP)
cisplatin  (ISO)
cocaine  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
coumestrol  (ISO)
dibenz[a,h]anthracene  (EXP)
dorsomorphin  (ISO)
Enterolactone  (ISO)
entinostat  (ISO)
flutamide  (ISO)
folic acid  (EXP)
formaldehyde  (ISO)
furan  (ISO)
gedunin  (ISO)
genistein  (ISO)
gentamycin  (ISO)
hydrogen peroxide  (ISO)
isobutanol  (ISO)
L-methionine  (EXP)
Licochalcone B  (ISO)
lithocholic acid  (ISO)
menadione  (EXP)
methylisothiazolinone  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
N-acetyl-L-cysteine  (ISO)
nitrofen  (ISO)
ozone  (EXP)
paracetamol  (ISO)
pentanal  (ISO)
phenobarbital  (EXP)
pirinixic acid  (EXP)
potassium chromate  (ISO)
progesterone  (ISO)
propanal  (ISO)
quercetin  (ISO)
resveratrol  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
streptozocin  (EXP)
sulforaphane  (ISO)
sunitinib  (ISO)
testosterone  (ISO)
testosterone enanthate  (ISO)
tetrachloromethane  (EXP)
thioacetamide  (ISO)
trichostatin A  (ISO)
trimellitic anhydride  (EXP)
triptonide  (EXP)
tris(2-butoxyethyl) phosphate  (ISO)
troglitazone  (EXP)
tunicamycin  (EXP,ISO)
urethane  (ISO)
valproic acid  (ISO)
vinclozolin  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal afferent lymphatic vessel morphology  (IAGP)
abnormal angiogenesis  (IAGP)
abnormal anogenital distance  (IAGP)
abnormal anterior cardinal vein morphology  (IAGP)
abnormal anterior commissure pars posterior morphology  (IAGP)
abnormal axon guidance  (IAGP)
abnormal axon morphology  (IAGP)
abnormal blood vessel morphology  (IAGP)
abnormal bone marrow cell morphology/development  (IAGP)
abnormal cardinal vein morphology  (IAGP)
abnormal cardiovascular development  (IAGP)
abnormal common crus morphology  (IAGP)
abnormal coronal suture morphology  (IAGP)
abnormal cranial neural crest cell migration  (IAGP)
abnormal developmental vascular remodeling  (IAGP)
abnormal dorsal-ventral polarity of the somites  (IAGP)
abnormal endocardium morphology  (IAGP)
abnormal endolymph physiology  (IAGP)
abnormal frontal bone morphology  (IAGP)
abnormal heart looping  (IAGP)
abnormal heart morphology  (IAGP)
abnormal heart valve morphology  (IAGP)
abnormal heart ventricle morphology  (IAGP)
abnormal intersomitic vessel morphology  (IAGP)
abnormal long-term depression  (IAGP)
abnormal lymph circulation  (IAGP)
abnormal lymphatic vessel morphology  (IAGP)
abnormal myocardium layer morphology  (IAGP)
abnormal neural crest cell migration  (IAGP)
abnormal penis morphology  (IAGP)
abnormal rostral-caudal patterning of the somites  (IAGP)
abnormal second pharyngeal arch morphology  (IAGP)
abnormal semicircular canal morphology  (IAGP)
abnormal septation of the cloaca  (IAGP)
abnormal skin physiology  (IAGP)
abnormal somite development  (IAGP)
abnormal T cell differentiation  (IAGP)
abnormal T-helper 1 cell differentiation  (IAGP)
abnormal T-helper 17 cell differentiation  (IAGP)
abnormal tracheal cartilage morphology  (IAGP)
abnormal trunk neural crest cell migration  (IAGP)
abnormal urethra morphology  (IAGP)
abnormal vascular development  (IAGP)
abnormal vestibular endolymph ionic homeostasis  (IAGP)
abnormal vestibular endolymph physiology  (IAGP)
abnormal vitelline vascular remodeling  (IAGP)
abnormal vitelline vasculature morphology  (IAGP)
absent myocardial trabeculae  (IAGP)
absent pharyngeal arch arteries  (IAGP)
absent second pharyngeal arch  (IAGP)
anal atresia  (IAGP)
aortic valve hyperplasia  (IAGP)
chylothorax  (IAGP)
circling  (IAGP)
cleft palate  (IAGP)
decreased CD4-positive, alpha-beta T cell number  (IAGP)
decreased CD8-positive, alpha-beta T cell number  (IAGP)
decreased cranial neural crest cell number  (IAGP)
decreased DN4 thymocyte number  (IAGP)
decreased double-positive T cell number  (IAGP)
decreased embryo size  (IAGP)
decreased endolymph production  (IAGP)
decreased posterior semicircular canal size  (IAGP)
decreased spleen weight  (IAGP)
decreased superior semicircular canal size  (IAGP)
decreased T cell number  (IAGP)
decreased thymus weight  (IAGP)
dilated endolymphatic duct  (IAGP)
dilated endolymphatic sac  (IAGP)
distended pericardium  (IAGP)
embryonic growth arrest  (IAGP)
embryonic growth retardation  (IAGP)
embryonic lethality between implantation and placentation, incomplete penetrance  (IAGP)
embryonic lethality during organogenesis, complete penetrance  (IAGP)
embryonic lethality, complete penetrance  (IAGP)
enlarged aortic valve  (IAGP)
enlarged heart  (IAGP)
enlarged pericardium  (IAGP)
enlarged pulmonary valve  (IAGP)
failure of eyelid fusion  (IAGP)
flaky skin  (IAGP)
head bobbing  (IAGP)
hyperkeratosis  (IAGP)
hypospadia  (IAGP)
increased cranial neural crest cell apoptosis  (IAGP)
increased DN3 thymocyte number  (IAGP)
increased double-negative T cell number  (IAGP)
increased length of allograft survival  (IAGP)
increased susceptibility to Riboviria infection  (IAGP)
increased thymocyte apoptosis  (IAGP)
male infertility  (IAGP)
neonatal lethality, complete penetrance  (IAGP)
no abnormal phenotype detected  (IAGP)
persistent cloaca  (IAGP)
postnatal growth retardation  (IAGP)
postnatal lethality, complete penetrance  (IAGP)
premature death  (IAGP)
pulmonary valve hyperplasia  (IAGP)
reduced long-term potentiation  (IAGP)
retarded hair growth  (IAGP)
small endolymphatic duct  (IAGP)
small first pharyngeal arch  (IAGP)
small hair follicles  (IAGP)
small pharyngeal arch  (IAGP)
small salivary gland  (IAGP)
small second pharyngeal arch  (IAGP)
small spleen  (IAGP)
small thymus  (IAGP)
small trigeminal ganglion  (IAGP)
splayed clitoris  (IAGP)
spleen hypoplasia  (IAGP)
thick aortic valve  (IAGP)
thick epidermis  (IAGP)
thick mitral valve cusps  (IAGP)
thick pulmonary valve  (IAGP)
thin hypodermis  (IAGP)
thymus hypoplasia  (IAGP)
tracheoesophageal fistula  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. DNA damage-induced ephrin-B2 reverse signaling promotes chemoresistance and drives EMT in colorectal carcinoma harboring mutant p53. Alam SK, etal., Cell Death Differ. 2016 Apr;23(4):707-22. doi: 10.1038/cdd.2015.133. Epub 2015 Oct 23.
2. Ephrin-B2 and EphB2 regulation of astrocyte-meningeal fibroblast interactions in response to spinal cord lesions in adult rats. Bundesen LQ, etal., J Neurosci. 2003 Aug 27;23(21):7789-800.
3. Expression profile of EFNB1, EFNB2, two ligands of EPHB2 in human gastric cancer. Kataoka H, etal., J Cancer Res Clin Oncol. 2002 Jul;128(7):343-8. doi: 10.1007/s00432-002-0355-0. Epub 2002 Jun 26.
4. Increased EphB2 expression predicts cholangiocarcinoma metastasis. Khansaard W, etal., Tumour Biol. 2014 Oct;35(10):10031-41. doi: 10.1007/s13277-014-2295-0. Epub 2014 Jul 11.
5. Effects of overexpression of ephrin-B2 on tumour growth in human colorectal cancer. Liu W, etal., Br J Cancer. 2004 Apr 19;90(8):1620-6. doi: 10.1038/sj.bjc.6601723.
6. MGDs mouse GO annotations MGD data from the GO Consortium
7. MGD IEA MGD IEA
8. Expression levels of EPHB4, EFNB2 and caspase-8 are associated with clinicopathological features and progression of esophageal squamous cell cancer. Ni Q, etal., Oncol Lett. 2020 Jan;19(1):917-929. doi: 10.3892/ol.2019.11160. Epub 2019 Nov 28.
9. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
10. Mouse MP Annotation Import Pipeline RGD automated import pipeline
11. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
12. BIBF1120 (Vargatef) Inhibits Preretinal Neovascularization and Enhances Normal Vascularization in a Model of Vasoproliferative Retinopathy. Rivera JC, etal., Invest Ophthalmol Vis Sci. 2015 Dec;56(13):7897-907. doi: 10.1167/iovs.15-17146.
13. Downregulation of the endothelial genes Notch1 and ephrinB2 in patients with nodular regenerative hyperplasia. Rothweiler S, etal., Liver Int. 2014 Apr;34(4):594-603. doi: 10.1111/liv.12261. Epub 2013 Jul 21.
14. Ephrin-B2 reverse signaling regulates progression and lymph node metastasis of oral squamous cell carcinoma. Sasabe E, etal., PLoS One. 2017 Nov 30;12(11):e0188965. doi: 10.1371/journal.pone.0188965. eCollection 2017.
15. Arterialization and anomalous vein wall remodeling in varicose veins is associated with upregulated FoxC2-Dll4 pathway. Surendran S, etal., Lab Invest. 2016 Apr;96(4):399-408. doi: 10.1038/labinvest.2015.167. Epub 2016 Jan 25.
16. Expression and prognostic significance of EFNB2 and EphB4 genes in patients with oesophageal squamous cell carcinoma. Tachibana M, etal., Dig Liver Dis. 2007 Aug;39(8):725-32. doi: 10.1016/j.dld.2007.05.013. Epub 2007 Jul 3.
17. Arteriovenous malformations in mice lacking activin receptor-like kinase-1. Urness LD, etal., Nat Genet 2000 Nov;26(3):328-31.
18. Homeodomain factor Nkx2-3 controls regional expression of leukocyte homing coreceptor MAdCAM-1 in specialized endothelial cells of the viscera. Wang CC, etal., Dev Biol 2000 Aug 15;224(2):152-67.
19. EphB2 knockdown decreases the formation of astroglial-fibrotic scars to promote nerve regeneration after spinal cord injury in rats. Wu J, etal., CNS Neurosci Ther. 2021 Jun;27(6):714-724. doi: 10.1111/cns.13641. Epub 2021 Apr 1.
20. EphrinB2/ephB2-mediated myenteric synaptic plasticity: mechanisms underlying the persistent muscle hypercontractility and pain in postinfectious IBS. Zhang L, etal., FASEB J. 2019 Dec;33(12):13644-13659. doi: 10.1096/fj.201901192R. Epub 2019 Oct 25.
21. [The expressions of EphrinB2 and VEGF in nasopharyngeal carcinoma and their clinical significance]. Zhang R, etal., Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2013 Feb;27(4):178-80.
Additional References at PubMed
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PMID:33039109   PMID:33253166   PMID:33454003   PMID:33789115   PMID:33830085   PMID:33907211   PMID:33934370   PMID:34157123   PMID:34281570   PMID:34321999   PMID:34403370   PMID:35288551  
PMID:35294885   PMID:35297995   PMID:35462405   PMID:35649376   PMID:35725568   PMID:36028553   PMID:36029930   PMID:36046192   PMID:36082581   PMID:36376513   PMID:36577057   PMID:36737666  
PMID:37149633   PMID:37212547   PMID:37317851   PMID:37324380   PMID:37551686   PMID:38187761   PMID:38224498   PMID:38231476   PMID:38280850   PMID:38345319   PMID:38374152  


Genomics

Comparative Map Data
Efnb2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3988,667,235 - 8,711,242 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl88,667,434 - 8,711,242 (-)EnsemblGRCm39 Ensembl
GRCm3888,617,235 - 8,661,242 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl88,617,434 - 8,661,242 (-)EnsemblGRCm38mm10GRCm38
MGSCv3788,617,439 - 8,660,773 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3688,617,406 - 8,660,745 (-)NCBIMGSCv36mm8
Celera88,790,063 - 8,833,410 (-)NCBICelera
Cytogenetic Map8A1.1NCBI
cM Map83.42NCBI
EFNB2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3813106,489,745 - 106,535,662 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl13106,489,745 - 106,535,662 (-)EnsemblGRCh38hg38GRCh38
GRCh3713107,142,093 - 107,188,010 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3613105,940,094 - 105,985,338 (-)NCBINCBI36Build 36hg18NCBI36
Build 3413105,940,097 - 105,985,338NCBI
Celera1387,986,327 - 88,031,570 (-)NCBICelera
Cytogenetic Map13q33.3NCBI
HuRef1387,733,581 - 87,778,804 (-)NCBIHuRef
CHM1_113107,110,751 - 107,156,066 (-)NCBICHM1_1
T2T-CHM13v2.013105,710,156 - 105,756,072 (-)NCBIT2T-CHM13v2.0
Efnb2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81687,485,215 - 87,529,224 (+)NCBIGRCr8
mRatBN7.21680,783,389 - 80,827,420 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1680,783,417 - 80,824,391 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1686,062,447 - 86,103,384 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01689,515,058 - 89,556,010 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01684,759,477 - 84,800,448 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01686,631,151 - 86,672,050 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1686,631,064 - 86,675,049 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01686,044,304 - 86,085,652 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41686,187,639 - 86,228,023 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11686,173,265 - 86,214,062 (+)NCBI
Celera1678,561,525 - 78,602,409 (+)NCBICelera
Cytogenetic Map16q12.5NCBI
Efnb2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554045,000,906 - 5,030,126 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554045,000,906 - 5,030,068 (+)NCBIChiLan1.0ChiLan1.0
EFNB2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v214107,986,859 - 108,032,680 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan113106,667,225 - 106,713,015 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01387,629,831 - 87,675,652 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.113106,770,296 - 106,815,542 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl13106,770,296 - 106,815,548 (-)Ensemblpanpan1.1panPan2
EFNB2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12255,567,992 - 55,609,210 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2255,566,039 - 55,609,443 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2255,325,721 - 55,366,922 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02256,079,969 - 56,121,281 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2256,078,458 - 56,121,514 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12255,672,831 - 55,714,054 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02255,659,581 - 55,700,849 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02255,698,309 - 55,739,598 (-)NCBIUU_Cfam_GSD_1.0
Efnb2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404945190,770,785 - 190,813,404 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364725,138,745 - 5,181,668 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364725,138,751 - 5,181,630 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
EFNB2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1174,186,640 - 74,233,354 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11174,188,337 - 74,232,768 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21181,565,082 - 81,609,512 (-)NCBISscrofa10.2Sscrofa10.2susScr3
EFNB2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1384,904,421 - 84,949,292 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl384,904,435 - 84,949,465 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604641,467,321 - 41,512,883 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Efnb2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247935,089,639 - 5,130,503 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247935,089,675 - 5,130,022 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Efnb2
1420 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1248
Count of miRNA genes:665
Interacting mature miRNAs:810
Transcripts:ENSMUST00000001319, ENSMUST00000152698
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
13432571Scvg1_msubcutaneous vessel growth QTL 1 (mouse)8124751082Mouse
11533914Mts5_mmammary tumor susceptibility 5 (mouse)8130447432Mouse
4140978Nilac5_mnicotine induced locomotor activity 5 (mouse)Not determined8131773288Mouse
27226756Femd2_mfemur midshaft diameter 2, 5 week (mouse)8495000035067154Mouse
1357525Pnhdlc3_mplasma non-HDL cholesterol 3 (mouse)Not determined8721249923753815Mouse
1301532Scc8_mcolon tumor susceptibility 8 (mouse)Not determined8721249935110107Mouse
1300906Ap8q_malcohol preference 8 QTL (mouse)Not determined8798418941984342Mouse
10412209Cypr7_mcytokine production 7 (mouse)Not determined8810320142103372Mouse
1301929Eae24_msusceptibility to experimental allergic encephalomyelitis 24 (mouse)Not determined8810320142103372Mouse
1301128Sluc20_msusceptibility to lung cancer 20 (mouse)Not determined8810320142103372Mouse

Markers in Region
Efnb2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm3888,619,362 - 8,620,091UniSTSGRCm38
MGSCv3788,619,362 - 8,620,091UniSTSGRCm37
Celera88,791,986 - 8,792,715UniSTS
Cytogenetic Map8A1.1UniSTS
cM Map82.0UniSTS
L38847  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm3888,619,636 - 8,619,794UniSTSGRCm38
MGSCv3788,619,636 - 8,619,794UniSTSGRCm37
Celera88,792,260 - 8,792,418UniSTS
Cytogenetic Map8A1.1UniSTS
Whitehead_YAC8 UniSTS
Efnb2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map8A1.1UniSTS
Efnb2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map8A1.1UniSTS
Efnb2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map8A1.1UniSTS
Efnb2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm3888,619,276 - 8,619,502UniSTSGRCm38
MGSCv3788,619,276 - 8,619,502UniSTSGRCm37
Celera88,791,900 - 8,792,126UniSTS
Cytogenetic Map8A1.1UniSTS
cM Map82.0UniSTS


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001368299 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_010111 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011242036 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC138368 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC161867 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK132512 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK132845 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK134108 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK137006 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK141300 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK142203 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK142283 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK143059 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC057009 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466566 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CT010381 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  L38847 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U16819 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U30244 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSMUST00000001319   ⟹   ENSMUSP00000001319
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl88,667,434 - 8,711,242 (-)Ensembl
GRCm38.p6 Ensembl88,617,434 - 8,661,242 (-)Ensembl
RefSeq Acc Id: ENSMUST00000152698   ⟹   ENSMUSP00000116027
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl88,670,597 - 8,689,363 (-)Ensembl
GRCm38.p6 Ensembl88,620,597 - 8,639,363 (-)Ensembl
RefSeq Acc Id: ENSMUST00000209169
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl88,708,422 - 8,711,239 (-)Ensembl
GRCm38.p6 Ensembl88,658,422 - 8,661,239 (-)Ensembl
RefSeq Acc Id: NM_001368299   ⟹   NP_001355228
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3988,667,434 - 8,711,242 (-)NCBI
GRCm3888,617,434 - 8,661,242 (-)NCBI
Sequence:
RefSeq Acc Id: NM_010111   ⟹   NP_034241
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3988,667,434 - 8,711,242 (-)NCBI
GRCm3888,617,434 - 8,661,242 (-)NCBI
MGSCv3788,617,439 - 8,660,773 (-)RGD
Celera88,790,063 - 8,833,410 (-)RGD
cM Map8 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_011242036   ⟹   XP_011240338
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3988,667,235 - 8,697,015 (-)NCBI
GRCm3888,617,235 - 8,647,015 (-)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_034241   ⟸   NM_010111
- Peptide Label: isoform 1 precursor
- UniProtKB: P52800 (UniProtKB/Swiss-Prot),   Q4FJM3 (UniProtKB/TrEMBL),   Q3V1E0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_011240338   ⟸   XM_011242036
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: NP_001355228   ⟸   NM_001368299
- Peptide Label: isoform 2
RefSeq Acc Id: ENSMUSP00000001319   ⟸   ENSMUST00000001319
RefSeq Acc Id: ENSMUSP00000116027   ⟸   ENSMUST00000152698
Protein Domains
Ephrin RBD

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P52800-F1-model_v2 AlphaFold P52800 1-336 view protein structure

Promoters
RGD ID:6848282
Promoter ID:MM_ACW:46752
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Brain,   Lung
Transcripts:EFNB2.DSEP07-UNSPLICED
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv3688,620,581 - 8,621,081 (-)MPROMDB
RGD ID:6843063
Promoter ID:MM_KWN:53575
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   MEF_B4
Transcripts:ENSMUST00000098947,   OTTMUST00000052622
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv3688,660,936 - 8,661,436 (-)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:105097 AgrOrtholog
Ensembl Genes ENSMUSG00000001300 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000001319 ENTREZGENE
  ENSMUST00000001319.15 UniProtKB/Swiss-Prot
  ENSMUST00000152698.2 UniProtKB/TrEMBL
Gene3D-CATH 2.60.40.420 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Cupredoxin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ephrin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ephrin-B_Ecto UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ephrin_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ephrin_RBD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:13642 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:105097 ENTREZGENE
NCBI Gene 13642 ENTREZGENE
PANTHER EPHRIN-B2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR11304 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Ephrin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB EFNB2 RGD
PhenoGen Efnb2 PhenoGen
PRINTS EPHRIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE EPHRIN_RBD_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EPHRIN_RBD_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF49503 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt EFNB2_MOUSE UniProtKB/Swiss-Prot
  F6RSU6_MOUSE UniProtKB/TrEMBL
  P52800 ENTREZGENE
  Q3V1E0 ENTREZGENE, UniProtKB/TrEMBL
  Q4FJM3 ENTREZGENE, UniProtKB/TrEMBL