Insm2 (insulinoma-associated 2) - Rat Genome Database

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Gene: Insm2 (insulinoma-associated 2) Mus musculus
Analyze
Symbol: Insm2
Name: insulinoma-associated 2
RGD ID: 1315854
MGI Page MGI
Description: Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and transcription corepressor activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II; neuron differentiation; and regulation of cell cycle process. Predicted to act upstream of or within negative regulation of DNA-templated transcription. Predicted to be located in cytoplasm. Predicted to be part of transcription repressor complex. Predicted to be active in nucleus. Is expressed in several structures, including adrenal gland; central nervous system; eye; genitourinary system; and pancreas. Orthologous to human INSM2 (INSM transcriptional repressor 2).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: insulinoma-associated protein 2; methylated in liver tumor 1; mlt 1; Mlt1
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391255,646,212 - 55,648,818 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1255,646,212 - 55,648,871 (+)EnsemblGRCm39 Ensembl
GRCm381255,598,917 - 55,602,018 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1255,599,427 - 55,602,086 (+)EnsemblGRCm38mm10GRCm38
MGSCv371256,699,904 - 56,703,005 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361256,517,603 - 56,519,084 (+)NCBIMGSCv36mm8
Celera1256,748,546 - 56,751,647 (+)NCBICelera
Cytogenetic Map12C1NCBI
cM Map1224.05NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. MGDs mouse GO annotations MGD data from the GO Consortium
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:11221845   PMID:12466851   PMID:15618518   PMID:16602821   PMID:20059953   PMID:21267068   PMID:21343251   PMID:21873635   PMID:22785238   PMID:29445148   PMID:30305733   PMID:30359270  
PMID:34170322   PMID:35786158  


Genomics

Comparative Map Data
Insm2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391255,646,212 - 55,648,818 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1255,646,212 - 55,648,871 (+)EnsemblGRCm39 Ensembl
GRCm381255,598,917 - 55,602,018 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1255,599,427 - 55,602,086 (+)EnsemblGRCm38mm10GRCm38
MGSCv371256,699,904 - 56,703,005 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361256,517,603 - 56,519,084 (+)NCBIMGSCv36mm8
Celera1256,748,546 - 56,751,647 (+)NCBICelera
Cytogenetic Map12C1NCBI
cM Map1224.05NCBI
INSM2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381435,534,164 - 35,537,054 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1435,534,164 - 35,537,054 (+)EnsemblGRCh38hg38GRCh38
GRCh371436,003,370 - 36,006,260 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361435,072,999 - 35,076,011 (+)NCBINCBI36Build 36hg18NCBI36
Build 341435,072,998 - 35,076,011NCBI
Celera1415,867,108 - 15,870,120 (+)NCBICelera
Cytogenetic Map14q13.2NCBI
HuRef1416,117,138 - 16,120,150 (+)NCBIHuRef
CHM1_11436,002,929 - 36,005,941 (+)NCBICHM1_1
T2T-CHM13v2.01429,721,890 - 29,724,780 (+)NCBIT2T-CHM13v2.0
Insm2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8678,708,983 - 78,711,575 (+)NCBIGRCr8
mRatBN7.2672,973,861 - 72,976,453 (+)NCBImRatBN7.2mRatBN7.2
UTH_Rnor_SHR_Utx673,395,488 - 73,398,078 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0673,701,858 - 73,704,448 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0673,129,368 - 73,131,958 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0676,380,681 - 76,386,240 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl676,383,446 - 76,384,933 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0685,914,501 - 85,919,811 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4675,846,090 - 75,847,587 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1675,849,225 - 75,850,715 (+)NCBI
Celera671,812,955 - 71,818,504 (+)NCBICelera
Cytogenetic Map6q23NCBI
Insm2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540925,584,904 - 25,585,998 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495540925,584,543 - 25,586,025 (-)NCBIChiLan1.0ChiLan1.0
INSM2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21536,848,522 - 36,851,469 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11436,065,025 - 36,067,972 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01416,287,866 - 16,290,884 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11434,468,831 - 34,470,476 (+)NCBIpanpan1.1PanPan1.1panPan2
INSM2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1814,217,694 - 14,220,661 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl814,217,785 - 14,219,458 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha814,013,937 - 14,016,656 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0814,324,080 - 14,326,798 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl814,324,080 - 14,325,753 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1814,025,158 - 14,027,875 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0814,090,754 - 14,093,472 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0814,380,468 - 14,383,186 (+)NCBIUU_Cfam_GSD_1.0
Insm2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864046,139,681 - 46,142,555 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364949,645,673 - 9,647,361 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364949,645,568 - 9,648,449 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
INSM2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl764,374,823 - 64,376,495 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1764,372,361 - 64,378,366 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2769,282,117 - 69,285,979 (-)NCBISscrofa10.2Sscrofa10.2susScr3
INSM2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12412,340,659 - 12,343,663 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2412,340,864 - 12,342,570 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660531,305,073 - 1,308,143 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Insm2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248381,271,100 - 1,272,764 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248381,269,909 - 1,272,849 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Insm2
58 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:371
Count of miRNA genes:275
Interacting mature miRNAs:319
Transcripts:ENSMUST00000051857
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4142234Tmc1m3_mTmc1 modifier 3 (mouse)Not determined12541844077031203Mouse
27226753Femd7_mfemur midshaft diameter 7, 10 week (mouse)12955000084146774Mouse
13207568Tcq14_mtotal cholesterol QTL 14 (mouse)121166000197176774Mouse
1558978Cplaq10_mcircadian period of locomotor activity 10 (mouse)Not determined121534102679040364Mouse
1301574Lmblgq5_mlimb length QTL 5 (mouse)Not determined121759644780956883Mouse
1302172Skts5_mskin tumor susceptibility 5 (mouse)Not determined122214886656149016Mouse
1301989Hdlq18_mHDL QTL 18 (mouse)Not determined122916068563160884Mouse
1300636Gct2_mgranulosa cell tumorigenesis 2 (mouse)Not determined122916068563160884Mouse
4141843Moen3_mmodifier of engrailed QTL 3 (mouse)Not determined122980158463801733Mouse
14747008Mancz10_mmandible centroid size 10 (mouse)122986352263863522Mouse
10402492Dipa8_mdrug induced psychomotor activation 8 (mouse)Not determined123493387268934019Mouse
1300818Bbaa10_mB.burgdorferi-associated arthritis 10 (mouse)Not determined123509100465511019Mouse
4142002Tbqt3_mtibia bone quality traits 3 (mouse)Not determined1235285496109936243Mouse
1357479Splwt1_mspleen weight 1 (mouse)Not determined124169317590887526Mouse
1357757Lnopy2_mlens opacity 2 (mouse)Not determined125284662686846796Mouse
1357749Vtbt13_mvertebral trabecular bone trait 13 (mouse)Not determined125313200287132145Mouse
12904004Opfaq11_mopen field activity QTL 11 (mouse)125315562457276756Mouse
12832727Ahrq1_mairway hyperresponsiveness QTL 1 (mouse)125469591082665939Mouse
12903999Opfaq8_mopen field activity QTL 8 (mouse)125490765357870585Mouse

Markers in Region
BB392842  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381255,601,705 - 55,601,815UniSTSGRCm38
MGSCv371256,702,692 - 56,702,802UniSTSGRCm37
Celera1256,751,334 - 56,751,444UniSTS
Cytogenetic Map12C1UniSTS
Whitehead/MRC_RH12572.3UniSTS
UniSTS:487867  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381255,599,473 - 55,600,954UniSTSGRCm38
MGSCv371256,700,460 - 56,701,941UniSTSGRCm37
Celera1256,749,102 - 56,750,583UniSTS
Cytogenetic Map12C1UniSTS


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000051857   ⟹   ENSMUSP00000061046
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1255,646,212 - 55,648,871 (+)Ensembl
GRCm38.p6 Ensembl1255,599,427 - 55,602,086 (+)Ensembl
RefSeq Acc Id: NM_020287   ⟹   NP_064683
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391255,646,212 - 55,648,818 (+)NCBI
GRCm381255,598,917 - 55,602,018 (+)ENTREZGENE
MGSCv371256,699,904 - 56,703,005 (+)RGD
Celera1256,748,546 - 56,751,647 (+)RGD
cM Map12 ENTREZGENE
Sequence:
Protein Sequences
Protein RefSeqs NP_064683 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein BAA92776 (Get FASTA)   NCBI Sequence Viewer  
  EDL36724 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSMUSP00000061046
  ENSMUSP00000061046.4
GenBank Protein Q9JMC2 (Get FASTA)   NCBI Sequence Viewer  
Reference Protein Sequences
RefSeq Acc Id: NP_064683   ⟸   NM_020287
- UniProtKB: E9QNA9 (UniProtKB/Swiss-Prot),   Q9JMC2 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSMUSP00000061046   ⟸   ENSMUST00000051857

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9JMC2-F1-model_v2 AlphaFold Q9JMC2 1-493 view protein structure

Promoters
RGD ID:8678308
Promoter ID:EPDNEW_M17182
Type:single initiation site
Name:Insm2_1
Description:Mus musculus insulinoma-associated 2 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381255,599,427 - 55,599,487EPDNEW
RGD ID:6823075
Promoter ID:MM_KWN:11684
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour,   BoneMarrow_4Hour,   Brain,   Kidney,   Lung
Transcripts:NM_020287
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361256,701,161 - 56,701,712 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1930787 AgrOrtholog
Ensembl Genes ENSMUSG00000045440 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000051857 ENTREZGENE
  ENSMUST00000051857.5 UniProtKB/Swiss-Prot
Gene3D-CATH Classic Zinc Finger UniProtKB/Swiss-Prot
InterPro INSM1/2 UniProtKB/Swiss-Prot
  Znf_C2H2_sf UniProtKB/Swiss-Prot
  Znf_C2H2_type UniProtKB/Swiss-Prot
KEGG Report mmu:56856 UniProtKB/Swiss-Prot
MGD MGI:1930787 ENTREZGENE
NCBI Gene 56856 ENTREZGENE
PANTHER INSULINOMA-ASSOCIATED PROTEIN 2 UniProtKB/Swiss-Prot
  PTHR15065 UniProtKB/Swiss-Prot
Pfam zf-C2H2 UniProtKB/Swiss-Prot
PhenoGen Insm2 PhenoGen
PROSITE ZINC_FINGER_C2H2_1 UniProtKB/Swiss-Prot
  ZINC_FINGER_C2H2_2 UniProtKB/Swiss-Prot
SMART ZnF_C2H2 UniProtKB/Swiss-Prot
Superfamily-SCOP SSF57667 UniProtKB/Swiss-Prot
UniProt E9QNA9 ENTREZGENE
  INSM2_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary E9QNA9 UniProtKB/Swiss-Prot