Hepacam (hepatocyte cell adhesion molecule) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Gene: Hepacam (hepatocyte cell adhesion molecule) Mus musculus
Analyze
Symbol: Hepacam
Name: hepatocyte cell adhesion molecule
RGD ID: 1315637
MGI Page MGI
Description: Acts upstream of or within protein localization. Located in membrane. Is expressed in several structures, including alimentary system; heart; nervous system; sensory organ; and skeleton. Used to study megalencephalic leukoencephalopathy with subcortical cysts. Human ortholog(s) of this gene implicated in megalencephalic leukoencephalopathy with subcortical cysts 2A and megalencephalic leukoencephalopathy with subcortical cysts 2B. Orthologous to human HEPACAM (hepatic and glial cell adhesion molecule).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 2900042E01Rik; Gli; Glialcam; hepatic and glial cell adhesion molecule; Hepn1
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39937,278,652 - 37,297,868 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl937,278,647 - 37,297,871 (+)EnsemblGRCm39 Ensembl
GRCm38937,367,356 - 37,386,572 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl937,367,351 - 37,386,575 (+)EnsemblGRCm38mm10GRCm38
MGSCv37937,175,191 - 37,194,157 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36937,117,277 - 37,136,243 (+)NCBIMGSCv36mm8
Celera934,581,970 - 34,600,929 (+)NCBICelera
Cytogenetic Map9A4NCBI
cM Map920.76NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. MGDs mouse GO annotations MGD data from the GO Consortium
2. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
3. Mouse MP Annotation Import Pipeline RGD automated import pipeline
4. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:8889548   PMID:10349636   PMID:11042159   PMID:11076861   PMID:11125038   PMID:11217851   PMID:12466851   PMID:12477932   PMID:14681479   PMID:16141072   PMID:16141073   PMID:17953485  
PMID:18293412   PMID:21419380   PMID:21873635   PMID:24154525   PMID:24647135   PMID:24824219   PMID:25382142   PMID:27889896   PMID:28695146   PMID:29466841   PMID:32325033   PMID:33187987  
PMID:34100078   PMID:34171291   PMID:34321999   PMID:36808153   PMID:37620511  


Genomics

Comparative Map Data
Hepacam
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39937,278,652 - 37,297,868 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl937,278,647 - 37,297,871 (+)EnsemblGRCm39 Ensembl
GRCm38937,367,356 - 37,386,572 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl937,367,351 - 37,386,575 (+)EnsemblGRCm38mm10GRCm38
MGSCv37937,175,191 - 37,194,157 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36937,117,277 - 37,136,243 (+)NCBIMGSCv36mm8
Celera934,581,970 - 34,600,929 (+)NCBICelera
Cytogenetic Map9A4NCBI
cM Map920.76NCBI
HEPACAM
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3811124,919,205 - 124,936,047 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl11124,919,205 - 124,936,412 (-)EnsemblGRCh38hg38GRCh38
GRCh3711124,789,101 - 124,805,943 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3611124,294,355 - 124,311,518 (-)NCBINCBI36Build 36hg18NCBI36
Celera11121,949,291 - 121,966,450 (-)NCBICelera
Cytogenetic Map11q24.2NCBI
HuRef11120,731,416 - 120,748,491 (-)NCBIHuRef
CHM1_111124,675,257 - 124,692,409 (-)NCBICHM1_1
T2T-CHM13v2.011124,947,841 - 124,964,684 (-)NCBIT2T-CHM13v2.0
Hepacam
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8845,276,594 - 45,294,006 (+)NCBIGRCr8
mRatBN7.2837,087,864 - 37,106,759 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl837,087,857 - 37,105,920 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.0839,848,264 - 39,866,969 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl839,848,448 - 39,865,130 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0839,849,478 - 39,867,855 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4838,622,954 - 38,639,861 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1838,631,648 - 38,648,624 (+)NCBI
Celera837,346,023 - 37,363,913 (-)NCBICelera
Cytogenetic Map8q22NCBI
Hepacam
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541225,980,460 - 25,998,482 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495541225,981,235 - 25,998,296 (-)NCBIChiLan1.0ChiLan1.0
HEPACAM
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v29125,615,350 - 125,632,494 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan111126,720,241 - 126,737,381 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v011119,746,915 - 119,764,062 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.111123,662,852 - 123,678,421 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl11123,663,210 - 123,678,015 (-)Ensemblpanpan1.1panPan2
HEPACAM
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.159,520,998 - 9,535,019 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl59,521,740 - 9,534,958 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha59,566,458 - 9,580,496 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.059,460,731 - 9,474,776 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl59,461,523 - 9,474,749 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.159,533,390 - 9,547,430 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.059,503,845 - 9,517,897 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.059,540,543 - 9,554,588 (+)NCBIUU_Cfam_GSD_1.0
Hepacam
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947107,105,778 - 107,119,096 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049367431,352,686 - 1,366,787 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049367431,353,340 - 1,366,724 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
HEPACAM
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl952,115,504 - 52,131,522 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1952,115,494 - 52,131,801 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2957,632,582 - 57,647,218 (-)NCBISscrofa10.2Sscrofa10.2susScr3
HEPACAM
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11116,063,150 - 116,080,620 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1116,063,166 - 116,080,125 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604310,038,405 - 10,055,236 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Hepacam
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624927919,908 - 939,762 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624927922,272 - 939,429 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Hepacam
571 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:709
Count of miRNA genes:420
Interacting mature miRNAs:504
Transcripts:ENSMUST00000051839
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300849Sles4_msystemic lupus erythmatosus suppressor 4 (mouse)Not determined9910756237306370Mouse
13504833Bglu19_mblood glucose level 19 (mouse)9991076843910768Mouse
1300532Tbs2_mtuberculosis severity 2 (mouse)Not determined91236997046370114Mouse
10043917Obq37_mobesity QTL 37 (mouse)Not determined91339117547391175Mouse
1357637Si5lq2_mserum IGFBP-5 level QTL 2 (mouse)Not determined91541175149411890Mouse
4141591Cq4_mcholesterol QTL 4 (mouse)Not determined91541175149411890Mouse
1301421Lgth4_mbody length 4 (mouse)Not determined91541175149411890Mouse
4141447Cfmq2_mcystic fibrosis modifier QTL 2 (mouse)Not determined91541175149411890Mouse
12790993Adq1_maortic diameter QTL 1 (mouse)91574962749749627Mouse
11354951Pdcc3_mplasmacytoid dentritic cell compartment 3 (mouse)91574962749749627Mouse
12790997Adq2_maortic diameter QTL 2 (mouse)91574962749749627Mouse
12880415V125Dq7_mvitamin D active form serum level QTL 7 (mouse)91601129650011296Mouse
12880416V125Dq8_mvitamin D active form serum level QTL 8 (mouse)91601129650011296Mouse
13504834Hdlq109_mHDL QTL 109 (mouse)91670964150709641Mouse
1357465Vtbt6_mvertebral trabecular bone trait 6 (mouse)Not determined91697884050978943Mouse
1300643Pvcan2_mprotection against vaginal candidiasis 2 (mouse)Not determined91994340653943525Mouse
1301439Morph2_mmorphine antinociception 2 (mouse)Not determined92015336254153492Mouse
1301883Skull12_mskull morphology 12 (mouse)Not determined92030619754306370Mouse
1301045Sluc10_msusceptibility to lung cancer 10 (mouse)Not determined92030619754306370Mouse
10043950Pbft5_mpercent body fat 5 (mouse)Not determined92030619754306370Mouse
4142352Lmr17_mleishmaniasis resistance 17 (mouse)Not determined92030619754306370Mouse
12904939Edlmmq8_mextensor digitorum longus muscle mass QTL 8 (mouse)92085274054852740Mouse
13208563Bmiq8_mbody mass index QTL 8 (mouse)92491129668907282Mouse
11532712Sluc39d_msusceptibility to lung cancer 39d (mouse)92558748559587581Mouse
11532696Sluc39c_msusceptibility to lung cancer 39c (mouse)92558748559587581Mouse
11532694Sluc39a_msusceptibility to lung cancer 39a (mouse)92558748559587581Mouse
11532695Sluc39b_msusceptibility to lung cancer 39b (mouse)92558748559587581Mouse
10043987Stheal13_msoft tissue heal 13 (mouse)Not determined92679642160796552Mouse
1300932Hdlq17_mHDL QTL 17 (mouse)Not determined92679642160796552Mouse
10043867Mtbcq9_mmultiple trait body composition QTL 9 (mouse)Not determined92679642160796552Mouse
10043878Adip20_madiposity 20 (mouse)Not determined92725119461251323Mouse
1301000Obq5_mobesity QTL 5 (mouse)Not determined92850333341799326Mouse
10043847Hdlq89_mHDL QTL 89 (mouse)Not determined92929292963293072Mouse
1301782Chol11_mcholesterol 11 (mouse)Not determined92929292963293072Mouse
1301365Ap5q_malcohol preference 5 QTL (mouse)Not determined93005316464053277Mouse
1558949Igan3_mIgA nephropathy 3 (mouse)Not determined93041469440565914Mouse
1357746Vtbt7_mvertebral trabecular bone trait 7 (mouse)Not determined93073991564740021Mouse
4142455Elnv_mepilepsy naive (mouse)Not determined93127155837306370Mouse
1302180Actd4_mactivity-distance traveled 4 (mouse)Not determined93243456366434857Mouse
4141148Cq5_mcholesterol QTL 5 (mouse)Not determined93245242166452546Mouse
1301692Hts_mhypothermia sensitivity (mouse)Not determined93251117266511421Mouse
4141323Ptnu3_mproteinuria 3 (mouse)Not determined93288970266889836Mouse
1357709Si5lq3_mserum IGFBP-5 level QTL 3 (mouse)Not determined93311102567111140Mouse
1558872Ibdq1_minflammatory bowel disease QTL 1 (mouse)Not determined93397884073439255Mouse
1357682Phdlc1_mplasma HDL cholesterol 1 (mouse)Not determined93410461942764866Mouse
1300868Tlf_mT lymphocyte fraction (mouse)Not determined93483774837306370Mouse
1301252Etohc3_methanol consumption 3 (mouse)Not determined93503447869034599Mouse
1301972Cocrb8_mcocaine related behavior 8 (mouse)Not determined93503447869034599Mouse
1558968Tbdr1_mbody temperature response to dietary restriction, QTL 1 (mouse)Not determined93503447869034599Mouse
10045613Rapop7_mradiation-induced apoptosis 6 (mouse)Not determined93673624349420511Mouse
1301501Lmr2_mleishmaniasis resistance 2 (mouse)Not determined93694340650111140Mouse
1301007Pid2_mprion incubation determinant 2 (mouse)Not determined93715336244251323Mouse

Markers in Region
RH132243  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38937,384,798 - 37,384,987UniSTSGRCm38
MGSCv37937,192,383 - 37,192,572UniSTSGRCm37
Celera934,599,113 - 34,599,302UniSTS
Cytogenetic Map9A4UniSTS
Hepacam  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map9A4UniSTS
cM Map9 UniSTS


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000051839   ⟹   ENSMUSP00000054105
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl937,278,647 - 37,297,871 (+)Ensembl
GRCm38.p6 Ensembl937,367,351 - 37,386,575 (+)Ensembl
RefSeq Acc Id: ENSMUST00000215951   ⟹   ENSMUSP00000150856
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl937,278,932 - 37,296,027 (+)Ensembl
GRCm38.p6 Ensembl937,367,636 - 37,384,731 (+)Ensembl
RefSeq Acc Id: NM_175189   ⟹   NP_780398
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39937,278,902 - 37,297,868 (+)NCBI
GRCm38937,367,606 - 37,386,572 (+)ENTREZGENE
MGSCv37937,175,191 - 37,194,157 (+)RGD
Celera934,581,970 - 34,600,929 (+)RGD
cM Map9 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006510638   ⟹   XP_006510701
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39937,278,652 - 37,297,868 (+)NCBI
GRCm38937,367,356 - 37,386,572 (+)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_780398   ⟸   NM_175189
- Peptide Label: precursor
- UniProtKB: Q640R3 (UniProtKB/Swiss-Prot),   B2RSY3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006510701   ⟸   XM_006510638
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSMUSP00000054105   ⟸   ENSMUST00000051839
RefSeq Acc Id: ENSMUSP00000150856   ⟸   ENSMUST00000215951
Protein Domains
Ig-like   Ig-like C2-type   Ig-like V-type

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q640R3-F1-model_v2 AlphaFold Q640R3 1-418 view protein structure

Promoters
RGD ID:8669224
Promoter ID:EPDNEW_M12643
Type:initiation region
Name:Hepacam_1
Description:Mus musculus hepatocyte cell adhesion molecule , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38937,367,636 - 37,367,696EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1920177 AgrOrtholog
Ensembl Genes ENSMUSG00000046240 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000051839 ENTREZGENE
  ENSMUST00000051839.9 UniProtKB/Swiss-Prot
  ENSMUST00000215951.2 UniProtKB/TrEMBL
Gene3D-CATH 2.60.40.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Ig-like_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig-like_fold UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig_sub UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig_sub2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig_V-set UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:72927 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:1920177 ENTREZGENE
NCBI Gene 72927 ENTREZGENE
PANTHER HEPACAM FAMILY MEMBER 2-RELATED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IG-LIKE DOMAIN-CONTAINING PROTEIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Ig_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  V-set UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Hepacam PhenoGen
PROSITE IG_LIKE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART IGc2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SM00409 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF48726 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A1L1SUR4_MOUSE UniProtKB/TrEMBL
  B2RSY3 ENTREZGENE, UniProtKB/TrEMBL
  HECAM_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE