Adam21 (a disintegrin and metallopeptidase domain 21) - Rat Genome Database

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Gene: Adam21 (a disintegrin and metallopeptidase domain 21) Mus musculus
Analyze
Symbol: Adam21
Name: a disintegrin and metallopeptidase domain 21
RGD ID: 1314847
MGI Page MGI
Description: Predicted to enable metalloendopeptidase activity. Predicted to be involved in male gonad development and proteolysis. Located in axon and neuronal cell body. Is expressed in several structures, including alimentary system; brain; eye; genitourinary system; and liver and biliary system. Orthologous to human ADAM21 (ADAM metallopeptidase domain 21).
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: a disintegrin and metalloprotease domain (ADAM) 21; a disintegrin and metalloprotease domain 21; ADAM; ADAM 21; ADAM 31; Adam31; disintegrin and metalloproteinase domain-containing protein 21; disintegrin and metalloproteinase domain-containing protein 31
RGD Orthologs
Human
Rat
Bonobo
Dog
Pig
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391281,605,349 - 81,615,248 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1281,605,358 - 81,615,248 (-)EnsemblGRCm39 Ensembl
GRCm381281,558,575 - 81,568,474 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1281,558,584 - 81,568,474 (-)EnsemblGRCm38mm10GRCm38
MGSCv371282,659,571 - 82,669,461 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361282,477,432 - 82,487,322 (-)NCBIMGSCv36mm8
Celera1283,025,745 - 83,035,635 (-)NCBICelera
Cytogenetic Map12D1NCBI
cM Map1237.79NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. Functional annotation of a full-length mouse cDNA collection. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
2. MGDs mouse GO annotations MGD data from the GO Consortium
3. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
4. Mouse MP Annotation Import Pipeline RGD automated import pipeline
5. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
6. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:10349636   PMID:10830287   PMID:10842103   PMID:11042159   PMID:11076861   PMID:12477932   PMID:16052496   PMID:16141072   PMID:16141073   PMID:16208538   PMID:18366138   PMID:20117247  
PMID:21677750   PMID:21873635   PMID:34631320  


Genomics

Comparative Map Data
Adam21
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391281,605,349 - 81,615,248 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1281,605,358 - 81,615,248 (-)EnsemblGRCm39 Ensembl
GRCm381281,558,575 - 81,568,474 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1281,558,584 - 81,568,474 (-)EnsemblGRCm38mm10GRCm38
MGSCv371282,659,571 - 82,669,461 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361282,477,432 - 82,487,322 (-)NCBIMGSCv36mm8
Celera1283,025,745 - 83,035,635 (-)NCBICelera
Cytogenetic Map12D1NCBI
cM Map1237.79NCBI
ADAM21
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381470,452,174 - 70,459,905 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1470,417,107 - 70,460,427 (+)EnsemblGRCh38hg38GRCh38
GRCh371470,918,891 - 70,926,622 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361469,993,970 - 69,996,375 (+)NCBINCBI36Build 36hg18NCBI36
Build 341469,993,969 - 69,996,375NCBI
Celera1450,988,177 - 50,990,582 (+)NCBICelera
Cytogenetic Map14q24.2NCBI
HuRef1451,087,543 - 51,095,293 (+)NCBIHuRef
CHM1_11470,856,830 - 70,864,579 (+)NCBICHM1_1
T2T-CHM13v2.01464,658,196 - 64,665,929 (+)NCBIT2T-CHM13v2.0
Adam21
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81643,351,935 - 43,361,020 (+)NCBIGRCr8
mRatBN7.21636,625,324 - 36,627,657 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1636,618,860 - 36,628,008 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.01639,138,561 - 39,148,460 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01638,925,310 - 38,934,356 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera1634,773,480 - 34,783,278 (+)NCBICelera
Cytogenetic Map16p11NCBI
ADAM21
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21571,539,713 - 71,581,469 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11470,756,226 - 70,797,982 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01451,009,420 - 51,051,012 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11469,913,385 - 69,921,117 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1469,918,713 - 69,920,880 (+)Ensemblpanpan1.1panPan2
ADAM21
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1844,238,624 - 44,269,244 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl844,238,864 - 44,241,023 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha843,903,984 - 43,934,597 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0844,463,005 - 44,493,634 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl844,463,245 - 44,465,404 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1844,115,179 - 44,145,773 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0844,161,974 - 44,192,612 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0844,522,701 - 44,553,570 (-)NCBIUU_Cfam_GSD_1.0
LOC100515389
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1794,084,019 - 94,087,956 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.27100,372,847 - 100,392,821 (+)NCBISscrofa10.2Sscrofa10.2susScr3

Variants

.
Variants in Adam21
350 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:61
Count of miRNA genes:60
Interacting mature miRNAs:61
Transcripts:ENSMUST00000008582
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
27226753Femd7_mfemur midshaft diameter 7, 10 week (mouse)12955000084146774Mouse
13207568Tcq14_mtotal cholesterol QTL 14 (mouse)121166000197176774Mouse
4142002Tbqt3_mtibia bone quality traits 3 (mouse)Not determined1235285496109936243Mouse
1357479Splwt1_mspleen weight 1 (mouse)Not determined124169317590887526Mouse
1357757Lnopy2_mlens opacity 2 (mouse)Not determined125284662686846796Mouse
1357749Vtbt13_mvertebral trabecular bone trait 13 (mouse)Not determined125313200287132145Mouse
12832727Ahrq1_mairway hyperresponsiveness QTL 1 (mouse)125469591082665939Mouse
27226728Tibl20_mtibia length 20, 16 week (mouse)125914678693866774Mouse
27226776Tibl6_mtibia length 6, 5 week (mouse)126064678692666774Mouse
10043948Pbft6_mpercent body fat 6 (mouse)Not determined126120542795205427Mouse
1301476Pbwg12_mpostnatal body weight growth 12 (mouse)Not determined126204016496040364Mouse
27226797Scvln19_msacral vertebrae length 2, 16 week (mouse)126214678699466259Mouse
10043895Bw20_mbody weight QTL 20 (mouse)Not determined126230825296308252Mouse
1301046Par3_mpulmonary adenoma resistance 3 (mouse)Not determined126395670897956883Mouse
1301337Cdcs8_mcytokine deficiency colitis susceptibility 8 (mouse)Not determined126468908398689229Mouse
1300633Cdcs7_mcytokine deficiency colitis susceptibility 7 (mouse)Not determined126468908398689229Mouse
14746976Manh73_mmandible shape 73 (mouse)126585713199857131Mouse
27226771Tibl14_mtibia length 14, 10 week (mouse)126834677498766259Mouse
27226793Feml10_mfemur length 10, 5 week (mouse)1268346774113363620Mouse
4141738Tgq23_mtriglyceride QTL 23 (mouse)Not determined72112877106112877Mouse
1301926Adip6_madiposity 6 (mouse)Not determined1273887422107887526Mouse
1301689Skull18_mskull morphology 18 (mouse)Not determined1273887422107887526Mouse
13524842Ppiq10a_mprepulse inhibition QTL 10a (mouse)1277512220111512220Mouse
1301868Fbgl1_mfasting blood glucose 1 (mouse)Not determined127904016483162211Mouse
4141610Tailaq1_mtail length adjusted QTL 1 (mouse)Not determined80956708113383533Mouse
4142401Egq10_mearly growth QTL 10 (mouse)Not determined80956708113383533Mouse
4141335W6q10_mweight 6 weeks QTL 10 (mouse)Not determined80956708113383533Mouse
39128213Lwq23_mliver weight QTL 10 (mouse)1280956708113383533Mouse
13524849Ppiq11a_mprepulse inhibition QTL 11a (mouse)1280989143114989143Mouse

Markers in Region
Adam21  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381281,560,847 - 81,560,923UniSTSGRCm38
MGSCv371282,661,834 - 82,661,910UniSTSGRCm37
Celera1283,028,008 - 83,028,084UniSTS
Cytogenetic Map12D1UniSTS
cM Map1228.0UniSTS
UniSTS:236900  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381281,559,938 - 81,560,214UniSTSGRCm38
MGSCv371282,660,925 - 82,661,201UniSTSGRCm37
Celera1283,027,099 - 83,027,375UniSTS
Cytogenetic Map12D1UniSTS
cM Map1228.0UniSTS


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000008582   ⟹   ENSMUSP00000008582
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1281,605,358 - 81,615,248 (-)Ensembl
GRCm38.p6 Ensembl1281,558,584 - 81,568,474 (-)Ensembl
RefSeq Acc Id: NM_020330   ⟹   NP_065063
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391281,605,349 - 81,615,248 (-)NCBI
GRCm381281,558,575 - 81,568,474 (-)NCBI
MGSCv371282,659,571 - 82,669,461 (-)RGD
Celera1283,025,745 - 83,035,635 (-)RGD
cM Map12 ENTREZGENE
Sequence:
Protein Sequences
Protein RefSeqs NP_065063 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAF74731 (Get FASTA)   NCBI Sequence Viewer  
  AAI32153 (Get FASTA)   NCBI Sequence Viewer  
  AAI32345 (Get FASTA)   NCBI Sequence Viewer  
  BAB29569 (Get FASTA)   NCBI Sequence Viewer  
  EDL02716 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSMUSP00000008582
  ENSMUSP00000008582.4
GenBank Protein Q9JI76 (Get FASTA)   NCBI Sequence Viewer  
Reference Protein Sequences
RefSeq Acc Id: NP_065063   ⟸   NM_020330
- Peptide Label: preproprotein
- UniProtKB: A2RSL1 (UniProtKB/Swiss-Prot),   Q9JI76 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSMUSP00000008582   ⟸   ENSMUST00000008582
Protein Domains
Disintegrin   EGF-like   Peptidase M12B

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9JI76-F1-model_v2 AlphaFold Q9JI76 1-729 view protein structure


Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1861229 AgrOrtholog
Ensembl Genes ENSMUSG00000008438 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000008582 ENTREZGENE
  ENSMUST00000008582.4 UniProtKB/Swiss-Prot
Gene3D-CATH 3.40.390.10 UniProtKB/Swiss-Prot
  4.10.70.10 UniProtKB/Swiss-Prot
InterPro ADAM_Cys-rich UniProtKB/Swiss-Prot
  Disintegrin_CS UniProtKB/Swiss-Prot
  Disintegrin_dom UniProtKB/Swiss-Prot
  Disintegrin_dom_sf UniProtKB/Swiss-Prot
  EGF-like_dom UniProtKB/Swiss-Prot
  MetalloPept_cat_dom_sf UniProtKB/Swiss-Prot
  Peptidase_M12B UniProtKB/Swiss-Prot
  Peptidase_M12B_N UniProtKB/Swiss-Prot
  Reprolysin_adamalysin UniProtKB/Swiss-Prot
KEGG Report mmu:56622 UniProtKB/Swiss-Prot
MGD MGI:1861229 ENTREZGENE
NCBI Gene 56622 ENTREZGENE
PANTHER ADAM A DISINTEGRIN AND METALLOPROTEASE DOMAIN UniProtKB/Swiss-Prot
  DISINTEGRIN AND METALLOPROTEINASE DOMAIN-CONTAINING PROTEIN 21 UniProtKB/Swiss-Prot
Pfam ADAM_CR UniProtKB/Swiss-Prot
  Disintegrin UniProtKB/Swiss-Prot
  Pep_M12B_propep UniProtKB/Swiss-Prot
  Reprolysin UniProtKB/Swiss-Prot
PhenoGen Adam21 PhenoGen
PRINTS DISINTEGRIN UniProtKB/Swiss-Prot
PROSITE ADAM_MEPRO UniProtKB/Swiss-Prot
  DISINTEGRIN_1 UniProtKB/Swiss-Prot
  DISINTEGRIN_2 UniProtKB/Swiss-Prot
  EGF_2 UniProtKB/Swiss-Prot
  EGF_3 UniProtKB/Swiss-Prot
  ZINC_PROTEASE UniProtKB/Swiss-Prot
SMART ACR UniProtKB/Swiss-Prot
  DISIN UniProtKB/Swiss-Prot
Superfamily-SCOP Metalloproteases ('zincins'), catalytic domain UniProtKB/Swiss-Prot
  SSF57552 UniProtKB/Swiss-Prot
UniProt A2RSL1 ENTREZGENE
  ADA21_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary A2RSL1 UniProtKB/Swiss-Prot