ADAM21 (ADAM metallopeptidase domain 21)

Gene: ADAM21 (ADAM metallopeptidase domain 21) Homo sapiens

Analyze

Symbol:

ADAM21

Name:

ADAM metallopeptidase domain 21

RGD ID:

1314846

HGNC Page

HGNC:200

Description:

Predicted to enable metalloendopeptidase activity. Predicted to be involved in male gonad development and proteolysis. Predicted to be located in axon; membrane; and neuronal cell body. Predicted to be active in external side of plasma membrane and sperm head plasma membrane.

Type:

protein-coding

RefSeq Status:

REVIEWED

Previously known as:

a disintegrin and metalloproteinase domain 21; ADAM 21; ADAM metallopeptidase domain 21, preproprotein; ADAM31; disintegrin and metalloproteinase domain-containing protein 21; MGC125389

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Related Pseudogenes:

AC022325.1 AC037471.1 AC127381.1 AC136428.2 ADAM1B ADAM21P1

Allele / Splice:

See ClinVar data

Latest Assembly:

GRCh38 - Human Genome Assembly GRCh38

Position:

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	14	70,452,174 - 70,459,905 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	14	70,417,107 - 70,460,427 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	14	70,918,891 - 70,926,622 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	14	69,993,970 - 69,996,375 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	14	69,993,969 - 69,996,375	NCBI
Celera	14	50,988,177 - 50,990,582 (+)	NCBI		Celera
Cytogenetic Map	14	q24.2	NCBI
HuRef	14	51,087,543 - 51,095,293 (+)	NCBI		HuRef
CHM1_1	14	70,856,830 - 70,864,579 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	14	64,658,196 - 64,665,929 (+)	NCBI		T2T-CHM13v2.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

2,2',4,4',5,5'-hexachlorobiphenyl (EXP)

2,2',4,4'-Tetrabromodiphenyl ether (EXP)

2,3,7,8-tetrachlorodibenzodioxine (ISO)

4,4'-sulfonyldiphenol (ISO)

aflatoxin B1 (EXP)

antirheumatic drug (EXP)

benzo[a]pyrene (EXP)

bisphenol A (EXP)

butanal (EXP)

cadmium atom (EXP)

cadmium dichloride (EXP)

epoxiconazole (ISO)

lipopolysaccharide (EXP)

paracetamol (ISO)

propanal (EXP)

S-(1,2-dichlorovinyl)-L-cysteine (EXP)

sodium arsenite (EXP,ISO)

sulforaphane (EXP)

testosterone enanthate (EXP)

triptonide (ISO)

valproic acid (EXP)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

male gonad development (IBA)

proteolysis (IBA,IEA)

single fertilization (TAS)

Cellular Component

axon (IEA)

external side of plasma membrane (IBA)

membrane (IEA)

neuron projection (IEA)

neuronal cell body (IEA)

plasma membrane (IBA,TAS)

sperm head plasma membrane (IBA)

Molecular Function

metal ion binding (IEA)

metalloendopeptidase activity (IBA,IEA)

metallopeptidase activity (IEA,TAS)

protein binding (IPI)

References

References - curated

#	Reference Title	Reference Citation
1.	GOAs Human GO annotations	GOA_HUMAN data from the GO Consortium
2.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
3.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:9469942	PMID:10524237	PMID:12477932	PMID:15489334	PMID:16344560	PMID:21873635	PMID:28514442	PMID:29138461	PMID:32296183	PMID:33961781	PMID:34857952

Genomics

Comparative Map Data

ADAM21
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	14	70,452,174 - 70,459,905 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	14	70,417,107 - 70,460,427 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	14	70,918,891 - 70,926,622 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	14	69,993,970 - 69,996,375 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	14	69,993,969 - 69,996,375	NCBI
Celera	14	50,988,177 - 50,990,582 (+)	NCBI		Celera
Cytogenetic Map	14	q24.2	NCBI
HuRef	14	51,087,543 - 51,095,293 (+)	NCBI		HuRef
CHM1_1	14	70,856,830 - 70,864,579 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	14	64,658,196 - 64,665,929 (+)	NCBI		T2T-CHM13v2.0

Adam21
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	12	81,605,349 - 81,615,248 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	12	81,605,358 - 81,615,248 (-)	Ensembl		GRCm39 Ensembl
GRCm38	12	81,558,575 - 81,568,474 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	12	81,558,584 - 81,568,474 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	12	82,659,571 - 82,669,461 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	12	82,477,432 - 82,487,322 (-)	NCBI		MGSCv36	mm8
Celera	12	83,025,745 - 83,035,635 (-)	NCBI		Celera
Cytogenetic Map	12	D1	NCBI
cM Map	12	37.79	NCBI

Adam21
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	16	43,351,935 - 43,361,020 (+)	NCBI		GRCr8
mRatBN7.2	16	36,625,324 - 36,627,657 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	16	36,618,860 - 36,628,008 (+)	Ensembl		mRatBN7.2 Ensembl
Rnor_6.0	16	39,138,561 - 39,148,460 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_5.0	16	38,925,310 - 38,934,356 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
Celera	16	34,773,480 - 34,783,278 (+)	NCBI		Celera
Cytogenetic Map	16	p11	NCBI

ADAM21
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	15	71,539,713 - 71,581,469 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	14	70,756,226 - 70,797,982 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	14	51,009,420 - 51,051,012 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	14	69,913,385 - 69,921,117 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	14	69,918,713 - 69,920,880 (+)	Ensembl	panpan1.1		panPan2

ADAM21
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	8	44,238,624 - 44,269,244 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	8	44,238,864 - 44,241,023 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	8	43,903,984 - 43,934,597 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	8	44,463,005 - 44,493,634 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	8	44,463,245 - 44,465,404 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	8	44,115,179 - 44,145,773 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	8	44,161,974 - 44,192,612 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	8	44,522,701 - 44,553,570 (-)	NCBI		UU_Cfam_GSD_1.0

LOC100515389
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1	7	94,084,019 - 94,087,956 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	7	100,372,847 - 100,392,821 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

Variants

Variants in ADAM21
28 total Variants

Clinical Variants

Name	Type	Condition(s)	Position(s)	Clinical significance
NM_003813.3(ADAM21):c.1614C>T (p.Asn538=)	single nucleotide variant	Malignant melanoma [RCV000062784]	Chr14:70459113 [GRCh38] Chr14:70925830 [GRCh37] Chr14:69995583 [NCBI36] Chr14:14q24.2	not provided
GRCh38/hg38 14q24.1-31.1(chr14:69562099-81975384)x1	copy number loss	See cases [RCV000134154]	Chr14:69562099..81975384 [GRCh38] Chr14:70028816..82441728 [GRCh37] Chr14:69098569..81511481 [NCBI36] Chr14:14q24.1-31.1	pathogenic
GRCh38/hg38 14q11.2-32.33(chr14:20151149-106855263)x3	copy number gain	See cases [RCV000135543]	Chr14:20151149..106855263 [GRCh38] Chr14:20619308..107263478 [GRCh37] Chr14:19689148..106334523 [NCBI36] Chr14:14q11.2-32.33	pathogenic
GRCh38/hg38 14q11.2-32.33(chr14:20043514-106877229)x3	copy number gain	See cases [RCV000143373]	Chr14:20043514..106877229 [GRCh38] Chr14:20511673..107285437 [GRCh37] Chr14:19581513..106356482 [NCBI36] Chr14:14q11.2-32.33	pathogenic
GRCh37/hg19 14q11.2-32.33(chr14:19794561-107234280)x3	copy number gain	See cases [RCV000446256]	Chr14:19794561..107234280 [GRCh37] Chr14:14q11.2-32.33	pathogenic
GRCh37/hg19 14q23.2-32.33(chr14:62493932-107285437)x3	copy number gain	See cases [RCV000448557]	Chr14:62493932..107285437 [GRCh37] Chr14:14q23.2-32.33	pathogenic
GRCh37/hg19 14q11.2-32.33(chr14:20511673-107285437)	copy number gain	See cases [RCV000512041]	Chr14:20511673..107285437 [GRCh37] Chr14:14q11.2-32.33	pathogenic
NM_003813.4(ADAM21):c.735G>A (p.Met245Ile)	single nucleotide variant	not specified [RCV004314757]	Chr14:70458234 [GRCh38] Chr14:70924951 [GRCh37] Chr14:14q24.2	likely benign
GRCh37/hg19 14q24.1-24.2(chr14:68035240-73568130)x1	copy number loss	See cases [RCV000512344]	Chr14:68035240..73568130 [GRCh37] Chr14:14q24.1-24.2	likely pathogenic
GRCh37/hg19 14q11.2-32.33(chr14:19280733-107287663)x3	copy number gain	not provided [RCV000738413]	Chr14:19280733..107287663 [GRCh37] Chr14:14q11.2-32.33	pathogenic
GRCh37/hg19 14q11.2-32.33(chr14:19327823-107287663)x3	copy number gain	not provided [RCV000738414]	Chr14:19327823..107287663 [GRCh37] Chr14:14q11.2-32.33	pathogenic
GRCh37/hg19 14q11.1-32.33(chr14:19000422-107289053)x3	copy number gain	not provided [RCV000738412]	Chr14:19000422..107289053 [GRCh37] Chr14:14q11.1-32.33	pathogenic
GRCh37/hg19 14q24.2(chr14:70911391-70992969)x1	copy number loss	not provided [RCV001259787]	Chr14:70911391..70992969 [GRCh37] Chr14:14q24.2	uncertain significance
GRCh37/hg19 14q22.2-24.3(chr14:54654001-75828024)x3	copy number gain	14q22.2q24.3 duplication [RCV001506967]	Chr14:54654001..75828024 [GRCh37] Chr14:14q22.2-24.3	likely pathogenic
GRCh37/hg19 14q13.3-32.33(chr14:37671058-106985955)x2	copy number gain	See cases [RCV002286356]	Chr14:37671058..106985955 [GRCh37] Chr14:14q13.3-32.33	pathogenic
NM_003813.4(ADAM21):c.1616G>A (p.Arg539His)	single nucleotide variant	not specified [RCV004184762]	Chr14:70459115 [GRCh38] Chr14:70925832 [GRCh37] Chr14:14q24.2	uncertain significance
NM_003813.4(ADAM21):c.1847G>A (p.Gly616Glu)	single nucleotide variant	not specified [RCV004088979]	Chr14:70459346 [GRCh38] Chr14:70926063 [GRCh37] Chr14:14q24.2	uncertain significance
NM_003813.4(ADAM21):c.1052A>G (p.His351Arg)	single nucleotide variant	not specified [RCV004136678]	Chr14:70458551 [GRCh38] Chr14:70925268 [GRCh37] Chr14:14q24.2	uncertain significance
NM_003813.4(ADAM21):c.1711A>T (p.Ile571Phe)	single nucleotide variant	not specified [RCV004203162]	Chr14:70459210 [GRCh38] Chr14:70925927 [GRCh37] Chr14:14q24.2	uncertain significance
NM_003813.4(ADAM21):c.140A>C (p.Lys47Thr)	single nucleotide variant	not specified [RCV004161725]	Chr14:70457639 [GRCh38] Chr14:70924356 [GRCh37] Chr14:14q24.2	uncertain significance
NM_003813.4(ADAM21):c.1319T>C (p.Leu440Pro)	single nucleotide variant	not specified [RCV004104524]	Chr14:70458818 [GRCh38] Chr14:70925535 [GRCh37] Chr14:14q24.2	uncertain significance
NM_003813.4(ADAM21):c.1453C>T (p.Pro485Ser)	single nucleotide variant	not specified [RCV004182099]	Chr14:70458952 [GRCh38] Chr14:70925669 [GRCh37] Chr14:14q24.2	uncertain significance
NM_003813.4(ADAM21):c.148A>G (p.Ser50Gly)	single nucleotide variant	not specified [RCV004227301]	Chr14:70457647 [GRCh38] Chr14:70924364 [GRCh37] Chr14:14q24.2	uncertain significance
NM_003813.4(ADAM21):c.2054C>T (p.Pro685Leu)	single nucleotide variant	not specified [RCV004070970]	Chr14:70459553 [GRCh38] Chr14:70926270 [GRCh37] Chr14:14q24.2	uncertain significance
NM_003813.4(ADAM21):c.852A>T (p.Gln284His)	single nucleotide variant	not specified [RCV004085669]	Chr14:70458351 [GRCh38] Chr14:70925068 [GRCh37] Chr14:14q24.2	uncertain significance
NM_003813.4(ADAM21):c.949C>T (p.Arg317Cys)	single nucleotide variant	not specified [RCV004073537]	Chr14:70458448 [GRCh38] Chr14:70925165 [GRCh37] Chr14:14q24.2	uncertain significance
NM_003813.4(ADAM21):c.773T>C (p.Ile258Thr)	single nucleotide variant	not specified [RCV004175911]	Chr14:70458272 [GRCh38] Chr14:70924989 [GRCh37] Chr14:14q24.2	uncertain significance
NM_003813.4(ADAM21):c.1919A>G (p.Asn640Ser)	single nucleotide variant	not specified [RCV004125525]	Chr14:70459418 [GRCh38] Chr14:70926135 [GRCh37] Chr14:14q24.2	uncertain significance
NM_003813.4(ADAM21):c.1223G>A (p.Arg408His)	single nucleotide variant	not specified [RCV004122177]	Chr14:70458722 [GRCh38] Chr14:70925439 [GRCh37] Chr14:14q24.2	uncertain significance
NM_003813.4(ADAM21):c.896T>C (p.Ile299Thr)	single nucleotide variant	not specified [RCV004134621]	Chr14:70458395 [GRCh38] Chr14:70925112 [GRCh37] Chr14:14q24.2	uncertain significance
NM_003813.4(ADAM21):c.538G>A (p.Val180Ile)	single nucleotide variant	not specified [RCV004094882]	Chr14:70458037 [GRCh38] Chr14:70924754 [GRCh37] Chr14:14q24.2	likely benign
NM_003813.4(ADAM21):c.890T>C (p.Met297Thr)	single nucleotide variant	not specified [RCV004090401]	Chr14:70458389 [GRCh38] Chr14:70925106 [GRCh37] Chr14:14q24.2	uncertain significance
NM_003813.4(ADAM21):c.923G>T (p.Gly308Val)	single nucleotide variant	not specified [RCV004224708]	Chr14:70458422 [GRCh38] Chr14:70925139 [GRCh37] Chr14:14q24.2	uncertain significance
NM_003813.4(ADAM21):c.1931T>G (p.Ile644Ser)	single nucleotide variant	not specified [RCV004281163]	Chr14:70459430 [GRCh38] Chr14:70926147 [GRCh37] Chr14:14q24.2	uncertain significance
NM_003813.4(ADAM21):c.2041G>A (p.Gly681Arg)	single nucleotide variant	not specified [RCV004253289]	Chr14:70459540 [GRCh38] Chr14:70926257 [GRCh37] Chr14:14q24.2	likely benign
NM_003813.4(ADAM21):c.217G>A (p.Val73Ile)	single nucleotide variant	not specified [RCV004254791]	Chr14:70457716 [GRCh38] Chr14:70924433 [GRCh37] Chr14:14q24.2	likely benign
NM_003813.4(ADAM21):c.1520G>A (p.Cys507Tyr)	single nucleotide variant	not specified [RCV004280634]	Chr14:70459019 [GRCh38] Chr14:70925736 [GRCh37] Chr14:14q24.2	uncertain significance
NM_003813.4(ADAM21):c.1615C>A (p.Arg539Ser)	single nucleotide variant	not specified [RCV004275955]	Chr14:70459114 [GRCh38] Chr14:70925831 [GRCh37] Chr14:14q24.2	uncertain significance
NM_003813.4(ADAM21):c.1157C>G (p.Thr386Ser)	single nucleotide variant	not specified [RCV004362124]	Chr14:70458656 [GRCh38] Chr14:70925373 [GRCh37] Chr14:14q24.2	uncertain significance
NM_003813.4(ADAM21):c.1216C>G (p.Leu406Val)	single nucleotide variant	not specified [RCV004344996]	Chr14:70458715 [GRCh38] Chr14:70925432 [GRCh37] Chr14:14q24.2	uncertain significance
GRCh37/hg19 14q24.2(chr14:70651622-70949256)x1	copy number loss	not provided [RCV003483210]	Chr14:70651622..70949256 [GRCh37] Chr14:14q24.2	uncertain significance
GRCh37/hg19 14q23.1-32.33(chr14:58894502-107227240)x3	copy number gain	not provided [RCV003485036]	Chr14:58894502..107227240 [GRCh37] Chr14:14q23.1-32.33	pathogenic
NM_003813.4(ADAM21):c.143T>A (p.Val48Glu)	single nucleotide variant	not specified [RCV004441679]	Chr14:70457642 [GRCh38] Chr14:70924359 [GRCh37] Chr14:14q24.2	uncertain significance
NM_003813.4(ADAM21):c.1717C>G (p.Leu573Val)	single nucleotide variant	not specified [RCV004441718]	Chr14:70459216 [GRCh38] Chr14:70925933 [GRCh37] Chr14:14q24.2	uncertain significance
NM_003813.4(ADAM21):c.1775G>A (p.Gly592Asp)	single nucleotide variant	not specified [RCV004441721]	Chr14:70459274 [GRCh38] Chr14:70925991 [GRCh37] Chr14:14q24.2	uncertain significance
NM_003813.4(ADAM21):c.1834G>C (p.Val612Leu)	single nucleotide variant	not specified [RCV004441730]	Chr14:70459333 [GRCh38] Chr14:70926050 [GRCh37] Chr14:14q24.2	uncertain significance
NM_003813.4(ADAM21):c.512T>C (p.Met171Thr)	single nucleotide variant	not specified [RCV004441767]	Chr14:70458011 [GRCh38] Chr14:70924728 [GRCh37] Chr14:14q24.2	uncertain significance
NM_003813.4(ADAM21):c.1453C>G (p.Pro485Ala)	single nucleotide variant	not specified [RCV004441684]	Chr14:70458952 [GRCh38] Chr14:70925669 [GRCh37] Chr14:14q24.2	uncertain significance
NM_003813.4(ADAM21):c.1504T>C (p.Cys502Arg)	single nucleotide variant	not specified [RCV004441703]	Chr14:70459003 [GRCh38] Chr14:70925720 [GRCh37] Chr14:14q24.2	uncertain significance
NM_003813.4(ADAM21):c.1671T>G (p.Asp557Glu)	single nucleotide variant	not specified [RCV004441715]	Chr14:70459170 [GRCh38] Chr14:70925887 [GRCh37] Chr14:14q24.2	uncertain significance
NM_003813.4(ADAM21):c.908T>G (p.Leu303Arg)	single nucleotide variant	not specified [RCV004441813]	Chr14:70458407 [GRCh38] Chr14:70925124 [GRCh37] Chr14:14q24.2	uncertain significance
NM_003813.4(ADAM21):c.1710C>A (p.Asp570Glu)	single nucleotide variant	not specified [RCV004441717]	Chr14:70459209 [GRCh38] Chr14:70925926 [GRCh37] Chr14:14q24.2	uncertain significance
NM_003813.4(ADAM21):c.1823A>G (p.Lys608Arg)	single nucleotide variant	not specified [RCV004441724]	Chr14:70459322 [GRCh38] Chr14:70926039 [GRCh37] Chr14:14q24.2	uncertain significance
NM_003813.4(ADAM21):c.398G>A (p.Arg133Gln)	single nucleotide variant	not specified [RCV004441762]	Chr14:70457897 [GRCh38] Chr14:70924614 [GRCh37] Chr14:14q24.2	likely benign
NM_003813.4(ADAM21):c.827T>G (p.Leu276Arg)	single nucleotide variant	not specified [RCV004441778]	Chr14:70458326 [GRCh38] Chr14:70925043 [GRCh37] Chr14:14q24.2	uncertain significance
NM_003813.4(ADAM21):c.895A>G (p.Ile299Val)	single nucleotide variant	not specified [RCV004441797]	Chr14:70458394 [GRCh38] Chr14:70925111 [GRCh37] Chr14:14q24.2	uncertain significance
NM_003813.4(ADAM21):c.1498G>T (p.Ala500Ser)	single nucleotide variant	not specified [RCV004441697]	Chr14:70458997 [GRCh38] Chr14:70925714 [GRCh37] Chr14:14q24.2	uncertain significance

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	149
Count of miRNA genes:	86
Interacting mature miRNAs:	86
Transcripts:	ENST00000267499, ENST00000603540
Prediction methods:	Miranda, Rnahybrid
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Markers in Region

RH103433

Human Assembly	Chr	Position (strand)	Source	JBrowse
GRCh37	14	70,924,842 - 70,925,030	UniSTS	GRCh37
GRCh37	14	70,713,564 - 70,713,752	UniSTS	GRCh37
Build 36	14	69,783,317 - 69,783,505	RGD	NCBI36
Celera	14	50,988,802 - 50,988,990	UniSTS
Celera	14	50,777,744 - 50,777,932	RGD
Cytogenetic Map	14	q24.1	UniSTS
Cytogenetic Map	14	q24.2	UniSTS
HuRef	14	50,881,670 - 50,881,858	UniSTS
HuRef	14	51,093,513 - 51,093,701	UniSTS
GeneMap99-GB4 RH Map	14	174.43	UniSTS

A009X03

Human Assembly	Chr	Position (strand)	Source	JBrowse
GRCh37	14	70,922,272 - 70,922,372	UniSTS	GRCh37
Build 36	14	69,992,025 - 69,992,125	RGD	NCBI36
Celera	14	50,986,232 - 50,986,332	RGD
Cytogenetic Map	14	q24.1	UniSTS
HuRef	14	51,090,943 - 51,091,043	UniSTS
GeneMap99-GB4 RH Map	14	174.53	UniSTS

ADAM21_4034

Human Assembly	Chr	Position (strand)	Source	JBrowse
GRCh37	14	70,925,805 - 70,926,725	UniSTS	GRCh37
GRCh37	14	70,711,870 - 70,712,789	UniSTS	GRCh37
Build 36	14	69,781,623 - 69,782,542	RGD	NCBI36
Celera	14	50,776,051 - 50,776,969	RGD
Celera	14	50,989,765 - 50,990,685	UniSTS
HuRef	14	51,094,476 - 51,095,396	UniSTS
HuRef	14	50,879,977 - 50,880,895	UniSTS

RH78730

Human Assembly	Chr	Position (strand)	Source	JBrowse
GRCh37	14	70,922,267 - 70,922,438	UniSTS	GRCh37
Build 36	14	69,992,020 - 69,992,191	RGD	NCBI36
Celera	14	50,986,227 - 50,986,398	RGD
Cytogenetic Map	14	q24.1	UniSTS
HuRef	14	51,090,938 - 51,091,109	UniSTS
GeneMap99-GB4 RH Map	14	178.18	UniSTS

G32933

Human Assembly	Chr	Position (strand)	Source	JBrowse
GRCh37	14	70,922,272 - 70,922,372	UniSTS	GRCh37
Celera	14	50,986,232 - 50,986,332	UniSTS
Cytogenetic Map	14	q24.1	UniSTS
HuRef	14	51,090,943 - 51,091,043	UniSTS

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system

circulatory system

endocrine system

exocrine system

hemolymphoid system

hepatobiliary system

integumental system

musculoskeletal system

nervous system

renal system

reproductive system

respiratory system

sensory system

adipose tissue

appendage

entire extraembryonic component

High

Medium

295

Low

326

547

487

226

581

205

1195

467

372

505

Below cutoff

2000

1891

1126

484

1074

330

3638

1939

2460

321

658

1181

164

1143

2225

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_003813	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AA758110	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AF029900	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AF158644	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AL357153	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AL391223	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC109024	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC109025	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH471061	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CP068264	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	DB035527	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENST00000603540 ⟹ ENSP00000474385

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38.p14 Ensembl	14	70,452,174 - 70,459,905 (+)	Ensembl

RefSeq Acc Id:

ENST00000679631 ⟹ ENSP00000506213

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38.p14 Ensembl	14	70,417,107 - 70,460,427 (+)	Ensembl

RefSeq Acc Id:

NM_003813 ⟹ NP_003804

RefSeq Status:

REVIEWED

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38	14	70,452,174 - 70,459,905 (+)	NCBI
GRCh37	14	70,918,874 - 70,926,622 (+)	ENTREZGENE
Build 36	14	69,993,970 - 69,996,375 (+)	NCBI Archive
Celera	14	50,988,177 - 50,990,582 (+)	RGD
HuRef	14	51,087,543 - 51,095,293 (+)	ENTREZGENE
CHM1_1	14	70,856,830 - 70,864,579 (+)	NCBI
T2T-CHM13v2.0	14	64,658,196 - 64,665,929 (+)	NCBI

Sequence:

show sequence

GTTCTGTGGCCTCAGCTACAAACCATTGATAAAGCATGGTATAAACCATCTAGACAGAAATGGC
CATGGAAACTACTGTTTCTTCTGATGCACTGCAGTTCTGATCTAACTCTGCCAGGACACAGATC
CACAGGGTCAGCCCTGCATCCTGAGCAGCTTAGAGGGAGAAGCCAGACCAGCAGTGCCTCACAC
CTTGTCCTCTTCTGCTCTGGACAGATGGCTCCATAACGACAGCTTCATAATGGCAGTGGATGGG
ACCCTCGTGTACATCAGAGTCACTCTTCTGCTGCTCTGGCTTGGGGTATTTTTGTCTATTTCCG
GCTACTGTCAGGCTGGGCCCTCCCAGCATTTCACTTCCCCGGAAGTGGTGATCCCCTTGAAGGT
GATCAGCAGGGGCAGAAGTGCAAAGGCTCCTGGATGGCTCTCCTATAGTCTGCGGTTTGGGGGC
CAGAAACACGTTGTTCATATGAGGGTCAAGAAGCTCTTAGTTTCTAGACACCTCCCAGTGTTCA
CCTACACAGATGACCGTGCACTCCTGGAGGATCAGCTCTTCATCCCAGATGACTGTTACTATCA
TGGTTACGTGGAGGCAGCCCCTGAGTCTCTGGTTGTGTTCAGTGCTTGTTTTGGGGGCTTTCGA
GGAGTATTAAAAATAAGTGGCCTCACTTATGAAATTGAACCCATCAGGCACTCTGCCACATTTG
AACACCTGGTTTATAAGATAAACAGTAATGAGACACAATTCCCAGCTATGAGATGTGGCTTAAC
AGAGAAGGAAGTAGCACGCCAACAGTTGGAATTTGAAGAGGCTGAGAACTCAGCTCTGGAACCA
AAATCTGCTGGTGACTGGTGGACTCATGCATGGTTTCTGGAGCTAGTTGTTGTGGTGAACCATG
ATTTCTTCATTTACTCTCAAAGCAACATCTCAAAGGTGCAAGAGGATGTATTTCTTGTTGTCAA
CATAGTGGATTCCATGTATAAGCAGTTAGGTACTTACATAATTTTGATTGGAATTGAAATTTGG
AATCAAGGAAATGTTTTCCCAATGACAAGCATAGAACAGGTCCTGAACGATTTCTCTCAATGGA
AACAAATCAGTCTTTCCCAGCTACAGCATGATGCTGCACATATGTTCATAAAAAATTCACTTAT
AAGTATACTTGGCCTAGCCTATGTTGCAGGAATATGTCGTCCACCTATTGATTGTGGAGTTGAT
AATTTTCAAGGAGATACCTGGTCTCTTTTTGCCAACACTGTGGCCCATGAGTTAGGTCATACGT
TAGGTATGCAGCATGATGAAGAATTCTGTTTTTGTGGGGAAAGAGGTTGCATCATGAATACTTT
TAGAGTGCCAGCAGAGAAATTCACCAATTGCAGTTACGCTGATTTTATGAAGACCACCTTAAAC
CAGGGATCATGTCTGCATAATCCTCCAAGATTGGGGGAAATCTTTATGCTAAAGCGCTGTGGGA
ATGGTGTGGTTGAAAGAGAAGAGCAGTGTGACTGTGGATCCGTACAGCAGTGTGAACAAGACGC
CTGTTGTCTGTTGAACTGCACTCTAAGGCCTGGGGCTGCCTGTGCTTTTGGGCTTTGTTGCAAA
GACTGCAAGTTCATGCCATCAGGGGAACTCTGTAGACAAGAGGTCAATGAATGTGACCTTCCAG
AATGGTGCAATGGAACATCTCATCAGTGTCCAGAAGATAGATATGTGCAGGACGGGATCCCCTG
TAGTGACAGTGCCTACTGCTATCAAAAGAGGTGTAATAACCATGACCAGCATTGCAGGGAGATT
TTTGGTAAAGATGCAAAAAGTGCATCTCAGAATTGCTATAAAGAAATCAATTCTCAGGGAAACC
GTTTTGGTCACTGTGGTATAAATGGCACAACATACCTAAAATGTCATATCTCTGATGTCTTTTG
TGGGAGAGTTCAATGTGAGAATGTGAGAGACATTCCTCTTCTCCAAGATCATTTTACTTTGCAG
CACACTCATATCAATGGTGTCACCTGCTGGGGTATTGACTATCATTTAAGGATGAACATATCTG
ACATTGGTGAAGTGAAAGATGGTACTGTGTGTGGCCCAGGAAAGATCTGCATCCATAAGAAGTG
TGTCAGTCTGTCTGTCTTGTCACATGTCTGCCTTCCTGAGACCTGCAATATGAAGGGGATCTGC
AATAACAAACATCACTGCCACTGTGGCTATGGGTGGTCCCCACCCTACTGCCAGCACAGAGGCT
ATGGGGGCAGTATTGACAGTGGCCCAGCATCTGCAAAGAGAGGAGTTTTTTTGCCGCTGATTGT
GATTCCTTCTTTGTCTGTTTTGACTTTCCTGTTTACTGTCGGGCTTCTTATGTATCTACGACAA
TGTTCTGGTCCCAAAGAAACTAAGGCTCATTCATCAGGTTAAGAAAATGTCTCTAACTTAATAT
TCCATGCATTAGTACACTTTAGTCTCTTGGCAGTAGAAACATTAGTACATCCCTGAAACTGAGC
ACATTTCTGACCATTTCCAGAAAGCTGCAAAGATCTTCCCTTACATTAGTACCACAAACATTGT
CATTAAGTTCAAGTTATTCTTAACATGTTTCTATCTATTGTTTATTGTTTTAAGCAGCAAATAA
AGCTACATCCTTCCCTCCCTTTA

hide sequence

Protein Sequences


Protein RefSeqs	NP_003804	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAC52042	(Get FASTA)	NCBI Sequence Viewer
	AAD55255	(Get FASTA)	NCBI Sequence Viewer
	AAI09025	(Get FASTA)	NCBI Sequence Viewer
	AAI09026	(Get FASTA)	NCBI Sequence Viewer
	EAW81035	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSP00000474385
	ENSP00000474385.1
	ENSP00000506213.1
GenBank Protein	Q9UKJ8	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:	NP_003804 ⟸ NM_003813
- Peptide Label:	preproprotein
- UniProtKB:	Q2VPC6 (UniProtKB/Swiss-Prot), O43507 (UniProtKB/Swiss-Prot), Q32MR0 (UniProtKB/Swiss-Prot), Q9UKJ8 (UniProtKB/Swiss-Prot)
- Sequence:	show sequence MAVDGTLVYIRVTLLLLWLGVFLSISGYCQAGPSQHFTSPEVVIPLKVISRGRSAKAPGWLSYS LRFGGQKHVVHMRVKKLLVSRHLPVFTYTDDRALLEDQLFIPDDCYYHGYVEAAPESLVVFSAC FGGFRGVLKISGLTYEIEPIRHSATFEHLVYKINSNETQFPAMRCGLTEKEVARQQLEFEEAEN SALEPKSAGDWWTHAWFLELVVVVNHDFFIYSQSNISKVQEDVFLVVNIVDSMYKQLGTYIILI GIEIWNQGNVFPMTSIEQVLNDFSQWKQISLSQLQHDAAHMFIKNSLISILGLAYVAGICRPPI DCGVDNFQGDTWSLFANTVAHELGHTLGMQHDEEFCFCGERGCIMNTFRVPAEKFTNCSYADFM KTTLNQGSCLHNPPRLGEIFMLKRCGNGVVEREEQCDCGSVQQCEQDACCLLNCTLRPGAACAF GLCCKDCKFMPSGELCRQEVNECDLPEWCNGTSHQCPEDRYVQDGIPCSDSAYCYQKRCNNHDQ HCREIFGKDAKSASQNCYKEINSQGNRFGHCGINGTTYLKCHISDVFCGRVQCENVRDIPLLQD HFTLQHTHINGVTCWGIDYHLRMNISDIGEVKDGTVCGPGKICIHKKCVSLSVLSHVCLPETCN MKGICNNKHHCHCGYGWSPPYCQHRGYGGSIDSGPASAKRGVFLPLIVIPSLSVLTFLFTVGLL MYLRQCSGPKETKAHSSG hide sequence

RefSeq Acc Id:

ENSP00000474385 ⟸ ENST00000603540

RefSeq Acc Id:

ENSP00000506213 ⟸ ENST00000679631

Protein Domains

Disintegrin EGF-like Peptidase M12B

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q9UKJ8-F1-model_v2	AlphaFold	Q9UKJ8	1-722	view protein structure

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	HGNC:200	AgrOrtholog
COSMIC	ADAM21	COSMIC
Ensembl Genes	ENSG00000139985	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript	ENST00000603540	ENTREZGENE
	ENST00000603540.2	UniProtKB/Swiss-Prot
	ENST00000679631.1	UniProtKB/Swiss-Prot
Gene3D-CATH	3.40.390.10	UniProtKB/Swiss-Prot
	4.10.70.10	UniProtKB/Swiss-Prot
GTEx	ENSG00000139985	GTEx
HGNC ID	HGNC:200	ENTREZGENE
Human Proteome Map	ADAM21	Human Proteome Map
InterPro	ADAM_Cys-rich	UniProtKB/Swiss-Prot
	Disintegrin_CS	UniProtKB/Swiss-Prot
	Disintegrin_dom	UniProtKB/Swiss-Prot
	Disintegrin_dom_sf	UniProtKB/Swiss-Prot
	EGF-like_dom	UniProtKB/Swiss-Prot
	MetalloPept_cat_dom_sf	UniProtKB/Swiss-Prot
	Peptidase_M12B	UniProtKB/Swiss-Prot
	Peptidase_M12B_N	UniProtKB/Swiss-Prot
	Reprolysin_adamalysin	UniProtKB/Swiss-Prot
KEGG Report	hsa:8747	UniProtKB/Swiss-Prot
NCBI Gene	8747	ENTREZGENE
OMIM	603713	OMIM
PANTHER	ADAM A DISINTEGRIN AND METALLOPROTEASE DOMAIN	UniProtKB/Swiss-Prot
	DISINTEGRIN AND METALLOPROTEINASE DOMAIN-CONTAINING PROTEIN 21	UniProtKB/Swiss-Prot
Pfam	ADAM_CR	UniProtKB/Swiss-Prot
	Disintegrin	UniProtKB/Swiss-Prot
	Pep_M12B_propep	UniProtKB/Swiss-Prot
	Reprolysin	UniProtKB/Swiss-Prot
PharmGKB	PA24517	PharmGKB
PRINTS	DISINTEGRIN	UniProtKB/Swiss-Prot
PROSITE	ADAM_MEPRO	UniProtKB/Swiss-Prot
	DISINTEGRIN_1	UniProtKB/Swiss-Prot
	DISINTEGRIN_2	UniProtKB/Swiss-Prot
	EGF_2	UniProtKB/Swiss-Prot
	ZINC_PROTEASE	UniProtKB/Swiss-Prot
SMART	ACR	UniProtKB/Swiss-Prot
	DISIN	UniProtKB/Swiss-Prot
Superfamily-SCOP	Metalloproteases ('zincins'), catalytic domain	UniProtKB/Swiss-Prot
	SSF57552	UniProtKB/Swiss-Prot
UniProt	ADA21_HUMAN	UniProtKB/Swiss-Prot
	O43507	ENTREZGENE
	Q2VPC6	ENTREZGENE
	Q32MR0	ENTREZGENE
	Q9UKJ8	ENTREZGENE
UniProt Secondary	O43507	UniProtKB/Swiss-Prot
	Q2VPC6	UniProtKB/Swiss-Prot
	Q32MR0	UniProtKB/Swiss-Prot

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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