Adam30 (a disintegrin and metallopeptidase domain 30) - Rat Genome Database

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Gene: Adam30 (a disintegrin and metallopeptidase domain 30) Mus musculus
Analyze
Symbol: Adam30
Name: a disintegrin and metallopeptidase domain 30
RGD ID: 1314449
MGI Page MGI
Description: Predicted to enable metalloendopeptidase activity. Predicted to be involved in male gonad development and proteolysis. Located in external side of plasma membrane and sperm head plasma membrane. Orthologous to human ADAM30 (ADAM metallopeptidase domain 30).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 4933424D07Rik; a disintegrin and metalloproteinase domain 30; disintegrin and metalloproteinase domain-containing protein 30; MGC132801; MGC132802; svph4
RGD Orthologs
Human
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39398,067,950 - 98,071,485 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl398,067,946 - 98,071,485 (+)EnsemblGRCm39 Ensembl
GRCm38398,160,634 - 98,164,169 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl398,160,630 - 98,164,169 (+)EnsemblGRCm38mm10GRCm38
MGSCv37397,964,735 - 97,967,096 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36398,246,217 - 98,248,578 (+)NCBIMGSCv36mm8
Celera399,560,033 - 99,562,394 (+)NCBICelera
Cytogenetic Map3F2.2NCBI
cM Map342.63NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Functional annotation of a full-length mouse cDNA collection. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
2. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
3. MGDs mouse GO annotations MGD data from the GO Consortium
4. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
5. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
6. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
7. Database resources of the National Center for Biotechnology Information. Wheeler DL, etal., Nucleic Acids Res 2001 Jan 1;29(1):11-6.
Additional References at PubMed
PMID:10349636   PMID:11042159   PMID:11076861   PMID:12477932   PMID:15028286   PMID:16141072   PMID:16141073   PMID:19129510   PMID:20562862   PMID:21267068   PMID:21873635   PMID:24079728  
PMID:38355793  


Genomics

Comparative Map Data
Adam30
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39398,067,950 - 98,071,485 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl398,067,946 - 98,071,485 (+)EnsemblGRCm39 Ensembl
GRCm38398,160,634 - 98,164,169 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl398,160,630 - 98,164,169 (+)EnsemblGRCm38mm10GRCm38
MGSCv37397,964,735 - 97,967,096 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36398,246,217 - 98,248,578 (+)NCBIMGSCv36mm8
Celera399,560,033 - 99,562,394 (+)NCBICelera
Cytogenetic Map3F2.2NCBI
cM Map342.63NCBI
ADAM30
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381119,893,533 - 119,896,515 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1119,893,533 - 119,896,515 (-)EnsemblGRCh38hg38GRCh38
GRCh371120,436,156 - 120,439,138 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361120,237,679 - 120,240,636 (-)NCBINCBI36Build 36hg18NCBI36
Build 341120,148,198 - 120,151,155NCBI
Celera1118,666,878 - 118,669,835 (-)NCBICelera
Cytogenetic Map1p12ENTREZGENE
HuRef1118,294,693 - 118,297,684 (-)NCBIHuRef
CHM1_11120,551,650 - 120,554,641 (-)NCBICHM1_1
T2T-CHM13v2.01119,906,790 - 119,909,772 (-)NCBIT2T-CHM13v2.0
Adam30
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82188,440,918 - 188,444,358 (+)NCBIGRCr8
mRatBN7.22185,752,183 - 185,755,623 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2185,752,072 - 185,755,599 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2193,400,568 - 193,404,009 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02191,208,751 - 191,212,192 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02186,033,146 - 186,036,587 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02200,328,498 - 200,331,938 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2200,328,387 - 200,331,914 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02219,804,507 - 219,807,947 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42192,997,466 - 193,000,906 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera2178,242,634 - 178,246,074 (+)NCBICelera
Cytogenetic Map2q34NCBI
ADAM30
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21112,535,910 - 112,542,053 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11112,138,361 - 112,144,504 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0182,630,734 - 82,633,448 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11117,628,391 - 117,631,178 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1117,628,573 - 117,631,026 (+)Ensemblpanpan1.1panPan2
LOC100682600
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11756,768,324 - 56,772,594 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1756,399,802 - 56,401,549 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01757,649,632 - 57,651,326 (-)NCBIROS_Cfam_1.0
UMICH_Zoey_3.11756,686,190 - 56,687,884 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01756,711,459 - 56,713,150 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01757,328,617 - 57,330,326 (-)NCBIUU_Cfam_GSD_1.0
Adam30
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244050582,557,503 - 2,560,461 (+)NCBIHiC_Itri_2
SpeTri2.0NW_004936872578,616 - 580,853 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ADAM30
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl4101,314,710 - 101,316,893 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.14101,314,710 - 101,316,974 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.24111,215,977 - 111,218,587 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ADAM30
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12013,887,509 - 13,890,543 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2013,887,666 - 13,890,095 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603816,517,240 - 16,520,650 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Variants

.
Variants in Adam30
97 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:77
Count of miRNA genes:77
Interacting mature miRNAs:77
Transcripts:ENSMUST00000050342
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
26884436Zlq3_mzygomatic length QTL 3, 10 week (mouse)33265060142405761Mouse
4142399Aec1_mautoimmune exocrinopathy 1 (mouse)Not determined7586174102690034Mouse
26884427Cvht4_mcranial vault height 4, 10 week (mouse)316054164109707316Mouse
13207570Tcq12_mtotal cholesterol QTL 12 (mouse)316504164130163649Mouse
26884422Cvht7_mcranial vault height 7, 16 week (mouse)328954149118893649Mouse
1302056Orgwq4_morgan weight QTL 4 (mouse)Not determined330067588147304689Mouse
1301705Sles3_msystemic lupus erythmatosus suppressor 3 (mouse)Not determined337174862143353183Mouse
13208566Bmiq5_mbody mass index QTL 5 (mouse)340954435115793649Mouse
26884380Skwq1_mskull length QTL 1, 5 week (mouse)343954435101607316Mouse
26884378Skwq6_mskull length QTL 6, 10 week (mouse)351907421102307316Mouse
26884382Bzwq1_mbi-zygomatic width QTL 1, 5 week (mouse)352207421137205761Mouse
11039519Ltpr3_mLeishmania tropica response 3 (mouse)356704102100464137Mouse
1301971Cia5_mcollagen induced arthritis QTL 5 (mouse)Not determined366046658100046795Mouse
25314313Syncl1_msynaptonemal complex length 1 (mouse)367907333128393649Mouse
11251721Ewc3_methanol withdrawal and consumption 3 (mouse)369568554103568554Mouse
1301791Char4_mP. chabaudi malaria resistance QTL 4 (mouse)Not determined369625509100655290Mouse
1301422Sle11_msystematic lupus erythematosus susceptibility 11 (mouse)Not determined370208904104209042Mouse
11049572Lmr11c_mleishmaniasis resistance 11c (mouse)372139967106140094Mouse
1300982Lmr11_mleishmaniasis resistance 11 (mouse)Not determined372139967106140094Mouse
1300595Tmevd2_mTheiler's murine encephalomyelitis virus induced demyelinating disease susceptibility 2 (mouse)Not determined375463302109463549Mouse
1301392Eae3_msusceptibility to experimental allergic encephalomyelitis 3 (mouse)Not determined379548730113548837Mouse
1301947Pcfm3_mperiosteal circumference and femur length 3 (mouse)Not determined381084652115084797Mouse
1301904Iba2_minduction of brown adipocytes 2 (mouse)Not determined382147043116147184Mouse
11041900Lmr11a_mleishmaniasis resistance 11a (mouse)383463991117464137Mouse
11039510Ltpr3d_mLeishmania tropica response 3d (mouse)383463991117464137Mouse
11039511Ltpr3c_mLeishmania tropica response 3c (mouse)383463991117464137Mouse
11039507Ltpr3g_mLeishmania tropica response 3g (mouse)383463991117464137Mouse
11039508Ltpr3f_mLeishmania tropica response 3f (mouse)383463991117464137Mouse
11039509Ltpr3e_mLeishmania tropica response 3e (mouse)383463991117464137Mouse
11039512Ltpr3b_mLeishmania tropica response 3b (mouse)383463991117464137Mouse
1301272Cfsw1_mcystic fibrosis survival to weaning 1 (mouse)Not determined383882912117883044Mouse
4142099Cq3_mcholesterol QTL 3 (mouse)Not determined384888918118889067Mouse
14746984Manh54_mmandible shape 54 (mouse)385289152119289152Mouse
1357583Sle18_msystematic lupus erythematosus susceptibility 18 (mouse)Not determined387208904125316236Mouse
12738440Twq3_mtestis weight QTL 3 (mouse)387228015121228015Mouse
4142178Ctrq2_mC. trachomatis resistance QTL 2 (mouse)Not determined389139967137453008Mouse
10766455Sle22_msystematic lupus erythematosus susceptibility 22 (mouse)390376936124377072Mouse
14747001Mancz4_mmandible centroid size 4 (mouse)390378017124378017Mouse
1301398Rapop3_mradiation-induced apoptosis 3 (mouse)Not determined390511217100464137Mouse
1302052Etohcta4_methanol conditioned taste aversion 4 (mouse)Not determined391000105125008748Mouse
1301349Pgia26_mproteoglycan induced arthritis 26 (mouse)Not determined392251533126251650Mouse
27226732Tibmd3_mtibia midshaft diameter 3, 10 week (mouse)396607316147805636Mouse
1301277nctm1_mNakano cataract modifier 1 (mouse)Not determined397698638100373060Mouse


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000050342   ⟹   ENSMUSP00000060505
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl398,067,976 - 98,071,485 (+)Ensembl
GRCm38.p6 Ensembl398,160,660 - 98,164,169 (+)Ensembl
RefSeq Acc Id: ENSMUST00000198363   ⟹   ENSMUSP00000142590
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl398,067,946 - 98,069,387 (+)Ensembl
GRCm38.p6 Ensembl398,160,630 - 98,162,071 (+)Ensembl
RefSeq Acc Id: NM_027665   ⟹   NP_081941
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39398,067,950 - 98,071,485 (+)NCBI
GRCm38398,160,634 - 98,164,169 (+)NCBI
MGSCv37397,964,735 - 97,967,096 (+)RGD
Celera399,560,033 - 99,562,394 (+)RGD
cM Map3 ENTREZGENE
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_081941   ⟸   NM_027665
- Peptide Label: precursor
- UniProtKB: Q811Q3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000142590   ⟸   ENSMUST00000198363
RefSeq Acc Id: ENSMUSP00000060505   ⟸   ENSMUST00000050342
Protein Domains
Disintegrin   EGF-like   Peptidase M12B

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q811Q3-F1-model_v2 AlphaFold Q811Q3 1-732 view protein structure

Promoters
RGD ID:6833344
Promoter ID:MM_KWN:35461
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour,   BoneMarrow_4Hour
Transcripts:NM_027665
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36397,963,801 - 97,966,252 (+)MPROMDB
RGD ID:6881756
Promoter ID:EPDNEW_M4329
Type:initiation region
Name:Adam30_1
Description:Mus musculus a disintegrin and metallopeptidase domain 30 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38398,160,634 - 98,160,694EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1918328 AgrOrtholog
Ensembl Genes ENSMUSG00000043468 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000050342 ENTREZGENE
  ENSMUST00000050342.5 UniProtKB/TrEMBL
  ENSMUST00000198363.2 UniProtKB/TrEMBL
Gene3D-CATH 3.40.390.10 UniProtKB/TrEMBL
  4.10.70.10 UniProtKB/TrEMBL
InterPro ADAM_Cys-rich UniProtKB/TrEMBL
  Blood-coag_inhib_Disintegrin UniProtKB/TrEMBL
  Disintegrin_CS UniProtKB/TrEMBL
  Disintegrin_dom_sf UniProtKB/TrEMBL
  EG-like_dom UniProtKB/TrEMBL
  MetalloPept_cat_dom UniProtKB/TrEMBL
  Peptidase_M12B UniProtKB/TrEMBL
  Peptidase_M12B_N UniProtKB/TrEMBL
  Reprolysin_adamalysin UniProtKB/TrEMBL
KEGG Report mmu:71078 UniProtKB/TrEMBL
MGD MGI:1918328 ENTREZGENE
NCBI Gene 71078 ENTREZGENE
PANTHER ADAM A DISINTEGRIN AND METALLOPROTEASE DOMAIN UniProtKB/TrEMBL
  DISINTEGRIN AND METALLOPROTEINASE DOMAIN-CONTAINING PROTEIN 30 UniProtKB/TrEMBL
Pfam ADAM_CR UniProtKB/TrEMBL
  Disintegrin UniProtKB/TrEMBL
  Pep_M12B_propep UniProtKB/TrEMBL
  Reprolysin UniProtKB/TrEMBL
PhenoGen Adam30 PhenoGen
PRINTS DISINTEGRIN UniProtKB/TrEMBL
PROSITE ADAM_MEPRO UniProtKB/TrEMBL
  DISINTEGRIN_1 UniProtKB/TrEMBL
  DISINTEGRIN_2 UniProtKB/TrEMBL
  EGF_2 UniProtKB/TrEMBL
  EGF_3 UniProtKB/TrEMBL
SMART ACR UniProtKB/TrEMBL
  DISIN UniProtKB/TrEMBL
Superfamily-SCOP Disintegrin UniProtKB/TrEMBL
  Metalloproteases ('zincins'), catalytic domain UniProtKB/TrEMBL
UniProt Q811Q3 ENTREZGENE, UniProtKB/TrEMBL
  Q9CUC4_MOUSE UniProtKB/TrEMBL