Arhgef12 (Rho guanine nucleotide exchange factor 12) - Rat Genome Database

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Gene: Arhgef12 (Rho guanine nucleotide exchange factor 12) Mus musculus
Analyze
Symbol: Arhgef12
Name: Rho guanine nucleotide exchange factor 12 (Ensembl:Rho guanine nucleotide exchange factor (GEF) 12)
RGD ID: 1312951
MGI Page MGI
Description: Predicted to enable G protein-coupled receptor binding activity and guanyl-nucleotide exchange factor activity. Involved in regulation of blood pressure. Predicted to be located in membrane. Predicted to be active in cytoplasm. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and skin. Orthologous to human ARHGEF12 (Rho guanine nucleotide exchange factor 12).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 2310014B11Rik; AU019857; KIAA0380; L; Larg; leukemia-associated Rho guanine-nucleotide exchange factor; leukemia-associated RhoGEF; mKIAA0382; Rho guanine nucleotide exchange factor (GEF) 12
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39942,875,138 - 43,017,069 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl942,875,138 - 43,018,534 (-)EnsemblGRCm39 Ensembl
GRCm38942,963,842 - 43,105,718 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl942,963,842 - 43,107,239 (-)EnsemblGRCm38mm10GRCm38
MGSCv37942,771,925 - 42,913,801 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36942,714,838 - 42,856,481 (-)NCBIMGSCv36mm8
Celera940,216,251 - 40,358,722 (-)NCBICelera
Cytogenetic Map9A5.1NCBI
cM Map924.14NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (IBA,ISO)
membrane  (IEA)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Functional annotation of a full-length mouse cDNA collection. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
2. Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Ko MS, etal., Development 2000 Apr;127(8):1737-49.
3. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
4. MGDs mouse GO annotations MGD data from the GO Consortium
5. Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, etal., DNA Res 2003 Feb 28;10(1):35-48.
6. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
7. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
8. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
9. Mouse MP Annotation Import Pipeline RGD automated import pipeline
10. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
11. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
12. Dynamic and coordinated expression profile of dbl-family guanine nucleotide exchange factors in the developing mouse brain. Yoshizawa M, etal., Gene Expr Patterns 2003 Jun;3(3):375-81.
Additional References at PubMed
PMID:8889548   PMID:10349636   PMID:10922068   PMID:11042159   PMID:11076861   PMID:12024019   PMID:12123608   PMID:12477932   PMID:12492428   PMID:12520002   PMID:14513355   PMID:14610273  
PMID:15276214   PMID:15741177   PMID:15755723   PMID:16141072   PMID:16141073   PMID:16602821   PMID:16618939   PMID:17959834   PMID:18084302   PMID:18164504   PMID:18287559   PMID:18799693  
PMID:19265163   PMID:19409815   PMID:19811534   PMID:20702813   PMID:21267068   PMID:21507947   PMID:21572419   PMID:21677750   PMID:21873635   PMID:22019888   PMID:23129751   PMID:23467409  
PMID:23530122   PMID:24106280   PMID:24194600   PMID:24448406   PMID:24469813   PMID:24740538   PMID:25857352   PMID:26334261   PMID:26531127   PMID:27345948   PMID:28106300   PMID:28465324  
PMID:28671696   PMID:29208526   PMID:29459677   PMID:31040226   PMID:31467124   PMID:31549965   PMID:32325033   PMID:35675330  


Genomics

Comparative Map Data
Arhgef12
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39942,875,138 - 43,017,069 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl942,875,138 - 43,018,534 (-)EnsemblGRCm39 Ensembl
GRCm38942,963,842 - 43,105,718 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl942,963,842 - 43,107,239 (-)EnsemblGRCm38mm10GRCm38
MGSCv37942,771,925 - 42,913,801 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36942,714,838 - 42,856,481 (-)NCBIMGSCv36mm8
Celera940,216,251 - 40,358,722 (-)NCBICelera
Cytogenetic Map9A5.1NCBI
cM Map924.14NCBI
ARHGEF12
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3811120,336,413 - 120,489,937 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl11120,336,413 - 120,489,937 (+)EnsemblGRCh38hg38GRCh38
GRCh3711120,207,122 - 120,360,646 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3611119,713,156 - 119,865,855 (+)NCBINCBI36Build 36hg18NCBI36
Build 3411119,713,155 - 119,865,855NCBI
Celera11117,367,395 - 117,520,075 (+)NCBICelera
Cytogenetic Map11q23.3NCBI
HuRef11116,148,609 - 116,301,456 (+)NCBIHuRef
CHM1_111120,095,071 - 120,248,048 (+)NCBICHM1_1
T2T-CHM13v2.011120,360,067 - 120,513,690 (+)NCBIT2T-CHM13v2.0
Arhgef12
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8852,247,047 - 52,373,158 (-)NCBIGRCr8
mRatBN7.2843,350,070 - 43,475,404 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl843,353,799 - 43,476,366 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx848,848,509 - 48,973,746 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0847,127,187 - 47,252,429 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0844,994,810 - 45,120,046 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0847,259,377 - 47,393,042 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl847,259,404 - 47,393,503 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0845,730,366 - 45,863,838 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4845,984,042 - 46,106,412 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1845,992,807 - 46,115,178 (-)NCBI
Celera842,945,029 - 43,066,538 (-)NCBICelera
Cytogenetic Map8q22NCBI
Arhgef12
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541221,355,575 - 21,497,951 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541221,344,671 - 21,497,951 (+)NCBIChiLan1.0ChiLan1.0
ARHGEF12
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v29121,040,732 - 121,193,474 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan111122,144,058 - 122,296,653 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v011115,173,575 - 115,327,040 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.111119,099,035 - 119,251,522 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl11119,098,903 - 119,251,522 (+)Ensemblpanpan1.1panPan2
ARHGEF12
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1513,519,094 - 13,669,154 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl513,522,896 - 13,669,155 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha513,572,143 - 13,722,335 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0513,463,369 - 13,613,585 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl513,466,750 - 13,613,459 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1513,600,939 - 13,751,061 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0513,504,903 - 13,655,035 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0513,544,086 - 13,694,183 (-)NCBIUU_Cfam_GSD_1.0
Arhgef12
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947102,275,948 - 102,413,933 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365425,262,217 - 5,331,426 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365425,197,100 - 5,335,338 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ARHGEF12
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl947,475,805 - 47,618,361 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1947,474,566 - 47,621,034 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2952,631,742 - 52,729,251 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ARHGEF12
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11111,744,526 - 111,893,886 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1111,744,597 - 111,894,251 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604314,169,489 - 14,316,953 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Arhgef12
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462478415,693,044 - 15,784,171 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Arhgef12
4162 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:3460
Count of miRNA genes:788
Interacting mature miRNAs:1010
Transcripts:ENSMUST00000072767, ENSMUST00000165665
Prediction methods:Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
13504833Bglu19_mblood glucose level 19 (mouse)9991076843910768Mouse
1300532Tbs2_mtuberculosis severity 2 (mouse)Not determined91236997046370114Mouse
10043917Obq37_mobesity QTL 37 (mouse)Not determined91339117547391175Mouse
1357637Si5lq2_mserum IGFBP-5 level QTL 2 (mouse)Not determined91541175149411890Mouse
4141591Cq4_mcholesterol QTL 4 (mouse)Not determined91541175149411890Mouse
1301421Lgth4_mbody length 4 (mouse)Not determined91541175149411890Mouse
4141447Cfmq2_mcystic fibrosis modifier QTL 2 (mouse)Not determined91541175149411890Mouse
12790993Adq1_maortic diameter QTL 1 (mouse)91574962749749627Mouse
11354951Pdcc3_mplasmacytoid dentritic cell compartment 3 (mouse)91574962749749627Mouse
12790997Adq2_maortic diameter QTL 2 (mouse)91574962749749627Mouse
12880415V125Dq7_mvitamin D active form serum level QTL 7 (mouse)91601129650011296Mouse
12880416V125Dq8_mvitamin D active form serum level QTL 8 (mouse)91601129650011296Mouse
13504834Hdlq109_mHDL QTL 109 (mouse)91670964150709641Mouse
1357465Vtbt6_mvertebral trabecular bone trait 6 (mouse)Not determined91697884050978943Mouse
1300643Pvcan2_mprotection against vaginal candidiasis 2 (mouse)Not determined91994340653943525Mouse
1301439Morph2_mmorphine antinociception 2 (mouse)Not determined92015336254153492Mouse
1301883Skull12_mskull morphology 12 (mouse)Not determined92030619754306370Mouse
1301045Sluc10_msusceptibility to lung cancer 10 (mouse)Not determined92030619754306370Mouse
10043950Pbft5_mpercent body fat 5 (mouse)Not determined92030619754306370Mouse
4142352Lmr17_mleishmaniasis resistance 17 (mouse)Not determined92030619754306370Mouse
12904939Edlmmq8_mextensor digitorum longus muscle mass QTL 8 (mouse)92085274054852740Mouse
13208563Bmiq8_mbody mass index QTL 8 (mouse)92491129668907282Mouse
11532712Sluc39d_msusceptibility to lung cancer 39d (mouse)92558748559587581Mouse
11532696Sluc39c_msusceptibility to lung cancer 39c (mouse)92558748559587581Mouse
11532694Sluc39a_msusceptibility to lung cancer 39a (mouse)92558748559587581Mouse
11532695Sluc39b_msusceptibility to lung cancer 39b (mouse)92558748559587581Mouse
10043987Stheal13_msoft tissue heal 13 (mouse)Not determined92679642160796552Mouse
1300932Hdlq17_mHDL QTL 17 (mouse)Not determined92679642160796552Mouse
10043867Mtbcq9_mmultiple trait body composition QTL 9 (mouse)Not determined92679642160796552Mouse
10043878Adip20_madiposity 20 (mouse)Not determined92725119461251323Mouse
10043847Hdlq89_mHDL QTL 89 (mouse)Not determined92929292963293072Mouse
1301782Chol11_mcholesterol 11 (mouse)Not determined92929292963293072Mouse
1301365Ap5q_malcohol preference 5 QTL (mouse)Not determined93005316464053277Mouse
1357746Vtbt7_mvertebral trabecular bone trait 7 (mouse)Not determined93073991564740021Mouse
1302180Actd4_mactivity-distance traveled 4 (mouse)Not determined93243456366434857Mouse
4141148Cq5_mcholesterol QTL 5 (mouse)Not determined93245242166452546Mouse
1301692Hts_mhypothermia sensitivity (mouse)Not determined93251117266511421Mouse
4141323Ptnu3_mproteinuria 3 (mouse)Not determined93288970266889836Mouse
1357709Si5lq3_mserum IGFBP-5 level QTL 3 (mouse)Not determined93311102567111140Mouse
1558872Ibdq1_minflammatory bowel disease QTL 1 (mouse)Not determined93397884073439255Mouse
1301252Etohc3_methanol consumption 3 (mouse)Not determined93503447869034599Mouse
1301972Cocrb8_mcocaine related behavior 8 (mouse)Not determined93503447869034599Mouse
1558968Tbdr1_mbody temperature response to dietary restriction, QTL 1 (mouse)Not determined93503447869034599Mouse
10045613Rapop7_mradiation-induced apoptosis 6 (mouse)Not determined93673624349420511Mouse
1301501Lmr2_mleishmaniasis resistance 2 (mouse)Not determined93694340650111140Mouse
1301007Pid2_mprion incubation determinant 2 (mouse)Not determined93715336244251323Mouse
4142042Alpq3_malcohol preference QTL 3 (mouse)Not determined93730619798701707Mouse
10043971Obq32_mobesity QTL 32 (mouse)Not determined93781952871819528Mouse
12790986Pcho9_mplasma cholesterol 9 (mouse)93809957572099575Mouse
12790992Arlsq1_maortic root lesion size QTL 1 (mouse)93809957572099575Mouse
12791002Arlsq2_maortic root lesion size QTL 2 (mouse)93809957572099575Mouse
12738449Spcq2_msperm count QTL 2 (mouse)93939988573399885Mouse
1558993Tdmq1_mtype 2 diabetes modifying QTL 1 (mouse)Not determined94041959451808670Mouse
4141071Ath29_matherosclerosis 29 (mouse)Not determined94041959474607925Mouse
11532693Sluc39_msusceptibility to lung cancer 39 (mouse)94064537448351476Mouse
1301702Brm1_mbrachyury modifier 1 (mouse)Not determined94080504774805204Mouse
12738415Lfibq8_mliver fibrosis QTL 8 (mouse)94140216245343743Mouse
13515055Adip20a_madiposity 20a (mouse)94269071644053852Mouse

Markers in Region
RH136306  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38942,964,209 - 42,964,412UniSTSGRCm38
MGSCv37942,772,292 - 42,772,495UniSTSGRCm37
Celera940,216,618 - 40,216,821UniSTS
Cytogenetic Map9A5.1UniSTS
Cytogenetic Map9BUniSTS
Cytogenetic Map1C5UniSTS
UniSTS:236103  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38943,052,089 - 43,052,342UniSTSGRCm38
MGSCv37942,860,172 - 42,860,425UniSTSGRCm37
Cytogenetic Map9BUniSTS


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001359232 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_027144 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011242597 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011242598 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017313565 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017313566 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017313567 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_030244571 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_030244572 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_030244573 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036155253 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036155254 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC110169 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC160123 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC173346 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF467766 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK009331 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK086080 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK122267 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK134855 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK162687 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC052785 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466522 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSMUST00000072767   ⟹   ENSMUSP00000072547
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl942,875,139 - 43,016,781 (-)Ensembl
GRCm38.p6 Ensembl942,963,843 - 43,105,486 (-)Ensembl
RefSeq Acc Id: ENSMUST00000165665   ⟹   ENSMUSP00000126598
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl942,875,138 - 43,017,282 (-)Ensembl
GRCm38.p6 Ensembl942,963,842 - 43,105,987 (-)Ensembl
RefSeq Acc Id: ENSMUST00000213566   ⟹   ENSMUSP00000150833
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl942,929,423 - 42,953,928 (-)Ensembl
GRCm38.p6 Ensembl943,018,127 - 43,042,632 (-)Ensembl
RefSeq Acc Id: ENSMUST00000214175
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl942,937,300 - 42,939,114 (-)Ensembl
GRCm38.p6 Ensembl943,026,004 - 43,027,818 (-)Ensembl
RefSeq Acc Id: ENSMUST00000215898
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl942,935,642 - 43,018,534 (-)Ensembl
GRCm38.p6 Ensembl943,024,346 - 43,107,239 (-)Ensembl
RefSeq Acc Id: ENSMUST00000217502
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl942,936,243 - 42,937,956 (-)Ensembl
GRCm38.p6 Ensembl943,024,947 - 43,026,660 (-)Ensembl
RefSeq Acc Id: NM_001359232   ⟹   NP_001346161
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39942,875,138 - 43,017,013 (-)NCBI
GRCm38942,963,842 - 43,105,718 (-)NCBI
Sequence:
RefSeq Acc Id: NM_027144   ⟹   NP_081420
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39942,875,138 - 43,017,013 (-)NCBI
GRCm38942,963,842 - 43,105,718 (-)ENTREZGENE
MGSCv37942,771,925 - 42,913,801 (-)RGD
Celera940,216,251 - 40,358,722 (-)RGD
cM Map9 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_011242597   ⟹   XP_011240899
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39942,875,142 - 43,017,069 (-)NCBI
GRCm38942,968,331 - 43,105,254 (-)NCBI
Sequence:
RefSeq Acc Id: XM_011242598   ⟹   XP_011240900
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39942,875,142 - 42,991,314 (-)NCBI
GRCm38942,968,331 - 43,072,367 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017313565   ⟹   XP_017169054
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39942,875,142 - 43,017,069 (-)NCBI
GRCm38942,968,331 - 43,105,263 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017313566   ⟹   XP_017169055
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39942,875,142 - 43,017,069 (-)NCBI
GRCm38942,968,331 - 43,105,254 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017313567   ⟹   XP_017169056
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39942,875,142 - 42,991,314 (-)NCBI
GRCm38942,968,331 - 43,072,367 (-)NCBI
Sequence:
RefSeq Acc Id: XM_030244571   ⟹   XP_030100431
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39942,875,142 - 42,991,314 (-)NCBI
GRCm38942,968,331 - 43,072,367 (-)NCBI
Sequence:
RefSeq Acc Id: XM_030244572   ⟹   XP_030100432
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39942,875,142 - 42,991,314 (-)NCBI
GRCm38942,968,331 - 43,072,367 (-)NCBI
Sequence:
RefSeq Acc Id: XM_030244573   ⟹   XP_030100433
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39942,875,142 - 42,991,314 (-)NCBI
GRCm38942,968,331 - 43,072,367 (-)NCBI
Sequence:
RefSeq Acc Id: XM_036155253   ⟹   XP_036011146
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39942,875,142 - 43,017,069 (-)NCBI
Sequence:
RefSeq Acc Id: XM_036155254   ⟹   XP_036011147
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39942,875,142 - 43,017,069 (-)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_081420   ⟸   NM_027144
- Peptide Label: isoform 1
- UniProtKB: F8VQN6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_011240899   ⟸   XM_011242597
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_011240900   ⟸   XM_011242598
- Peptide Label: isoform X7
- Sequence:
RefSeq Acc Id: XP_017169056   ⟸   XM_017313567
- Peptide Label: isoform X5
- Sequence:
RefSeq Acc Id: XP_017169054   ⟸   XM_017313565
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_017169055   ⟸   XM_017313566
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: NP_001346161   ⟸   NM_001359232
- Peptide Label: isoform 2
- UniProtKB: Q8R4H2 (UniProtKB/Swiss-Prot),   E9QPW9 (UniProtKB/Swiss-Prot),   Q80U18 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_030100433   ⟸   XM_030244573
- Peptide Label: isoform X6
RefSeq Acc Id: XP_030100432   ⟸   XM_030244572
- Peptide Label: isoform X6
RefSeq Acc Id: XP_030100431   ⟸   XM_030244571
- Peptide Label: isoform X5
RefSeq Acc Id: ENSMUSP00000072547   ⟸   ENSMUST00000072767
RefSeq Acc Id: ENSMUSP00000126598   ⟸   ENSMUST00000165665
RefSeq Acc Id: ENSMUSP00000150833   ⟸   ENSMUST00000213566
RefSeq Acc Id: XP_036011146   ⟸   XM_036155253
- Peptide Label: isoform X4
RefSeq Acc Id: XP_036011147   ⟸   XM_036155254
- Peptide Label: isoform X7
Protein Domains
DH   PDZ   PH   RGSL

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q8R4H2-F1-model_v2 AlphaFold Q8R4H2 1-1543 view protein structure

Promoters
RGD ID:6844180
Promoter ID:MM_KWN:57059
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day3,   3T3L1_Day6,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6
Transcripts:ENSMUST00000072767,   NM_027144,   UC009PBB.1,   UC009PBC.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36942,913,311 - 42,914,607 (-)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1916882 AgrOrtholog
Ensembl Genes ENSMUSG00000059495 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000072767 ENTREZGENE
  ENSMUST00000072767.7 UniProtKB/Swiss-Prot
  ENSMUST00000165665 ENTREZGENE
  ENSMUST00000165665.9 UniProtKB/TrEMBL
  ENSMUST00000213566.2 UniProtKB/TrEMBL
Gene3D-CATH 1.10.167.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  1.20.900.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  2.30.29.30 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  2.30.42.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro ARHGEF12_PH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DBL_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DH-domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GDS_CDC24_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LARG_RGS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PDZ UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PDZ_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PH-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PH_16 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PH_domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RGS-like_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RGS_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RGS_subdomain_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:1916882 ENTREZGENE
NCBI Gene 69632 ENTREZGENE
PANTHER RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 12 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 2, ISOFORM D UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam PDZ UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PH_16 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RGS-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RhoGEF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Arhgef12 PhenoGen
PROSITE DH_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DH_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PDZ UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PH_DOMAIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART PDZ UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RhoGEF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SM00233 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP PH domain-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF48065 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF48097 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF50156 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A1L1SUP5_MOUSE UniProtKB/TrEMBL
  ARHGC_MOUSE UniProtKB/Swiss-Prot
  E9QPW9 ENTREZGENE
  F8VQN6 ENTREZGENE, UniProtKB/TrEMBL
  Q3UY99_MOUSE UniProtKB/TrEMBL
  Q7TSU5_MOUSE UniProtKB/TrEMBL
  Q80U18 ENTREZGENE
  Q8R4H2 ENTREZGENE
  Q9D7D6_MOUSE UniProtKB/TrEMBL
UniProt Secondary E9QPW9 UniProtKB/Swiss-Prot
  Q80U18 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2023-06-27 Arhgef12  Rho guanine nucleotide exchange factor 12  Arhgef12  Rho guanine nucleotide exchange factor (GEF) 12  Symbol and/or name change 5135510 APPROVED