Them4 (thioesterase superfamily member 4) - Rat Genome Database

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Gene: Them4 (thioesterase superfamily member 4) Mus musculus
Analyze
Symbol: Them4
Name: thioesterase superfamily member 4
RGD ID: 1312333
MGI Page MGI
Description: Predicted to enable long-chain fatty acyl-CoA hydrolase activity. Predicted to be involved in fatty acid metabolic process; phosphatidylinositol 3-kinase/protein kinase B signal transduction; and regulation of mitochondrial membrane permeability involved in apoptotic process. Predicted to act upstream of or within apoptotic process and lipid metabolic process. Located in mitochondrion. Is expressed in ganglia; hindbrain; and trigeminal nerve. Orthologous to human THEM4 (thioesterase superfamily member 4).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 2700077M13Rik; 4921507I02Rik; acyl-CoA thioesterase THEM4; acyl-coenzyme A thioesterase THEM4; carboxyl-terminal modulator protein
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39394,217,415 - 94,239,847 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl394,217,396 - 94,239,847 (+)EnsemblGRCm39 Ensembl
GRCm38394,310,132 - 94,332,540 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl394,310,089 - 94,332,540 (+)EnsemblGRCm38mm10GRCm38
MGSCv37394,114,054 - 94,136,454 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36394,395,493 - 94,417,946 (+)NCBIMGSCv36mm8
Celera395,756,462 - 95,778,900 (+)NCBICelera
Cytogenetic Map3F2.1NCBI
cM Map340.51NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. Functional annotation of a full-length mouse cDNA collection. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
2. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
3. Mouse MP Annotation Import Pipeline RGD automated import pipeline
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:8889548   PMID:10349636   PMID:10922068   PMID:11042159   PMID:11076861   PMID:12477932   PMID:14610273   PMID:15782199   PMID:16141072   PMID:16141073   PMID:18614015   PMID:19421406  
PMID:21267068   PMID:21677750   PMID:24670215   PMID:29945911   PMID:30850672   PMID:32325033   PMID:36652767  


Genomics

Comparative Map Data
Them4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39394,217,415 - 94,239,847 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl394,217,396 - 94,239,847 (+)EnsemblGRCm39 Ensembl
GRCm38394,310,132 - 94,332,540 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl394,310,089 - 94,332,540 (+)EnsemblGRCm38mm10GRCm38
MGSCv37394,114,054 - 94,136,454 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36394,395,493 - 94,417,946 (+)NCBIMGSCv36mm8
Celera395,756,462 - 95,778,900 (+)NCBICelera
Cytogenetic Map3F2.1NCBI
cM Map340.51NCBI
THEM4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381151,870,866 - 151,909,511 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1151,870,866 - 151,909,637 (-)EnsemblGRCh38hg38GRCh38
GRCh371151,843,342 - 151,881,987 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361150,112,684 - 150,148,737 (-)NCBINCBI36Build 36hg18NCBI36
Celera1124,960,686 - 124,996,752 (-)NCBICelera
Cytogenetic Map1q21.3NCBI
HuRef1123,220,428 - 123,259,463 (-)NCBIHuRef
CHM1_11153,238,619 - 153,277,644 (-)NCBICHM1_1
T2T-CHM13v2.01150,994,382 - 151,033,015 (-)NCBIT2T-CHM13v2.0
Them4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82184,642,603 - 184,663,752 (+)NCBIGRCr8
mRatBN7.22181,953,550 - 181,974,708 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2181,953,550 - 181,974,708 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2189,610,680 - 189,631,387 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02187,421,627 - 187,442,278 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02182,243,148 - 182,263,858 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02195,554,092 - 195,576,710 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2195,553,971 - 195,577,680 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02215,034,646 - 215,055,404 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42189,287,025 - 189,308,334 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12189,237,130 - 189,258,440 (+)NCBI
Celera2174,503,573 - 174,524,410 (+)NCBICelera
Cytogenetic Map2q34NCBI
Them4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955589517,600 - 547,649 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955589517,489 - 545,779 (+)NCBIChiLan1.0ChiLan1.0
THEM4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2197,913,430 - 97,949,797 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1197,664,627 - 97,701,004 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01127,229,378 - 127,268,884 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11130,876,364 - 130,912,751 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1130,876,364 - 130,912,751 (-)Ensemblpanpan1.1panPan2
THEM4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11760,889,245 - 60,924,848 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1760,891,660 - 60,925,091 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1760,337,687 - 60,369,117 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01761,902,842 - 61,944,538 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1761,907,450 - 61,944,493 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11760,735,719 - 60,771,111 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01760,826,006 - 60,857,205 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01761,554,930 - 61,586,689 (-)NCBIUU_Cfam_GSD_1.0
Them4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505823,028,583 - 23,055,423 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365802,058,643 - 2,085,945 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365802,058,960 - 2,085,919 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
Them4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462477219,673,066 - 19,698,710 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462477219,673,079 - 19,704,635 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Them4
913 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:518
Count of miRNA genes:402
Interacting mature miRNAs:434
Transcripts:ENSMUST00000049822, ENSMUST00000142178, ENSMUST00000151753
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
26884436Zlq3_mzygomatic length QTL 3, 10 week (mouse)33265060142405761Mouse
4142399Aec1_mautoimmune exocrinopathy 1 (mouse)Not determined7586174102690034Mouse
26884427Cvht4_mcranial vault height 4, 10 week (mouse)316054164109707316Mouse
13207570Tcq12_mtotal cholesterol QTL 12 (mouse)316504164130163649Mouse
26884422Cvht7_mcranial vault height 7, 16 week (mouse)328954149118893649Mouse
1302056Orgwq4_morgan weight QTL 4 (mouse)Not determined330067588147304689Mouse
1301705Sles3_msystemic lupus erythmatosus suppressor 3 (mouse)Not determined337174862143353183Mouse
13208566Bmiq5_mbody mass index QTL 5 (mouse)340954435115793649Mouse
26884380Skwq1_mskull length QTL 1, 5 week (mouse)343954435101607316Mouse
26884378Skwq6_mskull length QTL 6, 10 week (mouse)351907421102307316Mouse
26884382Bzwq1_mbi-zygomatic width QTL 1, 5 week (mouse)352207421137205761Mouse
11039519Ltpr3_mLeishmania tropica response 3 (mouse)356704102100464137Mouse
4141294Bmd24_mbone mineral density 24 (mouse)Not determined36174006195740241Mouse
1301971Cia5_mcollagen induced arthritis QTL 5 (mouse)Not determined366046658100046795Mouse
25314313Syncl1_msynaptonemal complex length 1 (mouse)367907333128393649Mouse
11251721Ewc3_methanol withdrawal and consumption 3 (mouse)369568554103568554Mouse
1301791Char4_mP. chabaudi malaria resistance QTL 4 (mouse)Not determined369625509100655290Mouse
1301422Sle11_msystematic lupus erythematosus susceptibility 11 (mouse)Not determined370208904104209042Mouse
11049572Lmr11c_mleishmaniasis resistance 11c (mouse)372139967106140094Mouse
1300982Lmr11_mleishmaniasis resistance 11 (mouse)Not determined372139967106140094Mouse
1300595Tmevd2_mTheiler's murine encephalomyelitis virus induced demyelinating disease susceptibility 2 (mouse)Not determined375463302109463549Mouse
1301392Eae3_msusceptibility to experimental allergic encephalomyelitis 3 (mouse)Not determined379548730113548837Mouse
1301947Pcfm3_mperiosteal circumference and femur length 3 (mouse)Not determined381084652115084797Mouse
1301904Iba2_minduction of brown adipocytes 2 (mouse)Not determined382147043116147184Mouse
11041900Lmr11a_mleishmaniasis resistance 11a (mouse)383463991117464137Mouse
11039510Ltpr3d_mLeishmania tropica response 3d (mouse)383463991117464137Mouse
11039511Ltpr3c_mLeishmania tropica response 3c (mouse)383463991117464137Mouse
11039507Ltpr3g_mLeishmania tropica response 3g (mouse)383463991117464137Mouse
11039508Ltpr3f_mLeishmania tropica response 3f (mouse)383463991117464137Mouse
11039509Ltpr3e_mLeishmania tropica response 3e (mouse)383463991117464137Mouse
11039512Ltpr3b_mLeishmania tropica response 3b (mouse)383463991117464137Mouse
1301272Cfsw1_mcystic fibrosis survival to weaning 1 (mouse)Not determined383882912117883044Mouse
4142099Cq3_mcholesterol QTL 3 (mouse)Not determined384888918118889067Mouse
14746984Manh54_mmandible shape 54 (mouse)385289152119289152Mouse
1357583Sle18_msystematic lupus erythematosus susceptibility 18 (mouse)Not determined387208904125316236Mouse
12738440Twq3_mtestis weight QTL 3 (mouse)387228015121228015Mouse
4142178Ctrq2_mC. trachomatis resistance QTL 2 (mouse)Not determined389139967137453008Mouse
10766455Sle22_msystematic lupus erythematosus susceptibility 22 (mouse)390376936124377072Mouse
14747001Mancz4_mmandible centroid size 4 (mouse)390378017124378017Mouse
1301398Rapop3_mradiation-induced apoptosis 3 (mouse)Not determined390511217100464137Mouse
1302052Etohcta4_methanol conditioned taste aversion 4 (mouse)Not determined391000105125008748Mouse
1301349Pgia26_mproteoglycan induced arthritis 26 (mouse)Not determined392251533126251650Mouse


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000049822   ⟹   ENSMUSP00000062841
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl394,217,396 - 94,239,847 (+)Ensembl
GRCm38.p6 Ensembl394,310,089 - 94,332,540 (+)Ensembl
RefSeq Acc Id: ENSMUST00000196824
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl394,217,437 - 94,225,477 (+)Ensembl
GRCm38.p6 Ensembl394,310,130 - 94,318,170 (+)Ensembl
RefSeq Acc Id: ENSMUST00000198494
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl394,217,443 - 94,233,341 (+)Ensembl
GRCm38.p6 Ensembl394,310,136 - 94,326,034 (+)Ensembl
RefSeq Acc Id: NM_029431   ⟹   NP_083707
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39394,217,471 - 94,239,847 (+)NCBI
GRCm38394,310,132 - 94,332,532 (+)NCBI
MGSCv37394,114,054 - 94,136,454 (+)RGD
Celera395,756,462 - 95,778,900 (+)RGD
cM Map3 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_030252868   ⟹   XP_030108728
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39394,217,554 - 94,239,847 (+)NCBI
GRCm38394,310,247 - 94,332,540 (+)NCBI
Sequence:
RefSeq Acc Id: XM_036163383   ⟹   XP_036019276
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39394,217,415 - 94,239,847 (+)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_083707   ⟸   NM_029431
- UniProtKB: Q8R234 (UniProtKB/Swiss-Prot),   Q8BYS9 (UniProtKB/Swiss-Prot),   A3KPD5 (UniProtKB/Swiss-Prot),   Q9D5Y3 (UniProtKB/Swiss-Prot),   Q3UUI3 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_030108728   ⟸   XM_030252868
- Peptide Label: isoform X1
RefSeq Acc Id: ENSMUSP00000062841   ⟸   ENSMUST00000049822
RefSeq Acc Id: XP_036019276   ⟸   XM_036163383
- Peptide Label: isoform X1

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q3UUI3-F1-model_v2 AlphaFold Q3UUI3 1-230 view protein structure

Promoters
RGD ID:6834540
Promoter ID:MM_KWN:35191
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   3T3L1_Day6,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6
Transcripts:OTTMUST00000073403,   OTTMUST00000073405,   UC008QFT.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36394,113,804 - 94,114,304 (+)MPROMDB
RGD ID:6881484
Promoter ID:EPDNEW_M4193
Type:initiation region
Name:Them4_1
Description:Mus musculus thioesterase superfamily member 4 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38394,310,164 - 94,310,224EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1923028 AgrOrtholog
Ensembl Genes ENSMUSG00000028145 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000049822 ENTREZGENE
  ENSMUST00000049822.10 UniProtKB/Swiss-Prot
Gene3D-CATH Hotdog Thioesterase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro HotDog_dom_sf UniProtKB/Swiss-Prot
  Thioestr_dom UniProtKB/Swiss-Prot
KEGG Report mmu:75778 UniProtKB/Swiss-Prot
MGD MGI:1923028 ENTREZGENE
NCBI Gene 75778 ENTREZGENE
PANTHER ACYL-COENZYME A THIOESTERASE THEM4 UniProtKB/Swiss-Prot
  ACYL-COENZYME A THIOESTERASE THEM4 UniProtKB/Swiss-Prot
  ACYL-COENZYME A THIOESTERASE THEM4 UniProtKB/TrEMBL
  ACYL-COENZYME A THIOESTERASE THEM4 UniProtKB/TrEMBL
Pfam 4HBT UniProtKB/Swiss-Prot
PhenoGen Them4 PhenoGen
Superfamily-SCOP SSF54637 UniProtKB/Swiss-Prot
UniProt A3KPD5 ENTREZGENE
  Q3USX4_MOUSE UniProtKB/TrEMBL
  Q3UUI3 ENTREZGENE
  Q8BYS9 ENTREZGENE
  Q8R234 ENTREZGENE
  Q9D5Y3 ENTREZGENE
  THEM4_MOUSE UniProtKB/Swiss-Prot
UniProt Secondary A3KPD5 UniProtKB/Swiss-Prot
  Q8BYS9 UniProtKB/Swiss-Prot
  Q8R234 UniProtKB/Swiss-Prot
  Q9D5Y3 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-04-28 Them4  thioesterase superfamily member 4  Them4  thioesterase superfamily member 4  Data merged from RGD:1557524 737654 PROVISIONAL