Them4 (thioesterase superfamily member 4)

Gene: Them4 (thioesterase superfamily member 4) Chinchilla lanigera

Analyze

Symbol:

Them4

Name:

thioesterase superfamily member 4

RGD ID:

8876513

Description:

ENCODES a protein that exhibits long-chain fatty acyl-CoA hydrolase activity (ortholog); INVOLVED IN fatty acid metabolic process (ortholog); negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction (ortholog); regulation of mitochondrial membrane permeability involved in apoptotic process (ortholog); ASSOCIATED WITH gastrointestinal stromal tumor (ortholog); hepatocellular carcinoma (ortholog); immunodeficiency 42 (ortholog); FOUND IN cytosol (ortholog); mitochondrion (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

acyl-coenzyme A thioesterase THEM4

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

ChiLan1.0 - Chinchilla ChiLan1.0 Assembly

Position:

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955589	517,600 - 547,649 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955589	517,489 - 545,779 (+)	NCBI	ChiLan1.0	ChiLan1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

gastrointestinal stromal tumor (ISO)

hepatocellular carcinoma (ISO)

immunodeficiency 42 (ISO)

MHC class II deficiency (ISO)

parathyroid carcinoma (ISO)

severe congenital neutropenia 3 (ISO)

severe congenital neutropenia 5 (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

fatty acid metabolic process (ISO)

negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction (ISO)

regulation of mitochondrial membrane permeability involved in apoptotic process (ISO)

Cellular Component

cytosol (ISO)

mitochondrion (ISO)

Molecular Function

long-chain fatty acyl-CoA hydrolase activity (ISO)

protein binding (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Transitive Annotation Pipeline	Automated assignment of GO, PW and RDO ISO annotations across species

Genomics

Comparative Map Data

Them4
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955589	517,600 - 547,649 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955589	517,489 - 545,779 (+)	NCBI	ChiLan1.0	ChiLan1.0

THEM4
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	1	151,870,866 - 151,909,511 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	1	151,870,866 - 151,909,637 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	1	151,843,342 - 151,881,987 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	1	150,112,684 - 150,148,737 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Celera	1	124,960,686 - 124,996,752 (-)	NCBI		Celera
Cytogenetic Map	1	q21.3	NCBI
HuRef	1	123,220,428 - 123,259,463 (-)	NCBI		HuRef
CHM1_1	1	153,238,619 - 153,277,644 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	1	150,994,382 - 151,033,015 (-)	NCBI		T2T-CHM13v2.0

Them4
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	3	94,217,415 - 94,239,847 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	3	94,217,396 - 94,239,847 (+)	Ensembl		GRCm39 Ensembl
GRCm38	3	94,310,132 - 94,332,540 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	3	94,310,089 - 94,332,540 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	3	94,114,054 - 94,136,454 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	3	94,395,493 - 94,417,946 (+)	NCBI		MGSCv36	mm8
Celera	3	95,756,462 - 95,778,900 (+)	NCBI		Celera
Cytogenetic Map	3	F2.1	NCBI
cM Map	3	40.51	NCBI

Them4
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	2	184,642,603 - 184,663,752 (+)	NCBI		GRCr8
mRatBN7.2	2	181,953,550 - 181,974,708 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	2	181,953,550 - 181,974,708 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	2	189,610,680 - 189,631,387 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	2	187,421,627 - 187,442,278 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	2	182,243,148 - 182,263,858 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	2	195,554,092 - 195,576,710 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	2	195,553,971 - 195,577,680 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	2	215,034,646 - 215,055,404 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	2	189,287,025 - 189,308,334 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	2	189,237,130 - 189,258,440 (+)	NCBI
Celera	2	174,503,573 - 174,524,410 (+)	NCBI		Celera
Cytogenetic Map	2	q34	NCBI

THEM4
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	1	97,913,430 - 97,949,797 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	1	97,664,627 - 97,701,004 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	1	127,229,378 - 127,268,884 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	1	130,876,364 - 130,912,751 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	1	130,876,364 - 130,912,751 (-)	Ensembl	panpan1.1		panPan2

THEM4
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	17	60,889,245 - 60,924,848 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	17	60,891,660 - 60,925,091 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	17	60,337,687 - 60,369,117 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	17	61,902,842 - 61,944,538 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	17	61,907,450 - 61,944,493 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	17	60,735,719 - 60,771,111 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	17	60,826,006 - 60,857,205 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	17	61,554,930 - 61,586,689 (-)	NCBI		UU_Cfam_GSD_1.0

Them4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405058	23,028,583 - 23,055,423 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936580	2,058,643 - 2,085,945 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936580	2,058,960 - 2,085,919 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

Them4
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624772	19,673,066 - 19,698,710 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624772	19,673,079 - 19,704,635 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_005414537	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AGCD01076175	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	GBDF01122861	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSCLAT00000000517 ⟹ ENSCLAP00000000488

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0 Ensembl	NW_004955589	517,600 - 547,649 (+)	Ensembl

RefSeq Acc Id:

XM_005414537 ⟹ XP_005414594

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0	NW_004955589	517,489 - 545,779 (+)	NCBI

Sequence:

show sequence

CCCTTCGCGGGAGTTCATTCTGGCGTTCTTTGGGGCACCCGGCTTGCGAAGGGCTGCGCCGGCC
TGCCCGGCTGTCTCCGCAGAAGCCACGCTCATCCGCCGTCCGGAGCCATGCTGAGGAGCTGCGC
CGCGCGCCTGCGCACGCTCGGGGCCTCTCGGGGAGGTGCGCGCGGCCCGGGAGCTGCGAGGAGA
TCATTTGCTTCTGAGGAAGTTGTTGACAAGGACTGTGCTCTCCCCAACCCCAGCTGGAGCAAGG
ACTTACGACTTCTCTTTGACCAGTTCATGAAGAAGTGTGAGGAGGGCTCATGGAAGCGTTTGCC
TTCCTACAAACGGAGCTCTACTCAGAATTTTAAAGACTTCAGAACCCATTATGTTGACCCAAAG
CTTCTGAAAGAAGAACAAATGTCAGAGGCCCAGCTTTTCACCAGAAGCTTTGAGGACGGCCTAG
GCTTTGAGTATGTGATGTTCTGTAACGATGCCGAGAAAAGAGTTGTTTGCTTTTTCCAAGGAGG
CCCTCGCTTGCAGGGAGTACCTGGATTCACACACGGTGGTGCCATCGCATCCATCATCGATGCT
ACCGTTGGTACCTGTGCATTTAGAGCCGGAGGAGTTGTCATGACTGCCAACCTCAACATCAATT
ATAAAAGACCTATTCCCCTTTGTTCTGTTGTTGTGATAGATGGCCAACTTGATAGAGTTGAAGG
AAGGAAATTTTTTGTTTCCTGTAGTGTTCGAAGTGTCAGTGAGGAGACCTTGTACTCAGAGGCA
ACAAGCTTATTTATAGCACTGGACCCTAATAAAAAACTGACTTAGAAGAGCTTCTGGTGAATTC
CACCTCACTTTCTGTGAGGCTTCCCCTTCTCCAGAAGAGGAGGTGCCCCCACTCCTGCACTACG
GATGCGCGGGGAAGCTGCTGACACTGACCTTCGGGAACAGCCTTCTGAGCACCACTCCCGGAGC
CCCCTTTCCACCTTCTAACCTTTTTAAGAAGAAATACTCCCGTGAGAGTACTGGCAATTCTGTG
TAACTCCTTAGGGTACCTGTGTGGGGCTCCTGAAATTTGAATGGGCTCCTTAAAGTTGCACAAC
CGTGGCATCTGCCCCACCTCAGACTGAAGACAAAAATCTGTGTTGAAGCTTGCGCTGCAAACTA
GGAAATGCTAGACAACCGAAAAAGGAAATACGTGGGATTGTGTGTAGGTGTACACATGTGTGCG
TATGTACGTTGTAAATTACAAAGCCATCTTCGTTGTATCTGAACAAACATATCTTTTGGCCAGG
GTGGGAACACAGCTGGTTCCTATAAGAATGGATACCTCAGATCTCTTGCCTAGAGTTCTACGGA
TTAAACCACTGTACTTTTTTTAACA

hide sequence

Protein Sequences


Protein RefSeqs	XP_005414594	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSCLAP00000000488
	ENSCLAP00000000488.1

RefSeq Acc Id:

XP_005414594 ⟸ XM_005414537

- UniProtKB:

A0A8C2UIG8 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MLRSCAARLRTLGASRGGARGPGAARRSFASEEVVDKDCALPNPSWSKDLRLLFDQFMKKCEEG
SWKRLPSYKRSSTQNFKDFRTHYVDPKLLKEEQMSEAQLFTRSFEDGLGFEYVMFCNDAEKRVV
CFFQGGPRLQGVPGFTHGGAIASIIDATVGTCAFRAGGVVMTANLNINYKRPIPLCSVVVIDGQ
LDRVEGRKFFVSCSVRSVSEETLYSEATSLFIALDPNKKLT

hide sequence

RefSeq Acc Id:

ENSCLAP00000000488 ⟸ ENSCLAT00000000517

Protein Domains

Thioesterase

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSCLAG00000000400	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSCLAT00000000517	ENTREZGENE
	ENSCLAT00000000517.1	UniProtKB/TrEMBL
Gene3D-CATH	Hotdog Thioesterase	UniProtKB/TrEMBL
InterPro	HotDog_dom_sf	UniProtKB/TrEMBL
	Thioestr_dom	UniProtKB/TrEMBL
NCBI Gene	Them4	ENTREZGENE
PANTHER	ACYL-COENZYME A THIOESTERASE THEM4	UniProtKB/TrEMBL
	ACYL-COENZYME A THIOESTERASE THEM4	UniProtKB/TrEMBL
Pfam	4HBT	UniProtKB/TrEMBL
Superfamily-SCOP	SSF54637	UniProtKB/TrEMBL
UniProt	A0A8C2UIG8	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD