Dmpk (DM1 protein kinase) - Rat Genome Database

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Gene: Dmpk (DM1 protein kinase) Rattus norvegicus
Analyze
Symbol: Dmpk
Name: DM1 protein kinase
RGD ID: 1309825
Description: Predicted to enable ATP binding activity; myosin phosphatase regulator activity; and protein serine/threonine kinase activity. Predicted to be involved in several processes, including muscle cell apoptotic process; regulation of skeletal muscle contraction by calcium ion signaling; and regulation of synapse structural plasticity. Predicted to act upstream of or within regulation of excitatory postsynaptic membrane potential involved in skeletal muscle contraction and regulation of sodium ion transport. Predicted to be located in several cellular components, including bounding membrane of organelle; cytosol; and nuclear membrane. Human ortholog(s) of this gene implicated in myotonic dystrophy type 1. Orthologous to human DMPK (DM1 protein kinase); INTERACTS WITH (+)-schisandrin B; 2,3,7,8-tetrachlorodibenzodioxine; 3,3',5-triiodo-L-thyronine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Dm15; dystrophia myotonica kinase, B15; dystrophia myotonica-protein kinase; LOC308405; myotonin-protein kinase
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8187,858,294 - 87,868,624 (+)NCBIGRCr8
mRatBN7.2178,730,255 - 78,740,585 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl178,730,275 - 78,740,593 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx184,119,202 - 84,129,502 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0192,676,889 - 92,687,183 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0185,874,300 - 85,884,600 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0179,988,096 - 79,999,358 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl179,989,019 - 79,999,364 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0181,257,000 - 81,267,133 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4178,449,324 - 78,450,578 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1178,518,239 - 78,529,227 (+)NCBI
Celera173,194,993 - 73,206,254 (+)NCBICelera
Cytogenetic Map1q21NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. A novel homeodomain-encoding gene is associated with a large CpG island interrupted by the myotonic dystrophy unstable (CTG)n repeat. Boucher CA, etal., Hum Mol Genet. 1995 Oct;4(10):1919-25.
2. Mass spectrometry analysis of complexes formed by myotonic dystrophy protein kinase (DMPK). Forner F, etal., Biochim Biophys Acta. 2010 Jun;1804(6):1334-41. Epub 2010 Feb 25.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
5. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
6. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
7. GOA pipeline RGD automated data pipeline
8. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
9. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
10. Comprehensive gene review and curation RGD comprehensive gene curation
Additional References at PubMed
PMID:9294109   PMID:10913253   PMID:11287000   PMID:11526199   PMID:12612014   PMID:15598648   PMID:15684391   PMID:17719582   PMID:18729234   PMID:21949239   PMID:29648621  


Genomics

Comparative Map Data
Dmpk
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8187,858,294 - 87,868,624 (+)NCBIGRCr8
mRatBN7.2178,730,255 - 78,740,585 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl178,730,275 - 78,740,593 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx184,119,202 - 84,129,502 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0192,676,889 - 92,687,183 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0185,874,300 - 85,884,600 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0179,988,096 - 79,999,358 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl179,989,019 - 79,999,364 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0181,257,000 - 81,267,133 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4178,449,324 - 78,450,578 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1178,518,239 - 78,529,227 (+)NCBI
Celera173,194,993 - 73,206,254 (+)NCBICelera
Cytogenetic Map1q21NCBI
DMPK
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381945,769,709 - 45,782,490 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1945,769,709 - 45,782,552 (-)EnsemblGRCh38hg38GRCh38
GRCh371946,272,967 - 46,285,748 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361950,964,815 - 50,977,655 (-)NCBINCBI36Build 36hg18NCBI36
Build 341950,964,815 - 50,977,576NCBI
Celera1943,079,095 - 43,090,866 (-)NCBICelera
Cytogenetic Map19q13.32NCBI
HuRef1942,701,722 - 42,714,534 (-)NCBIHuRef
CHM1_11946,276,489 - 46,288,326 (-)NCBICHM1_1
T2T-CHM13v2.01948,597,244 - 48,609,980 (-)NCBIT2T-CHM13v2.0
Dmpk
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39718,817,571 - 18,827,746 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl718,817,774 - 18,827,746 (+)EnsemblGRCm39 Ensembl
GRCm38719,083,646 - 19,093,821 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl719,083,849 - 19,093,821 (+)EnsemblGRCm38mm10GRCm38
MGSCv37719,669,198 - 19,679,170 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36718,242,517 - 18,251,624 (+)NCBIMGSCv36mm8
Celera716,495,229 - 16,505,182 (+)NCBICelera
Cytogenetic Map7A3NCBI
cM Map79.46NCBI
Dmpk
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955574226,292 - 237,526 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955574225,615 - 237,526 (-)NCBIChiLan1.0ChiLan1.0
DMPK
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22051,935,294 - 51,948,741 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11953,806,747 - 53,819,563 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01942,779,173 - 42,791,981 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11951,316,099 - 51,329,421 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1951,316,099 - 51,329,355 (-)Ensemblpanpan1.1panPan2
DMPK
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11109,824,103 - 109,834,986 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1109,824,597 - 109,834,976 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1109,309,270 - 109,320,016 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01110,357,335 - 110,368,093 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1110,357,272 - 110,368,093 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11110,032,956 - 110,043,712 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01109,667,626 - 109,678,376 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01110,536,417 - 110,547,165 (+)NCBIUU_Cfam_GSD_1.0
Dmpk
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934917,777,894 - 17,788,794 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049367062,124,238 - 2,134,976 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049367062,125,237 - 2,135,974 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DMPK
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl652,100,259 - 52,110,478 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1652,100,259 - 52,110,822 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
DMPK
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1639,219,625 - 39,232,203 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl639,220,355 - 39,232,015 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607318,852,196 - 18,865,776 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Dmpk
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248327,419,689 - 7,429,084 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248327,419,529 - 7,429,744 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Dmpk
38 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:503
Count of miRNA genes:181
Interacting mature miRNAs:198
Transcripts:ENSRNOT00000020428, ENSRNOT00000038152, ENSRNOT00000041817, ENSRNOT00000067933
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1554320Bmd1Bone mineral density QTL 112.20.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)150910886060548Rat
631688Hcas2Hepatocarcinoma susceptibility QTL 230.0001liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)15925874115540829Rat
2313062Bmd73Bone mineral density QTL 733.90.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)11148131282174945Rat
2313065Bss67Bone structure and strength QTL 673.10.0001tibia area (VT:1000281)tibia total energy absorbed before break (CMO:0001736)11148131282174945Rat
2313069Bss68Bone structure and strength QTL 682.90.0001tibia size trait (VT:0100001)tibia total energy absorbed before break (CMO:0001736)11148131282174945Rat
2313075Bss66Bone structure and strength QTL 663.40.0001tibia length (VT:0004357)tibia length (CMO:0000450)11148131282174945Rat
2313077Bss69Bone structure and strength QTL 693.50.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)11148131282174945Rat
2313092Bmd72Bone mineral density QTL 722.50.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)11148131282174945Rat
2313097Bss70Bone structure and strength QTL 703.50.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)11148131282174945Rat
631495Bp96Blood pressure QTL 964.52arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)122340647102268831Rat
1358359Sradr1Stress Responsive Adrenal Weight QTL 14.74adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)130882023123479925Rat
70225Bp58Blood pressure QTL 583.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132356093162846471Rat
1300172Bp172Blood pressure QTL 1723.56arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)13273727390665040Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132737458199368955Rat
8552900Pigfal1Plasma insulin-like growth factor 1 level QTL 17.4blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)13483685879836858Rat
8552948Pigfal11Plasma insulin-like growth factor 1 level QTL 114.7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)13483685879836858Rat
9589820Insglur3Insulin/glucose ratio QTL 310.750.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)13483685879836858Rat
2313051Bss57Bone structure and strength QTL 573.70.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)143284731118944897Rat
2313059Bss55Bone structure and strength QTL 553.20.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)143284731118944897Rat
2313072Bss53Bone structure and strength QTL 534.30.0001tibia length (VT:0004357)tibia length (CMO:0000450)143284731118944897Rat
2313078Bss54Bone structure and strength QTL 543.50.0001tibia area (VT:1000281)tibia midshaft cross-sectional area (CMO:0001717)143284731118944897Rat
2313094Bss58Bone structure and strength QTL 583.70.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)143284731118944897Rat
2313098Bmd70Bone mineral density QTL 703.60.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)143284731118944897Rat
2313099Bss56Bone structure and strength QTL 562.40.0001tibia size trait (VT:0100001)tibia midshaft endosteal cross-sectional area (CMO:0001716)143284731118944897Rat
2302059Pia36Pristane induced arthritis QTL 363.80.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)14333300288333002Rat
2313402Anxrr24Anxiety related response QTL 24aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)148963584144267916Rat
4889962Bss94Bone structure and strength QTL 943.8tibia area (VT:1000281)tibia-fibula cortical bone endosteal cross-sectional area (CMO:0001722)14936146582174945Rat
1578649Bmd8Bone mineral density QTL 84.9femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)14939317294393172Rat
1578654Bss10Bone structure and strength QTL 104femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)149393172159356837Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)149393289199050459Rat
6903308Scl36Serum cholesterol QTL 3620.0125blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)15386304190532583Rat
4889919Bss86Bone structure and strength QTL 864.1tibia area (VT:1000281)tibia midshaft total cross-sectional area (CMO:0001715)15389511782174945Rat
4889929Bss87Bone structure and strength QTL 876.7tibia area (VT:1000281)tibia-fibula cortical bone endosteal cross-sectional area (CMO:0001722)15389511782174945Rat
61342Bp27Blood pressure QTL 273.40.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)15673266898773277Rat
2300164Bmd44Bone mineral density QTL 445.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)156949932101949932Rat
2298545Neuinf8Neuroinflammation QTL 84.6nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)157336763151090257Rat
1300121Hrtrt1Heart rate QTL 13.7heart pumping trait (VT:2000009)heart rate (CMO:0000002)165789093115540829Rat
7421628Bp361Blood pressure QTL 3610.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)166023617118608521Rat
631512Scl6Serum cholesterol level QTL 69.6blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)17219768090508767Rat
1358192Ept13Estrogen-induced pituitary tumorigenesis QTL 133.4pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)177494165122494165Rat
10054135Gmadr2Adrenal mass QTL 21.970.0129adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)177857876122857876Rat
1549903Bp267Blood pressure QTL 267arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)177876254106047988Rat
61344Bp29Blood pressure QTL 297.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)178350581123350581Rat
7411712Strs4Sensitivity to stroke QTL 48.7cerebrum integrity trait (VT:0010549)percentage of study population developing cerebrovascular lesions during a period of time (CMO:0000932)178430536123430536Rat
61433Cia2Collagen induced arthritis QTL 25joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)17843075491209302Rat
1582234Gluco18Glucose level QTL 183.40.0003blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)178479925123479925Rat

Markers in Region
Dm15  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_5.0181,265,083 - 81,266,858NCBIRnor5.0
RGSC_v3.4178,449,067 - 78,450,841UniSTSRGSC3.4
Celera173,204,205 - 73,205,979UniSTS
Cytogenetic Map1q21UniSTS
RH130797  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2178,740,351 - 78,740,551 (+)MAPPERmRatBN7.2
Rnor_6.0179,999,125 - 79,999,324NCBIRnor6.0
Rnor_5.0181,266,900 - 81,267,099UniSTSRnor5.0
RGSC_v3.4178,450,883 - 78,451,082UniSTSRGSC3.4
Celera173,206,021 - 73,206,220UniSTS
RH 3.4 Map1789.7UniSTS
Cytogenetic Map1q21UniSTS
RH139376  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2178,736,150 - 78,736,220 (+)MAPPERmRatBN7.2
Rnor_6.0179,994,924 - 79,994,993NCBIRnor6.0
Rnor_5.0181,262,699 - 81,262,768UniSTSRnor5.0
RGSC_v3.4178,446,682 - 78,446,751UniSTSRGSC3.4
Celera173,201,820 - 73,201,889UniSTS
RH 3.4 Map1789.0UniSTS
Cytogenetic Map1q21UniSTS
Dmpk  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2178,732,752 - 78,733,320 (+)MAPPERmRatBN7.2
Rnor_6.0179,991,526 - 79,992,093NCBIRnor6.0
Rnor_5.0181,259,498 - 81,260,065UniSTSRnor5.0
RGSC_v3.4178,442,586 - 78,443,153UniSTSRGSC3.4
Celera173,198,423 - 73,198,989UniSTS
Cytogenetic Map1q21UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 43 5 4 4 4 8 11 66 26 34 11 8
Low 52 37 15 37 8 9 7
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001372064 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001415847 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001415848 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001415849 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006223104 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006223105 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006223106 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006223107 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006223108 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006223109 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006223110 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006223112 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008759040 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008759041 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008759042 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008759044 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008759045 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008759048 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008759049 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008759051 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008774440 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008774441 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008774442 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008774443 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017588052 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017589995 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039111232 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039111235 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039111254 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039111256 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039111258 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063261308 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063261309 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063261312 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063261313 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063261319 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063261320 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063261324 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063261329 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063261330 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063261332 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063261333 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063261336 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC120692 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473979 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ217505 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ224460 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ235737 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000001 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

RefSeq Acc Id: ENSRNOT00000020428   ⟹   ENSRNOP00000020428
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl178,730,284 - 78,740,581 (+)Ensembl
Rnor_6.0 Ensembl179,989,019 - 79,999,364 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000105612   ⟹   ENSRNOP00000095056
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl178,730,275 - 78,740,593 (+)Ensembl
RefSeq Acc Id: NM_001372064   ⟹   NP_001358993
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8187,858,323 - 87,868,624 (+)NCBI
mRatBN7.2178,730,284 - 78,740,585 (+)NCBI
RefSeq Acc Id: NM_001415847   ⟹   NP_001402776
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8187,858,323 - 87,868,624 (+)NCBI
mRatBN7.2178,730,284 - 78,740,585 (+)NCBI
RefSeq Acc Id: NM_001415848   ⟹   NP_001402777
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8187,858,323 - 87,868,624 (+)NCBI
mRatBN7.2178,730,284 - 78,740,585 (+)NCBI
RefSeq Acc Id: NM_001415849   ⟹   NP_001402778
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8187,858,323 - 87,868,624 (+)NCBI
mRatBN7.2178,730,284 - 78,740,585 (+)NCBI
RefSeq Acc Id: XM_008759049   ⟹   XP_008757271
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8187,858,294 - 87,867,311 (+)NCBI
mRatBN7.2178,730,255 - 78,739,272 (+)NCBI
Rnor_6.0179,988,096 - 79,998,074 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017589995   ⟹   XP_017445484
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8187,858,294 - 87,868,624 (+)NCBI
mRatBN7.2178,730,255 - 78,740,585 (+)NCBI
Rnor_6.0179,988,096 - 79,999,358 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039111232   ⟹   XP_038967160
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8187,858,294 - 87,868,624 (+)NCBI
mRatBN7.2178,730,255 - 78,740,585 (+)NCBI
RefSeq Acc Id: XM_039111235   ⟹   XP_038967163
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8187,858,294 - 87,868,624 (+)NCBI
mRatBN7.2178,730,255 - 78,740,585 (+)NCBI
RefSeq Acc Id: XM_039111254   ⟹   XP_038967182
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8187,858,294 - 87,868,624 (+)NCBI
mRatBN7.2178,730,255 - 78,740,585 (+)NCBI
RefSeq Acc Id: XM_039111256   ⟹   XP_038967184
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8187,858,294 - 87,868,624 (+)NCBI
mRatBN7.2178,730,255 - 78,739,861 (+)NCBI
RefSeq Acc Id: XM_039111258   ⟹   XP_038967186
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8187,858,294 - 87,867,247 (+)NCBI
mRatBN7.2178,730,255 - 78,739,208 (+)NCBI
RefSeq Acc Id: XM_063261308   ⟹   XP_063117378
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8187,858,294 - 87,868,624 (+)NCBI
RefSeq Acc Id: XM_063261309   ⟹   XP_063117379
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8187,858,294 - 87,868,624 (+)NCBI
RefSeq Acc Id: XM_063261312   ⟹   XP_063117382
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8187,858,294 - 87,868,624 (+)NCBI
RefSeq Acc Id: XM_063261313   ⟹   XP_063117383
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8187,858,294 - 87,868,624 (+)NCBI
RefSeq Acc Id: XM_063261319   ⟹   XP_063117389
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8187,858,294 - 87,867,311 (+)NCBI
RefSeq Acc Id: XM_063261320   ⟹   XP_063117390
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8187,858,294 - 87,868,624 (+)NCBI
RefSeq Acc Id: XM_063261324   ⟹   XP_063117394
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8187,858,294 - 87,868,624 (+)NCBI
RefSeq Acc Id: XM_063261329   ⟹   XP_063117399
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8187,858,294 - 87,868,624 (+)NCBI
RefSeq Acc Id: XM_063261330   ⟹   XP_063117400
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8187,858,294 - 87,867,900 (+)NCBI
RefSeq Acc Id: XM_063261332   ⟹   XP_063117402
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8187,860,725 - 87,868,624 (+)NCBI
RefSeq Acc Id: XM_063261333   ⟹   XP_063117403
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8187,858,426 - 87,868,624 (+)NCBI
RefSeq Acc Id: XM_063261336   ⟹   XP_063117406
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8187,858,426 - 87,868,624 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001358993 (Get FASTA)   NCBI Sequence Viewer  
  NP_001402776 (Get FASTA)   NCBI Sequence Viewer  
  NP_001402777 (Get FASTA)   NCBI Sequence Viewer  
  NP_001402778 (Get FASTA)   NCBI Sequence Viewer  
  XP_008757271 (Get FASTA)   NCBI Sequence Viewer  
  XP_017445484 (Get FASTA)   NCBI Sequence Viewer  
  XP_038967160 (Get FASTA)   NCBI Sequence Viewer  
  XP_038967163 (Get FASTA)   NCBI Sequence Viewer  
  XP_038967182 (Get FASTA)   NCBI Sequence Viewer  
  XP_038967184 (Get FASTA)   NCBI Sequence Viewer  
  XP_038967186 (Get FASTA)   NCBI Sequence Viewer  
  XP_063117378 (Get FASTA)   NCBI Sequence Viewer  
  XP_063117379 (Get FASTA)   NCBI Sequence Viewer  
  XP_063117382 (Get FASTA)   NCBI Sequence Viewer  
  XP_063117383 (Get FASTA)   NCBI Sequence Viewer  
  XP_063117389 (Get FASTA)   NCBI Sequence Viewer  
  XP_063117390 (Get FASTA)   NCBI Sequence Viewer  
  XP_063117394 (Get FASTA)   NCBI Sequence Viewer  
  XP_063117399 (Get FASTA)   NCBI Sequence Viewer  
  XP_063117400 (Get FASTA)   NCBI Sequence Viewer  
  XP_063117402 (Get FASTA)   NCBI Sequence Viewer  
  XP_063117403 (Get FASTA)   NCBI Sequence Viewer  
  XP_063117406 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDM08238 (Get FASTA)   NCBI Sequence Viewer  
  EDM08239 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000020428
  ENSRNOP00000020428.8
  ENSRNOP00000095056
  ENSRNOP00000095056.1
RefSeq Acc Id: XP_008757271   ⟸   XM_008759049
- Peptide Label: isoform X12
- UniProtKB: A6J8J5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017445484   ⟸   XM_017589995
- Peptide Label: isoform X8
- UniProtKB: D3ZYV4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000020428   ⟸   ENSRNOT00000020428
RefSeq Acc Id: XP_038967182   ⟸   XM_039111254
- Peptide Label: isoform X10
- UniProtKB: A6J8J5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038967160   ⟸   XM_039111232
- Peptide Label: isoform X5
- UniProtKB: A0A8I6ANX6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038967163   ⟸   XM_039111235
- Peptide Label: isoform X6
- UniProtKB: A0A8I6ANX6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038967184   ⟸   XM_039111256
- Peptide Label: isoform X13
- UniProtKB: A6J8J5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038967186   ⟸   XM_039111258
- Peptide Label: isoform X14
- UniProtKB: A6J8J5 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001358993   ⟸   NM_001372064
- Peptide Label: isoform 2
- UniProtKB: D3ZYV4 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSRNOP00000095056   ⟸   ENSRNOT00000105612
RefSeq Acc Id: NP_001402776   ⟸   NM_001415847
- Peptide Label: isoform 1
RefSeq Acc Id: NP_001402777   ⟸   NM_001415848
- Peptide Label: isoform 3
RefSeq Acc Id: NP_001402778   ⟸   NM_001415849
- Peptide Label: isoform 4
RefSeq Acc Id: XP_063117379   ⟸   XM_063261309
- Peptide Label: isoform X2
RefSeq Acc Id: XP_063117378   ⟸   XM_063261308
- Peptide Label: isoform X1
RefSeq Acc Id: XP_063117383   ⟸   XM_063261313
- Peptide Label: isoform X4
RefSeq Acc Id: XP_063117382   ⟸   XM_063261312
- Peptide Label: isoform X3
RefSeq Acc Id: XP_063117394   ⟸   XM_063261324
- Peptide Label: isoform X11
RefSeq Acc Id: XP_063117399   ⟸   XM_063261329
- Peptide Label: isoform X15
RefSeq Acc Id: XP_063117390   ⟸   XM_063261320
- Peptide Label: isoform X9
RefSeq Acc Id: XP_063117400   ⟸   XM_063261330
- Peptide Label: isoform X16
RefSeq Acc Id: XP_063117389   ⟸   XM_063261319
- Peptide Label: isoform X7
RefSeq Acc Id: XP_063117406   ⟸   XM_063261336
- Peptide Label: isoform X19
RefSeq Acc Id: XP_063117403   ⟸   XM_063261333
- Peptide Label: isoform X18
RefSeq Acc Id: XP_063117402   ⟸   XM_063261332
- Peptide Label: isoform X17
Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZYV4-F1-model_v2 AlphaFold D3ZYV4 1-626 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13689758
Promoter ID:EPDNEW_R283
Type:multiple initiation site
Name:Dmpk_1
Description:DM1 protein kinase
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0179,989,057 - 79,989,117EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1309825 AgrOrtholog
BioCyc Gene G2FUF-60533 BioCyc
Ensembl Genes ENSRNOG00000015085 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000020428 ENTREZGENE
  ENSRNOT00000020428.9 UniProtKB/TrEMBL
  ENSRNOT00000105612 ENTREZGENE
  ENSRNOT00000105612.1 UniProtKB/TrEMBL
Gene3D-CATH 1.20.5.340 UniProtKB/TrEMBL
  Transferase(Phosphotransferase) domain 1 UniProtKB/TrEMBL
InterPro AGC-kinase_C UniProtKB/TrEMBL
  Kinase-like_dom UniProtKB/TrEMBL
  Myotonic_dystrophy_kinase_coil UniProtKB/TrEMBL
  Prot_kinase_cat_dom UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/TrEMBL
  Ser/Thr_kinase_AS UniProtKB/TrEMBL
NCBI Gene 308405 ENTREZGENE
PANTHER MYOTONIC DYSTROPHY S/T KINASE-RELATED UniProtKB/TrEMBL
  NON-SPECIFIC SERINE/THREONINE PROTEIN KINASE UniProtKB/TrEMBL
Pfam DMPK_coil UniProtKB/TrEMBL
  Pkinase UniProtKB/TrEMBL
PhenoGen Dmpk PhenoGen
PROSITE AGC_KINASE_CTER UniProtKB/TrEMBL
  PROTEIN_KINASE_ATP UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/TrEMBL
  PROTEIN_KINASE_ST UniProtKB/TrEMBL
RatGTEx ENSRNOG00000015085 RatGTEx
SMART S_TK_X UniProtKB/TrEMBL
  S_TKc UniProtKB/TrEMBL
Superfamily-SCOP Kinase_like UniProtKB/TrEMBL
UniProt A0A8I6ANX6 ENTREZGENE, UniProtKB/TrEMBL
  A6J8J5 ENTREZGENE, UniProtKB/TrEMBL
  D3ZYV4 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2017-06-12 Dmpk  DM1 protein kinase  Dmpk  dystrophia myotonica-protein kinase  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Dmpk  dystrophia myotonica-protein kinase   Dmpk_predicted  dystrophia myotonica-protein kinase (predicted)  'predicted' is removed 2292626 APPROVED
2006-03-30 Dmpk_predicted  dystrophia myotonica-protein kinase (predicted)  Dm15_predicted  dystrophia myotonica kinase, B15 (predicted)  Symbol and Name updated 1299863 APPROVED
2005-01-12 Dm15_predicted  dystrophia myotonica kinase, B15 (predicted)      Symbol and Name status set to approved 70820 APPROVED