Slc7a3 (solute carrier family 7 member 3)

Gene: Slc7a3 (solute carrier family 7 member 3) Ictidomys tridecemlineatus

Analyze

Symbol:

Slc7a3

Name:

solute carrier family 7 member 3

RGD ID:

12660558

Description:

ENCODES a protein that exhibits basic amino acid transmembrane transporter activity (ortholog); L-arginine transmembrane transporter activity (ortholog); L-lysine transmembrane transporter activity (ortholog); INVOLVED IN basic amino acid transmembrane transport (ortholog); L-arginine transmembrane transport (ortholog); lysine transport (ortholog); ASSOCIATED WITH autistic disorder (ortholog); FG Syndrome 1 (ortholog); genetic disease (ortholog); FOUND IN membrane (inferred); plasma membrane (inferred)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

cationic amino acid transporter 3

RGD Orthologs

Alliance Genes

More Info

more info ...

Latest Assembly:

SpeTri2.0 - Squirrel SpeTri2.0 Assembly

Position:

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	X	46,899,348 - 46,905,103 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936762	661,491 - 667,298 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936762	661,532 - 667,277 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

autistic disorder (ISO)

FG Syndrome 1 (ISO)

genetic disease (ISO)

intellectual disability (ISO)

syndromic X-linked intellectual disability Lubs type (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

amino acid transport (IEA)

basic amino acid transmembrane transport (ISO)

L-arginine import across plasma membrane (IEA)

L-arginine transmembrane transport (IEA,ISO)

L-lysine import across plasma membrane (IEA)

L-lysine transmembrane transport (IEA)

L-ornithine import across plasma membrane (IEA)

L-ornithine transmembrane transport (IEA)

lysine transport (ISO)

ornithine transport (ISO)

regulation of TOR signaling (ISO)

transmembrane transport (IEA)

Cellular Component

membrane (IEA)

plasma membrane (IEA)

Molecular Function

basic amino acid transmembrane transporter activity (IEA,ISO)

L-arginine transmembrane transporter activity (IEA,ISO)

L-lysine transmembrane transporter activity (IEA,ISO)

L-ornithine transmembrane transporter activity (IEA,ISO)

protein binding (ISO)

transmembrane transporter activity (IEA)

References

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

Slc7a3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	X	46,899,348 - 46,905,103 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936762	661,491 - 667,298 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936762	661,532 - 667,277 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

SLC7A3
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	X	70,925,579 - 70,931,096 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	X	70,925,579 - 70,931,125 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	X	70,145,429 - 70,150,946 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	X	70,062,154 - 70,067,684 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	X	69,928,452 - 69,933,951	NCBI
Celera	X	70,499,018 - 70,504,564 (-)	NCBI		Celera
Cytogenetic Map	X	q13.1	NCBI
HuRef	X	63,965,473 - 63,969,918 (-)	NCBI		HuRef
CHM1_1	X	70,036,878 - 70,042,423 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	X	69,359,629 - 69,365,145 (-)	NCBI		T2T-CHM13v2.0

Slc7a3
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	X	100,122,752 - 100,134,058 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	X	100,122,816 - 100,129,626 (-)	Ensembl		GRCm39 Ensembl
GRCm38	X	101,079,146 - 101,090,452 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	X	101,079,210 - 101,086,020 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	X	98,274,560 - 98,280,691 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	X	97,281,940 - 97,288,071 (-)	NCBI		MGSCv36	mm8
Celera	X	87,997,561 - 88,004,049 (-)	NCBI		Celera
Cytogenetic Map	X	C3- D	NCBI
cM Map	X	43.72	NCBI

Slc7a3
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	X	70,250,089 - 70,256,610 (-)	NCBI		GRCr8
mRatBN7.2	X	66,210,071 - 66,216,482 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	X	66,210,081 - 66,215,708 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	X	67,693,428 - 67,698,141 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	X	71,193,823 - 71,198,536 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	X	68,754,728 - 68,759,443 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	X	70,972,767 - 70,979,466 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	X	70,972,765 - 70,978,952 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	X	71,824,798 - 71,831,477 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	X	89,159,603 - 89,164,314 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	X	89,233,045 - 89,237,747 (-)	NCBI
Celera	X	66,566,815 - 66,571,524 (-)	NCBI		Celera
Cytogenetic Map	X	q22	NCBI

Slc7a3
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955475	10,457,787 - 10,464,514 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955475	10,457,859 - 10,463,828 (-)	NCBI	ChiLan1.0	ChiLan1.0

SLC7A3
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	X	70,603,135 - 70,608,707 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	X	70,606,738 - 70,612,310 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	X	60,193,997 - 60,199,564 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	X	70,253,432 - 70,258,991 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	X	70,253,441 - 70,258,991 (-)	Ensembl	panpan1.1		panPan2

SLC7A3
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	X	55,282,474 - 55,289,513 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
Dog10K_Boxer_Tasha	X	46,109,853 - 46,233,444 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	X	56,251,502 - 56,375,048 (-)	NCBI		ROS_Cfam_1.0
UMICH_Zoey_3.1	X	54,219,879 - 54,343,367 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	X	55,551,479 - 55,674,950 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	X	55,478,334 - 55,601,870 (-)	NCBI		UU_Cfam_GSD_1.0

SLC7A3
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	X	56,937,086 - 56,942,357 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	X	56,937,081 - 56,942,331 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	X	64,467,441 - 64,473,169 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

SLC7A3
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	X	60,714,846 - 60,721,813 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	X	60,714,896 - 60,719,594 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666065	2,576,649 - 2,582,634 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Slc7a3
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624903	1,100,424 - 1,107,087 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624903	1,100,518 - 1,106,993 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_005339977	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JAESOR010000614	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSSTOT00000014262 ⟹ ENSSTOP00000012774

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
SpeTri2.0 Ensembl	NW_004936762	661,491 - 667,298 (+)	Ensembl

RefSeq Acc Id:

XM_005339977 ⟹ XP_005340034

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
HiC_Itri_2	X	46,899,348 - 46,905,103 (+)	NCBI
SpeTri2.0	NW_004936762	661,532 - 667,277 (+)	NCBI

Sequence:

show sequence

ATAAGGGGCGCTTGGCGCGCAACGACCCTAAGCAGCAGCTTTGAAGCGAGAGCTGCTGAACTCG
GCAGCTCAAACCCAACTCGGTTTAAGTCAGCCTTTCCAACCTGACTGGAGATTCTCAGCTCCCT
GTGCTAGTCACAGCTCTCTGATCCTAGCATCCTCTTCAATTCCAGCTAGAATGCTGTGGCAGGC
ACTTCGCAGATTTGGTCGAAAGCTGGTACGGAGACGTACACTGGAGCCAGGCATGAATGAGACT
CGCCTTGCCAGATGCCTGAGCACTCTGGACTTAGTGGCCCTGGGTGTGGGCAGCACATTGGGTG
CAGGCGTATATGTTCTGGCTGGTGAGGTCGCCAAAGATAAAGCAGGACCATCCATTGTGATCTC
CTTTTTGGTGGCTGCTCTGTCTTCTGTGTTGGCTGGGCTGTGCTATGCTGAGTTTGGTGCTCGG
GTTCCCCGCTCTGGTTCTGCTTATCTCTACAGCTACGTCACTGTTGGAGAACTCTGGGCCTTCA
CCACTGGCTGGAATCTCATCCTCTCCTACGTCATTGGTACCGCCAGTGTGGCCCGTGCCTGGAG
CTCTGCTTTTGACAACCTGATTGGGAACCACATCTCTCAGACTCTAAAGGGGTCCATCTCACTG
CACGTGCCCCATTTCCTTGCAGAATATCCAGATTTCTTTGCTTTGGGCCTTGTGTTGCTGCTCA
CTGGATTGCTGGCTCTGGGGGCTAGTGAATCAGCCCTGGTTACCAAAGTGTTCACAGGGGTGAA
CCTTTTGGTTCTTGGTTTTATCATCATCTCTGGCTTCATTAAGGGAGACCTACACAACTGGAGG
CTCAGTGAAGAAGACTATGAATTGACCAAGGCTGGACTCAATGACACCAGTAGCTTGGGCCCTC
TGGGCTCTGGAGGATTTGTGCCATTCGGCATCCAGGGGATTCTCCGGGGAGCTGCTACCTGTTT
CTATGCGTTTGTTGGTTTTGACTGTATTGCTACCACCGGGGAAGAGGCCCAGAATCCACAGCGT
TCTATCCCCATGAGCATTGTGATCTCACTGTTTGTCTGCTTTTTGGCGTACTTTGGTGTCTCTT
CGGCACTCACCCTCATGATGCCTTACTACCAACTCCAGCCTGAAAGCCCATTGCCTGAGGCTTT
TCTCCATGTTGGATGGGCTCCTGCCCGCTATGTTGTGGCTGTTGGCTCCCTCTGTGCTCTTTCT
ACGAGCCTCTTGGGCTCTATGTTCCCCATGCCTCGGGTGATCTATGCAATGGCAGAGGATGGTC
TCCTATTCCGAGTCCTGGCTAGGATCCACACCGGCACTCATACCCCCATCATGGCCACTGTGGT
CTCTGGCATTATTGCAGCATTCATGGCATTCCTCTTTGAACTCACTGATCTTGTGGACCTCATG
TCAATTGGGACCCTGCTTGCTTACTCCCTGGTGTCCATTTGTGTTCTCATCCTCAGGTATCAGC
CTGATCAGGAAATGAAGCCTGGGGAAGAGGAAGTGGAGTTGCAGGAGGAGAAGGTTCCTGAAGC
AGAGAAACTGACCCTCCAGGCACTGTTTTGCCCACTCAACTCTGACCCTACTCCACTCTCTGGC
CAAGTTGTTTATGTTTGTTCCTCATTACTTGCTCTACTACTGACTGTCCTTTGCCTGGTGCCAT
TTCCACTGCTTTCTGGAGACCCAGTGTGGGTGGCAGTGGTTGTACTGCTTCTGTTGCTTATTAC
TGGAACGACTATGGTTATCTGCAGACAGCCACAGAACTCCAGTCCCCTTCACTTTAAGGTGCCT
GCTGTGCCTTTCCTCCCACTAGTGAGCATCTTTGTGAATGTTTACCTTATGATGCAGATGACAG
CTGGTACCTGGGCCCGGTTTGGGGTCTGGATGCTGATTGGGTTTGCTATCTACTTCAGCTATGG
AATCCAGCACAGCCTGGAAGAAGTTAAGCCTGACCAACCCAAATGCAAGTCAAGGGCCAAAACT
GTAGACCTTGATCTCAGCAATTCATGTGTCCACCAATTTTGACATAATTACAACCAAGTGCTGG
ATGGTTCCCCCCCCTGCACAATAATGGAGAGTACTCTTGATCCCATGGAGAGCCAACCCTCCCA
TATAATGTTGGTGGGGGTTATTAATAGAGCTCTGTATTTATTGTGGAGTGAAGGATGTGTCTTT
GCTGTTTCTCATCTATATTTTTTTTACTTGTCTACTTTTAAATGGTCTCTGTAGTTGCTTACTG
GCTTTAAAAAATATTATTAAAAGAAA

hide sequence

Protein Sequences


Protein RefSeqs	XP_005340034	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSSTOP00000012774.2
GenBank Protein	KAG3272371	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

XP_005340034 ⟸ XM_005339977

- UniProtKB:

I3MMK8 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MLWQALRRFGRKLVRRRTLEPGMNETRLARCLSTLDLVALGVGSTLGAGVYVLAGEVAKDKAGP
SIVISFLVAALSSVLAGLCYAEFGARVPRSGSAYLYSYVTVGELWAFTTGWNLILSYVIGTASV
ARAWSSAFDNLIGNHISQTLKGSISLHVPHFLAEYPDFFALGLVLLLTGLLALGASESALVTKV
FTGVNLLVLGFIIISGFIKGDLHNWRLSEEDYELTKAGLNDTSSLGPLGSGGFVPFGIQGILRG
AATCFYAFVGFDCIATTGEEAQNPQRSIPMSIVISLFVCFLAYFGVSSALTLMMPYYQLQPESP
LPEAFLHVGWAPARYVVAVGSLCALSTSLLGSMFPMPRVIYAMAEDGLLFRVLARIHTGTHTPI
MATVVSGIIAAFMAFLFELTDLVDLMSIGTLLAYSLVSICVLILRYQPDQEMKPGEEEVELQEE
KVPEAEKLTLQALFCPLNSDPTPLSGQVVYVCSSLLALLLTVLCLVPFPLLSGDPVWVAVVVLL
LLLITGTTMVICRQPQNSSPLHFKVPAVPFLPLVSIFVNVYLMMQMTAGTWARFGVWMLIGFAI
YFSYGIQHSLEEVKPDQPKCKSRAKTVDLDLSNSCVHQF

hide sequence

RefSeq Acc Id:

ENSSTOP00000012774 ⟸ ENSSTOT00000014262

Protein Domains

Cationic amino acid transporter C-terminal

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSSTOG00000014255	Ensembl, UniProtKB/TrEMBL
Ensembl Transcript	ENSSTOT00000014262.3	UniProtKB/TrEMBL
Gene3D-CATH	Amino acid/polyamine transporter I	UniProtKB/TrEMBL
InterPro	AA/rel_permease1	UniProtKB/TrEMBL
	Cat_AA_permease	UniProtKB/TrEMBL
	CAT_C	UniProtKB/TrEMBL
NCBI Gene	Slc7a3	ENTREZGENE
PANTHER	INNER MEMBRANE TRANSPORTER YGJI-RELATED	UniProtKB/TrEMBL
	PTHR43243:SF20	UniProtKB/TrEMBL
Pfam	AA_permease_2	UniProtKB/TrEMBL
	AA_permease_C	UniProtKB/TrEMBL
PIRSF	AA_transporter	UniProtKB/TrEMBL
UniProt	I3MMK8	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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