Otop1 (otopetrin 1) - Rat Genome Database

Name: Otop1
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

Gene: Otop1 (otopetrin 1) Ictidomys tridecemlineatus

Analyze

Symbol:

Otop1

Name:

otopetrin 1

RGD ID:

12582400

Description:

ENCODES a protein that exhibits proton channel activity (inferred); INVOLVED IN detection of gravity (ortholog); inner ear morphogenesis (ortholog); ASSOCIATED WITH Ellis-Van Creveld syndrome (ortholog); FOUND IN membrane (inferred); plasma membrane (inferred)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

otopetrin-1; proton channel OTOP1

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	OTOP1 (otopetrin 1)	NCBI	Ortholog
Mus musculus (house mouse):	Otop1 (otopetrin 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus norvegicus (Norway rat):	Otop1 (otopetrin 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Otop1 (otopetrin 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	OTOP1 (otopetrin 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	OTOP1 (otopetrin 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	OTOP1 (otopetrin 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	OTOP1 (otopetrin 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Otop1 (otopetrin 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline

Latest Assembly:

SpeTri2.0 - Squirrel SpeTri2.0 Assembly

Position:

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405285	63,173,931 - 63,197,685 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936477	16,876,725 - 16,899,007 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936477	16,876,725 - 16,899,007 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Ellis-Van Creveld syndrome (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

cellular response to insulin stimulus (IEA)

detection of gravity (IEA,ISO)

inner ear morphogenesis (IEA,ISO)

negative regulation of type II interferon-mediated signaling pathway (IEA)

proton transmembrane transport (IEA)

Cellular Component

membrane (IEA)

plasma membrane (IEA)

Molecular Function

proton channel activity (IEA)

References

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

Otop1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405285	63,173,931 - 63,197,685 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936477	16,876,725 - 16,899,007 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936477	16,876,725 - 16,899,007 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

OTOP1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	4	4,188,726 - 4,226,929 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	4	4,188,726 - 4,226,929 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	4	4,190,453 - 4,228,656 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	4	4,241,431 - 4,279,522 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	4	4,308,601 - 4,346,693	NCBI
Celera	4	4,088,176 - 4,126,241 (-)	NCBI		Celera
Cytogenetic Map	4	p16.3	NCBI
HuRef	4	4,126,235 - 4,164,307 (-)	NCBI		HuRef
CHM1_1	4	4,188,226 - 4,226,300 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	4	4,158,166 - 4,196,359 (-)	NCBI		T2T-CHM13v2.0

Otop1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	5	38,434,748 - 38,461,560 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	5	38,433,316 - 38,461,552 (+)	Ensembl		GRCm39 Ensembl
GRCm38	5	38,277,404 - 38,304,217 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	5	38,275,972 - 38,304,217 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	5	38,668,643 - 38,695,456 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	5	38,564,186 - 38,592,458 (+)	NCBI		MGSCv36	mm8
Celera	5	35,727,139 - 35,757,853 (+)	NCBI		Celera
Cytogenetic Map	5	B3	NCBI
cM Map	5	20.35	NCBI

Otop1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	14	76,717,330 - 76,744,785 (-)	NCBI		GRCr8
mRatBN7.2	14	72,505,036 - 72,532,497 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	14	72,503,592 - 72,532,497 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	14	76,946,691 - 76,974,144 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	14	78,187,579 - 78,215,028 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	14	74,627,630 - 74,655,089 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	14	77,236,278 - 77,263,729 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	14	77,236,278 - 77,263,729 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	14	77,217,741 - 77,245,192 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	14	77,784,515 - 77,811,966 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	14	77,786,905 - 77,814,357 (-)	NCBI
Celera	14	71,456,163 - 71,483,694 (-)	NCBI		Celera
Cytogenetic Map	14	q21	NCBI

Otop1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955514	5,407,946 - 5,435,605 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955514	5,407,931 - 5,436,547 (+)	NCBI	ChiLan1.0	ChiLan1.0

OTOP1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	3	4,455,586 - 4,494,139 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	4	4,388,488 - 4,427,064 (-)	NCBI		NHGRI_mPanPan1
PanPan1.1	4	4,269,521 - 4,307,585 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	4	4,269,521 - 4,307,585 (-)	Ensembl	panpan1.1		panPan2

OTOP1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	3	69,639,550 - 69,665,051 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	3	69,640,492 - 69,649,201 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	3	72,191,647 - 72,228,061 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	3	70,396,580 - 70,433,018 (-)	NCBI		ROS_Cfam_1.0
UMICH_Zoey_3.1	3	69,670,707 - 69,707,135 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	3	69,836,036 - 69,872,268 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	3	70,217,419 - 70,253,619 (-)	NCBI		UU_Cfam_GSD_1.0

OTOP1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	8	6,127,965 - 6,163,061 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	8	6,127,837 - 6,164,421 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	8	5,712,466 - 5,750,972 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

OTOP1
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	27	40,295,314 - 40,332,625 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	27	40,295,676 - 40,332,533 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666047	87,092,033 - 87,129,372 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Otop1
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624755	21,377,721 - 21,403,621 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624755	21,377,288 - 21,403,621 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_005318968	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JAESOR010000344	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSSTOT00000021695 ⟹ ENSSTOP00000022566

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
SpeTri2.0 Ensembl	NW_004936477	16,876,725 - 16,899,007 (-)	Ensembl

RefSeq Acc Id:

XM_005318968 ⟹ XP_005319025

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
HiC_Itri_2	NW_024405285	63,173,931 - 63,197,685 (-)	NCBI
SpeTri2.0	NW_004936477	16,876,725 - 16,899,007 (-)	NCBI

Sequence:

show sequence

ATGCCCGCGGGCCCCGGGACACCCGCCTCGCCGGGAGCATCAGCAAGCGCCTCGGACCGGGGCT
CATCGGGGCCCCCAGACTGCCCGCCCTCCCCGCTCCTGACTCGGGGGTCCCGGGAATCCCCGGC
CCTTAGACAGACCGCGGTTCGCGCCAGCGTTCCGCAAAAGCTGGCAGAGACGCTGAGCAGCCAG
TACGGGCTGAACGTGTTCGTGGCGGGGCTGCTGTTCCTGCTGGCCTGGGCGGTGCACGCCGCGG
GCGTGGGCAAGCGGGACCTGCTCTGCTTCCTCACGGCTCTCATGCTGCTGCAGCTGCTCTGGAT
GCTGTGGTACGTGGGCCGCAGCTACGCGCAGCGCCGCCTCATCCGCCCCAAGGACGCGCACGCC
GGGGCGCAGTGGCTCCGCGGAAGCATCTCACTGTTTGCCACCATCACCGTCATCCTGGGGTGCT
TCAAAGTTGGCTACTTCATTGGATTTTCCGAGTGTCTTTCGGCCATGGAAGGCGTTTTCCCTGT
CACACACGCGGTGCACACTCTGCTGCAGGTGTATTTTCTCTGGGGACATGCCAAGGATATCATC
CAGTCTTTCAAGACTCTGGAAAGGTTCGGGGTGATCCACTCTGTGGTCACCAACCTGCTCCTCT
GGGCCAACAGTGTCCTGAATGAGTCCAAGCACCAGCTGAACGAGCACAAGGAGCGGCTCCTCAC
TCTGGGCTTCGGGAACATAACCTTAGTCCTGGATGACCACACGCCGCAGTGCAACTGCACGCCG
CCGGCGCTGTGCCCGGCCGTGTCGCGCGTCATCTACTACCTGTACCCCTTCAACATCGAGTACC
AGATCCTGGCCTCCACCATGCTCTACGTCCTGTGGAAGAACGTGGGCCGCAGGGTGGACAGCCC
CGCGCGCCCCGAGATGCGGTTCCAGTTCAGCCGGGGGATGGCGGGCGCGGCGCTGGGCCTGGGC
GTGCTGGCGGCCACCATCGGGGTGGTGGCCGTGTACCTAGTCCACATCGGGCGCTCCAGGACCC
AGAGCGAGTGGGCGCTGGTGCTCTTCTACCTGTCGGCCACCAGCCTGCTGACCCTCATGGGCGC
CGCGGGGCTGCTGGGAATCTGGGTCTGCAGGATGGACAAGCAGTCGCTGGATGAGTCCAAAAAC
CCGGCCCGCAAGCTGGACGCGGACCTCCTGGTGGGCACGGCCTCGGGCTCCTGGCTCATCTCCT
GGGGCTCCATCCTGGCCATGCTCTGCGCCACCACCCGCCCGCGCTACACCTGGTTCAACCTGCC
CTACTCGGCCCTGGTGATCGCCGAGAAGTACATCCAGAACCTCTTCATCATCGAGTCGGTCCAC
CGCGAGCCCCAGCCGCTCCGCGAGGACATCCGCACGCTCCGCGTGGTAGCCGTCTGCAGCGGCG
GCACCTCCTCCCTGGCCTCTTTCGGGGCGGTCAACGGGAGTCTGCAGCCCGGTTGTGGCAAAGA
GGAAGAGGAGCCGGGCCGCCCGCCTCGCGAGCCTCGTGTCCTGCAGGGCAGCACCAGGAGGAGC
GTCCTGAGGAATGTGGCCGTCTTCCTGTTCCTCTGCAACATCTCGCTTTGGGTACCTCCCGCCT
TTGGCTGTCGCCCTGAGTACGACAACGGACTGGAGGAAGTCGTCTTCGGCTTCGAACCCTGGAT
AATTGTGGTCAACCTGGCCATGCCGTTTTCTATTTTCTATCGAATGCACGCGGCTGCCTCTCTC
TTTGAAGTCTATTGTAAGATCTAG

hide sequence

Protein Sequences


Protein RefSeqs	XP_005319025	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSSTOP00000022566.1
GenBank Protein	KAG3276904	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

XP_005319025 ⟸ XM_005318968

- UniProtKB:

I3NDW9 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MPAGPGTPASPGASASASDRGSSGPPDCPPSPLLTRGSRESPALRQTAVRASVPQKLAETLSSQ
YGLNVFVAGLLFLLAWAVHAAGVGKRDLLCFLTALMLLQLLWMLWYVGRSYAQRRLIRPKDAHA
GAQWLRGSISLFATITVILGCFKVGYFIGFSECLSAMEGVFPVTHAVHTLLQVYFLWGHAKDII
QSFKTLERFGVIHSVVTNLLLWANSVLNESKHQLNEHKERLLTLGFGNITLVLDDHTPQCNCTP
PALCPAVSRVIYYLYPFNIEYQILASTMLYVLWKNVGRRVDSPARPEMRFQFSRGMAGAALGLG
VLAATIGVVAVYLVHIGRSRTQSEWALVLFYLSATSLLTLMGAAGLLGIWVCRMDKQSLDESKN
PARKLDADLLVGTASGSWLISWGSILAMLCATTRPRYTWFNLPYSALVIAEKYIQNLFIIESVH
REPQPLREDIRTLRVVAVCSGGTSSLASFGAVNGSLQPGCGKEEEEPGRPPREPRVLQGSTRRS
VLRNVAVFLFLCNISLWVPPAFGCRPEYDNGLEEVVFGFEPWIIVVNLAMPFSIFYRMHAAASL
FEVYCKI

hide sequence

RefSeq Acc Id:

ENSSTOP00000022566 ⟸ ENSSTOT00000021695

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSSTOG00000025465	Ensembl, UniProtKB/TrEMBL
Ensembl Transcript	ENSSTOT00000021695.1	UniProtKB/TrEMBL
InterPro	Otopetrin	UniProtKB/TrEMBL
NCBI Gene	Otop1	ENTREZGENE
PANTHER	PROTON CHANNEL OTOP1	UniProtKB/TrEMBL
	PTHR21522	UniProtKB/TrEMBL
Pfam	Otopetrin	UniProtKB/TrEMBL
UniProt	I3NDW9	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Send us a Message

Imported Disease Annotations - ClinVar