OTOP1 (otopetrin 1) - Rat Genome Database

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Gene: OTOP1 (otopetrin 1) Canis lupus familiaris
Analyze
Symbol: OTOP1
Name: otopetrin 1
RGD ID: 12407629
Description: ENCODES a protein that exhibits proton channel activity (inferred); INVOLVED IN detection of gravity (ortholog); inner ear morphogenesis (ortholog); ASSOCIATED WITH Ellis-Van Creveld syndrome (ortholog); FOUND IN membrane (inferred); plasma membrane (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: otopetrin-1; proton channel OTOP1
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1369,639,550 - 69,665,051 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl369,640,492 - 69,649,201 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha372,191,647 - 72,228,061 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0370,396,580 - 70,433,018 (-)NCBIROS_Cfam_1.0
UMICH_Zoey_3.1369,670,707 - 69,707,135 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0369,836,036 - 69,872,268 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0370,217,419 - 70,253,619 (-)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
OTOP1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1369,639,550 - 69,665,051 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl369,640,492 - 69,649,201 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha372,191,647 - 72,228,061 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0370,396,580 - 70,433,018 (-)NCBIROS_Cfam_1.0
UMICH_Zoey_3.1369,670,707 - 69,707,135 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0369,836,036 - 69,872,268 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0370,217,419 - 70,253,619 (-)NCBIUU_Cfam_GSD_1.0
OTOP1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3844,188,726 - 4,226,929 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl44,188,726 - 4,226,929 (-)EnsemblGRCh38hg38GRCh38
GRCh3744,190,453 - 4,228,656 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3644,241,431 - 4,279,522 (-)NCBINCBI36Build 36hg18NCBI36
Build 3444,308,601 - 4,346,693NCBI
Celera44,088,176 - 4,126,241 (-)NCBICelera
Cytogenetic Map4p16.3NCBI
HuRef44,126,235 - 4,164,307 (-)NCBIHuRef
CHM1_144,188,226 - 4,226,300 (-)NCBICHM1_1
T2T-CHM13v2.044,158,166 - 4,196,359 (-)NCBIT2T-CHM13v2.0
Otop1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39538,434,748 - 38,461,560 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl538,433,316 - 38,461,552 (+)EnsemblGRCm39 Ensembl
GRCm38538,277,404 - 38,304,217 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl538,275,972 - 38,304,217 (+)EnsemblGRCm38mm10GRCm38
MGSCv37538,668,643 - 38,695,456 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36538,564,186 - 38,592,458 (+)NCBIMGSCv36mm8
Celera535,727,139 - 35,757,853 (+)NCBICelera
Cytogenetic Map5B3NCBI
cM Map520.35NCBI
Otop1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81476,717,330 - 76,744,785 (-)NCBIGRCr8
mRatBN7.21472,505,036 - 72,532,497 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1472,503,592 - 72,532,497 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1476,946,691 - 76,974,144 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01478,187,579 - 78,215,028 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01474,627,630 - 74,655,089 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01477,236,278 - 77,263,729 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1477,236,278 - 77,263,729 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01477,217,741 - 77,245,192 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41477,784,515 - 77,811,966 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11477,786,905 - 77,814,357 (-)NCBI
Celera1471,456,163 - 71,483,694 (-)NCBICelera
Cytogenetic Map14q21NCBI
Otop1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555145,407,946 - 5,435,605 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555145,407,931 - 5,436,547 (+)NCBIChiLan1.0ChiLan1.0
OTOP1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v234,455,586 - 4,494,139 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan144,388,488 - 4,427,064 (-)NCBINHGRI_mPanPan1
PanPan1.144,269,521 - 4,307,585 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl44,269,521 - 4,307,585 (-)Ensemblpanpan1.1panPan2
Otop1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440528563,173,931 - 63,197,685 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647716,876,725 - 16,899,007 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647716,876,725 - 16,899,007 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
OTOP1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl86,127,965 - 6,163,061 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.186,127,837 - 6,164,421 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.285,712,466 - 5,750,972 (-)NCBISscrofa10.2Sscrofa10.2susScr3
OTOP1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12740,295,314 - 40,332,625 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2740,295,676 - 40,332,533 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604787,092,033 - 87,129,372 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Otop1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475521,377,721 - 21,403,621 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475521,377,288 - 21,403,621 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in OTOP1
293 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system nervous system reproductive system respiratory system adipose tissue
High
Medium
Low 8
Below cutoff 2 4 1 2 1 6 9 3 2

Sequence


Reference Sequences
RefSeq Acc Id: ENSCAFT00000024815   ⟹   ENSCAFP00000023021
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl369,640,492 - 69,649,201 (-)Ensembl
RefSeq Acc Id: XM_038472730   ⟹   XP_038328658
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1369,670,707 - 69,707,135 (-)NCBI
RefSeq Acc Id: XM_038483383   ⟹   XP_038339311
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
Dog10K_Boxer_Tasha372,191,647 - 72,228,061 (-)NCBI
RefSeq Acc Id: XM_038533700   ⟹   XP_038389628
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0370,217,419 - 70,253,619 (-)NCBI
RefSeq Acc Id: XM_038597998   ⟹   XP_038453926
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0369,836,036 - 69,872,268 (-)NCBI
RefSeq Acc Id: XM_038660605   ⟹   XP_038516533
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0370,396,580 - 70,433,018 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: ENSCAFP00000023021   ⟸   ENSCAFT00000024815
RefSeq Acc Id: XP_038328658   ⟸   XM_038472730
RefSeq Acc Id: XP_038453926   ⟸   XM_038597998
RefSeq Acc Id: XP_038516533   ⟸   XM_038660605
- UniProtKB: A0A8C0SR61 (UniProtKB/TrEMBL),   A0A8I3RR34 (UniProtKB/TrEMBL),   A0A8P0SK26 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038339311   ⟸   XM_038483383
- UniProtKB: A0A8C0SR61 (UniProtKB/TrEMBL),   A0A8I3RR34 (UniProtKB/TrEMBL),   A0A8P0SK26 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038389628   ⟸   XM_038533700
- UniProtKB: A0A8C0SR61 (UniProtKB/TrEMBL),   A0A8I3RR34 (UniProtKB/TrEMBL),   A0A8P0SK26 (UniProtKB/TrEMBL)


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000015666 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00040015224 UniProtKB/TrEMBL
  ENSCAFG00845003003 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000024815.4 UniProtKB/TrEMBL
  ENSCAFT00040028030.1 UniProtKB/TrEMBL
  ENSCAFT00040028088.1 UniProtKB/TrEMBL
  ENSCAFT00845005318 ENTREZGENE
  ENSCAFT00845005318.1 UniProtKB/TrEMBL
InterPro Otopetrin UniProtKB/TrEMBL
NCBI Gene OTOP1 ENTREZGENE
PANTHER PROTON CHANNEL OTOP1 UniProtKB/TrEMBL
  PTHR21522 UniProtKB/TrEMBL
Pfam Otopetrin UniProtKB/TrEMBL
UniProt A0A8C0SNL4_CANLF UniProtKB/TrEMBL
  A0A8C0SR61 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3RR34 ENTREZGENE, UniProtKB/TrEMBL
  A0A8P0SK26 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:44179 ENTREZGENE