OTOP1 (otopetrin 1) - Rat Genome Database

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Gene: OTOP1 (otopetrin 1) Pan paniscus
Analyze
Symbol: OTOP1
Name: otopetrin 1
RGD ID: 11973408
Description: ENCODES a protein that exhibits proton channel activity (inferred); INVOLVED IN cellular response to insulin stimulus (ortholog); detection of gravity (ortholog); inner ear morphogenesis (ortholog); ASSOCIATED WITH Ellis-Van Creveld syndrome (ortholog); FOUND IN membrane (inferred); plasma membrane (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: otopetrin-1; proton channel OTOP1
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v234,455,586 - 4,494,139 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan144,388,488 - 4,427,064 (-)NCBINHGRI_mPanPan1
PanPan1.144,269,521 - 4,307,585 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl44,269,521 - 4,307,585 (-)Ensemblpanpan1.1panPan2


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
OTOP1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v234,455,586 - 4,494,139 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan144,388,488 - 4,427,064 (-)NCBINHGRI_mPanPan1
PanPan1.144,269,521 - 4,307,585 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl44,269,521 - 4,307,585 (-)Ensemblpanpan1.1panPan2
OTOP1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3844,188,726 - 4,226,929 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl44,188,726 - 4,226,929 (-)EnsemblGRCh38hg38GRCh38
GRCh3744,190,453 - 4,228,656 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3644,241,431 - 4,279,522 (-)NCBINCBI36Build 36hg18NCBI36
Build 3444,308,601 - 4,346,693NCBI
Celera44,088,176 - 4,126,241 (-)NCBICelera
Cytogenetic Map4p16.3NCBI
HuRef44,126,235 - 4,164,307 (-)NCBIHuRef
CHM1_144,188,226 - 4,226,300 (-)NCBICHM1_1
T2T-CHM13v2.044,158,166 - 4,196,359 (-)NCBIT2T-CHM13v2.0
Otop1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39538,434,748 - 38,461,560 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl538,433,316 - 38,461,552 (+)EnsemblGRCm39 Ensembl
GRCm38538,277,404 - 38,304,217 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl538,275,972 - 38,304,217 (+)EnsemblGRCm38mm10GRCm38
MGSCv37538,668,643 - 38,695,456 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36538,564,186 - 38,592,458 (+)NCBIMGSCv36mm8
Celera535,727,139 - 35,757,853 (+)NCBICelera
Cytogenetic Map5B3NCBI
cM Map520.35NCBI
Otop1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81476,717,330 - 76,744,785 (-)NCBIGRCr8
mRatBN7.21472,505,036 - 72,532,497 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1472,503,592 - 72,532,497 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1476,946,691 - 76,974,144 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01478,187,579 - 78,215,028 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01474,627,630 - 74,655,089 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01477,236,278 - 77,263,729 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1477,236,278 - 77,263,729 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01477,217,741 - 77,245,192 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41477,784,515 - 77,811,966 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11477,786,905 - 77,814,357 (-)NCBI
Celera1471,456,163 - 71,483,694 (-)NCBICelera
Cytogenetic Map14q21NCBI
Otop1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555145,407,946 - 5,435,605 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555145,407,931 - 5,436,547 (+)NCBIChiLan1.0ChiLan1.0
OTOP1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1369,639,550 - 69,665,051 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl369,640,492 - 69,649,201 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha372,191,647 - 72,228,061 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0370,396,580 - 70,433,018 (-)NCBIROS_Cfam_1.0
UMICH_Zoey_3.1369,670,707 - 69,707,135 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0369,836,036 - 69,872,268 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0370,217,419 - 70,253,619 (-)NCBIUU_Cfam_GSD_1.0
Otop1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440528563,173,931 - 63,197,685 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647716,876,725 - 16,899,007 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647716,876,725 - 16,899,007 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
OTOP1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl86,127,965 - 6,163,061 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.186,127,837 - 6,164,421 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.285,712,466 - 5,750,972 (-)NCBISscrofa10.2Sscrofa10.2susScr3
OTOP1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12740,295,314 - 40,332,625 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2740,295,676 - 40,332,533 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604787,092,033 - 87,129,372 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Otop1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475521,377,721 - 21,403,621 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475521,377,288 - 21,403,621 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression

RNA-SEQ Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts XM_063603680 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide JARIFH020000003 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSPPAT00000038010   ⟹   ENSPPAP00000015320
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl44,269,521 - 4,307,585 (-)Ensembl
RefSeq Acc Id: XM_063603680   ⟹   XP_063459750
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v234,455,586 - 4,494,139 (-)NCBI
Protein Sequences
Protein RefSeqs XP_063459750 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSPPAP00000015320.1
Ensembl Acc Id: ENSPPAP00000015320   ⟸   ENSPPAT00000038010
RefSeq Acc Id: XP_063459750   ⟸   XM_063603680
- UniProtKB: A0A2R9ADD4 (UniProtKB/TrEMBL)


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000030805 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000038010.1 UniProtKB/TrEMBL
InterPro Otopetrin UniProtKB/TrEMBL
KEGG Report pps:100992645 UniProtKB/TrEMBL
NCBI Gene OTOP1 ENTREZGENE
PANTHER PROTON CHANNEL OTOP1 UniProtKB/TrEMBL
  PTHR21522 UniProtKB/TrEMBL
Pfam Otopetrin UniProtKB/TrEMBL
UniProt A0A2R9ADD4 ENTREZGENE, UniProtKB/TrEMBL