Rgs12 (regulator of G protein signaling 12) - Rat Genome Database

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Gene: Rgs12 (regulator of G protein signaling 12) Ictidomys tridecemlineatus
Analyze
Symbol: Rgs12 (Ensembl: DOK7)
Name: regulator of G protein signaling 12 (Ensembl:docking protein 7)
RGD ID: 12573263
Description: ENCODES a protein that exhibits G-protein alpha-subunit binding (ortholog); GTPase activator activity (ortholog); INVOLVED IN negative regulation of G protein-coupled receptor signaling pathway (ortholog); termination of G protein-coupled receptor signaling pathway (ortholog); PARTICIPATES IN calcium signaling pathway via the calcium-sensing receptor; G protein mediated signaling pathway via Galpha12/Galpha13 family; ASSOCIATED WITH cherubism (ortholog); Ellis-Van Creveld syndrome (ortholog); genetic disease (ortholog); FOUND IN apical dendrite (ortholog); neuronal cell body (ortholog); protein-containing complex (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: docking protein 7; Dok7; regulator of G-protein signaling 12
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: SpeTri2.0 - Squirrel SpeTri2.0 Assembly
Position:
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440528566,544,669 - 66,706,669 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647720,257,965 - 20,278,434 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0 EnsemblNW_00493647720,300,521 - 20,388,221 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647720,300,528 - 20,388,212 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Rgs12
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440528566,544,669 - 66,706,669 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647720,257,965 - 20,278,434 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0 EnsemblNW_00493647720,300,521 - 20,388,221 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647720,300,528 - 20,388,212 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
RGS12
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3843,285,891 - 3,439,913 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl43,293,021 - 3,439,913 (+)EnsemblGRCh38hg38GRCh38
GRCh3743,287,618 - 3,441,640 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3643,285,672 - 3,411,438 (+)NCBINCBI36Build 36hg18NCBI36
Build 3443,425,087 - 3,478,607NCBI
Celera43,227,025 - 3,352,526 (+)NCBICelera
Cytogenetic Map4p16.3NCBI
HuRef43,253,766 - 3,378,780 (+)NCBIHuRef
CHM1_143,313,437 - 3,439,350 (+)NCBICHM1_1
T2T-CHM13v2.043,284,640 - 3,439,697 (+)NCBIT2T-CHM13v2.0
Rgs12
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39535,106,273 - 35,196,988 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl535,106,789 - 35,196,988 (+)EnsemblGRCm39 Ensembl
GRCm38534,948,929 - 35,039,642 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl534,949,445 - 35,039,644 (+)EnsemblGRCm38mm10GRCm38
MGSCv37535,292,097 - 35,376,244 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36535,266,308 - 35,350,456 (+)NCBIMGSCv36mm8
Celera532,423,269 - 32,508,385 (+)NCBICelera
Cytogenetic Map5B2NCBI
cM Map517.96NCBI
Rgs12
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81479,940,561 - 80,048,637 (-)NCBIGRCr8
mRatBN7.21475,715,925 - 75,824,012 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1475,715,934 - 75,794,596 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1480,175,876 - 80,263,170 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01481,416,503 - 81,503,793 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01477,861,725 - 77,949,017 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01480,975,239 - 81,069,519 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1480,975,322 - 81,053,906 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01481,664,122 - 81,771,788 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41481,363,542 - 81,436,194 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11481,365,932 - 81,438,585 (-)NCBI
Celera1474,648,755 - 74,720,676 (-)NCBICelera
Cytogenetic Map14q21NCBI
Rgs12
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555142,088,354 - 2,154,191 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555142,081,575 - 2,154,414 (+)NCBIChiLan1.0ChiLan1.0
RGS12
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v233,632,834 - 3,783,631 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan143,566,200 - 3,717,305 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v043,439,030 - 3,589,026 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.143,444,467 - 3,573,941 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl43,444,570 - 3,573,712 (+)Ensemblpanpan1.1panPan2
RGS12
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1360,917,033 - 61,011,812 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl360,917,072 - 61,009,131 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha363,567,210 - 63,619,308 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0361,392,603 - 61,512,294 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl361,392,635 - 61,512,321 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1360,884,355 - 61,003,999 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0361,090,461 - 61,208,240 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0361,446,826 - 61,566,535 (-)NCBIUU_Cfam_GSD_1.0
RGS12
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl81,963,308 - 2,075,971 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.181,971,390 - 2,074,970 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.281,649,955 - 1,729,384 (-)NCBISscrofa10.2Sscrofa10.2susScr3
RGS12
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12745,302,193 - 45,444,012 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_0236660511,647,849 - 1,802,824 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Rgs12
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475524,489,966 - 24,553,505 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475524,489,746 - 24,567,937 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSSTOT00000004952   ⟹   ENSSTOP00000004442
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0 EnsemblNW_00493647720,257,965 - 20,278,296 (-)Ensembl
RefSeq Acc Id: ENSSTOT00000028433   ⟹   ENSSTOP00000023316
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0 EnsemblNW_00493647720,300,521 - 20,388,221 (-)Ensembl
RefSeq Acc Id: ENSSTOT00000029204   ⟹   ENSSTOP00000022317
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0 EnsemblNW_00493647720,308,785 - 20,344,262 (-)Ensembl
RefSeq Acc Id: ENSSTOT00000038448   ⟹   ENSSTOP00000025606
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0 EnsemblNW_00493647720,263,184 - 20,278,434 (-)Ensembl
RefSeq Acc Id: XM_005318997   ⟹   XP_005319054
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440528566,544,669 - 66,591,410 (-)NCBI
Sequence:
RefSeq Acc Id: XM_005318999   ⟹   XP_005319056
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440528566,598,829 - 66,706,331 (-)NCBI
SpeTri2.0NW_00493647720,300,528 - 20,388,212 (-)NCBI
Sequence:
RefSeq Acc Id: XM_040292736   ⟹   XP_040148670
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440528566,598,829 - 66,706,669 (-)NCBI
RefSeq Acc Id: XM_040292737   ⟹   XP_040148671
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440528566,556,476 - 66,706,353 (-)NCBI
RefSeq Acc Id: XM_040292738   ⟹   XP_040148672
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440528566,606,958 - 66,706,331 (-)NCBI
RefSeq Acc Id: XM_040292739   ⟹   XP_040148673
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440528566,598,829 - 66,652,471 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: XP_005319056   ⟸   XM_005318999
- Peptide Label: isoform X1
- UniProtKB: I3NG19 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_005319054   ⟸   XM_005318997
- Peptide Label: isoform X5
- UniProtKB: I3M563 (UniProtKB/TrEMBL),   A0A287CWF0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_040148671   ⟸   XM_040292737
- Peptide Label: isoform X2
RefSeq Acc Id: XP_040148670   ⟸   XM_040292736
- Peptide Label: isoform X1
- UniProtKB: I3NG19 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_040148673   ⟸   XM_040292739
- Peptide Label: isoform X4
RefSeq Acc Id: XP_040148672   ⟸   XM_040292738
- Peptide Label: isoform X3
RefSeq Acc Id: ENSSTOP00000004442   ⟸   ENSSTOT00000004952
RefSeq Acc Id: ENSSTOP00000023316   ⟸   ENSSTOT00000028433
RefSeq Acc Id: ENSSTOP00000025606   ⟸   ENSSTOT00000038448
RefSeq Acc Id: ENSSTOP00000022317   ⟸   ENSSTOT00000029204
Protein Domains
IRS-type PTB   PDZ   PID   RBD   RGS


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSTOG00000004961 Ensembl, UniProtKB/TrEMBL
  ENSSTOG00000022380 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSSTOT00000004952.3 UniProtKB/TrEMBL
  ENSSTOT00000028433.2 UniProtKB/TrEMBL
  ENSSTOT00000029204.2 UniProtKB/TrEMBL
  ENSSTOT00000038448.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.167.10 UniProtKB/TrEMBL
  1.10.196.10 UniProtKB/TrEMBL
  2.30.29.30 UniProtKB/TrEMBL
  2.30.42.10 UniProtKB/TrEMBL
InterPro Dok-7 UniProtKB/TrEMBL
  Dok-7_PTB UniProtKB/TrEMBL
  GoLoco_motif UniProtKB/TrEMBL
  IRS_PTB UniProtKB/TrEMBL
  PDZ UniProtKB/TrEMBL
  PDZ_sf UniProtKB/TrEMBL
  PH-like_dom_sf UniProtKB/TrEMBL
  PTB/PI_dom UniProtKB/TrEMBL
  RBD_dom UniProtKB/TrEMBL
  RGS UniProtKB/TrEMBL
  RGS10/12/14-like UniProtKB/TrEMBL
  RGS12_RGS UniProtKB/TrEMBL
  RGS_sf UniProtKB/TrEMBL
  RGS_subdom1/3 UniProtKB/TrEMBL
  RGS_subdomain_2 UniProtKB/TrEMBL
  Ubiquitin-like_domsf UniProtKB/TrEMBL
NCBI Gene Rgs12 ENTREZGENE
PANTHER PROTEIN DOK-7 UniProtKB/TrEMBL
  PTHR21636 UniProtKB/TrEMBL
  REGULATOR OF G-PROTEIN SIGNALING 12 UniProtKB/TrEMBL
  REGULATOR OF G-PROTEIN SIGNALING LOCO UniProtKB/TrEMBL
Pfam GoLoco UniProtKB/TrEMBL
  IRS UniProtKB/TrEMBL
  PDZ UniProtKB/TrEMBL
  RBD UniProtKB/TrEMBL
  RGS UniProtKB/TrEMBL
  RGS12_us1 UniProtKB/TrEMBL
  RGS12_us2 UniProtKB/TrEMBL
  RGS12_usC UniProtKB/TrEMBL
PRINTS RGSPROTEIN UniProtKB/TrEMBL
PROSITE GOLOCO UniProtKB/TrEMBL
  IRS_PTB UniProtKB/TrEMBL
  PDZ UniProtKB/TrEMBL
  PID UniProtKB/TrEMBL
  RBD UniProtKB/TrEMBL
  RGS UniProtKB/TrEMBL
SMART GoLoco UniProtKB/TrEMBL
  IRS UniProtKB/TrEMBL
  PDZ UniProtKB/TrEMBL
  PTB UniProtKB/TrEMBL
  RBD UniProtKB/TrEMBL
  RGS UniProtKB/TrEMBL
Superfamily-SCOP PH domain-like UniProtKB/TrEMBL
  SSF48097 UniProtKB/TrEMBL
  SSF50156 UniProtKB/TrEMBL
  SSF54236 UniProtKB/TrEMBL
UniProt A0A287CWF0 ENTREZGENE, UniProtKB/TrEMBL
  I3M563 ENTREZGENE, UniProtKB/TrEMBL
  I3ND70_ICTTR UniProtKB/TrEMBL
  I3NG19 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-25 Rgs12  regulator of G protein signaling 12  Dok7  docking protein 7  Data merged from RGD:12730815 737654 PROVISIONAL
2017-07-13 Rgs12  regulator of G protein signaling 12    regulator of G-protein signaling 12  Symbol and/or name change 5135510 APPROVED