ZW10 (zw10 kinetochore protein) - Rat Genome Database

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Gene: ZW10 (zw10 kinetochore protein) Canis lupus familiaris
Analyze
Symbol: ZW10
Name: zw10 kinetochore protein
RGD ID: 12376196
Description: INVOLVED IN cell division (inferred); endoplasmic reticulum to Golgi vesicle-mediated transport (inferred); establishment of mitotic spindle orientation (inferred); ASSOCIATED WITH Chromosome 11, Partial Trisomy 11q (ortholog); intellectual disability (ortholog); osteosarcoma (ortholog); FOUND IN Dsl1/NZR complex (ortholog); RZZ complex (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: centromere/kinetochore protein zw10 homolog; ZW10, kinetochore associated, homolog
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1519,496,531 - 19,527,205 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl519,496,611 - 19,527,200 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha519,419,964 - 19,450,401 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0519,517,162 - 19,548,136 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl519,517,176 - 19,573,826 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1519,581,032 - 19,611,948 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0519,481,791 - 19,512,726 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0519,529,918 - 19,560,842 (+)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
ZW10
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1519,496,531 - 19,527,205 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl519,496,611 - 19,527,200 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha519,419,964 - 19,450,401 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0519,517,162 - 19,548,136 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl519,517,176 - 19,573,826 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1519,581,032 - 19,611,948 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0519,481,791 - 19,512,726 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0519,529,918 - 19,560,842 (+)NCBIUU_Cfam_GSD_1.0
ZW10
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3811113,733,187 - 113,773,692 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl11113,733,187 - 113,773,735 (-)EnsemblGRCh38hg38GRCh38
GRCh3711113,603,909 - 113,644,414 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3611113,109,119 - 113,149,635 (-)NCBINCBI36Build 36hg18NCBI36
Build 3411113,109,119 - 113,149,635NCBI
Celera11110,756,828 - 110,797,319 (-)NCBICelera
Cytogenetic Map11q23.2NCBI
HuRef11109,532,443 - 109,573,027 (-)NCBIHuRef
CHM1_111113,487,178 - 113,527,780 (-)NCBICHM1_1
T2T-CHM13v2.011113,743,514 - 113,784,012 (-)NCBIT2T-CHM13v2.0
Zw10
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39948,966,880 - 48,990,075 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl948,966,913 - 48,990,075 (+)EnsemblGRCm39 Ensembl
GRCm38949,055,576 - 49,078,775 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl949,055,613 - 49,078,775 (+)EnsemblGRCm38mm10GRCm38
MGSCv37948,863,737 - 48,886,878 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36948,807,564 - 48,830,705 (+)NCBIMGSCv36mm8
Celera946,352,736 - 46,375,856 (+)NCBICelera
Cytogenetic Map9A5.3NCBI
cM Map926.58NCBI
Zw10
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8858,292,959 - 58,317,881 (+)NCBIGRCr8
mRatBN7.2849,396,541 - 49,424,743 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl849,396,545 - 49,421,805 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx854,902,405 - 54,927,272 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0853,181,278 - 53,206,138 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0851,045,529 - 51,070,395 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0853,365,881 - 53,390,742 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl853,365,857 - 53,390,930 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0851,980,064 - 52,005,883 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4852,316,233 - 52,341,095 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1852,335,286 - 52,360,149 (+)NCBI
Celera848,953,761 - 48,978,510 (+)NCBICelera
Cytogenetic Map8q23NCBI
Zw10
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541215,350,285 - 15,391,996 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495541215,354,918 - 15,391,233 (-)NCBIChiLan1.0ChiLan1.0
ZW10
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v29114,476,266 - 114,517,225 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan111115,570,599 - 115,611,545 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v011108,611,818 - 108,652,444 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.111112,454,637 - 112,494,959 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl11112,454,637 - 112,495,316 (-)Ensemblpanpan1.1panPan2
Zw10
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494795,842,340 - 95,880,186 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936612825,419 - 860,971 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936612825,419 - 860,971 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ZW10
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl941,348,896 - 41,400,208 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1941,358,801 - 41,400,254 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
ZW10
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11105,108,531 - 105,152,921 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1105,109,040 - 105,152,862 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604320,866,303 - 20,906,831 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Zw10
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247849,221,128 - 9,255,284 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247849,221,123 - 9,255,294 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in ZW10
225 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 5 14 4 6 12 10 4
Low 5 8 6 2 6 6 8 2
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSCAFT00000021759   ⟹   ENSCAFP00000020211
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl519,496,611 - 19,527,200 (+)Ensembl
RefSeq Acc Id: ENSCAFT00845000821   ⟹   ENSCAFP00845000614
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl519,517,176 - 19,573,826 (+)Ensembl
RefSeq Acc Id: ENSCAFT00845000837   ⟹   ENSCAFP00845000629
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl519,517,176 - 19,567,588 (+)Ensembl
RefSeq Acc Id: ENSCAFT00845000860   ⟹   ENSCAFP00845000649
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl519,517,176 - 19,548,131 (+)Ensembl
RefSeq Acc Id: XM_038475002   ⟹   XP_038330930
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1519,581,032 - 19,611,948 (+)NCBI
RefSeq Acc Id: XM_038536129   ⟹   XP_038392057
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0519,529,918 - 19,560,842 (+)NCBI
RefSeq Acc Id: XM_038600323   ⟹   XP_038456251
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0519,481,791 - 19,512,726 (+)NCBI
RefSeq Acc Id: XM_038664853   ⟹   XP_038520781
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0519,517,162 - 19,548,136 (+)NCBI
RefSeq Acc Id: XM_536569   ⟹   XP_536569
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1519,496,531 - 19,527,205 (+)NCBI
Dog10K_Boxer_Tasha519,419,964 - 19,450,401 (+)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: XP_536569   ⟸   XM_536569
- UniProtKB: A0A8C0Q002 (UniProtKB/TrEMBL),   A0A8I3RP75 (UniProtKB/TrEMBL),   A0A8C0JUG0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCAFP00000020211   ⟸   ENSCAFT00000021759
RefSeq Acc Id: XP_038330930   ⟸   XM_038475002
RefSeq Acc Id: XP_038456251   ⟸   XM_038600323
RefSeq Acc Id: XP_038520781   ⟸   XM_038664853
- UniProtKB: A0A8C0Q002 (UniProtKB/TrEMBL),   A0A8I3RP75 (UniProtKB/TrEMBL),   A0A8C0JUG0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038392057   ⟸   XM_038536129
- UniProtKB: A0A8C0JUG0 (UniProtKB/TrEMBL),   A0A8C0Q002 (UniProtKB/TrEMBL),   A0A8I3RP75 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCAFP00845000614   ⟸   ENSCAFT00845000821
RefSeq Acc Id: ENSCAFP00845000649   ⟸   ENSCAFT00845000860
RefSeq Acc Id: ENSCAFP00845000629   ⟸   ENSCAFT00845000837
Protein Domains
Centromere/kinetochore protein zw10 C-terminal   Centromere/kinetochore protein zw10 middle   Centromere/kinetochore protein zw10 N-terminal

Promoters
RGD ID:13683153
Promoter ID:EPDNEW_C1222
Type:initiation region
Name:ZW10_1
Description:zw10 kinetochore protein
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1519,496,581 - 19,496,641EPDNEW

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000013720 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00030009346 UniProtKB/TrEMBL
  ENSCAFG00040004046 UniProtKB/TrEMBL
  ENSCAFG00845000507 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000021759.5 UniProtKB/TrEMBL
  ENSCAFT00000101312.1 UniProtKB/TrEMBL
  ENSCAFT00000105797.1 UniProtKB/TrEMBL
  ENSCAFT00030017306.1 UniProtKB/TrEMBL
  ENSCAFT00040007728.1 UniProtKB/TrEMBL
  ENSCAFT00845000821.1 UniProtKB/TrEMBL
  ENSCAFT00845000837.1 UniProtKB/TrEMBL
  ENSCAFT00845000860 ENTREZGENE
  ENSCAFT00845000860.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.357.150 UniProtKB/TrEMBL
InterPro RZZ-complex_Zw10 UniProtKB/TrEMBL
  Zw10/DSL1_C_sf UniProtKB/TrEMBL
  ZW10_C UniProtKB/TrEMBL
  Zw10_middle UniProtKB/TrEMBL
KEGG Report cfa:479433 UniProtKB/TrEMBL
NCBI Gene ZW10 ENTREZGENE
PANTHER CENTROMERE/KINETOCHORE PROTEIN ZW10 UniProtKB/TrEMBL
  CENTROMERE/KINETOCHORE PROTEIN ZW10 HOMOLOG UniProtKB/TrEMBL
Pfam Zw10 UniProtKB/TrEMBL
  ZW10_C UniProtKB/TrEMBL
  Zw10_middle UniProtKB/TrEMBL
UniProt A0A8C0JUG0 ENTREZGENE
  A0A8C0Q002 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3MFQ6_CANLF UniProtKB/TrEMBL
  A0A8I3MI25_CANLF UniProtKB/TrEMBL
  A0A8I3RP75 ENTREZGENE, UniProtKB/TrEMBL
  A0A8P0PNQ1_CANLF UniProtKB/TrEMBL
  A0A8P0TQL1_CANLF UniProtKB/TrEMBL
VGNC ID VGNC:48864 ENTREZGENE