GOT2 (glutamic-oxaloacetic transaminase 2) - Rat Genome Database

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Gene: GOT2 (glutamic-oxaloacetic transaminase 2) Canis lupus familiaris
Analyze
Symbol: GOT2
Name: glutamic-oxaloacetic transaminase 2
RGD ID: 12265282
Description: ENCODES a protein that exhibits amino acid binding (ortholog); carboxylic acid binding (ortholog); enzyme binding (ortholog); INVOLVED IN amino acid metabolic process (ortholog); aspartate biosynthetic process (ortholog); aspartate metabolic process (ortholog); PARTICIPATES IN 2-hydroxyglutaric aciduria pathway; argininosuccinic aciduria pathway; carbamoyl phosphate synthetase I deficiency pathway; ASSOCIATED WITH acute kidney failure (ortholog); Bardet-Biedl syndrome (ortholog); developmental and epileptic encephalopathy (ortholog); FOUND IN cell surface (ortholog); mitochondrial inner membrane (ortholog); mitochondrial matrix (ortholog)
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: aspartate aminotransferase, mitochondrial; glutamic-oxaloacetic transaminase 2, mitochondrial (aspartate aminotransferase 2)
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1257,968,833 - 57,994,219 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl257,968,833 - 57,994,218 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha254,600,250 - 54,625,432 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0258,509,907 - 58,535,139 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl258,509,974 - 58,535,138 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1255,357,609 - 55,362,222 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0256,341,620 - 56,366,972 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0257,239,528 - 57,264,732 (+)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
GOT2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1257,968,833 - 57,994,219 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl257,968,833 - 57,994,218 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha254,600,250 - 54,625,432 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0258,509,907 - 58,535,139 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl258,509,974 - 58,535,138 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1255,357,609 - 55,362,222 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0256,341,620 - 56,366,972 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0257,239,528 - 57,264,732 (+)NCBIUU_Cfam_GSD_1.0
GOT2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381658,707,131 - 58,734,316 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1658,707,131 - 58,734,342 (-)EnsemblGRCh38hg38GRCh38
GRCh371658,741,035 - 58,768,220 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361657,298,536 - 57,325,747 (-)NCBINCBI36Build 36hg18NCBI36
Build 341657,298,537 - 57,325,641NCBI
Celera1643,241,839 - 43,268,969 (-)NCBICelera
Cytogenetic Map16q21NCBI
HuRef1644,606,528 - 44,633,785 (-)NCBIHuRef
CHM1_11660,147,934 - 60,175,160 (-)NCBICHM1_1
T2T-CHM13v2.01664,499,639 - 64,526,824 (-)NCBIT2T-CHM13v2.0
Got2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39896,590,761 - 96,615,029 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl896,590,762 - 96,615,175 (-)EnsemblGRCm39 Ensembl
GRCm38895,864,133 - 95,888,401 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl895,864,134 - 95,888,547 (-)EnsemblGRCm38mm10GRCm38
MGSCv37898,388,037 - 98,412,265 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36898,753,266 - 98,777,494 (-)NCBIMGSCv36mm8
Celera8100,174,831 - 100,199,164 (-)NCBICelera
Cytogenetic Map8D1NCBI
cM Map847.79NCBI
Got2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8199,180,428 - 9,206,113 (+)NCBIGRCr8
mRatBN7.2199,174,304 - 9,199,995 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl199,174,311 - 9,199,994 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx199,143,186 - 9,168,707 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0199,910,004 - 9,935,525 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0199,196,308 - 9,221,830 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0199,587,637 - 9,613,323 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl199,587,653 - 9,613,340 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0199,572,757 - 9,598,443 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4199,629,687 - 9,655,336 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1199,634,512 - 9,660,162 (+)NCBI
Celera199,072,871 - 9,098,515 (+)NCBICelera
RH 3.4 Map1972.43RGD
Cytogenetic Map19p13NCBI
Got2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543316,122,824 - 16,145,113 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495543316,121,795 - 16,145,129 (-)NCBIChiLan1.0ChiLan1.0
GOT2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21868,190,297 - 68,217,343 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11674,113,908 - 74,140,940 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01638,995,770 - 39,022,750 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11658,120,781 - 58,147,378 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1658,120,781 - 58,147,378 (-)Ensemblpanpan1.1panPan2
GOT2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl620,407,200 - 20,432,067 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1620,407,203 - 20,431,849 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2618,502,171 - 18,527,683 (-)NCBISscrofa10.2Sscrofa10.2susScr3
GOT2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1544,645,721 - 44,670,917 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl544,645,602 - 44,670,918 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604731,493,979 - 31,519,503 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Got2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474627,558,005 - 27,586,257 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474627,557,994 - 27,586,257 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in GOT2
233 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 5 5 22 6 6 6 6 6 12 8 10 6
Low
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001287024 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038460438 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038468912 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038530878 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038595099 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038659176 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AAEX04000002 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CK997992 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CN005542 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CO665552 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DN355212 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DN376236 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DN387577 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DN414950 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DN441521 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  GR893421 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HB922353 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HC979762 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAHUQ010000031 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAQRD010000045 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAUVH010000373 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  REHQ01000002 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  REHQ01000042 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSCAFT00000013304   ⟹   ENSCAFP00000012308
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl257,968,833 - 57,994,218 (+)Ensembl
RefSeq Acc Id: ENSCAFT00000073846   ⟹   ENSCAFP00000055308
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl257,968,833 - 57,994,218 (+)Ensembl
RefSeq Acc Id: ENSCAFT00845002432   ⟹   ENSCAFP00845001933
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl258,509,974 - 58,535,138 (+)Ensembl
RefSeq Acc Id: XM_038460438   ⟹   XP_038316366
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
Dog10K_Boxer_Tasha254,600,250 - 54,625,432 (+)NCBI
RefSeq Acc Id: XM_038468912   ⟹   XP_038324840
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1255,357,609 - 55,362,222 (+)NCBI
RefSeq Acc Id: XM_038530878   ⟹   XP_038386806
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0257,239,528 - 57,264,732 (+)NCBI
RefSeq Acc Id: XM_038595099   ⟹   XP_038451027
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0256,341,620 - 56,366,972 (+)NCBI
RefSeq Acc Id: XM_038659176   ⟹   XP_038515104
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0258,509,907 - 58,535,139 (+)NCBI
Reference Protein Sequences
RefSeq Acc Id: ENSCAFP00000055308   ⟸   ENSCAFT00000073846
RefSeq Acc Id: ENSCAFP00000012308   ⟸   ENSCAFT00000013304
RefSeq Acc Id: XP_038324840   ⟸   XM_038468912
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038451027   ⟸   XM_038595099
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038515104   ⟸   XM_038659176
- Peptide Label: isoform X1
- UniProtKB: A0A8C0KSR7 (UniProtKB/TrEMBL),   A0A8C0LW07 (UniProtKB/TrEMBL),   A0A8P0SDE3 (UniProtKB/TrEMBL),   A0A8C0TSN2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038316366   ⟸   XM_038460438
- Peptide Label: isoform X1
- UniProtKB: A0A8C0KSR7 (UniProtKB/TrEMBL),   A0A8C0LW07 (UniProtKB/TrEMBL),   A0A8P0SDE3 (UniProtKB/TrEMBL),   A0A8C0TSN2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038386806   ⟸   XM_038530878
- Peptide Label: isoform X1
- UniProtKB: A0A8C0KSR7 (UniProtKB/TrEMBL),   A0A8C0LW07 (UniProtKB/TrEMBL),   A0A8C0TSN2 (UniProtKB/TrEMBL),   A0A8P0SDE3 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCAFP00845001933   ⟸   ENSCAFT00845002432
Protein Domains
Aminotransferase class I/classII

Promoters
RGD ID:13682503
Promoter ID:EPDNEW_C569
Type:initiation region
Name:GOT2_1
Description:aspartate aminotransferase, mitochondrial
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1257,968,894 - 57,968,954EPDNEW

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000008357 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00030000783 UniProtKB/TrEMBL
  ENSCAFG00040024430 UniProtKB/TrEMBL
  ENSCAFG00845001418 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000013304.5 UniProtKB/TrEMBL
  ENSCAFT00000073846.2 UniProtKB/TrEMBL
  ENSCAFT00030001353.1 UniProtKB/TrEMBL
  ENSCAFT00030001358.1 UniProtKB/TrEMBL
  ENSCAFT00040045513.1 UniProtKB/TrEMBL
  ENSCAFT00040045523.1 UniProtKB/TrEMBL
  ENSCAFT00040045543.1 UniProtKB/TrEMBL
  ENSCAFT00845002432 ENTREZGENE
  ENSCAFT00845002432.1 UniProtKB/TrEMBL
Gene3D-CATH 3.40.640.10 UniProtKB/TrEMBL
  3.90.1150.10 UniProtKB/TrEMBL
InterPro Aminotransferase_I/II UniProtKB/TrEMBL
  Asp_trans UniProtKB/TrEMBL
  NHTrfase_class1_PyrdxlP-BS UniProtKB/TrEMBL
  PyrdxlP-dep_Trfase UniProtKB/TrEMBL
  PyrdxlP-dep_Trfase_major UniProtKB/TrEMBL
  PyrdxlP-dep_Trfase_small UniProtKB/TrEMBL
NCBI Gene GOT2 ENTREZGENE
PANTHER ASPARTATE AMINOTRANSFERASE, MITOCHONDRIAL UniProtKB/TrEMBL
  PTHR11879 UniProtKB/TrEMBL
Pfam Aminotran_1_2 UniProtKB/TrEMBL
PRINTS TRANSAMINASE UniProtKB/TrEMBL
PROSITE AA_TRANSFER_CLASS_1 UniProtKB/TrEMBL
Superfamily-SCOP SSF53383 UniProtKB/TrEMBL
UniProt A0A8C0KSR7 ENTREZGENE
  A0A8C0LW07 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C0LY21_CANLF UniProtKB/TrEMBL
  A0A8C0TSN2 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C0Z653_CANLF UniProtKB/TrEMBL
  A0A8I3MPF7_CANLF UniProtKB/TrEMBL
  A0A8P0SDE3 ENTREZGENE
UniProt Secondary A0A8P0SDE3 UniProtKB/TrEMBL
  A0A8P0T7K6 UniProtKB/TrEMBL