AASS (aminoadipate-semialdehyde synthase) - Rat Genome Database

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Gene: AASS (aminoadipate-semialdehyde synthase) Canis lupus familiaris
Analyze
Symbol: AASS
Name: aminoadipate-semialdehyde synthase
RGD ID: 12207187
Description: ENCODES a protein that exhibits oxidoreductase activity (inferred); saccharopine dehydrogenase (NAD+, L-glutamate-forming) activity (inferred); saccharopine dehydrogenase (NADP+, L-lysine-forming) activity (inferred); INVOLVED IN L-lysine catabolic process (ortholog); PARTICIPATES IN 2-aminoadipic 2-oxoadipic aciduria pathway; glutaric aciduria type I pathway; hyperlysinemia pathway; ASSOCIATED WITH Chemical and Drug Induced Liver Injury (ortholog); genetic disease (ortholog); hyperlysinemia (ortholog); FOUND IN cytoplasm (inferred); intracellular membrane-bounded organelle (inferred); mitochondrion (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: alpha-aminoadipic semialdehyde synthase, mitochondrial
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11459,950,123 - 59,993,457 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1459,951,216 - 60,000,212 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1459,366,730 - 59,419,159 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01459,984,503 - 60,037,014 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1459,986,237 - 60,035,749 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11460,076,161 - 60,128,175 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01459,703,783 - 59,756,172 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01460,081,118 - 60,133,517 (-)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:30032202  


Genomics

Comparative Map Data
AASS
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11459,950,123 - 59,993,457 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1459,951,216 - 60,000,212 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1459,366,730 - 59,419,159 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01459,984,503 - 60,037,014 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1459,986,237 - 60,035,749 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11460,076,161 - 60,128,175 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01459,703,783 - 59,756,172 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01460,081,118 - 60,133,517 (-)NCBIUU_Cfam_GSD_1.0
AASS
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh387122,073,549 - 122,144,249 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl7122,064,583 - 122,144,308 (-)EnsemblGRCh38hg38GRCh38
GRCh377121,713,603 - 121,784,303 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 367121,503,423 - 121,561,112 (-)NCBINCBI36Build 36hg18NCBI36
Build 347121,310,137 - 121,367,827NCBI
Celera7116,522,826 - 116,593,571 (-)NCBICelera
Cytogenetic Map7q31.32NCBI
HuRef7116,077,048 - 116,147,810 (-)NCBIHuRef
CHM1_17121,646,898 - 121,717,645 (-)NCBICHM1_1
T2T-CHM13v2.07123,389,454 - 123,460,169 (-)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v27121,108,272 - 121,179,018 (-)NCBI
Aass
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39623,072,172 - 23,132,985 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl623,072,172 - 23,132,985 (-)EnsemblGRCm39 Ensembl
GRCm38623,072,173 - 23,132,986 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl623,072,173 - 23,132,986 (-)EnsemblGRCm38mm10GRCm38
MGSCv37623,022,173 - 23,082,986 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36623,022,171 - 23,082,975 (-)NCBIMGSCv36mm8
Celera623,117,896 - 23,183,403 (-)NCBICelera
Cytogenetic Map6A3.1NCBI
cM Map610.27NCBI
Aass
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8452,572,146 - 52,628,811 (-)NCBIGRCr8
mRatBN7.2451,606,461 - 51,663,136 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl451,606,462 - 51,663,136 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx456,573,037 - 56,636,497 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0452,494,066 - 52,557,519 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0450,935,584 - 50,999,363 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0450,152,005 - 50,208,935 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl450,152,452 - 50,200,328 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0449,938,569 - 49,993,864 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4449,479,938 - 49,539,782 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1449,710,958 - 49,806,368 (-)NCBI
Celera446,798,734 - 46,861,408 (-)NCBICelera
Cytogenetic Map4q22NCBI
Aass
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554793,742,757 - 3,814,338 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554793,746,003 - 3,805,835 (-)NCBIChiLan1.0ChiLan1.0
AASS
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v26158,945,704 - 159,016,545 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1710,955,958 - 11,026,799 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v07114,084,792 - 114,155,558 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.17126,769,655 - 126,840,346 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl7126,769,655 - 126,840,346 (-)Ensemblpanpan1.1panPan2
Aass
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440511849,012,960 - 49,067,984 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366053,136,018 - 3,190,948 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366053,135,977 - 3,190,956 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
AASS
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1824,974,754 - 25,039,195 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11824,938,366 - 25,039,197 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21826,579,353 - 26,641,402 (+)NCBISscrofa10.2Sscrofa10.2susScr3
AASS
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12190,891,781 - 90,959,351 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2190,892,023 - 90,959,343 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604212,584,431 - 12,655,125 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Aass
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462478313,831,150 - 13,902,082 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462478313,831,220 - 13,904,806 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in AASS
841 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 9 6 6 3 3
Low 3 5 13 6 3 6 9 8 8 6
Below cutoff 2 2

Sequence

Nucleotide Sequences
RefSeq Transcripts XM_022427647 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038441754 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038441760 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038495207 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038557486 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038557487 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038621418 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038621419 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038621420 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038687114 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038687115 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038687116 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AAEX04000014 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAHUQ010000159 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAQRD010000017 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAUVH010000208 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  REHQ01000014 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSCAFT00000005673   ⟹   ENSCAFP00000005251
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl1459,951,216 - 60,000,212 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845026055   ⟹   ENSCAFP00845020545
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl1459,986,237 - 60,035,749 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845026111   ⟹   ENSCAFP00845020587
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl1459,986,237 - 60,035,749 (-)Ensembl
RefSeq Acc Id: XM_038441754   ⟹   XP_038297682
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
Dog10K_Boxer_Tasha1459,368,726 - 59,417,634 (-)NCBI
RefSeq Acc Id: XM_038441760   ⟹   XP_038297688
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
Dog10K_Boxer_Tasha1459,366,730 - 59,419,159 (-)NCBI
RefSeq Acc Id: XM_038495207   ⟹   XP_038351135
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.11460,076,161 - 60,128,175 (-)NCBI
RefSeq Acc Id: XM_038557486   ⟹   XP_038413414
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.01460,083,113 - 60,131,986 (-)NCBI
RefSeq Acc Id: XM_038557487   ⟹   XP_038413415
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.01460,081,118 - 60,133,517 (-)NCBI
RefSeq Acc Id: XM_038621418   ⟹   XP_038477346
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.01459,705,779 - 59,754,880 (-)NCBI
RefSeq Acc Id: XM_038621419   ⟹   XP_038477347
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.01459,703,783 - 59,756,172 (-)NCBI
RefSeq Acc Id: XM_038621420   ⟹   XP_038477348
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.01459,705,779 - 59,744,991 (-)NCBI
RefSeq Acc Id: XM_038687114   ⟹   XP_038543042
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.01459,986,498 - 60,037,014 (-)NCBI
RefSeq Acc Id: XM_038687115   ⟹   XP_038543043
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.01459,984,503 - 60,035,498 (-)NCBI
RefSeq Acc Id: XM_038687116   ⟹   XP_038543044
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.01459,986,498 - 60,025,537 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: ENSCAFP00000005251   ⟸   ENSCAFT00000005673
RefSeq Acc Id: XP_038351135   ⟸   XM_038495207
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038477347   ⟸   XM_038621419
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038477346   ⟸   XM_038621418
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038477348   ⟸   XM_038621420
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038543043   ⟸   XM_038687115
- Peptide Label: isoform X1
- UniProtKB: A0A8I3NR48 (UniProtKB/TrEMBL),   A0A8P0N6F7 (UniProtKB/TrEMBL),   A0A8C0QF09 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038543042   ⟸   XM_038687114
- Peptide Label: isoform X1
- UniProtKB: A0A8I3NR48 (UniProtKB/TrEMBL),   A0A8P0N6F7 (UniProtKB/TrEMBL),   A0A8C0QF09 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038543044   ⟸   XM_038687116
- Peptide Label: isoform X2
- UniProtKB: A0A8C0QF09 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038297688   ⟸   XM_038441760
- Peptide Label: isoform X1
- UniProtKB: A0A8I3NR48 (UniProtKB/TrEMBL),   A0A8P0N6F7 (UniProtKB/TrEMBL),   A0A8C0QF09 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038297682   ⟸   XM_038441754
- Peptide Label: isoform X1
- UniProtKB: A0A8I3NR48 (UniProtKB/TrEMBL),   A0A8P0N6F7 (UniProtKB/TrEMBL),   A0A8C0QF09 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038413415   ⟸   XM_038557487
- Peptide Label: isoform X1
- UniProtKB: A0A8C0QF09 (UniProtKB/TrEMBL),   A0A8I3NR48 (UniProtKB/TrEMBL),   A0A8P0N6F7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038413414   ⟸   XM_038557486
- Peptide Label: isoform X1
- UniProtKB: A0A8C0QF09 (UniProtKB/TrEMBL),   A0A8I3NR48 (UniProtKB/TrEMBL),   A0A8P0N6F7 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCAFP00845020545   ⟸   ENSCAFT00845026055
RefSeq Acc Id: ENSCAFP00845020587   ⟸   ENSCAFT00845026111
Protein Domains
Alanine dehydrogenase/pyridine nucleotide


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000003532 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00030015777 UniProtKB/TrEMBL
  ENSCAFG00040007625 UniProtKB/TrEMBL
  ENSCAFG00845014560 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000005673.5 UniProtKB/TrEMBL
  ENSCAFT00000103261.1 UniProtKB/TrEMBL
  ENSCAFT00030029063.1 UniProtKB/TrEMBL
  ENSCAFT00030029292.1 UniProtKB/TrEMBL
  ENSCAFT00040014202.1 UniProtKB/TrEMBL
  ENSCAFT00845026055 ENTREZGENE
  ENSCAFT00845026055.1 UniProtKB/TrEMBL
  ENSCAFT00845026111 ENTREZGENE
  ENSCAFT00845026111.1 UniProtKB/TrEMBL
Gene3D-CATH Domain 3, Saccharopine reductase UniProtKB/TrEMBL
  NAD(P)-binding Rossmann-like Domain UniProtKB/TrEMBL
InterPro AlaDH/PNT_N UniProtKB/TrEMBL
  AlaDH/PNT_NAD(H)-bd UniProtKB/TrEMBL
  NAD(P)-bd_dom_sf UniProtKB/TrEMBL
  Sacchrp_dh-like_C UniProtKB/TrEMBL
  Sacchrp_dh_NADP UniProtKB/TrEMBL
NCBI Gene AASS ENTREZGENE
PANTHER ALPHA-AMINOADIPIC SEMIALDEHYDE SYNTHASE, MITOCHONDRIAL UniProtKB/TrEMBL
  SACCHAROPINE DEHYDROGENASE UniProtKB/TrEMBL
Pfam AlaDh_PNT_N UniProtKB/TrEMBL
  Sacchrp_dh_C UniProtKB/TrEMBL
  Sacchrp_dh_NADP UniProtKB/TrEMBL
SMART AlaDh_PNT_C UniProtKB/TrEMBL
  AlaDh_PNT_N UniProtKB/TrEMBL
Superfamily-SCOP Formate/glycerate dehydrogenase catalytic domain-like UniProtKB/TrEMBL
  Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain UniProtKB/TrEMBL
  SSF51735 UniProtKB/TrEMBL
UniProt A0A8C0NER6_CANLF UniProtKB/TrEMBL
  A0A8C0NHY6_CANLF UniProtKB/TrEMBL
  A0A8C0QF09 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3NR48 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3P2P7_CANLF UniProtKB/TrEMBL
  A0A8P0N6F7 ENTREZGENE, UniProtKB/TrEMBL
  A0A8P0TM48_CANLF UniProtKB/TrEMBL
VGNC ID VGNC:37419 ENTREZGENE