ATP5F1A (ATP synthase F1 subunit alpha) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Gene: ATP5F1A (ATP synthase F1 subunit alpha) Canis lupus familiaris
Analyze
Symbol: ATP5F1A
Name: ATP synthase F1 subunit alpha
RGD ID: 12154862
Description: ENCODES a protein that exhibits ADP binding (ortholog); angiostatin binding (ortholog); ATP binding (ortholog); INVOLVED IN cellular response to dexamethasone stimulus (ortholog); cellular response to nitric oxide (ortholog); lipid metabolic process (ortholog); PARTICIPATES IN electron transport chain pathway; ASSOCIATED WITH Alzheimer's disease (ortholog); combined oxidative phosphorylation deficiency 22 (ortholog); Endotoxemia (ortholog); FOUND IN cell surface (ortholog); COP9 signalosome (ortholog); membrane raft (ortholog)
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: ATP synthase subunit alpha, mitochondrial; ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1, cardiac muscle; ATP5A1; mitochondrial ATP synthase subunit alpha subunit
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1745,118,188 - 45,127,048 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl745,117,657 - 45,127,048 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha744,600,134 - 44,608,995 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0745,071,120 - 45,079,950 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl745,071,075 - 45,079,951 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1744,770,243 - 44,779,076 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0744,823,645 - 44,832,526 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0745,108,044 - 45,116,902 (+)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:21817160   PMID:22301074   PMID:30032202   PMID:37756605  


Genomics

Comparative Map Data
ATP5F1A
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1745,118,188 - 45,127,048 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl745,117,657 - 45,127,048 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha744,600,134 - 44,608,995 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0745,071,120 - 45,079,950 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl745,071,075 - 45,079,951 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1744,770,243 - 44,779,076 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0744,823,645 - 44,832,526 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0745,108,044 - 45,116,902 (+)NCBIUU_Cfam_GSD_1.0
ATP5F1A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381846,080,248 - 46,104,227 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1846,080,248 - 46,104,334 (-)EnsemblGRCh38hg38GRCh38
GRCh371843,660,214 - 43,684,193 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361841,918,108 - 41,938,197 (-)NCBINCBI36Build 36hg18NCBI36
Build 341841,918,107 - 41,932,285NCBI
Celera1840,472,298 - 40,486,450 (-)NCBICelera
Cytogenetic Map18q21.1NCBI
HuRef1840,521,726 - 40,541,788 (-)NCBIHuRef
CHM1_11843,591,321 - 43,611,335 (-)NCBICHM1_1
T2T-CHM13v2.01846,271,209 - 46,295,188 (-)NCBIT2T-CHM13v2.0
Atp5f1a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391877,861,468 - 77,870,569 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1877,861,429 - 77,870,569 (+)EnsemblGRCm39 Ensembl
GRCm381877,773,768 - 77,782,869 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1877,773,729 - 77,782,869 (+)EnsemblGRCm38mm10GRCm38
MGSCv371878,012,507 - 78,021,608 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361877,978,093 - 77,986,942 (+)NCBIMGSCv36mm8
Celera1878,959,749 - 78,968,850 (+)NCBICelera
Cytogenetic Map18E3NCBI
cM Map1852.38NCBI
Atp5f1a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81873,567,537 - 73,575,473 (+)NCBIGRCr8
mRatBN7.21871,292,406 - 71,300,342 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1871,292,374 - 71,300,794 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1873,391,830 - 73,399,766 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01874,061,095 - 74,069,031 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01871,917,686 - 71,925,622 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01874,156,553 - 74,164,490 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1874,156,553 - 74,164,495 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01873,830,604 - 73,838,477 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41874,735,267 - 74,743,088 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11874,808,539 - 74,816,361 (+)NCBI
Celera1869,811,132 - 69,819,068 (+)NCBICelera
Cytogenetic Map18q12.3NCBI
Atp5f1a
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540231,651,960 - 31,662,762 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495540231,652,226 - 31,662,114 (-)NCBIChiLan1.0ChiLan1.0
ATP5F1A
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21763,508,983 - 63,523,359 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11849,201,584 - 49,215,960 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01839,366,384 - 39,380,514 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11842,904,136 - 42,918,626 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1842,904,136 - 42,923,326 (-)Ensemblpanpan1.1panPan2
Atp5f1a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494441,415,655 - 41,425,434 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936517742,791 - 753,336 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936517743,036 - 752,836 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ATP5F1A
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl195,733,090 - 95,750,841 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1195,738,789 - 95,750,835 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21105,944,306 - 105,955,798 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ATP5F1A
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11834,815,924 - 34,828,052 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1834,816,027 - 34,830,924 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660509,183,131 - 9,195,639 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Atp5f1a
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247789,773,064 - 9,784,533 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247789,773,365 - 9,784,564 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in ATP5F1A
137 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High 5 3
Medium 5 22 6 6 6 6 3 12 8 10 6
Low
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSCAFT00000027989   ⟹   ENSCAFP00000026032
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl745,117,657 - 45,127,048 (+)Ensembl
RefSeq Acc Id: ENSCAFT00000061168   ⟹   ENSCAFP00000059342
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl745,118,188 - 45,126,800 (+)Ensembl
RefSeq Acc Id: ENSCAFT00845005798   ⟹   ENSCAFP00845004604
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl745,071,075 - 45,079,951 (+)Ensembl
RefSeq Acc Id: NM_001287154   ⟹   NP_001274083
RefSeq Status: VALIDATED
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1745,118,188 - 45,127,048 (+)NCBI
Dog10K_Boxer_Tasha744,600,134 - 44,608,995 (+)NCBI
ROS_Cfam_1.0745,071,120 - 45,079,950 (+)NCBI
UMICH_Zoey_3.1744,770,243 - 44,779,076 (+)NCBI
UNSW_CanFamBas_1.0744,823,645 - 44,832,526 (+)NCBI
UU_Cfam_GSD_1.0745,108,044 - 45,116,902 (+)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_001274083   ⟸   NM_001287154
- UniProtKB: A0A1B1X469 (UniProtKB/TrEMBL),   A0A8C0KDX6 (UniProtKB/TrEMBL),   A0A8C0QKG4 (UniProtKB/TrEMBL),   A0A8C0NQM6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCAFP00000026032   ⟸   ENSCAFT00000027989
RefSeq Acc Id: ENSCAFP00000059342   ⟸   ENSCAFT00000061168
RefSeq Acc Id: ENSCAFP00845004604   ⟸   ENSCAFT00845005798
Protein Domains
ATP synthase alpha subunit C-terminal   ATPase F1/V1/A1 complex alpha/beta subunit   ATPase F1/V1/A1 complex alpha/beta subunit N-

Promoters
RGD ID:13684050
Promoter ID:EPDNEW_C2120
Type:multiple initiation site
Name:ATP5F1A_1
Description:Canis lupus familiaris ATP synthase F1 subunit alpha , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1745,118,188 - 45,118,248EPDNEW

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000017648 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00030015819 UniProtKB/TrEMBL
  ENSCAFG00040005335 UniProtKB/TrEMBL
  ENSCAFG00845003277 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000027989.5 UniProtKB/TrEMBL
  ENSCAFT00030029307.1 UniProtKB/TrEMBL
  ENSCAFT00030029484.1 UniProtKB/TrEMBL
  ENSCAFT00030029570.1 UniProtKB/TrEMBL
  ENSCAFT00030029687.1 UniProtKB/TrEMBL
  ENSCAFT00040010015.1 UniProtKB/TrEMBL
  ENSCAFT00845005798 ENTREZGENE
  ENSCAFT00845005798.1 UniProtKB/TrEMBL
Gene3D-CATH 1.20.150.20 UniProtKB/TrEMBL
  2.40.30.20 UniProtKB/TrEMBL
  3.40.50.12240 UniProtKB/TrEMBL
  3.40.50.300 UniProtKB/TrEMBL
InterPro ATP_synth_asu-like_sf UniProtKB/TrEMBL
  ATP_synth_asu_C UniProtKB/TrEMBL
  ATP_synth_asu_C_sf UniProtKB/TrEMBL
  ATP_synth_F1_a UniProtKB/TrEMBL
  ATP_synth_F1_asu UniProtKB/TrEMBL
  ATPase_a/bsu_AS UniProtKB/TrEMBL
  ATPase_F1/V1/A1_a/bsu_N UniProtKB/TrEMBL
  ATPase_F1/V1/A1_a/bsu_N_sf UniProtKB/TrEMBL
  ATPase_F1/V1/A1_a/bsu_nucl-bd UniProtKB/TrEMBL
  P-loop_NTPase UniProtKB/TrEMBL
KEGG Report cfa:480149 UniProtKB/TrEMBL
NCBI Gene ATP5A1 ENTREZGENE
PANTHER ATP SYNTHASE SUBUNIT ALPHA, MITOCHONDRIAL UniProtKB/TrEMBL
  ATP SYNTHASE SUBUNIT ALPHA, MITOCHONDRIAL UniProtKB/TrEMBL
Pfam ATP-synt_ab UniProtKB/TrEMBL
  ATP-synt_ab_C UniProtKB/TrEMBL
  ATP-synt_ab_N UniProtKB/TrEMBL
PIRSF F_ATPase_subunit_alpha UniProtKB/TrEMBL
PROSITE ATPASE_ALPHA_BETA UniProtKB/TrEMBL
Superfamily-SCOP C-terminal domain of alpha and beta subunits of F1 ATP synthase UniProtKB/TrEMBL
  SSF50615 UniProtKB/TrEMBL
  SSF52540 UniProtKB/TrEMBL
UniProt A0A1B1X469 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C0KDX6 ENTREZGENE
  A0A8C0NEX0_CANLF UniProtKB/TrEMBL
  A0A8C0NQM6 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C0NUQ9_CANLF UniProtKB/TrEMBL
  A0A8C0QKG4 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C0RL80_CANLF UniProtKB/TrEMBL
  A0A8P0NIY6_CANLF UniProtKB/TrEMBL
VGNC ID VGNC:53332 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2017-11-28 ATP5F1A  ATP synthase F1 subunit alpha  ATP5A1  ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1, cardiac muscle  Symbol and/or name change 5135510 APPROVED