TYMS (thymidylate synthetase) - Rat Genome Database

Name: TYMS
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

Gene: TYMS (thymidylate synthetase) Canis lupus familiaris

Analyze

Symbol:

TYMS

Name:

thymidylate synthetase

RGD ID:

12131630

Description:

ENCODES a protein that exhibits folic acid binding (ortholog); heterocyclic compound binding (ortholog); mRNA binding (ortholog); INVOLVED IN cartilage development (ortholog); circadian rhythm (ortholog); developmental growth (ortholog); PARTICIPATES IN beta-ureidopropionase deficiency pathway; capecitabine pharmacodynamics pathway; capecitabine pharmacokinetics pathway; ASSOCIATED WITH abdominal aortic aneurysm (ortholog); acute lymphoblastic leukemia (ortholog); acute myeloid leukemia (ortholog); FOUND IN nucleus (ortholog)

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

thymidylate synthase; TS

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	TYMS (thymidylate synthetase)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, Treefam
Mus musculus (house mouse):	Tyms (thymidylate synthase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus norvegicus (Norway rat):	Tyms (thymidylate synthetase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Tyms (thymidylate synthetase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	TYMS (thymidylate synthetase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Tyms (thymidylate synthetase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	TYMS (thymidylate synthetase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	TYMS (thymidylate synthetase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Tyms (thymidylate synthetase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline

Related Pseudogenes:

LOC476100

Latest Assembly:

CanFam3.1 - Dog CanFam3.1 Assembly

Position:

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	7	67,487,927 - 67,497,747 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	7	67,487,927 - 67,497,747 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	7	66,941,464 - 66,951,243 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	7	67,553,912 - 67,563,695 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	7	67,553,912 - 67,563,695 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	7	67,230,668 - 67,240,435 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	7	67,242,107 - 67,251,886 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	7	67,544,017 - 67,553,794 (+)	NCBI		UU_Cfam_GSD_1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

abdominal aortic aneurysm (ISO)

acute lymphoblastic leukemia (ISO)

acute myeloid leukemia (ISO)

anemia (ISO)

Animal Disease Models (ISO)

autistic disorder (ISO)

brain disease (ISO)

Breast Neoplasms (ISO)

cerebral infarction (ISO)

cleft lip (ISO)

cleft palate (ISO)

colon carcinoma (ISO)

Colonic Neoplasms (ISO)

colorectal adenocarcinoma (ISO)

Colorectal Neoplasms (ISO)

COVID-19 (ISO)

Digestive System Neoplasms (ISO)

dyskeratosis congenita (ISO)

DYSKERATOSIS CONGENITA, DIGENIC (ISO)

Experimental Mammary Neoplasms (ISO)

follicular lymphoma (ISO)

genetic disease (ISO)

Head and Neck Neoplasms (ISO)

hepatocellular carcinoma (ISO)

Hyperammonemia (ISO)

lung adenocarcinoma (ISO)

Lung Neoplasms (ISO)

multiple myeloma (ISO)

Neoplasm Metastasis (ISO)

Neoplasm Recurrence, Local (ISO)

nervous system disease (ISO)

Neurodevelopmental Disorders (ISO)

neuroendocrine tumor (ISO)

non-Hodgkin lymphoma (ISO)

Ovarian Neoplasms (ISO)

pancreatic cancer (ISO)

Prostatic Neoplasms (ISO)

rectal benign neoplasm (ISO)

rheumatoid arthritis (ISO)

Splenomegaly (ISO)

squamous cell carcinoma (ISO)

Stomach Neoplasms (ISO)

Tongue Neoplasms (ISO)

urinary bladder cancer (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

cartilage development (ISO)

circadian rhythm (ISO)

developmental growth (ISO)

dTMP biosynthetic process (IEA,ISO)

dTTP biosynthetic process (IEA)

intestinal epithelial cell maturation (ISO)

liver regeneration (ISO)

methylation (IEA)

modulation by virus of host process (ISO)

negative regulation of translation (IEA)

nucleotide biosynthetic process (IEA)

pyrimidine nucleobase metabolic process (ISO)

regulation of translation (ISO)

response to cytokine (ISO)

response to ethanol (ISO)

response to folic acid (ISO)

response to glucocorticoid (ISO)

response to organic cyclic compound (ISO)

response to organophosphorus (IEA)

response to progesterone (ISO)

response to toxic substance (ISO)

response to vitamin A (ISO)

response to xenobiotic stimulus (ISO)

tetrahydrofolate interconversion (IEA)

tetrahydrofolate metabolic process (ISO)

uracil metabolic process (ISO)

Cellular Component

cytoplasm (IEA)

cytosol (IEA)

mitochondrial inner membrane (IEA)

mitochondrial matrix (IEA)

mitochondrion (IEA)

nucleus (IEA,ISO)

Molecular Function

dihydrofolate reductase activity (IEA)

folic acid binding (ISO)

heterocyclic compound binding (ISO)

methyltransferase activity (IEA)

mRNA binding (ISO)

mRNA regulatory element binding translation repressor activity (IEA)

protein homodimerization activity (ISO)

sequence-specific mRNA binding (IEA)

thymidylate synthase activity (IEA,ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

beta-ureidopropionase deficiency pathway (ISO)

capecitabine pharmacodynamics pathway (ISO)

capecitabine pharmacokinetics pathway (ISO)

dihydropyrimidinase deficiency pathway (ISO)

folate mediated one-carbon metabolic pathway (ISO)

folate metabolic pathway (ISO)

gemcitabine pharmacodynamics pathway (ISO)

gemcitabine pharmacokinetics pathway (ISO)

mitochondrial neurogastrointestinal encephalopathy syndrome pathway (ISO)

orotic aciduria 1 pathway (ISO)

pyrimidine metabolic pathway (ISO)

References

Additional References at PubMed

PMID:11130975	PMID:22301074	PMID:30032202	PMID:30578659	PMID:33038064

Genomics

Comparative Map Data

TYMS
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	7	67,487,927 - 67,497,747 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	7	67,487,927 - 67,497,747 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	7	66,941,464 - 66,951,243 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	7	67,553,912 - 67,563,695 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	7	67,553,912 - 67,563,695 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	7	67,230,668 - 67,240,435 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	7	67,242,107 - 67,251,886 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	7	67,544,017 - 67,553,794 (+)	NCBI		UU_Cfam_GSD_1.0

TYMS
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	18	657,653 - 673,578 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	18	657,653 - 673,578 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	18	657,653 - 673,578 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	18	647,651 - 663,492 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	18	647,650 - 663,492	NCBI
Celera	18	532,413 - 547,810 (+)	NCBI		Celera
Cytogenetic Map	18	p11.32	NCBI
HuRef	18	617,665 - 633,936 (+)	NCBI		HuRef
CHM1_1	18	656,968 - 672,692 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	18	811,985 - 827,856 (+)	NCBI		T2T-CHM13v2.0

Tyms
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	5	30,243,544 - 30,279,261 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	5	30,263,200 - 30,278,615 (-)	Ensembl		GRCm39 Ensembl
GRCm38	5	30,038,546 - 30,073,645 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	5	30,058,202 - 30,073,617 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	5	30,384,740 - 30,400,165 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	5	30,389,614 - 30,404,368 (-)	NCBI		MGSCv36	mm8
Celera	5	27,575,630 - 27,591,037 (-)	NCBI		Celera
Cytogenetic Map	5	B1	NCBI
cM Map	5	15.81	NCBI

Tyms
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	9	120,760,057 - 120,776,149 (-)	NCBI		GRCr8
mRatBN7.2	9	113,313,454 - 113,329,551 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	9	113,313,452 - 113,329,536 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	9	121,800,847 - 121,813,531 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	9	126,929,987 - 126,942,671 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	9	125,275,890 - 125,288,575 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	9	121,918,875 - 121,931,564 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	9	121,918,947 - 121,931,564 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	9	121,368,418 - 121,381,493 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	9	112,604,912 - 112,617,706 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	9	112,814,399 - 112,827,186 (-)	NCBI
Celera	9	110,420,900 - 110,433,600 (-)	NCBI		Celera
RH 3.4 Map	9	866.0	RGD
Cytogenetic Map	9	q38	NCBI

Tyms
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955402	9,296,321 - 9,306,631 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955402	9,295,862 - 9,304,952 (-)	NCBI	ChiLan1.0	ChiLan1.0

TYMS
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	17	37,829,504 - 37,845,090 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	18	23,522,096 - 23,537,682 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	18	13,653,085 - 13,668,478 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	18	17,295,182 - 17,310,311 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	18	17,295,182 - 17,310,320 (-)	Ensembl	panpan1.1		panPan2

Tyms
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404944	63,774,083 - 63,783,067 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936550	34,048 - 41,840 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936550	33,797 - 42,233 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

TYMS
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	6	105,642,381 - 105,660,578 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	6	105,642,730 - 105,660,279 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1

TYMS
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	18	60,030,640 - 60,043,297 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	18	60,030,658 - 60,041,856 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666050	34,821,625 - 34,834,281 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Tyms
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624770	11,138,652 - 11,149,600 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624770	11,138,673 - 11,149,600 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in TYMS
158 total Variants

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	reproductive system	respiratory system	adipose tissue
High
Medium	5	5	22	6	6	6	6	5	12		10	6
Low								1		8
Below cutoff

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001252174	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AAEX04000007	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AF201743	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AF202073	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CO666735	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	DN272700	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	GR902238	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	HC907295	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAAHUQ010000084	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAAQRD010000093	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAAUVH010000022	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	REHQ01000007	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSCAFT00000018205 ⟹ ENSCAFP00000032342

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
CanFam3.1 Ensembl	7	67,488,039 - 67,497,747 (+)	Ensembl

RefSeq Acc Id:

ENSCAFT00000029138 ⟹ ENSCAFP00000027096

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
CanFam3.1 Ensembl	7	67,487,927 - 67,497,747 (+)	Ensembl

RefSeq Acc Id:

ENSCAFT00000036918 ⟹ ENSCAFP00000032347

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
CanFam3.1 Ensembl	7	67,487,927 - 67,497,747 (+)	Ensembl

RefSeq Acc Id:

ENSCAFT00845003376 ⟹ ENSCAFP00845002679

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
ROS_Cfam_1.0 Ensembl	7	67,553,912 - 67,563,695 (+)	Ensembl

RefSeq Acc Id:

ENSCAFT00845003401 ⟹ ENSCAFP00845002703

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
ROS_Cfam_1.0 Ensembl	7	67,553,912 - 67,563,695 (+)	Ensembl

RefSeq Acc Id:

ENSCAFT00845003416 ⟹ ENSCAFP00845002714

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
ROS_Cfam_1.0 Ensembl	7	67,553,912 - 67,563,695 (+)	Ensembl

RefSeq Acc Id:

ENSCAFT00845003450 ⟹ ENSCAFP00845002735

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
ROS_Cfam_1.0 Ensembl	7	67,554,024 - 67,563,695 (+)	Ensembl

RefSeq Acc Id:

NM_001252174 ⟹ NP_001239103

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
CanFam3.1	7	67,487,927 - 67,497,747 (+)	NCBI
Dog10K_Boxer_Tasha	7	66,941,464 - 66,951,243 (+)	NCBI
ROS_Cfam_1.0	7	67,553,912 - 67,563,695 (+)	NCBI
UMICH_Zoey_3.1	7	67,230,668 - 67,240,435 (+)	NCBI
UNSW_CanFamBas_1.0	7	67,242,107 - 67,251,886 (+)	NCBI
UU_Cfam_GSD_1.0	7	67,544,017 - 67,553,794 (+)	NCBI

Sequence:

show sequence

CCACGGCGGCGGGAAAAGAGGCGCGCAGGAAGGCACGGCCCCGCGGCAGCCCGCCGCCCGCCGC
CCGCCCGCCGCCCGCTCTGCCGCCCGCTCTGCCGCCGCCGCCCGCGCCATGCCCGCCCCCGGCT
CCGAGCTGCAGCGCCCGCCGTCGCCGCCCGCCGCGCAGAAGCCGCGCGCCCGGCCGCAGCCGCC
TCCCCACGGGGAGCTGCAGTACCTGGGGCAGGTGGAGCACATCCTGAGCTGCGGGGCCCGGAAG
CACGACCGCACGGGCACGGGCACGCTGTCGGTGTTCGGCATGCAGGCGCGCTACAGCCTGAGAG
ATGAATTTCCTCTGCTGACAACCAAACGTGTATTTTGGAAGGGTGTTTTGGAGGAGTTGCTGTG
GTTTATCAAGGGATCCACAAACGCTAAGGAACTGTCTTCCAGGGGAGTGAAAATCTGGGATGCC
AATGGGTCTCGAGACTTTTTGGACAGCCTGGGATTCGCCAACCGAGAAGAAGGGGATTTAGGCC
CAATTTATGGCTTTCAGTGGAGGCATTTTGGGGCAGAATACAAAGATAAGGATTCAGATTATTC
AGGTCAAGGAGTCGACCAGCTGCAAAAAGTGATTGACACAATCAAAACCAACCCTGACGACAGA
AGAATTATTCTGTGTGGTTGGAATCCAAAAGATCTTCCTCTGATGGCCCTACCTCCGTGCCATG
CCCTCTGCCAGTTCTATGTGGTGAACGGTGAGCTGTCCTGCCAGCTATACCAGAGGTCAGGAGA
CATGGGGCTGGGCGTGCCCTTCAACATCGCCAGCTACGCCCTGCTCACCTACATGATCGCACAC
ATCACAGGCCTGAAGCCAGGTGACTTCATACATACTTTGGGAGATGCGCATATTTACCTGAATC
ACATTGAGCCGCTGAAAATACAGCTGCAGCGAGAACCAAGGCCTTTCCCGAAGCTCAGAATCCT
TCGAAGAGTTGAGAAAATTGATGACTTCAAGGCTGAAGACTTTCAGATCGAGGGGTACAATCCT
CACCCAACTATTAAAATGGAAATGGCTGTGTAAAGTGCTTTTAAAAGAGGTGATATTCAGTCTG
TAGGGGTTGACTGAATGCCCAGGCTTTCACTCCGTTTGCCCTAGAGGGAGGAGGAGGAACTAGG
TCAAAAATCTCTCGTGACCAGCAGCTATTATTCATTAACTTATAAGATGTTGCCACTGGCAAAC
ATAATCTTGTGGCTTCTCTTAGTAACCAAAAGCTTTGAGTTTGGTTGACTCACTAAGGTGTGAA
AGTGCCGAGTTTGGGAATAAAGTCAGGAAAGTGAACACTGAAATACACTTAAAATATGTACATG
CATTTCAATCCGTTTTTATGAAGGTCTGCGAATTTCAAGAATTACACATCAGCTGTTAACCCCA
AATTTGAGCAAGCTGAGGAACACCAGCATTCTTAATGTACAATTGTGGCTATGAACATTTAAAG
TTATTTGCTTTATATATTGTTATAATAAAGGTGTGTATTGCAAAAGTTA

hide sequence

Protein Sequences


Protein RefSeqs	NP_001239103	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAF17556	(Get FASTA)	NCBI Sequence Viewer
	AAF20918	(Get FASTA)	NCBI Sequence Viewer
	CBN68008	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSCAFP00000027096.4
	ENSCAFP00000032342.4
	ENSCAFP00000032347.4
	ENSCAFP00000069383.1
	ENSCAFP00000074523.1
	ENSCAFP00030025321.1
	ENSCAFP00030025342.1
	ENSCAFP00030025390.1
	ENSCAFP00030025485.1
	ENSCAFP00040002366.1
	ENSCAFP00040002374.1
	ENSCAFP00040002387.1
	ENSCAFP00040002410.1
	ENSCAFP00845002679
	ENSCAFP00845002679.1
	ENSCAFP00845002703.1
	ENSCAFP00845002714.1
	ENSCAFP00845002735.1

RefSeq Acc Id:

NP_001239103 ⟸ NM_001252174

- UniProtKB:

A0A8C0KZV3 (UniProtKB/TrEMBL), A0A8C0PYK6 (UniProtKB/TrEMBL), A0A8I3RRU2 (UniProtKB/TrEMBL), A0A8C0PWE5 (UniProtKB/TrEMBL), A0A8I3RRU6 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MPAPGSELQRPPSPPAAQKPRARPQPPPHGELQYLGQVEHILSCGARKHDRTGTGTLSVFGMQA
RYSLRDEFPLLTTKRVFWKGVLEELLWFIKGSTNAKELSSRGVKIWDANGSRDFLDSLGFANRE
EGDLGPIYGFQWRHFGAEYKDKDSDYSGQGVDQLQKVIDTIKTNPDDRRIILCGWNPKDLPLMA
LPPCHALCQFYVVNGELSCQLYQRSGDMGLGVPFNIASYALLTYMIAHITGLKPGDFIHTLGDA
HIYLNHIEPLKIQLQREPRPFPKLRILRRVEKIDDFKAEDFQIEGYNPHPTIKMEMAV

hide sequence

RefSeq Acc Id:

ENSCAFP00000027096 ⟸ ENSCAFT00000029138

RefSeq Acc Id:

ENSCAFP00000032342 ⟸ ENSCAFT00000018205

RefSeq Acc Id:

ENSCAFP00000032347 ⟸ ENSCAFT00000036918

RefSeq Acc Id:

ENSCAFP00845002703 ⟸ ENSCAFT00845003401

RefSeq Acc Id:

ENSCAFP00845002735 ⟸ ENSCAFT00845003450

RefSeq Acc Id:

ENSCAFP00845002679 ⟸ ENSCAFT00845003376

RefSeq Acc Id:

ENSCAFP00845002714 ⟸ ENSCAFT00845003416

Protein Domains

Thymidylate synthase/dCMP hydroxymethylase

Promoters

RGD ID:

13684090

Promoter ID:

EPDNEW_C2159

Type:

initiation region

Name:

TYMS_1

Description:

thymidylate synthetase

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Dog Assembly	Chr	Position (strand)	Source
CanFam3.1	7	67,487,920 - 67,487,980	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSCAFG00000018341	Ensembl, UniProtKB/TrEMBL
	ENSCAFG00030015727	UniProtKB/TrEMBL
	ENSCAFG00040001435	UniProtKB/TrEMBL
	ENSCAFG00845001914	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSCAFT00000018205.5	UniProtKB/TrEMBL
	ENSCAFT00000029138.5	UniProtKB/TrEMBL
	ENSCAFT00000036918.5	UniProtKB/TrEMBL
	ENSCAFT00000098935.1	UniProtKB/TrEMBL
	ENSCAFT00000108160.1	UniProtKB/TrEMBL
	ENSCAFT00030029046.1	UniProtKB/TrEMBL
	ENSCAFT00030029070.1	UniProtKB/TrEMBL
	ENSCAFT00030029124.1	UniProtKB/TrEMBL
	ENSCAFT00030029236.1	UniProtKB/TrEMBL
	ENSCAFT00040002740.1	UniProtKB/TrEMBL
	ENSCAFT00040002747.1	UniProtKB/TrEMBL
	ENSCAFT00040002761.1	UniProtKB/TrEMBL
	ENSCAFT00040002787.1	UniProtKB/TrEMBL
	ENSCAFT00845003376	ENTREZGENE
	ENSCAFT00845003376.1	UniProtKB/TrEMBL
	ENSCAFT00845003401.1	UniProtKB/TrEMBL
	ENSCAFT00845003416.1	UniProtKB/TrEMBL
	ENSCAFT00845003450.1	UniProtKB/TrEMBL
Gene3D-CATH	3.30.572.10	UniProtKB/TrEMBL
InterPro	Thymidate_synth/dCMP_Mease	UniProtKB/TrEMBL
	Thymidate_synth/dCMP_Mease	UniProtKB/TrEMBL
	Thymidate_synth/dCMP_Mease_sf	UniProtKB/TrEMBL
	Thymidylate_synthase	UniProtKB/TrEMBL
	Thymidylate_synthase_AS	UniProtKB/TrEMBL
KEGG Report	cfa:607417	UniProtKB/TrEMBL
NCBI Gene	TYMS	ENTREZGENE
PANTHER	PTHR11548	UniProtKB/TrEMBL
	THYMIDYLATE SYNTHASE	UniProtKB/TrEMBL
Pfam	Thymidylat_synt	UniProtKB/TrEMBL
PRINTS	THYMDSNTHASE	UniProtKB/TrEMBL
PROSITE	THYMIDYLATE_SYNTHASE	UniProtKB/TrEMBL
Superfamily-SCOP	SSF55831	UniProtKB/TrEMBL
UniProt	A0A8C0KZV3	ENTREZGENE
	A0A8C0NDJ8_CANLF	UniProtKB/TrEMBL
	A0A8C0PWE5	ENTREZGENE, UniProtKB/TrEMBL
	A0A8C0PYK6	ENTREZGENE, UniProtKB/TrEMBL
	A0A8C0Q5W9_CANLF	UniProtKB/TrEMBL
	A0A8I3MF02_CANLF	UniProtKB/TrEMBL
	A0A8I3MMV4_CANLF	UniProtKB/TrEMBL
	A0A8I3RRU2	ENTREZGENE, UniProtKB/TrEMBL
	A0A8I3RRU6	ENTREZGENE, UniProtKB/TrEMBL
	A0A8P0TLP7_CANLF	UniProtKB/TrEMBL
VGNC ID	VGNC:48025	ENTREZGENE

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

RGD Manual Annotations

Imported Annotations - SMPDB

Send us a Message

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

RGD Manual Annotations

Imported Annotations - SMPDB