RGD Reference Report - Additive effects of medroxyprogesterone acetate and 5-fluorouracil derivative on 7,12-dimethylbenzanthracene-induced rat mammary tumors. - Rat Genome Database

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Additive effects of medroxyprogesterone acetate and 5-fluorouracil derivative on 7,12-dimethylbenzanthracene-induced rat mammary tumors.

Authors: Sakamoto, S  Hara, Y  Mitamura, T  Sassa, S  Kudo, H  Suzuki, S  Kuwa, K  Okayasu, I  Shinoda, H 
Citation: Sakamoto S, etal., Anticancer Drugs. 1998 Apr;9(4):351-7.
RGD ID: 2315839
Pubmed: PMID:9635926   (View Abstract at PubMed)

Chronic oral administration of 1-(2-tetrahydrofuryl)-5-fluorouracil in combination with uracil suppressed thymidylate synthetase (TS) gene expression followed by reduction of TS activity in rat mammary tumors induced with 7,12-dimethylbenz[a]anthracene. Addition of medroxyprogesterone acetate (MPA) to the anticancer drug caused an additional decrease in TS and thymidine kinase activities in the tumor growth and restoration of bone loss. These results suggest that the simultaneous administration of MPA and anticancer drugs causes increased inhibition of mammary tumor growth and also diminishes the bone loss.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Experimental Mammary Neoplasms  ISOTyms (Rattus norvegicus)2315839; 2315839 RGD 
Experimental Mammary Neoplasms  IMP 2315839 RGD 

Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
response to progesterone  IEP 2315839medroxyprogesterone acetateRGD 

Objects Annotated

Genes (Rattus norvegicus)
Tyms  (thymidylate synthetase)

Genes (Mus musculus)
Tyms  (thymidylate synthase)

Genes (Homo sapiens)
TYMS  (thymidylate synthetase)


Additional Information