AIM2 (absent in melanoma 2) - Rat Genome Database

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Gene: AIM2 (absent in melanoma 2) Pan paniscus
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Symbol: AIM2
Name: absent in melanoma 2
RGD ID: 12037888
Description: ENCODES a protein that exhibits cysteine-type endopeptidase activator activity (inferred); double-stranded DNA binding (inferred); identical protein binding (inferred); INVOLVED IN cellular response to interferon-beta (ortholog); cellular response to xenobiotic stimulus (ortholog); positive regulation of interleukin-1 beta production (ortholog); PARTICIPATES IN interleukin-1 signaling pathway; ASSOCIATED WITH autoimmune interstitial lung, joint, and kidney disease (ortholog); gastrointestinal stromal tumor (ortholog); genetic disease (ortholog); FOUND IN AIM2 inflammasome complex (ortholog); cytoplasm (ortholog); nucleus (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: interferon-inducible protein AIM2
RGD Orthologs
Human
Mouse
Rat
Squirrel
Green Monkey
Alliance Genes
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2190,683,036 - 90,793,080 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1190,420,118 - 90,532,386 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01134,413,232 - 134,540,344 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11138,210,738 - 138,336,219 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1138,210,946 - 138,221,753 (-)Ensemblpanpan1.1panPan2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:30032202  


Genomics

Comparative Map Data
AIM2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2190,683,036 - 90,793,080 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1190,420,118 - 90,532,386 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01134,413,232 - 134,540,344 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11138,210,738 - 138,336,219 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1138,210,946 - 138,221,753 (-)Ensemblpanpan1.1panPan2
AIM2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381159,055,051 - 159,147,132 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1159,061,599 - 159,187,843 (-)EnsemblGRCh38hg38GRCh38
GRCh371159,032,274 - 159,046,556 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361157,298,899 - 157,313,271 (-)NCBINCBI36Build 36hg18NCBI36
Build 341155,845,347 - 155,859,720NCBI
Celera1132,102,542 - 132,116,908 (-)NCBICelera
Cytogenetic Map1q23.1NCBI
HuRef1130,389,543 - 130,403,802 (-)NCBIHuRef
CHM1_11160,427,707 - 160,442,075 (-)NCBICHM1_1
T2T-CHM13v2.01158,193,165 - 158,260,630 (-)NCBIT2T-CHM13v2.0
Aim2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391173,177,105 - 173,293,606 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1173,178,445 - 173,293,606 (+)EnsemblGRCm39 Ensembl
GRCm381173,349,547 - 173,466,040 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1173,350,879 - 173,466,040 (+)EnsemblGRCm38mm10GRCm38
MGSCv371175,350,735 - 175,396,171 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361175,298,822 - 175,302,715 (+)NCBIMGSCv36mm8
Celera1176,275,753 - 176,321,623 (+)NCBICelera
Cytogenetic Map1H3NCBI
cM Map180.33NCBI
Aim2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81388,397,516 - 88,439,325 (+)NCBIGRCr8
mRatBN7.21385,865,206 - 85,906,996 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1385,866,284 - 85,906,975 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.01391,919,834 - 91,963,080 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1391,954,138 - 91,962,588 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01396,436,637 - 96,478,372 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41389,631,797 - 89,640,265 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11389,820,680 - 89,826,398 (+)NCBI
Celera1385,466,773 - 85,510,053 (+)NCBICelera
Cytogenetic Map13q24NCBI
Aim2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244050585,293,355 - 5,440,024 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049367401,451,001 - 1,460,836 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049367401,447,869 - 1,460,836 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
AIM2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1204,759,746 - 4,884,460 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl204,873,008 - 4,884,764 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660383,907,037 - 4,044,542 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts XM_003820978 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008974458 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_024929370 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_034938222 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_034938225 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_034938235 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_034938240 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_055112813 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_055112815 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_055112817 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_055112819 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_055112822 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_055112827 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_055112828 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_055112830 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_055112832 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063598923 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063598925 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide JARIFH020000001 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

RefSeq Acc Id: ENSPPAT00000050248   ⟹   ENSPPAP00000027408
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1138,210,946 - 138,221,753 (-)Ensembl
RefSeq Acc Id: XM_003820978   ⟹   XP_003821026
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2190,778,698 - 90,793,080 (+)NCBI
NHGRI_mPanPan1190,516,034 - 90,532,386 (+)NCBI
Mhudiblu_PPA_v01134,413,232 - 134,427,600 (-)NCBI
PanPan1.11138,210,738 - 138,225,105 (-)NCBI
Sequence:
RefSeq Acc Id: XM_034938225   ⟹   XP_034794116
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2190,708,062 - 90,793,080 (+)NCBI
NHGRI_mPanPan1190,445,294 - 90,532,386 (+)NCBI
Mhudiblu_PPA_v01134,413,232 - 134,473,366 (-)NCBI
RefSeq Acc Id: XM_055112813   ⟹   XP_054968788
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2190,683,036 - 90,793,080 (+)NCBI
NHGRI_mPanPan1190,420,118 - 90,532,386 (+)NCBI
RefSeq Acc Id: XM_055112815   ⟹   XP_054968790
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2190,713,206 - 90,793,080 (+)NCBI
NHGRI_mPanPan1190,450,439 - 90,532,386 (+)NCBI
RefSeq Acc Id: XM_055112817   ⟹   XP_054968792
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2190,683,036 - 90,793,080 (+)NCBI
NHGRI_mPanPan1190,420,118 - 90,532,386 (+)NCBI
RefSeq Acc Id: XM_055112819   ⟹   XP_054968794
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2190,708,044 - 90,793,080 (+)NCBI
NHGRI_mPanPan1190,445,276 - 90,532,386 (+)NCBI
RefSeq Acc Id: XM_055112822   ⟹   XP_054968797
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2190,708,044 - 90,793,080 (+)NCBI
NHGRI_mPanPan1190,445,276 - 90,532,386 (+)NCBI
RefSeq Acc Id: XM_055112827   ⟹   XP_054968802
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2190,708,256 - 90,793,080 (+)NCBI
NHGRI_mPanPan1190,445,488 - 90,532,386 (+)NCBI
RefSeq Acc Id: XM_055112828   ⟹   XP_054968803
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2190,708,062 - 90,793,080 (+)NCBI
NHGRI_mPanPan1190,445,294 - 90,532,386 (+)NCBI
RefSeq Acc Id: XM_055112830   ⟹   XP_054968805
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2190,781,275 - 90,793,080 (+)NCBI
NHGRI_mPanPan1190,518,505 - 90,532,386 (+)NCBI
RefSeq Acc Id: XM_055112832   ⟹   XP_054968807
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2190,770,337 - 90,793,080 (+)NCBI
NHGRI_mPanPan1190,507,576 - 90,532,386 (+)NCBI
RefSeq Acc Id: XM_063598923   ⟹   XP_063454993
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2190,778,796 - 90,793,080 (+)NCBI
RefSeq Acc Id: XM_063598925   ⟹   XP_063454995
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2190,778,796 - 90,793,080 (+)NCBI
RefSeq Acc Id: XP_003821026   ⟸   XM_003820978
- Peptide Label: isoform X1
- UniProtKB: A0A2R9BCP0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_034794116   ⟸   XM_034938225
- Peptide Label: isoform X1
- UniProtKB: A0A2R9BCP0 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSPPAP00000027408   ⟸   ENSPPAT00000050248
RefSeq Acc Id: XP_054968792   ⟸   XM_055112817
- Peptide Label: isoform X1
RefSeq Acc Id: XP_054968788   ⟸   XM_055112813
- Peptide Label: isoform X1
RefSeq Acc Id: XP_054968794   ⟸   XM_055112819
- Peptide Label: isoform X1
RefSeq Acc Id: XP_054968797   ⟸   XM_055112822
- Peptide Label: isoform X1
RefSeq Acc Id: XP_054968803   ⟸   XM_055112828
- Peptide Label: isoform X1
RefSeq Acc Id: XP_054968802   ⟸   XM_055112827
- Peptide Label: isoform X1
RefSeq Acc Id: XP_054968790   ⟸   XM_055112815
- Peptide Label: isoform X1
RefSeq Acc Id: XP_054968807   ⟸   XM_055112832
- Peptide Label: isoform X1
RefSeq Acc Id: XP_054968805   ⟸   XM_055112830
- Peptide Label: isoform X1
RefSeq Acc Id: XP_063454993   ⟸   XM_063598923
- Peptide Label: isoform X2
RefSeq Acc Id: XP_063454995   ⟸   XM_063598925
- Peptide Label: isoform X3
Protein Domains
HIN-200   Pyrin


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000036780 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000050248.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.533.10 UniProtKB/TrEMBL
  2.40.50.140 UniProtKB/TrEMBL
InterPro DAPIN UniProtKB/TrEMBL
  DEATH-like_dom_sf UniProtKB/TrEMBL
  HIN-200 UniProtKB/TrEMBL
  HIN200/IF120x UniProtKB/TrEMBL
  NA-bd_OB-fold UniProtKB/TrEMBL
NCBI Gene AIM2 ENTREZGENE
PANTHER INTERFERON-INDUCIBLE PROTEIN AIM2 UniProtKB/TrEMBL
  PTHR12200 UniProtKB/TrEMBL
Pfam HIN UniProtKB/TrEMBL
  PYRIN UniProtKB/TrEMBL
PROSITE DAPIN UniProtKB/TrEMBL
  HIN_200 UniProtKB/TrEMBL
SMART PYRIN UniProtKB/TrEMBL
Superfamily-SCOP HIN-2000 domain-like UniProtKB/TrEMBL
  SSF47986 UniProtKB/TrEMBL
UniProt A0A2R9BCP0 ENTREZGENE, UniProtKB/TrEMBL