Aim2 (absent in melanoma 2) - Rat Genome Database

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Gene: Aim2 (absent in melanoma 2) Rattus norvegicus
Analyze
Symbol: Aim2
Name: absent in melanoma 2
RGD ID: 1307283
Description: Predicted to enable several functions, including cysteine-type endopeptidase activator activity; identical protein binding activity; and signaling adaptor activity. Predicted to be involved in several processes, including cellular response to cytokine stimulus; protein-containing complex assembly; and regulation of defense response. Predicted to act upstream of or within cellular response to xenobiotic stimulus and positive regulation of interleukin-1 beta production. Predicted to be located in mitochondrion. Predicted to be part of AIM2 inflammasome complex. Predicted to be active in cytosol; nucleoplasm; and site of double-strand break. Orthologous to human AIM2 (absent in melanoma 2); PARTICIPATES IN interleukin-1 signaling pathway; INTERACTS WITH 17beta-estradiol; 17beta-estradiol 3-benzoate; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: interferon-inducible protein AIM2; LOC304987
RGD Orthologs
Human
Mouse
Bonobo
Squirrel
Green Monkey
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81388,397,516 - 88,439,325 (+)NCBIGRCr8
mRatBN7.21385,865,206 - 85,906,996 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1385,866,284 - 85,906,975 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.01391,919,834 - 91,963,080 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1391,954,138 - 91,962,588 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01396,436,637 - 96,478,372 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41389,631,797 - 89,640,265 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11389,820,680 - 89,826,398 (+)NCBI
Celera1385,466,773 - 85,510,053 (+)NCBICelera
Cytogenetic Map13q24NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
4. Comprehensive gene review and curation RGD comprehensive gene curation
5. The inflammasomes. Schroder K and Tschopp J, Cell. 2010 Mar 19;140(6):821-32. doi: 10.1016/j.cell.2010.01.040.
Additional References at PubMed
PMID:15896773   PMID:16432157   PMID:19131592   PMID:19158675   PMID:19158676   PMID:19158679   PMID:23567559   PMID:23997220   PMID:24531343   PMID:24630722   PMID:31794744   PMID:32645874  
PMID:34117866   PMID:36622632  


Genomics

Comparative Map Data
Aim2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81388,397,516 - 88,439,325 (+)NCBIGRCr8
mRatBN7.21385,865,206 - 85,906,996 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1385,866,284 - 85,906,975 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.01391,919,834 - 91,963,080 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1391,954,138 - 91,962,588 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01396,436,637 - 96,478,372 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41389,631,797 - 89,640,265 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11389,820,680 - 89,826,398 (+)NCBI
Celera1385,466,773 - 85,510,053 (+)NCBICelera
Cytogenetic Map13q24NCBI
AIM2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381159,055,051 - 159,147,132 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1159,061,599 - 159,187,843 (-)EnsemblGRCh38hg38GRCh38
GRCh371159,032,274 - 159,046,556 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361157,298,899 - 157,313,271 (-)NCBINCBI36Build 36hg18NCBI36
Build 341155,845,347 - 155,859,720NCBI
Celera1132,102,542 - 132,116,908 (-)NCBICelera
Cytogenetic Map1q23.1NCBI
HuRef1130,389,543 - 130,403,802 (-)NCBIHuRef
CHM1_11160,427,707 - 160,442,075 (-)NCBICHM1_1
T2T-CHM13v2.01158,193,165 - 158,260,630 (-)NCBIT2T-CHM13v2.0
Aim2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391173,177,105 - 173,293,606 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1173,178,445 - 173,293,606 (+)EnsemblGRCm39 Ensembl
GRCm381173,349,547 - 173,466,040 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1173,350,879 - 173,466,040 (+)EnsemblGRCm38mm10GRCm38
MGSCv371175,350,735 - 175,396,171 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361175,298,822 - 175,302,715 (+)NCBIMGSCv36mm8
Celera1176,275,753 - 176,321,623 (+)NCBICelera
Cytogenetic Map1H3NCBI
cM Map180.33NCBI
AIM2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2190,683,036 - 90,793,080 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1190,420,118 - 90,532,386 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01134,413,232 - 134,540,344 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11138,210,738 - 138,336,219 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1138,210,946 - 138,221,753 (-)Ensemblpanpan1.1panPan2
Aim2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244050585,293,355 - 5,440,024 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049367401,451,001 - 1,460,836 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049367401,447,869 - 1,460,836 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
AIM2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1204,759,746 - 4,884,460 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl204,873,008 - 4,884,764 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660383,907,037 - 4,044,542 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Variants

.
Variants in Aim2
160 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:79
Count of miRNA genes:65
Interacting mature miRNAs:72
Transcripts:ENSRNOT00000037655, ENSRNOT00000074608
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)131101056920Rat
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)131101056920Rat
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)131101056920Rat
1581570Eae17Experimental allergic encephalomyelitis QTL 174.1nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)138897350101631289Rat
7207885Glom27Glomerulus QTL 273.9kidney glomerulus integrity trait (VT:0010546)kidney crescentic glomeruli count to kidney normal glomeruli count ratio (CMO:0002139)1320605871101339738Rat
1354621Rf47Renal function QTL 473.7kidney renin amount (VT:0010559)kidney renin level (CMO:0002166)1330395351101056920Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)133124133193395974Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133124133193395974Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)133124133193395974Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)133124133193395974Rat
12879444Bp397Blood pressure QTL 397arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)134504940490049404Rat
12879471Bp398Blood pressure QTL 398arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)134551471990514719Rat
12879441Bp396Blood pressure QTL 396arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)134569998390699983Rat
1298066Bp159Blood pressure QTL 1590.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134608804691088046Rat
1641901Alcrsp6Alcohol response QTL 6response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)135236217197362171Rat
1354655Bp241Blood pressure QTL 2413.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1356056920101056920Rat
12879475Bp400Blood pressure QTL 400arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1361825626106807694Rat
2293702Bss34Bone structure and strength QTL 344.610.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1365103704106807694Rat
2293687Bss26Bone structure and strength QTL 264.60.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)1365103704106807694Rat
8655945Rf61Renal function QTL 613.6blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)136906051986800898Rat
1331783Bp221Blood pressure QTL 2213.72886arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)136906051986800898Rat
1300166Kidm6Kidney mass QTL 63.93kidney mass (VT:0002707)single kidney wet weight to body weight ratio (CMO:0000622)136906051986800898Rat
8655959Pur32Proteinuria QTL 328.4urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)137402391897213863Rat
2293341Glom15Glomerulus QTL 159.1kidney glomerulus integrity trait (VT:0010546)kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)1374862117101339893Rat
4889606Gluco63Glucose level QTL 632.860.003blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1380753256106807694Rat
1302791Stl29Serum triglyceride level QTL 293.30.0011blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)138473078886800898Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 2 8 19 2
Low 1 14 45 38 38 3 3 72 17 27 11 3
Below cutoff 25 4 3 3 5 7 18 13 5

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001427493 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_001057147 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006221556 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006221557 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006250335 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006250336 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008763559 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008763561 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008763566 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008769802 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008769805 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017599003 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017604652 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039091426 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039091427 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063272376 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_222949 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide JAXUCZ010000013 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000037655   ⟹   ENSRNOP00000033110
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1385,866,284 - 85,906,975 (+)Ensembl
Rnor_6.0 Ensembl1391,954,138 - 91,962,588 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000074608   ⟹   ENSRNOP00000065557
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1391,954,138 - 91,959,810 (+)Ensembl
RefSeq Acc Id: NM_001427493   ⟹   NP_001414422
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81388,398,622 - 88,439,318 (+)NCBI
RefSeq Acc Id: XM_006250336   ⟹   XP_006250398
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81388,402,897 - 88,439,325 (+)NCBI
mRatBN7.21385,870,036 - 85,906,996 (+)NCBI
Rnor_6.01391,919,834 - 91,963,080 (+)NCBI
Rnor_5.01396,436,637 - 96,478,372 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008769802   ⟹   XP_008768024
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81388,409,964 - 88,439,325 (+)NCBI
mRatBN7.21385,877,640 - 85,906,996 (+)NCBI
Rnor_6.01391,936,173 - 91,963,080 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039091426   ⟹   XP_038947354
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81388,397,516 - 88,439,325 (+)NCBI
mRatBN7.21385,865,206 - 85,906,996 (+)NCBI
RefSeq Acc Id: XM_039091427   ⟹   XP_038947355
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81388,434,583 - 88,439,325 (+)NCBI
mRatBN7.21385,902,253 - 85,906,996 (+)NCBI
RefSeq Acc Id: XM_063272376   ⟹   XP_063128446
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81388,402,895 - 88,439,325 (+)NCBI
RefSeq Acc Id: XM_222949   ⟹   XP_222949
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81388,397,516 - 88,439,325 (+)NCBI
mRatBN7.21385,865,206 - 85,906,996 (+)NCBI
Rnor_6.01391,919,834 - 91,963,080 (+)NCBI
Rnor_5.01396,436,637 - 96,478,372 (+)NCBI
RGSC_v3.41389,631,797 - 89,640,265 (+)RGD
Sequence:
Reference Protein Sequences
RefSeq Acc Id: XP_222949   ⟸   XM_222949
- Peptide Label: isoform X1
- UniProtKB: D4A9W0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006250398   ⟸   XM_006250336
- Peptide Label: isoform X1
- UniProtKB: D4A9W0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008768024   ⟸   XM_008769802
- Peptide Label: isoform X1
- UniProtKB: D4A9W0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000033110   ⟸   ENSRNOT00000037655
RefSeq Acc Id: ENSRNOP00000065557   ⟸   ENSRNOT00000074608
RefSeq Acc Id: XP_038947354   ⟸   XM_039091426
- Peptide Label: isoform X1
- UniProtKB: D4A9W0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038947355   ⟸   XM_039091427
- Peptide Label: isoform X2
RefSeq Acc Id: NP_001414422   ⟸   NM_001427493
- UniProtKB: D4A9W0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063128446   ⟸   XM_063272376
- Peptide Label: isoform X1
- UniProtKB: D4A9W0 (UniProtKB/TrEMBL)
Protein Domains
HIN-200   Pyrin

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D4A9W0-F1-model_v2 AlphaFold D4A9W0 1-356 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1307283 AgrOrtholog
BioCyc Gene G2FUF-17274 BioCyc
Ensembl Genes ENSRNOG00000003480 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000037655.8 UniProtKB/TrEMBL
Gene3D-CATH 1.10.533.10 UniProtKB/TrEMBL
  2.40.50.140 UniProtKB/TrEMBL
InterPro DAPIN UniProtKB/TrEMBL
  DEATH-like_dom UniProtKB/TrEMBL
  HIN-200 UniProtKB/TrEMBL
  HIN200/IF120x UniProtKB/TrEMBL
  NA-bd_OB-fold UniProtKB/TrEMBL
KEGG Report rno:304987 UniProtKB/TrEMBL
NCBI Gene 304987 ENTREZGENE
PANTHER INTERFERON-INDUCIBLE PROTEIN AIM2 UniProtKB/TrEMBL
  PTHR12200 UniProtKB/TrEMBL
Pfam HIN UniProtKB/TrEMBL
  PYRIN UniProtKB/TrEMBL
PhenoGen Aim2 PhenoGen
PROSITE DAPIN UniProtKB/TrEMBL
  HIN_200 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000003480 RatGTEx
SMART PYRIN UniProtKB/TrEMBL
Superfamily-SCOP DEATH_like UniProtKB/TrEMBL
  HIN-2000 domain-like UniProtKB/TrEMBL
UniProt D4A9W0 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-04-30 Aim2  absent in melanoma 2   Aim2_predicted  absent in melanoma 2 (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Aim2_predicted  absent in melanoma 2 (predicted)      Symbol and Name status set to approved 70820 APPROVED