FURIN (furin, paired basic amino acid cleaving enzyme) - Rat Genome Database

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Gene: FURIN (furin, paired basic amino acid cleaving enzyme) Pan paniscus
Analyze
Symbol: FURIN
Name: furin, paired basic amino acid cleaving enzyme
RGD ID: 11852929
Description: ENCODES a protein that exhibits serine-type endopeptidase activity (ortholog); INVOLVED IN negative regulation of nerve growth factor production (ortholog); positive regulation of cell migration (ortholog); positive regulation of transforming growth factor beta receptor signaling pathway (ortholog); PARTICIPATES IN glypican signaling pathway; hypoxia inducible factor pathway; Notch signaling pathway; ASSOCIATED WITH Animal Mammary Neoplasms (ortholog); arteriosclerosis (ortholog); Bloom syndrome (ortholog); FOUND IN endoplasmic reticulum membrane (ortholog); extracellular space (ortholog); Golgi cisterna (ortholog)
Type: protein-coding
RefSeq Status: MODEL
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21680,423,872 - 80,436,846 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11584,121,785 - 84,134,845 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01569,560,774 - 69,576,007 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11588,759,729 - 88,774,023 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1588,763,269 - 88,774,023 (+)Ensemblpanpan1.1panPan2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
FURIN
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21680,423,872 - 80,436,846 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11584,121,785 - 84,134,845 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01569,560,774 - 69,576,007 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11588,759,729 - 88,774,023 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1588,763,269 - 88,774,023 (+)Ensemblpanpan1.1panPan2
FURIN
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381590,868,588 - 90,883,457 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1590,868,588 - 90,883,564 (+)EnsemblGRCh38hg38GRCh38
GRCh371591,411,818 - 91,426,687 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361589,212,889 - 89,227,691 (+)NCBINCBI36Build 36hg18NCBI36
Build 341589,212,888 - 89,227,691NCBI
Celera1567,820,515 - 67,835,658 (+)NCBICelera
Cytogenetic Map15q26.1NCBI
HuRef1567,523,022 - 67,538,192 (+)NCBIHuRef
CHM1_11591,253,454 - 91,268,261 (+)NCBICHM1_1
T2T-CHM13v2.01588,627,830 - 88,643,054 (+)NCBIT2T-CHM13v2.0
Furin
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39780,038,942 - 80,055,188 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl780,038,333 - 80,055,184 (-)EnsemblGRCm39 Ensembl
GRCm38780,389,194 - 80,405,441 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl780,388,585 - 80,405,436 (-)EnsemblGRCm38mm10GRCm38
MGSCv37787,534,080 - 87,550,317 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36780,262,709 - 80,276,275 (-)NCBIMGSCv36mm8
Celera777,789,167 - 77,805,351 (-)NCBICelera
Cytogenetic Map7D2NCBI
cM Map745.65NCBI
Furin
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81143,757,389 - 143,770,430 (-)NCBIGRCr8
mRatBN7.21134,348,142 - 134,361,182 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1134,348,144 - 134,364,314 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1142,257,013 - 142,269,107 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01149,426,407 - 149,438,502 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01142,344,416 - 142,356,506 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01142,185,092 - 142,198,167 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1142,185,094 - 142,197,182 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01143,137,721 - 143,153,628 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41136,209,969 - 136,222,057 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11136,288,374 - 136,300,463NCBI
Celera1126,407,744 - 126,419,832 (-)NCBICelera
RH 3.4 Map11074.0RGD
Cytogenetic Map1q31NCBI
Furin
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541614,936,546 - 14,949,252 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541614,915,031 - 14,947,634 (+)NCBIChiLan1.0ChiLan1.0
FURIN
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1353,357,491 - 53,368,285 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl353,358,045 - 53,365,423 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha355,995,115 - 56,006,746 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0353,773,528 - 53,785,153 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl353,773,530 - 53,785,145 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1353,292,643 - 53,304,269 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0353,503,862 - 53,515,505 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0353,844,352 - 53,855,974 (-)NCBIUU_Cfam_GSD_1.0
Furin
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640130,182,463 - 130,198,421 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648316,136,099 - 16,144,635 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493648316,136,099 - 16,147,945 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FURIN
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl753,460,017 - 53,472,787 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1753,455,634 - 53,472,791 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2758,486,815 - 58,503,979 (+)NCBISscrofa10.2Sscrofa10.2susScr3
FURIN
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1298,980,367 - 8,992,257 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl298,979,720 - 8,988,235 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605937,732,423 - 37,745,148 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Furin
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476817,371,628 - 17,387,881 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462476817,372,754 - 17,387,732 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSPPAT00000045291   ⟹   ENSPPAP00000022481
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1588,763,269 - 88,774,023 (+)Ensembl
RefSeq Acc Id: XM_034939430   ⟹   XP_034795321
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21680,424,828 - 80,436,846 (+)NCBI
NHGRI_mPanPan11584,122,847 - 84,134,845 (+)NCBI
Mhudiblu_PPA_v01569,564,008 - 69,576,007 (+)NCBI
RefSeq Acc Id: XM_034939431   ⟹   XP_034795322
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21680,425,293 - 80,436,846 (+)NCBI
NHGRI_mPanPan11584,123,297 - 84,134,845 (+)NCBI
Mhudiblu_PPA_v01569,564,634 - 69,576,007 (+)NCBI
RefSeq Acc Id: XM_057299866   ⟹   XP_057155849
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21680,423,872 - 80,436,846 (+)NCBI
NHGRI_mPanPan11584,121,785 - 84,134,845 (+)NCBI
Protein Sequences
Protein RefSeqs XP_034795321 (Get FASTA)   NCBI Sequence Viewer  
  XP_034795322 (Get FASTA)   NCBI Sequence Viewer  
  XP_057155849 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSPPAP00000022481.1
Reference Protein Sequences
RefSeq Acc Id: XP_034795321   ⟸   XM_034939430
- UniProtKB: A0A2R9B4W5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_034795322   ⟸   XM_034939431
- UniProtKB: A0A2R9B4W5 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSPPAP00000022481   ⟸   ENSPPAT00000045291
RefSeq Acc Id: XP_057155849   ⟸   XM_057299866
- UniProtKB: A0A2R9B4W5 (UniProtKB/TrEMBL)
Protein Domains
P/Homo B


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000034430 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000045291.1 UniProtKB/TrEMBL
Gene3D-CATH 3.30.70.850 UniProtKB/TrEMBL
  3.40.50.200 UniProtKB/TrEMBL
  Galactose-binding domain-like UniProtKB/TrEMBL
InterPro Furin_repeat UniProtKB/TrEMBL
  Galactose-bd-like_sf UniProtKB/TrEMBL
  Growth_fac_rcpt_cys_sf UniProtKB/TrEMBL
  Kexin/furin UniProtKB/TrEMBL
  P_dom UniProtKB/TrEMBL
  Peptidase_S8/S53_dom UniProtKB/TrEMBL
  Peptidase_S8/S53_dom_sf UniProtKB/TrEMBL
  Peptidase_S8_Asp-AS UniProtKB/TrEMBL
  Peptidase_S8_His-AS UniProtKB/TrEMBL
  Peptidase_S8_Ser-AS UniProtKB/TrEMBL
  Peptidase_S8_subtilisin-rel UniProtKB/TrEMBL
  S8_pro-domain UniProtKB/TrEMBL
  S8_pro-domain_sf UniProtKB/TrEMBL
KEGG Report pps:100978848 UniProtKB/TrEMBL
NCBI Gene FURIN ENTREZGENE
PANTHER FURIN UniProtKB/TrEMBL
  PROPROTEIN CONVERTASE SUBTILISIN/KEXIN-RELATED UniProtKB/TrEMBL
Pfam P_proprotein UniProtKB/TrEMBL
  Peptidase_S8 UniProtKB/TrEMBL
  S8_pro-domain UniProtKB/TrEMBL
PRINTS SUBTILISIN UniProtKB/TrEMBL
PROSITE P_HOMO_B UniProtKB/TrEMBL
  SUBTILASE UniProtKB/TrEMBL
  SUBTILASE_ASP UniProtKB/TrEMBL
  SUBTILASE_HIS UniProtKB/TrEMBL
  SUBTILASE_SER UniProtKB/TrEMBL
SMART SM00261 UniProtKB/TrEMBL
Superfamily-SCOP Protease propeptides/inhibitors UniProtKB/TrEMBL
  SSF49785 UniProtKB/TrEMBL
  SSF52743 UniProtKB/TrEMBL
  SSF57184 UniProtKB/TrEMBL
UniProt A0A2R9B4W5 ENTREZGENE, UniProtKB/TrEMBL