GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Parp1 | affects cleavage | ISO | PARP1 (Homo sapiens) | 6480464 | CTD | dimethyl sulfone affects the cleavage of PARP1 protein | PMID:32562081 | Parp1 | increases expression | ISO | PARP1 (Homo sapiens) | 6480464 | CTD | dimethyl sulfone results in increased expression of PARP1 mRNA | PMID:32562081 | Parp1 | multiple interactions | ISO | PARP1 (Homo sapiens) | 6480464 | CTD | [Doxorubicin co-treated with dimethyl sulfone] results in increased expression of PARP1 mRNA; dimethyl sulfone affects the reaction [Doxorubicin results in increased cleavage of PARP1 protein]; dimethyl sulfone promotes the reaction [Doxorubicin results in increased expression of PARP1 mRNA]; Doxorubicin affects the reaction [dimethyl sulfone results in increased cleavage of PARP1 protein] | PMID:32562081 | | ||||||||||||||||||||||
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