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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3772
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Stat3
Name: signal transducer and activator of transcription 3
Acc ID: CHEBI:83784
Term: galaxolide
Definition: An organic heterotricyclic compound that is 1,3,4,6,7,8-hexahydrocyclopenta[g]isochromene substituted by methyl groups at positions 4, 6, 6, 7, 8 and 8 respectively. It is a synthetic musk used as a fragrance in cosmetics.
Chemical ID: MESH:C033119
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Stat3increases expressionISOSTAT3 (Homo sapiens)6480464CTDgalaxolide results in increased expression of STAT3 mRNAPMID:34687775
Stat3multiple interactionsISOSTAT3 (Homo sapiens)6480464CTD[galaxolide co-treated with acetyl methyl tetramethyl tetralin] results in increased expression of STAT3 mRNAPMID:34687775
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